Chr Mutation (hg38) CAid Gene Transcript Linkouts
2g.25234280_25234293dupCA2658167808DNMT3Ac.974_987dup
c.1871_1884dup (n.1871_1884dup)
c.2056_2069dup (p.Ter690TyrextTer14)
c.2725_2738dup (p.Ter913TyrextTer14)
c.2158_2171dup (p.Ter724TyrextTer14)
c.*578_*591dup (n.*578_*591dup)
c.2281_2294dup (p.Ter765TyrextTer14)
c.2578_2591dup (p.Ter864TyrextTer14)
c.2560_2573dup (p.Ter858TyrextTer14)
c.2269_2282dup (p.Ter761TyrextTer14)
c.2197_2210dup (p.Ter737TyrextTer14)
n.3262_3275dup
n.2932_2945dup
n.3155_3168dup
 gnomAD v4
2g.25234287_25234288delCA2523588083DNMT3Ac.985_986del
c.1882_1883del (n.1882_1883del)
c.2067_2068del (p.Ter690ArgextTer7)
c.2736_2737del (p.Ter913ArgextTer7)
c.2169_2170del (p.Ter724ArgextTer7)
c.*589_*590del (n.*589_*590del)
c.2292_2293del (p.Ter765ArgextTer7)
c.2589_2590del (p.Ter864ArgextTer7)
c.2571_2572del (p.Ter858ArgextTer7)
c.2280_2281del (p.Ter761ArgextTer7)
c.2208_2209del (p.Ter737ArgextTer7)
n.3273_3274del
n.2943_2944del
n.3166_3167del
 ClinVar dbSNP
2g.25234283A>CCA346067995DNMT3Ac.984T>G
c.1881T>G (n.1881T>G)
c.2066T>G (p.Val689Gly)
c.2735T>G (p.Val912Gly)
c.2168T>G (p.Val723Gly)
c.*588T>G (n.*588T>G)
c.2291T>G (p.Val764Gly)
c.2588T>G (p.Val863Gly)
c.2570T>G (p.Val857Gly)
c.2279T>G (p.Val760Gly)
c.2207T>G (p.Val736Gly)
n.3272T>G
n.2942T>G
n.3165T>G
2g.25234283A>GCA346067996DNMT3Ac.984T>C
c.1881T>C (n.1881T>C)
c.2066T>C (p.Val689Ala)
c.2735T>C (p.Val912Ala)
c.2168T>C (p.Val723Ala)
c.*588T>C (n.*588T>C)
c.2291T>C (p.Val764Ala)
c.2588T>C (p.Val863Ala)
c.2570T>C (p.Val857Ala)
c.2279T>C (p.Val760Ala)
c.2207T>C (p.Val736Ala)
n.3272T>C
n.2942T>C
n.3165T>C
2g.25234283A>TCA346067997DNMT3Ac.984T>A
c.1881T>A (n.1881T>A)
c.2066T>A (p.Val689Glu)
c.2735T>A (p.Val912Glu)
c.2168T>A (p.Val723Glu)
c.*588T>A (n.*588T>A)
c.2291T>A (p.Val764Glu)
c.2588T>A (p.Val863Glu)
c.2570T>A (p.Val857Glu)
c.2279T>A (p.Val760Glu)
c.2207T>A (p.Val736Glu)
n.3272T>A
n.2942T>A
n.3165T>A
2g.25234283_25234289dupCA2658167813DNMT3Ac.978_984dup
c.1875_1881dup (n.1875_1881dup)
c.2060_2066dup (p.Ter690ValextTer10)
c.2729_2735dup (p.Ter913ValextTer10)
c.2162_2168dup (p.Ter724ValextTer10)
c.*582_*588dup (n.*582_*588dup)
c.2285_2291dup (p.Ter765ValextTer10)
c.2582_2588dup (p.Ter864ValextTer10)
c.2564_2570dup (p.Ter858ValextTer10)
c.2273_2279dup (p.Ter761ValextTer10)
c.2201_2207dup (p.Ter737ValextTer10)
n.3266_3272dup
n.2936_2942dup
n.3159_3165dup
 gnomAD v4
2g.25234284C>ACA346067998DNMT3Ac.983G>T
c.1880G>T (n.1880G>T)
c.2065G>T (p.Val689Leu)
c.2734G>T (p.Val912Leu)
c.2167G>T (p.Val723Leu)
c.*587G>T (n.*587G>T)
c.2290G>T (p.Val764Leu)
c.2587G>T (p.Val863Leu)
c.2569G>T (p.Val857Leu)
c.2278G>T (p.Val760Leu)
c.2206G>T (p.Val736Leu)
n.3271G>T
n.2941G>T
n.3164G>T
2g.25234284C>GCA346067999DNMT3Ac.983G>C
c.1880G>C (n.1880G>C)
c.2065G>C (p.Val689Leu)
c.2734G>C (p.Val912Leu)
c.2167G>C (p.Val723Leu)
c.*587G>C (n.*587G>C)
c.2290G>C (p.Val764Leu)
c.2587G>C (p.Val863Leu)
c.2569G>C (p.Val857Leu)
c.2278G>C (p.Val760Leu)
c.2206G>C (p.Val736Leu)
n.3271G>C
n.2941G>C
n.3164G>C
2g.25234284C>TCA346068000DNMT3Ac.983G>A
c.1880G>A (n.1880G>A)
c.2065G>A (p.Val689Met)
c.2734G>A (p.Val912Met)
c.2167G>A (p.Val723Met)
c.*587G>A (n.*587G>A)
c.2290G>A (p.Val764Met)
c.2587G>A (p.Val863Met)
c.2569G>A (p.Val857Met)
c.2278G>A (p.Val760Met)
c.2206G>A (p.Val736Met)
n.3271G>A
n.2941G>A
n.3164G>A
 dbSNP
2g.25234284_25234287delinsCACACA1239260230DNMT3Ac.980_983delinsTGTG
c.1877_1880delinsTGTG (n.1877_1880delinsTGTG)
c.2062_2065delinsTGTG (p.Cys688=)
c.2731_2734delinsTGTG (p.Cys911=)
c.2164_2167delinsTGTG (p.Cys722=)
c.*584_*587delinsTGTG (n.*584_*587delinsTGTG)
c.2287_2290delinsTGTG (p.Cys763=)
c.2584_2587delinsTGTG (p.Cys862=)
c.2566_2569delinsTGTG (p.Cys856=)
c.2275_2278delinsTGTG (p.Cys759=)
c.2203_2206delinsTGTG (p.Cys735=)
n.3268_3271delinsTGTG
n.2938_2941delinsTGTG
n.3161_3164delinsTGTG
2g.25234285A>CCA346068002DNMT3Ac.982T>G
c.1879T>G (n.1879T>G)
c.2064T>G (p.Cys688Trp)
c.2733T>G (p.Cys911Trp)
c.2166T>G (p.Cys722Trp)
c.*586T>G (n.*586T>G)
c.2289T>G (p.Cys763Trp)
c.2586T>G (p.Cys862Trp)
c.2568T>G (p.Cys856Trp)
c.2277T>G (p.Cys759Trp)
c.2205T>G (p.Cys735Trp)
n.3270T>G
n.2940T>G
n.3163T>G
2g.25234285A>GCA425180825DNMT3Ac.982T>C
c.1879T>C (n.1879T>C)
c.2064T>C (p.Cys688=)
c.2733T>C (p.Cys911=)
c.2166T>C (p.Cys722=)
c.*586T>C (n.*586T>C)
c.2289T>C (p.Cys763=)
c.2586T>C (p.Cys862=)
c.2568T>C (p.Cys856=)
c.2277T>C (p.Cys759=)
c.2205T>C (p.Cys735=)
n.3270T>C
n.2940T>C
n.3163T>C
2g.25234285A>TCA346068001DNMT3Ac.982T>A
c.1879T>A (n.1879T>A)
c.2064T>A (p.Cys688Ter)
c.2733T>A (p.Cys911Ter)
c.2166T>A (p.Cys722Ter)
c.*586T>A (n.*586T>A)
c.2289T>A (p.Cys763Ter)
c.2586T>A (p.Cys862Ter)
c.2568T>A (p.Cys856Ter)
c.2277T>A (p.Cys759Ter)
c.2205T>A (p.Cys735Ter)
n.3270T>A
n.2940T>A
n.3163T>A
2g.25234285_25234287delCA1239260231DNMT3Ac.980_982del
c.1877_1879del (n.1877_1879del)
c.2062_2064del (p.Cys688del)
c.2731_2733del (p.Cys911del)
c.2164_2166del (p.Cys722del)
c.*584_*586del (n.*584_*586del)
c.2287_2289del (p.Cys763del)
c.2584_2586del (p.Cys862del)
c.2566_2568del (p.Cys856del)
c.2275_2277del (p.Cys759del)
c.2203_2205del (p.Cys735del)
n.3268_3270del
n.2938_2940del
n.3161_3163del
 dbSNP
2g.25234286_25234293delCA2699055073DNMT3Ac.975_982del
c.1872_1879del (n.1872_1879del)
c.2057_2064del (p.Phe686CysfsTer9)
c.2726_2733del (p.Phe909CysfsTer9)
c.2159_2166del (p.Phe720CysfsTer9)
c.*579_*586del (n.*579_*586del)
c.2282_2289del (p.Phe761CysfsTer9)
c.2579_2586del (p.Phe860CysfsTer9)
c.2561_2568del (p.Phe854CysfsTer9)
c.2270_2277del (p.Phe757CysfsTer9)
c.2198_2205del (p.Phe733CysfsTer9)
n.3263_3270del
n.2933_2940del
n.3156_3163del
 dbSNP
2g.25234286C>ACA346068003DNMT3Ac.981G>T
c.1878G>T (n.1878G>T)
c.2063G>T (p.Cys688Phe)
c.2732G>T (p.Cys911Phe)
c.2165G>T (p.Cys722Phe)
c.*585G>T (n.*585G>T)
c.2288G>T (p.Cys763Phe)
c.2585G>T (p.Cys862Phe)
c.2567G>T (p.Cys856Phe)
c.2276G>T (p.Cys759Phe)
c.2204G>T (p.Cys735Phe)
n.3269G>T
n.2939G>T
n.3162G>T
2g.25234286C=CA1239260232DNMT3Ac.981G=
c.1878G= (n.1878G=)
c.2063G= (p.Cys688=)
c.2732G= (p.Cys911=)
c.2165G= (p.Cys722=)
c.*585G= (n.*585G=)
c.2288G= (p.Cys763=)
c.2585G= (p.Cys862=)
c.2567G= (p.Cys856=)
c.2276G= (p.Cys759=)
c.2204G= (p.Cys735=)
n.3269G=
n.2939G=
n.3162G=
2g.25234286C>GCA346068004DNMT3Ac.981G>C
c.1878G>C (n.1878G>C)
c.2063G>C (p.Cys688Ser)
c.2732G>C (p.Cys911Ser)
c.2165G>C (p.Cys722Ser)
c.*585G>C (n.*585G>C)
c.2288G>C (p.Cys763Ser)
c.2585G>C (p.Cys862Ser)
c.2567G>C (p.Cys856Ser)
c.2276G>C (p.Cys759Ser)
c.2204G>C (p.Cys735Ser)
n.3269G>C
n.2939G>C
n.3162G>C
2g.25234286C>TCA16044437DNMT3Ac.981G>A
c.1878G>A (n.1878G>A)
c.2063G>A (p.Cys688Tyr)
c.2732G>A (p.Cys911Tyr)
c.2165G>A (p.Cys722Tyr)
c.*585G>A (n.*585G>A)
c.2288G>A (p.Cys763Tyr)
c.2585G>A (p.Cys862Tyr)
c.2567G>A (p.Cys856Tyr)
c.2276G>A (p.Cys759Tyr)
c.2204G>A (p.Cys735Tyr)
n.3269G>A
n.2939G>A
n.3162G>A
 dbSNP gnomAD v4
2g.25234287A>CCA346068005DNMT3Ac.980T>G
c.1877T>G (n.1877T>G)
c.2062T>G (p.Cys688Gly)
c.2731T>G (p.Cys911Gly)
c.2164T>G (p.Cys722Gly)
c.*584T>G (n.*584T>G)
c.2287T>G (p.Cys763Gly)
c.2584T>G (p.Cys862Gly)
c.2566T>G (p.Cys856Gly)
c.2275T>G (p.Cys759Gly)
c.2203T>G (p.Cys735Gly)
n.3268T>G
n.2938T>G
n.3161T>G
2g.25234287A>GCA346068006DNMT3Ac.980T>C
c.1877T>C (n.1877T>C)
c.2062T>C (p.Cys688Arg)
c.2731T>C (p.Cys911Arg)
c.2164T>C (p.Cys722Arg)
c.*584T>C (n.*584T>C)
c.2287T>C (p.Cys763Arg)
c.2584T>C (p.Cys862Arg)
c.2566T>C (p.Cys856Arg)
c.2275T>C (p.Cys759Arg)
c.2203T>C (p.Cys735Arg)
n.3268T>C
n.2938T>C
n.3161T>C
 COSMIC
2g.25234287A>TCA346068007DNMT3Ac.980T>A
c.1877T>A (n.1877T>A)
c.2062T>A (p.Cys688Ser)
c.2731T>A (p.Cys911Ser)
c.2164T>A (p.Cys722Ser)
c.*584T>A (n.*584T>A)
c.2287T>A (p.Cys763Ser)
c.2584T>A (p.Cys862Ser)
c.2566T>A (p.Cys856Ser)
c.2275T>A (p.Cys759Ser)
c.2203T>A (p.Cys735Ser)
n.3268T>A
n.2938T>A
n.3161T>A
2g.25234288C>ACA425180826DNMT3Ac.979G>T
c.1876G>T (n.1876G>T)
c.2061G>T (p.Ala687=)
c.2730G>T (p.Ala910=)
c.2163G>T (p.Ala721=)
c.*583G>T (n.*583G>T)
c.2286G>T (p.Ala762=)
c.2583G>T (p.Ala861=)
c.2565G>T (p.Ala855=)
c.2274G>T (p.Ala758=)
c.2202G>T (p.Ala734=)
n.3267G>T
n.2937G>T
n.3160G>T
 dbSNP
2g.25234288C=CA1239260233DNMT3Ac.979G=
c.1876G= (n.1876G=)
c.2061G= (p.Ala687=)
c.2730G= (p.Ala910=)
c.2163G= (p.Ala721=)
c.*583G= (n.*583G=)
c.2286G= (p.Ala762=)
c.2583G= (p.Ala861=)
c.2565G= (p.Ala855=)
c.2274G= (p.Ala758=)
c.2202G= (p.Ala734=)
n.3267G=
n.2937G=
n.3160G=
2g.25234288C>GCA425180827DNMT3Ac.979G>C
c.1876G>C (n.1876G>C)
c.2061G>C (p.Ala687=)
c.2730G>C (p.Ala910=)
c.2163G>C (p.Ala721=)
c.*583G>C (n.*583G>C)
c.2286G>C (p.Ala762=)
c.2583G>C (p.Ala861=)
c.2565G>C (p.Ala855=)
c.2274G>C (p.Ala758=)
c.2202G>C (p.Ala734=)
n.3267G>C
n.2937G>C
n.3160G>C
 gnomAD v4
2g.25234288C>TCA1555456DNMT3Ac.979G>A
c.1876G>A (n.1876G>A)
c.2061G>A (p.Ala687=)
c.2730G>A (p.Ala910=)
c.2163G>A (p.Ala721=)
c.*583G>A (n.*583G>A)
c.2286G>A (p.Ala762=)
c.2583G>A (p.Ala861=)
c.2565G>A (p.Ala855=)
c.2274G>A (p.Ala758=)
c.2202G>A (p.Ala734=)
n.3267G>A
n.2937G>A
n.3160G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC COSMIC
2g.25234289delCA531368291DNMT3Ac.978del
c.1875del (n.1875del)
c.2060del (p.Ala687GlyfsTer12)
c.2729del (p.Ala910GlyfsTer12)
c.2162del (p.Ala721GlyfsTer12)
c.*582del (n.*582del)
c.2285del (p.Ala762GlyfsTer12)
c.2582del (p.Ala861GlyfsTer12)
c.2564del (p.Ala855GlyfsTer12)
c.2273del (p.Ala758GlyfsTer12)
c.2201del (p.Ala734GlyfsTer12)
n.3266del
n.2936del
n.3159del
 gnomAD v2
2g.25234289G>ACA346068008DNMT3Ac.978C>T
c.1875C>T (n.1875C>T)
c.2060C>T (p.Ala687Val)
c.2729C>T (p.Ala910Val)
c.2162C>T (p.Ala721Val)
c.*582C>T (n.*582C>T)
c.2285C>T (p.Ala762Val)
c.2582C>T (p.Ala861Val)
c.2564C>T (p.Ala855Val)
c.2273C>T (p.Ala758Val)
c.2201C>T (p.Ala734Val)
n.3266C>T
n.2936C>T
n.3159C>T
 ClinVar dbSNP gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234289G>CCA346068009DNMT3Ac.978C>G
c.1875C>G (n.1875C>G)
c.2060C>G (p.Ala687Gly)
c.2729C>G (p.Ala910Gly)
c.2162C>G (p.Ala721Gly)
c.*582C>G (n.*582C>G)
c.2285C>G (p.Ala762Gly)
c.2582C>G (p.Ala861Gly)
c.2564C>G (p.Ala855Gly)
c.2273C>G (p.Ala758Gly)
c.2201C>G (p.Ala734Gly)
n.3266C>G
n.2936C>G
n.3159C>G
 dbSNP
2g.25234289G=CA1239260234DNMT3Ac.978C=
c.1875C= (n.1875C=)
c.2060C= (p.Ala687=)
c.2729C= (p.Ala910=)
c.2162C= (p.Ala721=)
c.*582C= (n.*582C=)
c.2285C= (p.Ala762=)
c.2582C= (p.Ala861=)
c.2564C= (p.Ala855=)
c.2273C= (p.Ala758=)
c.2201C= (p.Ala734=)
n.3266C=
n.2936C=
n.3159C=
2g.25234289G>TCA346068010DNMT3Ac.978C>A
c.1875C>A (n.1875C>A)
c.2060C>A (p.Ala687Glu)
c.2729C>A (p.Ala910Glu)
c.2162C>A (p.Ala721Glu)
c.*582C>A (n.*582C>A)
c.2285C>A (p.Ala762Glu)
c.2582C>A (p.Ala861Glu)
c.2564C>A (p.Ala855Glu)
c.2273C>A (p.Ala758Glu)
c.2201C>A (p.Ala734Glu)
n.3266C>A
n.2936C>A
n.3159C>A
2g.25234291_25234306delCA2658167837DNMT3Ac.963_978del
c.1860_1875del (n.1860_1875del)
c.2045_2060del (p.Leu682ArgfsTer12)
c.2714_2729del (p.Leu905ArgfsTer12)
c.2147_2162del (p.Leu716ArgfsTer12)
c.*567_*582del (n.*567_*582del)
c.2270_2285del (p.Leu757ArgfsTer12)
c.2567_2582del (p.Leu856ArgfsTer12)
c.2549_2564del (p.Leu850ArgfsTer12)
c.2258_2273del (p.Leu753ArgfsTer12)
c.2186_2201del (p.Leu729ArgfsTer12)
n.3251_3266del
n.2921_2936del
n.3144_3159del
 gnomAD v4
2g.25234290C>ACA346068011DNMT3Ac.977G>T
c.1874G>T (n.1874G>T)
c.2059G>T (p.Ala687Ser)
c.2728G>T (p.Ala910Ser)
c.2161G>T (p.Ala721Ser)
c.*581G>T (n.*581G>T)
c.2284G>T (p.Ala762Ser)
c.2581G>T (p.Ala861Ser)
c.2563G>T (p.Ala855Ser)
c.2272G>T (p.Ala758Ser)
c.2200G>T (p.Ala734Ser)
n.3265G>T
n.2935G>T
n.3158G>T
2g.25234290C=CA1239260235DNMT3Ac.977G=
c.1874G= (n.1874G=)
c.2059G= (p.Ala687=)
c.2728G= (p.Ala910=)
c.2161G= (p.Ala721=)
c.*581G= (n.*581G=)
c.2284G= (p.Ala762=)
c.2581G= (p.Ala861=)
c.2563G= (p.Ala855=)
c.2272G= (p.Ala758=)
c.2200G= (p.Ala734=)
n.3265G=
n.2935G=
n.3158G=
2g.25234290C>GCA346068012DNMT3Ac.977G>C
c.1874G>C (n.1874G>C)
c.2059G>C (p.Ala687Pro)
c.2728G>C (p.Ala910Pro)
c.2161G>C (p.Ala721Pro)
c.*581G>C (n.*581G>C)
c.2284G>C (p.Ala762Pro)
c.2581G>C (p.Ala861Pro)
c.2563G>C (p.Ala855Pro)
c.2272G>C (p.Ala758Pro)
c.2200G>C (p.Ala734Pro)
n.3265G>C
n.2935G>C
n.3158G>C
 dbSNP gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234290C>TCA346068013DNMT3Ac.977G>A
c.1874G>A (n.1874G>A)
c.2059G>A (p.Ala687Thr)
c.2728G>A (p.Ala910Thr)
c.2161G>A (p.Ala721Thr)
c.*581G>A (n.*581G>A)
c.2284G>A (p.Ala762Thr)
c.2581G>A (p.Ala861Thr)
c.2563G>A (p.Ala855Thr)
c.2272G>A (p.Ala758Thr)
c.2200G>A (p.Ala734Thr)
n.3265G>A
n.2935G>A
n.3158G>A
 COSMIC COSMIC
2g.25234290_25234291delinsCACA1239260236DNMT3Ac.976_977delinsTG
c.1873_1874delinsTG (n.1873_1874delinsTG)
c.2058_2059delinsTG (p.Phe686=)
c.2727_2728delinsTG (p.Phe909=)
c.2160_2161delinsTG (p.Phe720=)
c.*580_*581delinsTG (n.*580_*581delinsTG)
c.2283_2284delinsTG (p.Phe761=)
c.2580_2581delinsTG (p.Phe860=)
c.2562_2563delinsTG (p.Phe854=)
c.2271_2272delinsTG (p.Phe757=)
c.2199_2200delinsTG (p.Phe733=)
n.3264_3265delinsTG
n.2934_2935delinsTG
n.3157_3158delinsTG
2g.25234291A>CCA346068015DNMT3Ac.976T>G
c.1873T>G (n.1873T>G)
c.2058T>G (p.Phe686Leu)
c.2727T>G (p.Phe909Leu)
c.2160T>G (p.Phe720Leu)
c.*580T>G (n.*580T>G)
c.2283T>G (p.Phe761Leu)
c.2580T>G (p.Phe860Leu)
c.2562T>G (p.Phe854Leu)
c.2271T>G (p.Phe757Leu)
c.2199T>G (p.Phe733Leu)
n.3264T>G
n.2934T>G
n.3157T>G
 gnomAD v4
2g.25234291A>GCA425180828DNMT3Ac.976T>C
c.1873T>C (n.1873T>C)
c.2058T>C (p.Phe686=)
c.2727T>C (p.Phe909=)
c.2160T>C (p.Phe720=)
c.*580T>C (n.*580T>C)
c.2283T>C (p.Phe761=)
c.2580T>C (p.Phe860=)
c.2562T>C (p.Phe854=)
c.2271T>C (p.Phe757=)
c.2199T>C (p.Phe733=)
n.3264T>C
n.2934T>C
n.3157T>C
2g.25234291A>TCA346068014DNMT3Ac.976T>A
c.1873T>A (n.1873T>A)
c.2058T>A (p.Phe686Leu)
c.2727T>A (p.Phe909Leu)
c.2160T>A (p.Phe720Leu)
c.*580T>A (n.*580T>A)
c.2283T>A (p.Phe761Leu)
c.2580T>A (p.Phe860Leu)
c.2562T>A (p.Phe854Leu)
c.2271T>A (p.Phe757Leu)
c.2199T>A (p.Phe733Leu)
n.3264T>A
n.2934T>A
n.3157T>A
 gnomAD v4
2g.25234294dupCA2658167866DNMT3Ac.976dup
c.1873dup (n.1873dup)
c.2058dup (p.Ala687CysfsTer11)
c.2727dup (p.Ala910CysfsTer11)
c.2160dup (p.Ala721CysfsTer11)
c.*580dup (n.*580dup)
c.2283dup (p.Ala762CysfsTer11)
c.2580dup (p.Ala861CysfsTer11)
c.2562dup (p.Ala855CysfsTer11)
c.2271dup (p.Ala758CysfsTer11)
c.2199dup (p.Ala734CysfsTer11)
n.3264dup
n.2934dup
n.3157dup
 gnomAD v4
2g.25234294delCA531368293DNMT3Ac.976del
c.1873del (n.1873del)
c.2058del (p.Phe686LeufsTer13)
c.2727del (p.Phe909LeufsTer13)
c.2160del (p.Phe720LeufsTer13)
c.*580del (n.*580del)
c.2283del (p.Phe761LeufsTer13)
c.2580del (p.Phe860LeufsTer13)
c.2562del (p.Phe854LeufsTer13)
c.2271del (p.Phe757LeufsTer13)
c.2199del (p.Phe733LeufsTer13)
n.3264del
n.2934del
n.3157del
 dbSNP gnomAD v2 gnomAD v4
2g.25234293_25234294delCA531368292DNMT3Ac.975_976del
c.1872_1873del (n.1872_1873del)
c.2057_2058del (p.Phe686CysfsTer11)
c.2726_2727del (p.Phe909CysfsTer11)
c.2159_2160del (p.Phe720CysfsTer11)
c.*579_*580del (n.*579_*580del)
c.2282_2283del (p.Phe761CysfsTer11)
c.2579_2580del (p.Phe860CysfsTer11)
c.2561_2562del (p.Phe854CysfsTer11)
c.2270_2271del (p.Phe757CysfsTer11)
c.2198_2199del (p.Phe733CysfsTer11)
n.3263_3264del
n.2933_2934del
n.3156_3157del
 gnomAD v2 gnomAD v4
2g.25234292A=CA1239260237DNMT3Ac.975T=
c.1872T= (n.1872T=)
c.2057T= (p.Phe686=)
c.2726T= (p.Phe909=)
c.2159T= (p.Phe720=)
c.*579T= (n.*579T=)
c.2282T= (p.Phe761=)
c.2579T= (p.Phe860=)
c.2561T= (p.Phe854=)
c.2270T= (p.Phe757=)
c.2198T= (p.Phe733=)
n.3263T=
n.2933T=
n.3156T=
2g.25234292A>CCA346068016DNMT3Ac.975T>G
c.1872T>G (n.1872T>G)
c.2057T>G (p.Phe686Cys)
c.2726T>G (p.Phe909Cys)
c.2159T>G (p.Phe720Cys)
c.*579T>G (n.*579T>G)
c.2282T>G (p.Phe761Cys)
c.2579T>G (p.Phe860Cys)
c.2561T>G (p.Phe854Cys)
c.2270T>G (p.Phe757Cys)
c.2198T>G (p.Phe733Cys)
n.3263T>G
n.2933T>G
n.3156T>G
 dbSNP gnomAD v4 COSMIC COSMIC
2g.25234292A>GCA346068018DNMT3Ac.975T>C
c.1872T>C (n.1872T>C)
c.2057T>C (p.Phe686Ser)
c.2726T>C (p.Phe909Ser)
c.2159T>C (p.Phe720Ser)
c.*579T>C (n.*579T>C)
c.2282T>C (p.Phe761Ser)
c.2579T>C (p.Phe860Ser)
c.2561T>C (p.Phe854Ser)
c.2270T>C (p.Phe757Ser)
c.2198T>C (p.Phe733Ser)
n.3263T>C
n.2933T>C
n.3156T>C
 ClinVar dbSNP gnomAD v4
2g.25234292A>TCA346068017DNMT3Ac.975T>A
c.1872T>A (n.1872T>A)
c.2057T>A (p.Phe686Tyr)
c.2726T>A (p.Phe909Tyr)
c.2159T>A (p.Phe720Tyr)
c.*579T>A (n.*579T>A)
c.2282T>A (p.Phe761Tyr)
c.2579T>A (p.Phe860Tyr)
c.2561T>A (p.Phe854Tyr)
c.2270T>A (p.Phe757Tyr)
c.2198T>A (p.Phe733Tyr)
n.3263T>A
n.2933T>A
n.3156T>A
2g.25234293A=CA1239260238DNMT3Ac.974T=
c.1871T= (n.1871T=)
c.2056T= (p.Phe686=)
c.2725T= (p.Phe909=)
c.2158T= (p.Phe720=)
c.*578T= (n.*578T=)
c.2281T= (p.Phe761=)
c.2578T= (p.Phe860=)
c.2560T= (p.Phe854=)
c.2269T= (p.Phe757=)
c.2197T= (p.Phe733=)
n.3262T=
n.2932T=
n.3155T=
2g.25234293A>CCA346068019DNMT3Ac.974T>G
c.1871T>G (n.1871T>G)
c.2056T>G (p.Phe686Val)
c.2725T>G (p.Phe909Val)
c.2158T>G (p.Phe720Val)
c.*578T>G (n.*578T>G)
c.2281T>G (p.Phe761Val)
c.2578T>G (p.Phe860Val)
c.2560T>G (p.Phe854Val)
c.2269T>G (p.Phe757Val)
c.2197T>G (p.Phe733Val)
n.3262T>G
n.2932T>G
n.3155T>G
 gnomAD v4
2g.25234293A>GCA346068020DNMT3Ac.974T>C
c.1871T>C (n.1871T>C)
c.2056T>C (p.Phe686Leu)
c.2725T>C (p.Phe909Leu)
c.2158T>C (p.Phe720Leu)
c.*578T>C (n.*578T>C)
c.2281T>C (p.Phe761Leu)
c.2578T>C (p.Phe860Leu)
c.2560T>C (p.Phe854Leu)
c.2269T>C (p.Phe757Leu)
c.2197T>C (p.Phe733Leu)
n.3262T>C
n.2932T>C
n.3155T>C
 gnomAD v4
2g.25234293A>TCA346068021DNMT3Ac.974T>A
c.1871T>A (n.1871T>A)
c.2056T>A (p.Phe686Ile)
c.2725T>A (p.Phe909Ile)
c.2158T>A (p.Phe720Ile)
c.*578T>A (n.*578T>A)
c.2281T>A (p.Phe761Ile)
c.2578T>A (p.Phe860Ile)
c.2560T>A (p.Phe854Ile)
c.2269T>A (p.Phe757Ile)
c.2197T>A (p.Phe733Ile)
n.3262T>A
n.2932T>A
n.3155T>A
 dbSNP gnomAD v4
2g.25234294A>CCA346068022DNMT3Ac.973T>G
c.1870T>G (n.1870T>G)
c.2055T>G (p.Tyr685Ter)
c.2724T>G (p.Tyr908Ter)
c.2157T>G (p.Tyr719Ter)
c.*577T>G (n.*577T>G)
c.2280T>G (p.Tyr760Ter)
c.2577T>G (p.Tyr859Ter)
c.2559T>G (p.Tyr853Ter)
c.2268T>G (p.Tyr756Ter)
c.2196T>G (p.Tyr732Ter)
n.3261T>G
n.2931T>G
n.3154T>G
 gnomAD v3 gnomAD v4
2g.25234294A>GCA425180829DNMT3Ac.973T>C
c.1870T>C (n.1870T>C)
c.2055T>C (p.Tyr685=)
c.2724T>C (p.Tyr908=)
c.2157T>C (p.Tyr719=)
c.*577T>C (n.*577T>C)
c.2280T>C (p.Tyr760=)
c.2577T>C (p.Tyr859=)
c.2559T>C (p.Tyr853=)
c.2268T>C (p.Tyr756=)
c.2196T>C (p.Tyr732=)
n.3261T>C
n.2931T>C
n.3154T>C
2g.25234294A>TCA346068023DNMT3Ac.973T>A
c.1870T>A (n.1870T>A)
c.2055T>A (p.Tyr685Ter)
c.2724T>A (p.Tyr908Ter)
c.2157T>A (p.Tyr719Ter)
c.*577T>A (n.*577T>A)
c.2280T>A (p.Tyr760Ter)
c.2577T>A (p.Tyr859Ter)
c.2559T>A (p.Tyr853Ter)
c.2268T>A (p.Tyr756Ter)
c.2196T>A (p.Tyr732Ter)
n.3261T>A
n.2931T>A
n.3154T>A
2g.25234295delCA2576693552DNMT3Ac.972del
c.1869del (n.1869del)
c.2054del (p.Tyr685PhefsTer14)
c.2723del (p.Tyr908PhefsTer14)
c.2156del (p.Tyr719PhefsTer14)
c.*576del (n.*576del)
c.2279del (p.Tyr760PhefsTer14)
c.2576del (p.Tyr859PhefsTer14)
c.2558del (p.Tyr853PhefsTer14)
c.2267del (p.Tyr756PhefsTer14)
c.2195del (p.Tyr732PhefsTer14)
n.3260del
n.2930del
n.3153del
2g.25234295T>ACA346068024DNMT3Ac.972A>T
c.1869A>T (n.1869A>T)
c.2054A>T (p.Tyr685Phe)
c.2723A>T (p.Tyr908Phe)
c.2156A>T (p.Tyr719Phe)
c.*576A>T (n.*576A>T)
c.2279A>T (p.Tyr760Phe)
c.2576A>T (p.Tyr859Phe)
c.2558A>T (p.Tyr853Phe)
c.2267A>T (p.Tyr756Phe)
c.2195A>T (p.Tyr732Phe)
n.3260A>T
n.2930A>T
n.3153A>T
2g.25234295T>CCA1555457DNMT3Ac.972A>G
c.1869A>G (n.1869A>G)
c.2054A>G (p.Tyr685Cys)
c.2723A>G (p.Tyr908Cys)
c.2156A>G (p.Tyr719Cys)
c.*576A>G (n.*576A>G)
c.2279A>G (p.Tyr760Cys)
c.2576A>G (p.Tyr859Cys)
c.2558A>G (p.Tyr853Cys)
c.2267A>G (p.Tyr756Cys)
c.2195A>G (p.Tyr732Cys)
n.3260A>G
n.2930A>G
n.3153A>G
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234295T>GCA346068025DNMT3Ac.972A>C
c.1869A>C (n.1869A>C)
c.2054A>C (p.Tyr685Ser)
c.2723A>C (p.Tyr908Ser)
c.2156A>C (p.Tyr719Ser)
c.*576A>C (n.*576A>C)
c.2279A>C (p.Tyr760Ser)
c.2576A>C (p.Tyr859Ser)
c.2558A>C (p.Tyr853Ser)
c.2267A>C (p.Tyr756Ser)
c.2195A>C (p.Tyr732Ser)
n.3260A>C
n.2930A>C
n.3153A>C
2g.25234295T=CA1239260239DNMT3Ac.972A=
c.1869A= (n.1869A=)
c.2054A= (p.Tyr685=)
c.2723A= (p.Tyr908=)
c.2156A= (p.Tyr719=)
c.*576A= (n.*576A=)
c.2279A= (p.Tyr760=)
c.2576A= (p.Tyr859=)
c.2558A= (p.Tyr853=)
c.2267A= (p.Tyr756=)
c.2195A= (p.Tyr732=)
n.3260A=
n.2930A=
n.3153A=
2g.25234296_25234302delCA2658167887DNMT3Ac.966_972del
c.1863_1869del (n.1863_1869del)
c.2048_2054del (p.Lys683IlefsTer14)
c.2717_2723del (p.Lys906IlefsTer14)
c.2150_2156del (p.Lys717IlefsTer14)
c.*570_*576del (n.*570_*576del)
c.2273_2279del (p.Lys758IlefsTer14)
c.2570_2576del (p.Lys857IlefsTer14)
c.2552_2558del (p.Lys851IlefsTer14)
c.2261_2267del (p.Lys754IlefsTer14)
c.2189_2195del (p.Lys730IlefsTer14)
n.3254_3260del
n.2924_2930del
n.3147_3153del
 gnomAD v4
2g.25234296A=CA1239260241DNMT3Ac.971T=
c.1868T= (n.1868T=)
c.2053T= (p.Tyr685=)
c.2722T= (p.Tyr908=)
c.2155T= (p.Tyr719=)
c.*575T= (n.*575T=)
c.2278T= (p.Tyr760=)
c.2575T= (p.Tyr859=)
c.2557T= (p.Tyr853=)
c.2266T= (p.Tyr756=)
c.2194T= (p.Tyr732=)
n.3259T=
n.2929T=
n.3152T=
2g.25234296A>CCA346068026DNMT3Ac.971T>G
c.1868T>G (n.1868T>G)
c.2053T>G (p.Tyr685Asp)
c.2722T>G (p.Tyr908Asp)
c.2155T>G (p.Tyr719Asp)
c.*575T>G (n.*575T>G)
c.2278T>G (p.Tyr760Asp)
c.2575T>G (p.Tyr859Asp)
c.2557T>G (p.Tyr853Asp)
c.2266T>G (p.Tyr756Asp)
c.2194T>G (p.Tyr732Asp)
n.3259T>G
n.2929T>G
n.3152T>G
 gnomAD v4
2g.25234296A>GCA346068027DNMT3Ac.971T>C
c.1868T>C (n.1868T>C)
c.2053T>C (p.Tyr685His)
c.2722T>C (p.Tyr908His)
c.2155T>C (p.Tyr719His)
c.*575T>C (n.*575T>C)
c.2278T>C (p.Tyr760His)
c.2575T>C (p.Tyr859His)
c.2557T>C (p.Tyr853His)
c.2266T>C (p.Tyr756His)
c.2194T>C (p.Tyr732His)
n.3259T>C
n.2929T>C
n.3152T>C
 gnomAD v4
2g.25234296A>TCA346068028DNMT3Ac.971T>A
c.1868T>A (n.1868T>A)
c.2053T>A (p.Tyr685Asn)
c.2722T>A (p.Tyr908Asn)
c.2155T>A (p.Tyr719Asn)
c.*575T>A (n.*575T>A)
c.2278T>A (p.Tyr760Asn)
c.2575T>A (p.Tyr859Asn)
c.2557T>A (p.Tyr853Asn)
c.2266T>A (p.Tyr756Asn)
c.2194T>A (p.Tyr732Asn)
n.3259T>A
n.2929T>A
n.3152T>A
 ClinVar dbSNP gnomAD v2 gnomAD v4
2g.25234296dupCA1239260240DNMT3Ac.971dup
c.1868dup (n.1868dup)
c.2053dup (p.Tyr685LeufsTer13)
c.2722dup (p.Tyr908LeufsTer13)
c.2155dup (p.Tyr719LeufsTer13)
c.*575dup (n.*575dup)
c.2278dup (p.Tyr760LeufsTer13)
c.2575dup (p.Tyr859LeufsTer13)
c.2557dup (p.Tyr853LeufsTer13)
c.2266dup (p.Tyr756LeufsTer13)
c.2194dup (p.Tyr732LeufsTer13)
n.3259dup
n.2929dup
n.3152dup
 dbSNP gnomAD v4
2g.25234297_25234313delCA2695202538DNMT3Ac.955_971del
c.1852_1868del (n.1852_1868del)
c.2037_2053del (p.Phe679LeufsTer13)
c.2706_2722del (p.Phe902LeufsTer13)
c.2139_2155del (p.Phe713LeufsTer13)
c.*559_*575del (n.*559_*575del)
c.2262_2278del (p.Phe754LeufsTer13)
c.2559_2575del (p.Phe853LeufsTer13)
c.2541_2557del (p.Phe847LeufsTer13)
c.2250_2266del (p.Phe750LeufsTer13)
c.2178_2194del (p.Phe726LeufsTer13)
n.3243_3259del
n.2913_2929del
n.3136_3152del
2g.25234296_25234297insGGGCA2497029011DNMT3Ac.970_971insCCC
c.1867_1868insCCC (n.1867_1868insCCC)
c.2052_2053insCCC (p.Glu684_Tyr685insPro)
c.2721_2722insCCC (p.Glu907_Tyr908insPro)
c.2154_2155insCCC (p.Glu718_Tyr719insPro)
c.*574_*575insCCC (n.*574_*575insCCC)
c.2277_2278insCCC (p.Glu759_Tyr760insPro)
c.2574_2575insCCC (p.Glu858_Tyr859insPro)
c.2556_2557insCCC (p.Glu852_Tyr853insPro)
c.2265_2266insCCC (p.Glu755_Tyr756insPro)
c.2193_2194insCCC (p.Glu731_Tyr732insPro)
n.3258_3259insCCC
n.2928_2929insCCC
n.3151_3152insCCC
2g.25234297delCA2576693553DNMT3Ac.970del
c.1867del (n.1867del)
c.2052del (p.Glu684AspfsTer15)
c.2721del (p.Glu907AspfsTer15)
c.2154del (p.Glu718AspfsTer15)
c.*574del (n.*574del)
c.2277del (p.Glu759AspfsTer15)
c.2574del (p.Glu858AspfsTer15)
c.2556del (p.Glu852AspfsTer15)
c.2265del (p.Glu755AspfsTer15)
c.2193del (p.Glu731AspfsTer15)
n.3258del
n.2928del
n.3151del
2g.25234297C>ACA346068030DNMT3Ac.970G>T
c.1867G>T (n.1867G>T)
c.2052G>T (p.Glu684Asp)
c.2721G>T (p.Glu907Asp)
c.2154G>T (p.Glu718Asp)
c.*574G>T (n.*574G>T)
c.2277G>T (p.Glu759Asp)
c.2574G>T (p.Glu858Asp)
c.2556G>T (p.Glu852Asp)
c.2265G>T (p.Glu755Asp)
c.2193G>T (p.Glu731Asp)
n.3258G>T
n.2928G>T
n.3151G>T
2g.25234297C=CA1239260242DNMT3Ac.970G=
c.1867G= (n.1867G=)
c.2052G= (p.Glu684=)
c.2721G= (p.Glu907=)
c.2154G= (p.Glu718=)
c.*574G= (n.*574G=)
c.2277G= (p.Glu759=)
c.2574G= (p.Glu858=)
c.2556G= (p.Glu852=)
c.2265G= (p.Glu755=)
c.2193G= (p.Glu731=)
n.3258G=
n.2928G=
n.3151G=
2g.25234297C>GCA346068029DNMT3Ac.970G>C
c.1867G>C (n.1867G>C)
c.2052G>C (p.Glu684Asp)
c.2721G>C (p.Glu907Asp)
c.2154G>C (p.Glu718Asp)
c.*574G>C (n.*574G>C)
c.2277G>C (p.Glu759Asp)
c.2574G>C (p.Glu858Asp)
c.2556G>C (p.Glu852Asp)
c.2265G>C (p.Glu755Asp)
c.2193G>C (p.Glu731Asp)
n.3258G>C
n.2928G>C
n.3151G>C
2g.25234297C>TCA425180830DNMT3Ac.970G>A
c.1867G>A (n.1867G>A)
c.2052G>A (p.Glu684=)
c.2721G>A (p.Glu907=)
c.2154G>A (p.Glu718=)
c.*574G>A (n.*574G>A)
c.2277G>A (p.Glu759=)
c.2574G>A (p.Glu858=)
c.2556G>A (p.Glu852=)
c.2265G>A (p.Glu755=)
c.2193G>A (p.Glu731=)
n.3258G>A
n.2928G>A
n.3151G>A
 dbSNP gnomAD v2 gnomAD v4
2g.25234298_25234299dupCA1555458DNMT3Ac.969_970dup
c.1866_1867dup (n.1866_1867dup)
c.2051_2052dup (p.Tyr685SerfsTer15)
c.2720_2721dup (p.Tyr908SerfsTer15)
c.2153_2154dup (p.Tyr719SerfsTer15)
c.*573_*574dup (n.*573_*574dup)
c.2276_2277dup (p.Tyr760SerfsTer15)
c.2573_2574dup (p.Tyr859SerfsTer15)
c.2555_2556dup (p.Tyr853SerfsTer15)
c.2264_2265dup (p.Tyr756SerfsTer15)
c.2192_2193dup (p.Tyr732SerfsTer15)
n.3257_3258dup
n.2927_2928dup
n.3150_3151dup
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234297_25234300delCA645515113DNMT3Ac.967_970del
c.1864_1867del (n.1864_1867del)
c.2049_2052del (p.Lys683AsnfsTer15)
c.2718_2721del (p.Lys906AsnfsTer15)
c.2151_2154del (p.Lys717AsnfsTer15)
c.*571_*574del (n.*571_*574del)
c.2274_2277del (p.Lys758AsnfsTer15)
c.2571_2574del (p.Lys857AsnfsTer15)
c.2553_2556del (p.Lys851AsnfsTer15)
c.2262_2265del (p.Lys754AsnfsTer15)
c.2190_2193del (p.Lys730AsnfsTer15)
n.3255_3258del
n.2925_2928del
n.3148_3151del
 COSMIC COSMIC
2g.25234299_25234301delCA2658167903DNMT3Ac.968_970del
c.1865_1867del (n.1865_1867del)
c.2050_2052del (p.Glu684del)
c.2719_2721del (p.Glu907del)
c.2152_2154del (p.Glu718del)
c.*572_*574del (n.*572_*574del)
c.2275_2277del (p.Glu759del)
c.2572_2574del (p.Glu858del)
c.2554_2556del (p.Glu852del)
c.2263_2265del (p.Glu755del)
c.2191_2193del (p.Glu731del)
n.3256_3258del
n.2926_2928del
n.3149_3151del
 gnomAD v4
2g.25234298delCA2576693554DNMT3Ac.969del
c.1866del (n.1866del)
c.2051del (p.Glu684GlyfsTer15)
c.2720del (p.Glu907GlyfsTer15)
c.2153del (p.Glu718GlyfsTer15)
c.*573del (n.*573del)
c.2276del (p.Glu759GlyfsTer15)
c.2573del (p.Glu858GlyfsTer15)
c.2555del (p.Glu852GlyfsTer15)
c.2264del (p.Glu755GlyfsTer15)
c.2192del (p.Glu731GlyfsTer15)
n.3257del
n.2927del
n.3150del
 gnomAD v4
2g.25234298T>ACA346068031DNMT3Ac.969A>T
c.1866A>T (n.1866A>T)
c.2051A>T (p.Glu684Val)
c.2720A>T (p.Glu907Val)
c.2153A>T (p.Glu718Val)
c.*573A>T (n.*573A>T)
c.2276A>T (p.Glu759Val)
c.2573A>T (p.Glu858Val)
c.2555A>T (p.Glu852Val)
c.2264A>T (p.Glu755Val)
c.2192A>T (p.Glu731Val)
n.3257A>T
n.2927A>T
n.3150A>T
 gnomAD v4 COSMIC COSMIC
2g.25234298T>CCA346068032DNMT3Ac.969A>G
c.1866A>G (n.1866A>G)
c.2051A>G (p.Glu684Gly)
c.2720A>G (p.Glu907Gly)
c.2153A>G (p.Glu718Gly)
c.*573A>G (n.*573A>G)
c.2276A>G (p.Glu759Gly)
c.2573A>G (p.Glu858Gly)
c.2555A>G (p.Glu852Gly)
c.2264A>G (p.Glu755Gly)
c.2192A>G (p.Glu731Gly)
n.3257A>G
n.2927A>G
n.3150A>G
 gnomAD v4
2g.25234298T>GCA346068033DNMT3Ac.969A>C
c.1866A>C (n.1866A>C)
c.2051A>C (p.Glu684Ala)
c.2720A>C (p.Glu907Ala)
c.2153A>C (p.Glu718Ala)
c.*573A>C (n.*573A>C)
c.2276A>C (p.Glu759Ala)
c.2573A>C (p.Glu858Ala)
c.2555A>C (p.Glu852Ala)
c.2264A>C (p.Glu755Ala)
c.2192A>C (p.Glu731Ala)
n.3257A>C
n.2927A>C
n.3150A>C
2g.25234299C>ACA346068034DNMT3Ac.968G>T
c.1865G>T (n.1865G>T)
c.2050G>T (p.Glu684Ter)
c.2719G>T (p.Glu907Ter)
c.2152G>T (p.Glu718Ter)
c.*572G>T (n.*572G>T)
c.2275G>T (p.Glu759Ter)
c.2572G>T (p.Glu858Ter)
c.2554G>T (p.Glu852Ter)
c.2263G>T (p.Glu755Ter)
c.2191G>T (p.Glu731Ter)
n.3256G>T
n.2926G>T
n.3149G>T
 gnomAD v4
2g.25234299C=CA1239260244DNMT3Ac.968G=
c.1865G= (n.1865G=)
c.2050G= (p.Glu684=)
c.2719G= (p.Glu907=)
c.2152G= (p.Glu718=)
c.*572G= (n.*572G=)
c.2275G= (p.Glu759=)
c.2572G= (p.Glu858=)
c.2554G= (p.Glu852=)
c.2263G= (p.Glu755=)
c.2191G= (p.Glu731=)
n.3256G=
n.2926G=
n.3149G=
2g.25234299C>GCA346068035DNMT3Ac.968G>C
c.1865G>C (n.1865G>C)
c.2050G>C (p.Glu684Gln)
c.2719G>C (p.Glu907Gln)
c.2152G>C (p.Glu718Gln)
c.*572G>C (n.*572G>C)
c.2275G>C (p.Glu759Gln)
c.2572G>C (p.Glu858Gln)
c.2554G>C (p.Glu852Gln)
c.2263G>C (p.Glu755Gln)
c.2191G>C (p.Glu731Gln)
n.3256G>C
n.2926G>C
n.3149G>C
2g.25234299C>TCA1555459DNMT3Ac.968G>A
c.1865G>A (n.1865G>A)
c.2050G>A (p.Glu684Lys)
c.2719G>A (p.Glu907Lys)
c.2152G>A (p.Glu718Lys)
c.*572G>A (n.*572G>A)
c.2275G>A (p.Glu759Lys)
c.2572G>A (p.Glu858Lys)
c.2554G>A (p.Glu852Lys)
c.2263G>A (p.Glu755Lys)
c.2191G>A (p.Glu731Lys)
n.3256G>A
n.2926G>A
n.3149G>A
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234300dupCA2576693556DNMT3Ac.968dup
c.1865dup (n.1865dup)
c.2050dup (p.Glu684GlyfsTer14)
c.2719dup (p.Glu907GlyfsTer14)
c.2152dup (p.Glu718GlyfsTer14)
c.*572dup (n.*572dup)
c.2275dup (p.Glu759GlyfsTer14)
c.2572dup (p.Glu858GlyfsTer14)
c.2554dup (p.Glu852GlyfsTer14)
c.2263dup (p.Glu755GlyfsTer14)
c.2191dup (p.Glu731GlyfsTer14)
n.3256dup
n.2926dup
n.3149dup
 gnomAD v4
2g.25234300delCA2576693555DNMT3Ac.968del
c.1865del (n.1865del)
c.2050del (p.Glu684SerfsTer15)
c.2719del (p.Glu907SerfsTer15)
c.2152del (p.Glu718SerfsTer15)
c.*572del (n.*572del)
c.2275del (p.Glu759SerfsTer15)
c.2572del (p.Glu858SerfsTer15)
c.2554del (p.Glu852SerfsTer15)
c.2263del (p.Glu755SerfsTer15)
c.2191del (p.Glu731SerfsTer15)
n.3256del
n.2926del
n.3149del
 gnomAD v4
2g.25234299_25234302delinsCCTTCA1239260243DNMT3Ac.965_968delinsAAGG
c.1862_1865delinsAAGG (n.1862_1865delinsAAGG)
c.2047_2050delinsAAGG (p.Lys683=)
c.2716_2719delinsAAGG (p.Lys906=)
c.2149_2152delinsAAGG (p.Lys717=)
c.*569_*572delinsAAGG (n.*569_*572delinsAAGG)
c.2272_2275delinsAAGG (p.Lys758=)
c.2569_2572delinsAAGG (p.Lys857=)
c.2551_2554delinsAAGG (p.Lys851=)
c.2260_2263delinsAAGG (p.Lys754=)
c.2188_2191delinsAAGG (p.Lys730=)
n.3253_3256delinsAAGG
n.2923_2926delinsAAGG
n.3146_3149delinsAAGG
2g.25234300C>ACA346068036DNMT3Ac.967G>T
c.1864G>T (n.1864G>T)
c.2049G>T (p.Lys683Asn)
c.2718G>T (p.Lys906Asn)
c.2151G>T (p.Lys717Asn)
c.*571G>T (n.*571G>T)
c.2274G>T (p.Lys758Asn)
c.2571G>T (p.Lys857Asn)
c.2553G>T (p.Lys851Asn)
c.2262G>T (p.Lys754Asn)
c.2190G>T (p.Lys730Asn)
n.3255G>T
n.2925G>T
n.3148G>T
 gnomAD v4
2g.25234300C>GCA346068037DNMT3Ac.967G>C
c.1864G>C (n.1864G>C)
c.2049G>C (p.Lys683Asn)
c.2718G>C (p.Lys906Asn)
c.2151G>C (p.Lys717Asn)
c.*571G>C (n.*571G>C)
c.2274G>C (p.Lys758Asn)
c.2571G>C (p.Lys857Asn)
c.2553G>C (p.Lys851Asn)
c.2262G>C (p.Lys754Asn)
c.2190G>C (p.Lys730Asn)
n.3255G>C
n.2925G>C
n.3148G>C
2g.25234300C>TCA425180831DNMT3Ac.967G>A
c.1864G>A (n.1864G>A)
c.2049G>A (p.Lys683=)
c.2718G>A (p.Lys906=)
c.2151G>A (p.Lys717=)
c.*571G>A (n.*571G>A)
c.2274G>A (p.Lys758=)
c.2571G>A (p.Lys857=)
c.2553G>A (p.Lys851=)
c.2262G>A (p.Lys754=)
c.2190G>A (p.Lys730=)
n.3255G>A
n.2925G>A
n.3148G>A
 dbSNP
2g.25234301_25234303dupCA2580611250DNMT3Ac.965_967dup
c.1862_1864dup (n.1862_1864dup)
c.2047_2049dup (p.Lys683_Glu684insLys)
c.2716_2718dup (p.Lys906_Glu907insLys)
c.2149_2151dup (p.Lys717_Glu718insLys)
c.*569_*571dup (n.*569_*571dup)
c.2272_2274dup (p.Lys758_Glu759insLys)
c.2569_2571dup (p.Lys857_Glu858insLys)
c.2551_2553dup (p.Lys851_Glu852insLys)
c.2260_2262dup (p.Lys754_Glu755insLys)
c.2188_2190dup (p.Lys730_Glu731insLys)
n.3253_3255dup
n.2923_2925dup
n.3146_3148dup
 ClinVar
2g.25234301_25234303delCA1555460DNMT3Ac.965_967del
c.1862_1864del (n.1862_1864del)
c.2047_2049del (p.Lys683del)
c.2716_2718del (p.Lys906del)
c.2149_2151del (p.Lys717del)
c.*569_*571del (n.*569_*571del)
c.2272_2274del (p.Lys758del)
c.2569_2571del (p.Lys857del)
c.2551_2553del (p.Lys851del)
c.2260_2262del (p.Lys754del)
c.2188_2190del (p.Lys730del)
n.3253_3255del
n.2923_2925del
n.3146_3148del
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234301T>ACA346068038DNMT3Ac.966A>T
c.1863A>T (n.1863A>T)
c.2048A>T (p.Lys683Met)
c.2717A>T (p.Lys906Met)
c.2150A>T (p.Lys717Met)
c.*570A>T (n.*570A>T)
c.2273A>T (p.Lys758Met)
c.2570A>T (p.Lys857Met)
c.2552A>T (p.Lys851Met)
c.2261A>T (p.Lys754Met)
c.2189A>T (p.Lys730Met)
n.3254A>T
n.2924A>T
n.3147A>T
2g.25234301T>CCA346068039DNMT3Ac.966A>G
c.1863A>G (n.1863A>G)
c.2048A>G (p.Lys683Arg)
c.2717A>G (p.Lys906Arg)
c.2150A>G (p.Lys717Arg)
c.*570A>G (n.*570A>G)
c.2273A>G (p.Lys758Arg)
c.2570A>G (p.Lys857Arg)
c.2552A>G (p.Lys851Arg)
c.2261A>G (p.Lys754Arg)
c.2189A>G (p.Lys730Arg)
n.3254A>G
n.2924A>G
n.3147A>G
2g.25234301T>GCA346068040DNMT3Ac.966A>C
c.1863A>C (n.1863A>C)
c.2048A>C (p.Lys683Thr)
c.2717A>C (p.Lys906Thr)
c.2150A>C (p.Lys717Thr)
c.*570A>C (n.*570A>C)
c.2273A>C (p.Lys758Thr)
c.2570A>C (p.Lys857Thr)
c.2552A>C (p.Lys851Thr)
c.2261A>C (p.Lys754Thr)
c.2189A>C (p.Lys730Thr)
n.3254A>C
n.2924A>C
n.3147A>C
 gnomAD v4
2g.25234302dupCA2658167921DNMT3Ac.966dup
c.1863dup (n.1863dup)
c.2048dup (p.Glu684GlyfsTer14)
c.2717dup (p.Glu907GlyfsTer14)
c.2150dup (p.Glu718GlyfsTer14)
c.*570dup (n.*570dup)
c.2273dup (p.Glu759GlyfsTer14)
c.2570dup (p.Glu858GlyfsTer14)
c.2552dup (p.Glu852GlyfsTer14)
c.2261dup (p.Glu755GlyfsTer14)
c.2189dup (p.Glu731GlyfsTer14)
n.3254dup
n.2924dup
n.3147dup
 gnomAD v4
2g.25234302delCA2576693557DNMT3Ac.966del
c.1863del (n.1863del)
c.2048del (p.Lys683ArgfsTer16)
c.2717del (p.Lys906ArgfsTer16)
c.2150del (p.Lys717ArgfsTer16)
c.*570del (n.*570del)
c.2273del (p.Lys758ArgfsTer16)
c.2570del (p.Lys857ArgfsTer16)
c.2552del (p.Lys851ArgfsTer16)
c.2261del (p.Lys754ArgfsTer16)
c.2189del (p.Lys730ArgfsTer16)
n.3254del
n.2924del
n.3147del
2g.25234301_25234307delCA2658167923DNMT3Ac.960_966del
c.1857_1863del (n.1857_1863del)
c.2042_2048del (p.Pro681ArgfsTer16)
c.2711_2717del (p.Pro904ArgfsTer16)
c.2144_2150del (p.Pro715ArgfsTer16)
c.*564_*570del (n.*564_*570del)
c.2267_2273del (p.Pro756ArgfsTer16)
c.2564_2570del (p.Pro855ArgfsTer16)
c.2546_2552del (p.Pro849ArgfsTer16)
c.2255_2261del (p.Pro752ArgfsTer16)
c.2183_2189del (p.Pro728ArgfsTer16)
n.3248_3254del
n.2918_2924del
n.3141_3147del
 gnomAD v4
2g.25234301_25234316delCA2658167924DNMT3Ac.951_966del
c.1848_1863del (n.1848_1863del)
c.2033_2048del (p.Leu678ArgfsTer16)
c.2702_2717del (p.Leu901ArgfsTer16)
c.2135_2150del (p.Leu712ArgfsTer16)
c.*555_*570del (n.*555_*570del)
c.2258_2273del (p.Leu753ArgfsTer16)
c.2555_2570del (p.Leu852ArgfsTer16)
c.2537_2552del (p.Leu846ArgfsTer16)
c.2246_2261del (p.Leu749ArgfsTer16)
c.2174_2189del (p.Leu725ArgfsTer16)
n.3239_3254del
n.2909_2924del
n.3132_3147del
 gnomAD v4
2g.25234302T>ACA346068041DNMT3Ac.965A>T
c.1862A>T (n.1862A>T)
c.2047A>T (p.Lys683Ter)
c.2716A>T (p.Lys906Ter)
c.2149A>T (p.Lys717Ter)
c.*569A>T (n.*569A>T)
c.2272A>T (p.Lys758Ter)
c.2569A>T (p.Lys857Ter)
c.2551A>T (p.Lys851Ter)
c.2260A>T (p.Lys754Ter)
c.2188A>T (p.Lys730Ter)
n.3253A>T
n.2923A>T
n.3146A>T
 gnomAD v3 gnomAD v4 COSMIC
2g.25234302T>CCA346068043DNMT3Ac.965A>G
c.1862A>G (n.1862A>G)
c.2047A>G (p.Lys683Glu)
c.2716A>G (p.Lys906Glu)
c.2149A>G (p.Lys717Glu)
c.*569A>G (n.*569A>G)
c.2272A>G (p.Lys758Glu)
c.2569A>G (p.Lys857Glu)
c.2551A>G (p.Lys851Glu)
c.2260A>G (p.Lys754Glu)
c.2188A>G (p.Lys730Glu)
n.3253A>G
n.2923A>G
n.3146A>G
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25234302T>GCA346068042DNMT3Ac.965A>C
c.1862A>C (n.1862A>C)
c.2047A>C (p.Lys683Gln)
c.2716A>C (p.Lys906Gln)
c.2149A>C (p.Lys717Gln)
c.*569A>C (n.*569A>C)
c.2272A>C (p.Lys758Gln)
c.2569A>C (p.Lys857Gln)
c.2551A>C (p.Lys851Gln)
c.2260A>C (p.Lys754Gln)
c.2188A>C (p.Lys730Gln)
n.3253A>C
n.2923A>C
n.3146A>C
2g.25234302T=CA1239260245DNMT3Ac.965A=
c.1862A= (n.1862A=)
c.2047A= (p.Lys683=)
c.2716A= (p.Lys906=)
c.2149A= (p.Lys717=)
c.*569A= (n.*569A=)
c.2272A= (p.Lys758=)
c.2569A= (p.Lys857=)
c.2551A= (p.Lys851=)
c.2260A= (p.Lys754=)
c.2188A= (p.Lys730=)
n.3253A=
n.2923A=
n.3146A=
2g.25234303C>ACA425180832DNMT3Ac.964G>T
c.1861G>T (n.1861G>T)
c.2046G>T (p.Leu682=)
c.2715G>T (p.Leu905=)
c.2148G>T (p.Leu716=)
c.*568G>T (n.*568G>T)
c.2271G>T (p.Leu757=)
c.2568G>T (p.Leu856=)
c.2550G>T (p.Leu850=)
c.2259G>T (p.Leu753=)
c.2187G>T (p.Leu729=)
n.3252G>T
n.2922G>T
n.3145G>T
 dbSNP gnomAD v2 gnomAD v4
2g.25234303C=CA1239260246DNMT3Ac.964G=
c.1861G= (n.1861G=)
c.2046G= (p.Leu682=)
c.2715G= (p.Leu905=)
c.2148G= (p.Leu716=)
c.*568G= (n.*568G=)
c.2271G= (p.Leu757=)
c.2568G= (p.Leu856=)
c.2550G= (p.Leu850=)
c.2259G= (p.Leu753=)
c.2187G= (p.Leu729=)
n.3252G=
n.2922G=
n.3145G=
2g.25234303C>GCA425180833DNMT3Ac.964G>C
c.1861G>C (n.1861G>C)
c.2046G>C (p.Leu682=)
c.2715G>C (p.Leu905=)
c.2148G>C (p.Leu716=)
c.*568G>C (n.*568G>C)
c.2271G>C (p.Leu757=)
c.2568G>C (p.Leu856=)
c.2550G>C (p.Leu850=)
c.2259G>C (p.Leu753=)
c.2187G>C (p.Leu729=)
n.3252G>C
n.2922G>C
n.3145G>C
 gnomAD v3 gnomAD v4
2g.25234303C>TCA425180834DNMT3Ac.964G>A
c.1861G>A (n.1861G>A)
c.2046G>A (p.Leu682=)
c.2715G>A (p.Leu905=)
c.2148G>A (p.Leu716=)
c.*568G>A (n.*568G>A)
c.2271G>A (p.Leu757=)
c.2568G>A (p.Leu856=)
c.2550G>A (p.Leu850=)
c.2259G>A (p.Leu753=)
c.2187G>A (p.Leu729=)
n.3252G>A
n.2922G>A
n.3145G>A
 dbSNP
2g.25234304_25234322delCA2658167939DNMT3Ac.946_964del
c.1843_1861del (n.1843_1861del)
c.2028_2046del (p.His677ArgfsTer16)
c.2697_2715del (p.His900ArgfsTer16)
c.2130_2148del (p.His711ArgfsTer16)
c.*550_*568del (n.*550_*568del)
c.2253_2271del (p.His752ArgfsTer16)
c.2550_2568del (p.His851ArgfsTer16)
c.2532_2550del (p.His845ArgfsTer16)
c.2241_2259del (p.His748ArgfsTer16)
c.2169_2187del (p.His724ArgfsTer16)
n.3234_3252del
n.2904_2922del
n.3127_3145del
 gnomAD v4
2g.25234304A=CA1239260248DNMT3Ac.963T=
c.1860T= (n.1860T=)
c.2045T= (p.Leu682=)
c.2714T= (p.Leu905=)
c.2147T= (p.Leu716=)
c.*567T= (n.*567T=)
c.2270T= (p.Leu757=)
c.2567T= (p.Leu856=)
c.2549T= (p.Leu850=)
c.2258T= (p.Leu753=)
c.2186T= (p.Leu729=)
n.3251T=
n.2921T=
n.3144T=
2g.25234304A>CCA1555462DNMT3Ac.963T>G
c.1860T>G (n.1860T>G)
c.2045T>G (p.Leu682Arg)
c.2714T>G (p.Leu905Arg)
c.2147T>G (p.Leu716Arg)
c.*567T>G (n.*567T>G)
c.2270T>G (p.Leu757Arg)
c.2567T>G (p.Leu856Arg)
c.2549T>G (p.Leu850Arg)
c.2258T>G (p.Leu753Arg)
c.2186T>G (p.Leu729Arg)
n.3251T>G
n.2921T>G
n.3144T>G
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234304A>GCA346068044DNMT3Ac.963T>C
c.1860T>C (n.1860T>C)
c.2045T>C (p.Leu682Pro)
c.2714T>C (p.Leu905Pro)
c.2147T>C (p.Leu716Pro)
c.*567T>C (n.*567T>C)
c.2270T>C (p.Leu757Pro)
c.2567T>C (p.Leu856Pro)
c.2549T>C (p.Leu850Pro)
c.2258T>C (p.Leu753Pro)
c.2186T>C (p.Leu729Pro)
n.3251T>C
n.2921T>C
n.3144T>C
 dbSNP gnomAD v4
2g.25234304A>TCA1555461DNMT3Ac.963T>A
c.1860T>A (n.1860T>A)
c.2045T>A (p.Leu682Gln)
c.2714T>A (p.Leu905Gln)
c.2147T>A (p.Leu716Gln)
c.*567T>A (n.*567T>A)
c.2270T>A (p.Leu757Gln)
c.2567T>A (p.Leu856Gln)
c.2549T>A (p.Leu850Gln)
c.2258T>A (p.Leu753Gln)
c.2186T>A (p.Leu729Gln)
n.3251T>A
n.2921T>A
n.3144T>A
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234304dupCA1239260247DNMT3Ac.963dup
c.1860dup (n.1860dup)
c.2045dup (p.Lys683GlufsTer15)
c.2714dup (p.Lys906GlufsTer15)
c.2147dup (p.Lys717GlufsTer15)
c.*567dup (n.*567dup)
c.2270dup (p.Lys758GlufsTer15)
c.2567dup (p.Lys857GlufsTer15)
c.2549dup (p.Lys851GlufsTer15)
c.2258dup (p.Lys754GlufsTer15)
c.2186dup (p.Lys730GlufsTer15)
n.3251dup
n.2921dup
n.3144dup
 dbSNP
2g.25234304_25234305delinsAGCA1239260249DNMT3Ac.962_963delinsCT
c.1859_1860delinsCT (n.1859_1860delinsCT)
c.2044_2045delinsCT (p.Leu682=)
c.2713_2714delinsCT (p.Leu905=)
c.2146_2147delinsCT (p.Leu716=)
c.*566_*567delinsCT (n.*566_*567delinsCT)
c.2269_2270delinsCT (p.Leu757=)
c.2566_2567delinsCT (p.Leu856=)
c.2548_2549delinsCT (p.Leu850=)
c.2257_2258delinsCT (p.Leu753=)
c.2185_2186delinsCT (p.Leu729=)
n.3250_3251delinsCT
n.2920_2921delinsCT
n.3143_3144delinsCT
2g.25234308_25234312delCA645515115DNMT3Ac.959_963del
c.1856_1860del (n.1856_1860del)
c.2041_2045del (p.Pro681GlufsTer15)
c.2710_2714del (p.Pro904GlufsTer15)
c.2143_2147del (p.Pro715GlufsTer15)
c.*563_*567del (n.*563_*567del)
c.2266_2270del (p.Pro756GlufsTer15)
c.2563_2567del (p.Pro855GlufsTer15)
c.2545_2549del (p.Pro849GlufsTer15)
c.2254_2258del (p.Pro752GlufsTer15)
c.2182_2186del (p.Pro728GlufsTer15)
n.3247_3251del
n.2917_2921del
n.3140_3144del
 gnomAD v4 COSMIC
2g.25234305delCA1239260250DNMT3Ac.962del
c.1859del (n.1859del)
c.2044del (p.Leu682Ter)
c.2713del (p.Leu905Ter)
c.2146del (p.Leu716Ter)
c.*566del (n.*566del)
c.2269del (p.Leu757Ter)
c.2566del (p.Leu856Ter)
c.2548del (p.Leu850Ter)
c.2257del (p.Leu753Ter)
c.2185del (p.Leu729Ter)
n.3250del
n.2920del
n.3143del
 dbSNP
2g.25234305G>ACA425180835DNMT3Ac.962C>T
c.1859C>T (n.1859C>T)
c.2044C>T (p.Leu682=)
c.2713C>T (p.Leu905=)
c.2146C>T (p.Leu716=)
c.*566C>T (n.*566C>T)
c.2269C>T (p.Leu757=)
c.2566C>T (p.Leu856=)
c.2548C>T (p.Leu850=)
c.2257C>T (p.Leu753=)
c.2185C>T (p.Leu729=)
n.3250C>T
n.2920C>T
n.3143C>T
 COSMIC COSMIC
2g.25234305G>CCA346068045DNMT3Ac.962C>G
c.1859C>G (n.1859C>G)
c.2044C>G (p.Leu682Val)
c.2713C>G (p.Leu905Val)
c.2146C>G (p.Leu716Val)
c.*566C>G (n.*566C>G)
c.2269C>G (p.Leu757Val)
c.2566C>G (p.Leu856Val)
c.2548C>G (p.Leu850Val)
c.2257C>G (p.Leu753Val)
c.2185C>G (p.Leu729Val)
n.3250C>G
n.2920C>G
n.3143C>G
 gnomAD v3 gnomAD v4
2g.25234305G>TCA346068046DNMT3Ac.962C>A
c.1859C>A (n.1859C>A)
c.2044C>A (p.Leu682Met)
c.2713C>A (p.Leu905Met)
c.2146C>A (p.Leu716Met)
c.*566C>A (n.*566C>A)
c.2269C>A (p.Leu757Met)
c.2566C>A (p.Leu856Met)
c.2548C>A (p.Leu850Met)
c.2257C>A (p.Leu753Met)
c.2185C>A (p.Leu729Met)
n.3250C>A
n.2920C>A
n.3143C>A
2g.25234306_25234318delCA2658167952DNMT3Ac.950_962del
c.1847_1859del (n.1847_1859del)
c.2032_2044del (p.Leu678Ter)
c.2701_2713del (p.Leu901Ter)
c.2134_2146del (p.Leu712Ter)
c.*554_*566del (n.*554_*566del)
c.2257_2269del (p.Leu753Ter)
c.2554_2566del (p.Leu852Ter)
c.2536_2548del (p.Leu846Ter)
c.2245_2257del (p.Leu749Ter)
c.2173_2185del (p.Leu725Ter)
n.3238_3250del
n.2908_2920del
n.3131_3143del
 gnomAD v4
2g.25234306C>ACA425180836DNMT3Ac.961G>T
c.1858G>T (n.1858G>T)
c.2043G>T (p.Pro681=)
c.2712G>T (p.Pro904=)
c.2145G>T (p.Pro715=)
c.*565G>T (n.*565G>T)
c.2268G>T (p.Pro756=)
c.2565G>T (p.Pro855=)
c.2547G>T (p.Pro849=)
c.2256G>T (p.Pro752=)
c.2184G>T (p.Pro728=)
n.3249G>T
n.2919G>T
n.3142G>T
2g.25234306C=CA1239260251DNMT3Ac.961G=
c.1858G= (n.1858G=)
c.2043G= (p.Pro681=)
c.2712G= (p.Pro904=)
c.2145G= (p.Pro715=)
c.*565G= (n.*565G=)
c.2268G= (p.Pro756=)
c.2565G= (p.Pro855=)
c.2547G= (p.Pro849=)
c.2256G= (p.Pro752=)
c.2184G= (p.Pro728=)
n.3249G=
n.2919G=
n.3142G=
2g.25234306C>GCA425180837DNMT3Ac.961G>C
c.1858G>C (n.1858G>C)
c.2043G>C (p.Pro681=)
c.2712G>C (p.Pro904=)
c.2145G>C (p.Pro715=)
c.*565G>C (n.*565G>C)
c.2268G>C (p.Pro756=)
c.2565G>C (p.Pro855=)
c.2547G>C (p.Pro849=)
c.2256G>C (p.Pro752=)
c.2184G>C (p.Pro728=)
n.3249G>C
n.2919G>C
n.3142G>C
 dbSNP
2g.25234306C>TCA1555463DNMT3Ac.961G>A
c.1858G>A (n.1858G>A)
c.2043G>A (p.Pro681=)
c.2712G>A (p.Pro904=)
c.2145G>A (p.Pro715=)
c.*565G>A (n.*565G>A)
c.2268G>A (p.Pro756=)
c.2565G>A (p.Pro855=)
c.2547G>A (p.Pro849=)
c.2256G>A (p.Pro752=)
c.2184G>A (p.Pro728=)
n.3249G>A
n.2919G>A
n.3142G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234306_25234307delinsCGCA1239260252DNMT3Ac.960_961delinsCG
c.1857_1858delinsCG (n.1857_1858delinsCG)
c.2042_2043delinsCG (p.Pro681=)
c.2711_2712delinsCG (p.Pro904=)
c.2144_2145delinsCG (p.Pro715=)
c.*564_*565delinsCG (n.*564_*565delinsCG)
c.2267_2268delinsCG (p.Pro756=)
c.2564_2565delinsCG (p.Pro855=)
c.2546_2547delinsCG (p.Pro849=)
c.2255_2256delinsCG (p.Pro752=)
c.2183_2184delinsCG (p.Pro728=)
n.3248_3249delinsCG
n.2918_2919delinsCG
n.3141_3142delinsCG
2g.25234306_25234307insACA1028525322DNMT3Ac.960_961insT
c.1857_1858insT (n.1857_1858insT)
c.2042_2043insT (p.Leu682AlafsTer16)
c.2711_2712insT (p.Leu905AlafsTer16)
c.2144_2145insT (p.Leu716AlafsTer16)
c.*564_*565insT (n.*564_*565insT)
c.2267_2268insT (p.Leu757AlafsTer16)
c.2564_2565insT (p.Leu856AlafsTer16)
c.2546_2547insT (p.Leu850AlafsTer16)
c.2255_2256insT (p.Leu753AlafsTer16)
c.2183_2184insT (p.Leu729AlafsTer16)
n.3248_3249insT
n.2918_2919insT
n.3141_3142insT
 dbSNP gnomAD v3 gnomAD v4
2g.25234307G>ACA1555464DNMT3Ac.960C>T
c.1857C>T (n.1857C>T)
c.2042C>T (p.Pro681Leu)
c.2711C>T (p.Pro904Leu)
c.2144C>T (p.Pro715Leu)
c.*564C>T (n.*564C>T)
c.2267C>T (p.Pro756Leu)
c.2564C>T (p.Pro855Leu)
c.2546C>T (p.Pro849Leu)
c.2255C>T (p.Pro752Leu)
c.2183C>T (p.Pro728Leu)
n.3248C>T
n.2918C>T
n.3141C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234307G>CCA1555466DNMT3Ac.960C>G
c.1857C>G (n.1857C>G)
c.2042C>G (p.Pro681Arg)
c.2711C>G (p.Pro904Arg)
c.2144C>G (p.Pro715Arg)
c.*564C>G (n.*564C>G)
c.2267C>G (p.Pro756Arg)
c.2564C>G (p.Pro855Arg)
c.2546C>G (p.Pro849Arg)
c.2255C>G (p.Pro752Arg)
c.2183C>G (p.Pro728Arg)
n.3248C>G
n.2918C>G
n.3141C>G
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234307G=CA1239260253DNMT3Ac.960C=
c.1857C= (n.1857C=)
c.2042C= (p.Pro681=)
c.2711C= (p.Pro904=)
c.2144C= (p.Pro715=)
c.*564C= (n.*564C=)
c.2267C= (p.Pro756=)
c.2564C= (p.Pro855=)
c.2546C= (p.Pro849=)
c.2255C= (p.Pro752=)
c.2183C= (p.Pro728=)
n.3248C=
n.2918C=
n.3141C=
2g.25234307G>TCA1555465DNMT3Ac.960C>A
c.1857C>A (n.1857C>A)
c.2042C>A (p.Pro681Gln)
c.2711C>A (p.Pro904Gln)
c.2144C>A (p.Pro715Gln)
c.*564C>A (n.*564C>A)
c.2267C>A (p.Pro756Gln)
c.2564C>A (p.Pro855Gln)
c.2546C>A (p.Pro849Gln)
c.2255C>A (p.Pro752Gln)
c.2183C>A (p.Pro728Gln)
n.3248C>A
n.2918C>A
n.3141C>A
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234308dupCA1239260255DNMT3Ac.960dup
c.1857dup (n.1857dup)
c.2042dup (p.Leu682AlafsTer16)
c.2711dup (p.Leu905AlafsTer16)
c.2144dup (p.Leu716AlafsTer16)
c.*564dup (n.*564dup)
c.2267dup (p.Leu757AlafsTer16)
c.2564dup (p.Leu856AlafsTer16)
c.2546dup (p.Leu850AlafsTer16)
c.2255dup (p.Leu753AlafsTer16)
c.2183dup (p.Leu729AlafsTer16)
n.3248dup
n.2918dup
n.3141dup
 dbSNP
2g.25234308delCA1239260254DNMT3Ac.960del
c.1857del (n.1857del)
c.2042del (p.Pro681ArgfsTer2)
c.2711del (p.Pro904ArgfsTer2)
c.2144del (p.Pro715ArgfsTer2)
c.*564del (n.*564del)
c.2267del (p.Pro756ArgfsTer2)
c.2564del (p.Pro855ArgfsTer2)
c.2546del (p.Pro849ArgfsTer2)
c.2255del (p.Pro752ArgfsTer2)
c.2183del (p.Pro728ArgfsTer2)
n.3248del
n.2918del
n.3141del
 dbSNP
2g.25234308G>ACA346068047DNMT3Ac.959C>T
c.1856C>T (n.1856C>T)
c.2041C>T (p.Pro681Ser)
c.2710C>T (p.Pro904Ser)
c.2143C>T (p.Pro715Ser)
c.*563C>T (n.*563C>T)
c.2266C>T (p.Pro756Ser)
c.2563C>T (p.Pro855Ser)
c.2545C>T (p.Pro849Ser)
c.2254C>T (p.Pro752Ser)
c.2182C>T (p.Pro728Ser)
n.3247C>T
n.2917C>T
n.3140C>T
 ClinVar dbSNP gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234308G>CCA346068048DNMT3Ac.959C>G
c.1856C>G (n.1856C>G)
c.2041C>G (p.Pro681Ala)
c.2710C>G (p.Pro904Ala)
c.2143C>G (p.Pro715Ala)
c.*563C>G (n.*563C>G)
c.2266C>G (p.Pro756Ala)
c.2563C>G (p.Pro855Ala)
c.2545C>G (p.Pro849Ala)
c.2254C>G (p.Pro752Ala)
c.2182C>G (p.Pro728Ala)
n.3247C>G
n.2917C>G
n.3140C>G
 gnomAD v4 COSMIC
2g.25234308G=CA1239260256DNMT3Ac.959C=
c.1856C= (n.1856C=)
c.2041C= (p.Pro681=)
c.2710C= (p.Pro904=)
c.2143C= (p.Pro715=)
c.*563C= (n.*563C=)
c.2266C= (p.Pro756=)
c.2563C= (p.Pro855=)
c.2545C= (p.Pro849=)
c.2254C= (p.Pro752=)
c.2182C= (p.Pro728=)
n.3247C=
n.2917C=
n.3140C=
2g.25234308G>TCA346068049DNMT3Ac.959C>A
c.1856C>A (n.1856C>A)
c.2041C>A (p.Pro681Thr)
c.2710C>A (p.Pro904Thr)
c.2143C>A (p.Pro715Thr)
c.*563C>A (n.*563C>A)
c.2266C>A (p.Pro756Thr)
c.2563C>A (p.Pro855Thr)
c.2545C>A (p.Pro849Thr)
c.2254C>A (p.Pro752Thr)
c.2182C>A (p.Pro728Thr)
n.3247C>A
n.2917C>A
n.3140C>A
 dbSNP
2g.25234309A>CCA425180838DNMT3Ac.958T>G
c.1855T>G (n.1855T>G)
c.2040T>G (p.Ala680=)
c.2709T>G (p.Ala903=)
c.2142T>G (p.Ala714=)
c.*562T>G (n.*562T>G)
c.2265T>G (p.Ala755=)
c.2562T>G (p.Ala854=)
c.2544T>G (p.Ala848=)
c.2253T>G (p.Ala751=)
c.2181T>G (p.Ala727=)
n.3246T>G
n.2916T>G
n.3139T>G
2g.25234309A>GCA425180839DNMT3Ac.958T>C
c.1855T>C (n.1855T>C)
c.2040T>C (p.Ala680=)
c.2709T>C (p.Ala903=)
c.2142T>C (p.Ala714=)
c.*562T>C (n.*562T>C)
c.2265T>C (p.Ala755=)
c.2562T>C (p.Ala854=)
c.2544T>C (p.Ala848=)
c.2253T>C (p.Ala751=)
c.2181T>C (p.Ala727=)
n.3246T>C
n.2916T>C
n.3139T>C
2g.25234309A>TCA425180840DNMT3Ac.958T>A
c.1855T>A (n.1855T>A)
c.2040T>A (p.Ala680=)
c.2709T>A (p.Ala903=)
c.2142T>A (p.Ala714=)
c.*562T>A (n.*562T>A)
c.2265T>A (p.Ala755=)
c.2562T>A (p.Ala854=)
c.2544T>A (p.Ala848=)
c.2253T>A (p.Ala751=)
c.2181T>A (p.Ala727=)
n.3246T>A
n.2916T>A
n.3139T>A
2g.25234309_25234320delinsAGCGAAGAGGTGCA1239260257DNMT3Ac.947_958delinsCACCTCTTCGCT
c.1844_1855delinsCACCTCTTCGCT (n.1844_1855delinsCACCTCTTCGCT)
c.2029_2040delinsCACCTCTTCGCT (p.His677=)
c.2698_2709delinsCACCTCTTCGCT (p.His900=)
c.2131_2142delinsCACCTCTTCGCT (p.His711=)
c.*551_*562delinsCACCTCTTCGCT (n.*551_*562delinsCACCTCTTCGCT)
c.2254_2265delinsCACCTCTTCGCT (p.His752=)
c.2551_2562delinsCACCTCTTCGCT (p.His851=)
c.2533_2544delinsCACCTCTTCGCT (p.His845=)
c.2242_2253delinsCACCTCTTCGCT (p.His748=)
c.2170_2181delinsCACCTCTTCGCT (p.His724=)
n.3235_3246delinsCACCTCTTCGCT
n.2905_2916delinsCACCTCTTCGCT
n.3128_3139delinsCACCTCTTCGCT
2g.25234310G>ACA346068050DNMT3Ac.957C>T
c.1854C>T (n.1854C>T)
c.2039C>T (p.Ala680Val)
c.2708C>T (p.Ala903Val)
c.2141C>T (p.Ala714Val)
c.*561C>T (n.*561C>T)
c.2264C>T (p.Ala755Val)
c.2561C>T (p.Ala854Val)
c.2543C>T (p.Ala848Val)
c.2252C>T (p.Ala751Val)
c.2180C>T (p.Ala727Val)
n.3245C>T
n.2915C>T
n.3138C>T
2g.25234310G>CCA346068051DNMT3Ac.957C>G
c.1854C>G (n.1854C>G)
c.2039C>G (p.Ala680Gly)
c.2708C>G (p.Ala903Gly)
c.2141C>G (p.Ala714Gly)
c.*561C>G (n.*561C>G)
c.2264C>G (p.Ala755Gly)
c.2561C>G (p.Ala854Gly)
c.2543C>G (p.Ala848Gly)
c.2252C>G (p.Ala751Gly)
c.2180C>G (p.Ala727Gly)
n.3245C>G
n.2915C>G
n.3138C>G
2g.25234310G>TCA346068052DNMT3Ac.957C>A
c.1854C>A (n.1854C>A)
c.2039C>A (p.Ala680Asp)
c.2708C>A (p.Ala903Asp)
c.2141C>A (p.Ala714Asp)
c.*561C>A (n.*561C>A)
c.2264C>A (p.Ala755Asp)
c.2561C>A (p.Ala854Asp)
c.2543C>A (p.Ala848Asp)
c.2252C>A (p.Ala751Asp)
c.2180C>A (p.Ala727Asp)
n.3245C>A
n.2915C>A
n.3138C>A
 gnomAD v4
2g.25234310_25234311delinsGCCA1239260259DNMT3Ac.956_957delinsGC
c.1853_1854delinsGC (n.1853_1854delinsGC)
c.2038_2039delinsGC (p.Ala680=)
c.2707_2708delinsGC (p.Ala903=)
c.2140_2141delinsGC (p.Ala714=)
c.*560_*561delinsGC (n.*560_*561delinsGC)
c.2263_2264delinsGC (p.Ala755=)
c.2560_2561delinsGC (p.Ala854=)
c.2542_2543delinsGC (p.Ala848=)
c.2251_2252delinsGC (p.Ala751=)
c.2179_2180delinsGC (p.Ala727=)
n.3244_3245delinsGC
n.2914_2915delinsGC
n.3137_3138delinsGC
2g.25234313_25234323dupCA531368314DNMT3Ac.947_957dup
c.1844_1854dup (n.1844_1854dup)
c.2029_2039dup (p.Pro681ThrfsTer6)
c.2698_2708dup (p.Pro904ThrfsTer6)
c.2131_2141dup (p.Pro715ThrfsTer6)
c.*551_*561dup (n.*551_*561dup)
c.2254_2264dup (p.Pro756ThrfsTer6)
c.2551_2561dup (p.Pro855ThrfsTer6)
c.2533_2543dup (p.Pro849ThrfsTer6)
c.2242_2252dup (p.Pro752ThrfsTer6)
c.2170_2180dup (p.Pro728ThrfsTer6)
n.3235_3245dup
n.2905_2915dup
n.3128_3138dup
 dbSNP gnomAD v2 gnomAD v4
2g.25234313_25234323delCA1239260258DNMT3Ac.947_957del
c.1844_1854del (n.1844_1854del)
c.2029_2039del (p.His677SerfsTer17)
c.2698_2708del (p.His900SerfsTer17)
c.2131_2141del (p.His711SerfsTer17)
c.*551_*561del (n.*551_*561del)
c.2254_2264del (p.His752SerfsTer17)
c.2551_2561del (p.His851SerfsTer17)
c.2533_2543del (p.His845SerfsTer17)
c.2242_2252del (p.His748SerfsTer17)
c.2170_2180del (p.His724SerfsTer17)
n.3235_3245del
n.2905_2915del
n.3128_3138del
 dbSNP
2g.25234312_25234333delCA2658167998DNMT3Ac.936_957del
c.1833_1854del (n.1833_1854del)
c.2018_2039del (p.Pro673LeufsTer3)
c.2687_2708del (p.Pro896LeufsTer3)
c.2120_2141del (p.Pro707LeufsTer3)
c.*540_*561del (n.*540_*561del)
c.2243_2264del (p.Pro748LeufsTer3)
c.2540_2561del (p.Pro847LeufsTer3)
c.2522_2543del (p.Pro841LeufsTer3)
c.2231_2252del (p.Pro744LeufsTer3)
c.2159_2180del (p.Pro720LeufsTer3)
n.3224_3245del
n.2894_2915del
n.3117_3138del
 gnomAD v4
2g.25234311delCA531368315DNMT3Ac.956del
c.1853del (n.1853del)
c.2038del (p.Ala680LeufsTer3)
c.2707del (p.Ala903LeufsTer3)
c.2140del (p.Ala714LeufsTer3)
c.*560del (n.*560del)
c.2263del (p.Ala755LeufsTer3)
c.2560del (p.Ala854LeufsTer3)
c.2542del (p.Ala848LeufsTer3)
c.2251del (p.Ala751LeufsTer3)
c.2179del (p.Ala727LeufsTer3)
n.3244del
n.2914del
n.3137del
 dbSNP gnomAD v2 gnomAD v4
2g.25234311C>ACA346068053DNMT3Ac.956G>T
c.1853G>T (n.1853G>T)
c.2038G>T (p.Ala680Ser)
c.2707G>T (p.Ala903Ser)
c.2140G>T (p.Ala714Ser)
c.*560G>T (n.*560G>T)
c.2263G>T (p.Ala755Ser)
c.2560G>T (p.Ala854Ser)
c.2542G>T (p.Ala848Ser)
c.2251G>T (p.Ala751Ser)
c.2179G>T (p.Ala727Ser)
n.3244G>T
n.2914G>T
n.3137G>T
2g.25234311C=CA1239260261DNMT3Ac.956G=
c.1853G= (n.1853G=)
c.2038G= (p.Ala680=)
c.2707G= (p.Ala903=)
c.2140G= (p.Ala714=)
c.*560G= (n.*560G=)
c.2263G= (p.Ala755=)
c.2560G= (p.Ala854=)
c.2542G= (p.Ala848=)
c.2251G= (p.Ala751=)
c.2179G= (p.Ala727=)
n.3244G=
n.2914G=
n.3137G=
2g.25234311C>GCA346068054DNMT3Ac.956G>C
c.1853G>C (n.1853G>C)
c.2038G>C (p.Ala680Pro)
c.2707G>C (p.Ala903Pro)
c.2140G>C (p.Ala714Pro)
c.*560G>C (n.*560G>C)
c.2263G>C (p.Ala755Pro)
c.2560G>C (p.Ala854Pro)
c.2542G>C (p.Ala848Pro)
c.2251G>C (p.Ala751Pro)
c.2179G>C (p.Ala727Pro)
n.3244G>C
n.2914G>C
n.3137G>C
 ClinVar dbSNP gnomAD v3 gnomAD v4
2g.25234311C>TCA1555467DNMT3Ac.956G>A
c.1853G>A (n.1853G>A)
c.2038G>A (p.Ala680Thr)
c.2707G>A (p.Ala903Thr)
c.2140G>A (p.Ala714Thr)
c.*560G>A (n.*560G>A)
c.2263G>A (p.Ala755Thr)
c.2560G>A (p.Ala854Thr)
c.2542G>A (p.Ala848Thr)
c.2251G>A (p.Ala751Thr)
c.2179G>A (p.Ala727Thr)
n.3244G>A
n.2914G>A
n.3137G>A
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234311_25234312delinsCGCA1239260260DNMT3Ac.955_956delinsCG
c.1852_1853delinsCG (n.1852_1853delinsCG)
c.2037_2038delinsCG (p.Phe679=)
c.2706_2707delinsCG (p.Phe902=)
c.2139_2140delinsCG (p.Phe713=)
c.*559_*560delinsCG (n.*559_*560delinsCG)
c.2262_2263delinsCG (p.Phe754=)
c.2559_2560delinsCG (p.Phe853=)
c.2541_2542delinsCG (p.Phe847=)
c.2250_2251delinsCG (p.Phe750=)
c.2178_2179delinsCG (p.Phe726=)
n.3243_3244delinsCG
n.2913_2914delinsCG
n.3136_3137delinsCG
2g.25234312delCA425180841DNMT3Ac.955del
c.1852del (n.1852del)
c.2037del (p.Phe679LeufsTer4)
c.2706del (p.Phe902LeufsTer4)
c.2139del (p.Phe713LeufsTer4)
c.*559del (n.*559del)
c.2262del (p.Phe754LeufsTer4)
c.2559del (p.Phe853LeufsTer4)
c.2541del (p.Phe847LeufsTer4)
c.2250del (p.Phe750LeufsTer4)
c.2178del (p.Phe726LeufsTer4)
n.3243del
n.2913del
n.3136del
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234312G>ACA1555468DNMT3Ac.955C>T
c.1852C>T (n.1852C>T)
c.2037C>T (p.Phe679=)
c.2706C>T (p.Phe902=)
c.2139C>T (p.Phe713=)
c.*559C>T (n.*559C>T)
c.2262C>T (p.Phe754=)
c.2559C>T (p.Phe853=)
c.2541C>T (p.Phe847=)
c.2250C>T (p.Phe750=)
c.2178C>T (p.Phe726=)
n.3243C>T
n.2913C>T
n.3136C>T
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234312G>CCA346068056DNMT3Ac.955C>G
c.1852C>G (n.1852C>G)
c.2037C>G (p.Phe679Leu)
c.2706C>G (p.Phe902Leu)
c.2139C>G (p.Phe713Leu)
c.*559C>G (n.*559C>G)
c.2262C>G (p.Phe754Leu)
c.2559C>G (p.Phe853Leu)
c.2541C>G (p.Phe847Leu)
c.2250C>G (p.Phe750Leu)
c.2178C>G (p.Phe726Leu)
n.3243C>G
n.2913C>G
n.3136C>G
 dbSNP
2g.25234312G=CA1239260262DNMT3Ac.955C=
c.1852C= (n.1852C=)
c.2037C= (p.Phe679=)
c.2706C= (p.Phe902=)
c.2139C= (p.Phe713=)
c.*559C= (n.*559C=)
c.2262C= (p.Phe754=)
c.2559C= (p.Phe853=)
c.2541C= (p.Phe847=)
c.2250C= (p.Phe750=)
c.2178C= (p.Phe726=)
n.3243C=
n.2913C=
n.3136C=
2g.25234312G>TCA346068055DNMT3Ac.955C>A
c.1852C>A (n.1852C>A)
c.2037C>A (p.Phe679Leu)
c.2706C>A (p.Phe902Leu)
c.2139C>A (p.Phe713Leu)
c.*559C>A (n.*559C>A)
c.2262C>A (p.Phe754Leu)
c.2559C>A (p.Phe853Leu)
c.2541C>A (p.Phe847Leu)
c.2250C>A (p.Phe750Leu)
c.2178C>A (p.Phe726Leu)
n.3243C>A
n.2913C>A
n.3136C>A
2g.25234312_25234313delinsGACA1239260263DNMT3Ac.954_955delinsTC
c.1851_1852delinsTC (n.1851_1852delinsTC)
c.2036_2037delinsTC (p.Phe679=)
c.2705_2706delinsTC (p.Phe902=)
c.2138_2139delinsTC (p.Phe713=)
c.*558_*559delinsTC (n.*558_*559delinsTC)
c.2261_2262delinsTC (p.Phe754=)
c.2558_2559delinsTC (p.Phe853=)
c.2540_2541delinsTC (p.Phe847=)
c.2249_2250delinsTC (p.Phe750=)
c.2177_2178delinsTC (p.Phe726=)
n.3242_3243delinsTC
n.2912_2913delinsTC
n.3135_3136delinsTC
2g.25234312_25234314delinsGAACA1239260264DNMT3Ac.953_955delinsTTC
c.1850_1852delinsTTC (n.1850_1852delinsTTC)
c.2035_2037delinsTTC (p.Phe679=)
c.2704_2706delinsTTC (p.Phe902=)
c.2137_2139delinsTTC (p.Phe713=)
c.*557_*559delinsTTC (n.*557_*559delinsTTC)
c.2260_2262delinsTTC (p.Phe754=)
c.2557_2559delinsTTC (p.Phe853=)
c.2539_2541delinsTTC (p.Phe847=)
c.2248_2250delinsTTC (p.Phe750=)
c.2176_2178delinsTTC (p.Phe726=)
n.3241_3243delinsTTC
n.2911_2913delinsTTC
n.3134_3136delinsTTC
2g.25234314_25234316delCA645515117DNMT3Ac.953_955del
c.1850_1852del (n.1850_1852del)
c.2035_2037del (p.Phe679del)
c.2704_2706del (p.Phe902del)
c.2137_2139del (p.Phe713del)
c.*557_*559del (n.*557_*559del)
c.2260_2262del (p.Phe754del)
c.2557_2559del (p.Phe853del)
c.2539_2541del (p.Phe847del)
c.2248_2250del (p.Phe750del)
c.2176_2178del (p.Phe726del)
n.3241_3243del
n.2911_2913del
n.3134_3136del
 COSMIC
2g.25234312_25234313insTCA2576693559DNMT3Ac.954_955insA
c.1851_1852insA (n.1851_1852insA)
c.2036_2037insA (p.Phe679LeufsTer19)
c.2705_2706insA (p.Phe902LeufsTer19)
c.2138_2139insA (p.Phe713LeufsTer19)
c.*558_*559insA (n.*558_*559insA)
c.2261_2262insA (p.Phe754LeufsTer19)
c.2558_2559insA (p.Phe853LeufsTer19)
c.2540_2541insA (p.Phe847LeufsTer19)
c.2249_2250insA (p.Phe750LeufsTer19)
c.2177_2178insA (p.Phe726LeufsTer19)
n.3242_3243insA
n.2912_2913insA
n.3135_3136insA
2g.25234313A=CA1239260265DNMT3Ac.954T=
c.1851T= (n.1851T=)
c.2036T= (p.Phe679=)
c.2705T= (p.Phe902=)
c.2138T= (p.Phe713=)
c.*558T= (n.*558T=)
c.2261T= (p.Phe754=)
c.2558T= (p.Phe853=)
c.2540T= (p.Phe847=)
c.2249T= (p.Phe750=)
c.2177T= (p.Phe726=)
n.3242T=
n.2912T=
n.3135T=
2g.25234313A>CCA346068057DNMT3Ac.954T>G
c.1851T>G (n.1851T>G)
c.2036T>G (p.Phe679Cys)
c.2705T>G (p.Phe902Cys)
c.2138T>G (p.Phe713Cys)
c.*558T>G (n.*558T>G)
c.2261T>G (p.Phe754Cys)
c.2558T>G (p.Phe853Cys)
c.2540T>G (p.Phe847Cys)
c.2249T>G (p.Phe750Cys)
c.2177T>G (p.Phe726Cys)
n.3242T>G
n.2912T>G
n.3135T>G
2g.25234313A>GCA163326DNMT3Ac.954T>C
c.1851T>C (n.1851T>C)
c.2036T>C (p.Phe679Ser)
c.2705T>C (p.Phe902Ser)
c.2138T>C (p.Phe713Ser)
c.*558T>C (n.*558T>C)
c.2261T>C (p.Phe754Ser)
c.2558T>C (p.Phe853Ser)
c.2540T>C (p.Phe847Ser)
c.2249T>C (p.Phe750Ser)
c.2177T>C (p.Phe726Ser)
n.3242T>C
n.2912T>C
n.3135T>C
 ClinVar dbSNP gnomAD v2 gnomAD v4
2g.25234313A>TCA346068058DNMT3Ac.954T>A
c.1851T>A (n.1851T>A)
c.2036T>A (p.Phe679Tyr)
c.2705T>A (p.Phe902Tyr)
c.2138T>A (p.Phe713Tyr)
c.*558T>A (n.*558T>A)
c.2261T>A (p.Phe754Tyr)
c.2558T>A (p.Phe853Tyr)
c.2540T>A (p.Phe847Tyr)
c.2249T>A (p.Phe750Tyr)
c.2177T>A (p.Phe726Tyr)
n.3242T>A
n.2912T>A
n.3135T>A
2g.25234313_25234314delCA916494336DNMT3Ac.953_954del
c.1850_1851del (n.1850_1851del)
c.2035_2036del (p.Phe679ArgfsTer18)
c.2704_2705del (p.Phe902ArgfsTer18)
c.2137_2138del (p.Phe713ArgfsTer18)
c.*557_*558del (n.*557_*558del)
c.2260_2261del (p.Phe754ArgfsTer18)
c.2557_2558del (p.Phe853ArgfsTer18)
c.2539_2540del (p.Phe847ArgfsTer18)
c.2248_2249del (p.Phe750ArgfsTer18)
c.2176_2177del (p.Phe726ArgfsTer18)
n.3241_3242del
n.2911_2912del
n.3134_3135del
 dbSNP
2g.25234314dupCA2576693558DNMT3Ac.954dup
c.1851dup (n.1851dup)
c.2036dup (p.Ala680ArgfsTer18)
c.2705dup (p.Ala903ArgfsTer18)
c.2138dup (p.Ala714ArgfsTer18)
c.*558dup (n.*558dup)
c.2261dup (p.Ala755ArgfsTer18)
c.2558dup (p.Ala854ArgfsTer18)
c.2540dup (p.Ala848ArgfsTer18)
c.2249dup (p.Ala751ArgfsTer18)
c.2177dup (p.Ala727ArgfsTer18)
n.3242dup
n.2912dup
n.3135dup
 gnomAD v4
2g.25234314delCA767169213DNMT3Ac.954del
c.1851del (n.1851del)
c.2036del (p.Phe679SerfsTer4)
c.2705del (p.Phe902SerfsTer4)
c.2138del (p.Phe713SerfsTer4)
c.*558del (n.*558del)
c.2261del (p.Phe754SerfsTer4)
c.2558del (p.Phe853SerfsTer4)
c.2540del (p.Phe847SerfsTer4)
c.2249del (p.Phe750SerfsTer4)
c.2177del (p.Phe726SerfsTer4)
n.3242del
n.2912del
n.3135del
 dbSNP
2g.25234314A>CCA346068059DNMT3Ac.953T>G
c.1850T>G (n.1850T>G)
c.2035T>G (p.Phe679Val)
c.2704T>G (p.Phe902Val)
c.2137T>G (p.Phe713Val)
c.*557T>G (n.*557T>G)
c.2260T>G (p.Phe754Val)
c.2557T>G (p.Phe853Val)
c.2539T>G (p.Phe847Val)
c.2248T>G (p.Phe750Val)
c.2176T>G (p.Phe726Val)
n.3241T>G
n.2911T>G
n.3134T>G
2g.25234314A>GCA346068060DNMT3Ac.953T>C
c.1850T>C (n.1850T>C)
c.2035T>C (p.Phe679Leu)
c.2704T>C (p.Phe902Leu)
c.2137T>C (p.Phe713Leu)
c.*557T>C (n.*557T>C)
c.2260T>C (p.Phe754Leu)
c.2557T>C (p.Phe853Leu)
c.2539T>C (p.Phe847Leu)
c.2248T>C (p.Phe750Leu)
c.2176T>C (p.Phe726Leu)
n.3241T>C
n.2911T>C
n.3134T>C
2g.25234314A>TCA346068061DNMT3Ac.953T>A
c.1850T>A (n.1850T>A)
c.2035T>A (p.Phe679Ile)
c.2704T>A (p.Phe902Ile)
c.2137T>A (p.Phe713Ile)
c.*557T>A (n.*557T>A)
c.2260T>A (p.Phe754Ile)
c.2557T>A (p.Phe853Ile)
c.2539T>A (p.Phe847Ile)
c.2248T>A (p.Phe750Ile)
c.2176T>A (p.Phe726Ile)
n.3241T>A
n.2911T>A
n.3134T>A
2g.25234314_25234318dupCA2658168031DNMT3Ac.949_953dup
c.1846_1850dup (n.1846_1850dup)
c.2031_2035dup (p.Phe679SerfsTer6)
c.2700_2704dup (p.Phe902SerfsTer6)
c.2133_2137dup (p.Phe713SerfsTer6)
c.*553_*557dup (n.*553_*557dup)
c.2256_2260dup (p.Phe754SerfsTer6)
c.2553_2557dup (p.Phe853SerfsTer6)
c.2535_2539dup (p.Phe847SerfsTer6)
c.2244_2248dup (p.Phe750SerfsTer6)
c.2172_2176dup (p.Phe726SerfsTer6)
n.3237_3241dup
n.2907_2911dup
n.3130_3134dup
 gnomAD v4
2g.25234315G>ACA425180842DNMT3Ac.952C>T
c.1849C>T (n.1849C>T)
c.2034C>T (p.Leu678=)
c.2703C>T (p.Leu901=)
c.2136C>T (p.Leu712=)
c.*556C>T (n.*556C>T)
c.2259C>T (p.Leu753=)
c.2556C>T (p.Leu852=)
c.2538C>T (p.Leu846=)
c.2247C>T (p.Leu749=)
c.2175C>T (p.Leu725=)
n.3240C>T
n.2910C>T
n.3133C>T
2g.25234315G>CCA425180843DNMT3Ac.952C>G
c.1849C>G (n.1849C>G)
c.2034C>G (p.Leu678=)
c.2703C>G (p.Leu901=)
c.2136C>G (p.Leu712=)
c.*556C>G (n.*556C>G)
c.2259C>G (p.Leu753=)
c.2556C>G (p.Leu852=)
c.2538C>G (p.Leu846=)
c.2247C>G (p.Leu749=)
c.2175C>G (p.Leu725=)
n.3240C>G
n.2910C>G
n.3133C>G
 ClinVar dbSNP
2g.25234315G>TCA425180844DNMT3Ac.952C>A
c.1849C>A (n.1849C>A)
c.2034C>A (p.Leu678=)
c.2703C>A (p.Leu901=)
c.2136C>A (p.Leu712=)
c.*556C>A (n.*556C>A)
c.2259C>A (p.Leu753=)
c.2556C>A (p.Leu852=)
c.2538C>A (p.Leu846=)
c.2247C>A (p.Leu749=)
c.2175C>A (p.Leu725=)
n.3240C>A
n.2910C>A
n.3133C>A
2g.25234315_25234316insTCA2576693560DNMT3Ac.951_952insA
c.1848_1849insA (n.1848_1849insA)
c.2033_2034insA (p.Phe679LeufsTer19)
c.2702_2703insA (p.Phe902LeufsTer19)
c.2135_2136insA (p.Phe713LeufsTer19)
c.*555_*556insA (n.*555_*556insA)
c.2258_2259insA (p.Phe754LeufsTer19)
c.2555_2556insA (p.Phe853LeufsTer19)
c.2537_2538insA (p.Phe847LeufsTer19)
c.2246_2247insA (p.Phe750LeufsTer19)
c.2174_2175insA (p.Phe726LeufsTer19)
n.3239_3240insA
n.2909_2910insA
n.3132_3133insA
2g.25234316A=CA1239260266DNMT3Ac.951T=
c.1848T= (n.1848T=)
c.2033T= (p.Leu678=)
c.2702T= (p.Leu901=)
c.2135T= (p.Leu712=)
c.*555T= (n.*555T=)
c.2258T= (p.Leu753=)
c.2555T= (p.Leu852=)
c.2537T= (p.Leu846=)
c.2246T= (p.Leu749=)
c.2174T= (p.Leu725=)
n.3239T=
n.2909T=
n.3132T=
2g.25234316A>CCA346068062DNMT3Ac.951T>G
c.1848T>G (n.1848T>G)
c.2033T>G (p.Leu678Arg)
c.2702T>G (p.Leu901Arg)
c.2135T>G (p.Leu712Arg)
c.*555T>G (n.*555T>G)
c.2258T>G (p.Leu753Arg)
c.2555T>G (p.Leu852Arg)
c.2537T>G (p.Leu846Arg)
c.2246T>G (p.Leu749Arg)
c.2174T>G (p.Leu725Arg)
n.3239T>G
n.2909T>G
n.3132T>G
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25234316A>GCA1555469DNMT3Ac.951T>C
c.1848T>C (n.1848T>C)
c.2033T>C (p.Leu678Pro)
c.2702T>C (p.Leu901Pro)
c.2135T>C (p.Leu712Pro)
c.*555T>C (n.*555T>C)
c.2258T>C (p.Leu753Pro)
c.2555T>C (p.Leu852Pro)
c.2537T>C (p.Leu846Pro)
c.2246T>C (p.Leu749Pro)
c.2174T>C (p.Leu725Pro)
n.3239T>C
n.2909T>C
n.3132T>C
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234316A>TCA346068063DNMT3Ac.951T>A
c.1848T>A (n.1848T>A)
c.2033T>A (p.Leu678His)
c.2702T>A (p.Leu901His)
c.2135T>A (p.Leu712His)
c.*555T>A (n.*555T>A)
c.2258T>A (p.Leu753His)
c.2555T>A (p.Leu852His)
c.2537T>A (p.Leu846His)
c.2246T>A (p.Leu749His)
c.2174T>A (p.Leu725His)
n.3239T>A
n.2909T>A
n.3132T>A
 gnomAD v4 COSMIC
2g.25234316_25234342delCA1028525344DNMT3Ac.925_951del
c.1822_1848del (n.1822_1848del)
c.2007_2033del (p.Trp670_Leu678del)
c.2676_2702del (p.Trp893_Leu901del)
c.2109_2135del (p.Trp704_Leu712del)
c.*529_*555del (n.*529_*555del)
c.2232_2258del (p.Trp745_Leu753del)
c.2529_2555del (p.Trp844_Leu852del)
c.2511_2537del (p.Trp838_Leu846del)
c.2220_2246del (p.Trp741_Leu749del)
c.2148_2174del (p.Trp717_Leu725del)
n.3213_3239del
n.2883_2909del
n.3106_3132del
 gnomAD v3 gnomAD v4
2g.25234317G>ACA346068064DNMT3Ac.950C>T
c.1847C>T (n.1847C>T)
c.2032C>T (p.Leu678Phe)
c.2701C>T (p.Leu901Phe)
c.2134C>T (p.Leu712Phe)
c.*554C>T (n.*554C>T)
c.2257C>T (p.Leu753Phe)
c.2554C>T (p.Leu852Phe)
c.2536C>T (p.Leu846Phe)
c.2245C>T (p.Leu749Phe)
c.2173C>T (p.Leu725Phe)
n.3238C>T
n.2908C>T
n.3131C>T
2g.25234317G>CCA346068065DNMT3Ac.950C>G
c.1847C>G (n.1847C>G)
c.2032C>G (p.Leu678Val)
c.2701C>G (p.Leu901Val)
c.2134C>G (p.Leu712Val)
c.*554C>G (n.*554C>G)
c.2257C>G (p.Leu753Val)
c.2554C>G (p.Leu852Val)
c.2536C>G (p.Leu846Val)
c.2245C>G (p.Leu749Val)
c.2173C>G (p.Leu725Val)
n.3238C>G
n.2908C>G
n.3131C>G
 dbSNP gnomAD v4
2g.25234317G=CA1239260267DNMT3Ac.950C=
c.1847C= (n.1847C=)
c.2032C= (p.Leu678=)
c.2701C= (p.Leu901=)
c.2134C= (p.Leu712=)
c.*554C= (n.*554C=)
c.2257C= (p.Leu753=)
c.2554C= (p.Leu852=)
c.2536C= (p.Leu846=)
c.2245C= (p.Leu749=)
c.2173C= (p.Leu725=)
n.3238C=
n.2908C=
n.3131C=
2g.25234317G>TCA346068066DNMT3Ac.950C>A
c.1847C>A (n.1847C>A)
c.2032C>A (p.Leu678Ile)
c.2701C>A (p.Leu901Ile)
c.2134C>A (p.Leu712Ile)
c.*554C>A (n.*554C>A)
c.2257C>A (p.Leu753Ile)
c.2554C>A (p.Leu852Ile)
c.2536C>A (p.Leu846Ile)
c.2245C>A (p.Leu749Ile)
c.2173C>A (p.Leu725Ile)
n.3238C>A
n.2908C>A
n.3131C>A
2g.25234318G>ACA425180845DNMT3Ac.949C>T
c.1846C>T (n.1846C>T)
c.2031C>T (p.His677=)
c.2700C>T (p.His900=)
c.2133C>T (p.His711=)
c.*553C>T (n.*553C>T)
c.2256C>T (p.His752=)
c.2553C>T (p.His851=)
c.2535C>T (p.His845=)
c.2244C>T (p.His748=)
c.2172C>T (p.His724=)
n.3237C>T
n.2907C>T
n.3130C>T
 dbSNP
2g.25234318G>CCA346068068DNMT3Ac.949C>G
c.1846C>G (n.1846C>G)
c.2031C>G (p.His677Gln)
c.2700C>G (p.His900Gln)
c.2133C>G (p.His711Gln)
c.*553C>G (n.*553C>G)
c.2256C>G (p.His752Gln)
c.2553C>G (p.His851Gln)
c.2535C>G (p.His845Gln)
c.2244C>G (p.His748Gln)
c.2172C>G (p.His724Gln)
n.3237C>G
n.2907C>G
n.3130C>G
2g.25234318G=CA1239260268DNMT3Ac.949C=
c.1846C= (n.1846C=)
c.2031C= (p.His677=)
c.2700C= (p.His900=)
c.2133C= (p.His711=)
c.*553C= (n.*553C=)
c.2256C= (p.His752=)
c.2553C= (p.His851=)
c.2535C= (p.His845=)
c.2244C= (p.His748=)
c.2172C= (p.His724=)
n.3237C=
n.2907C=
n.3130C=
2g.25234318G>TCA346068067DNMT3Ac.949C>A
c.1846C>A (n.1846C>A)
c.2031C>A (p.His677Gln)
c.2700C>A (p.His900Gln)
c.2133C>A (p.His711Gln)
c.*553C>A (n.*553C>A)
c.2256C>A (p.His752Gln)
c.2553C>A (p.His851Gln)
c.2535C>A (p.His845Gln)
c.2244C>A (p.His748Gln)
c.2172C>A (p.His724Gln)
n.3237C>A
n.2907C>A
n.3130C>A
2g.25234319T>ACA346068069DNMT3Ac.948A>T
c.1845A>T (n.1845A>T)
c.2030A>T (p.His677Leu)
c.2699A>T (p.His900Leu)
c.2132A>T (p.His711Leu)
c.*552A>T (n.*552A>T)
c.2255A>T (p.His752Leu)
c.2552A>T (p.His851Leu)
c.2534A>T (p.His845Leu)
c.2243A>T (p.His748Leu)
c.2171A>T (p.His724Leu)
n.3236A>T
n.2906A>T
n.3129A>T
2g.25234319T>CCA346068070DNMT3Ac.948A>G
c.1845A>G (n.1845A>G)
c.2030A>G (p.His677Arg)
c.2699A>G (p.His900Arg)
c.2132A>G (p.His711Arg)
c.*552A>G (n.*552A>G)
c.2255A>G (p.His752Arg)
c.2552A>G (p.His851Arg)
c.2534A>G (p.His845Arg)
c.2243A>G (p.His748Arg)
c.2171A>G (p.His724Arg)
n.3236A>G
n.2906A>G
n.3129A>G
 gnomAD v4
2g.25234319T>GCA346068071DNMT3Ac.948A>C
c.1845A>C (n.1845A>C)
c.2030A>C (p.His677Pro)
c.2699A>C (p.His900Pro)
c.2132A>C (p.His711Pro)
c.*552A>C (n.*552A>C)
c.2255A>C (p.His752Pro)
c.2552A>C (p.His851Pro)
c.2534A>C (p.His845Pro)
c.2243A>C (p.His748Pro)
c.2171A>C (p.His724Pro)
n.3236A>C
n.2906A>C
n.3129A>C
2g.25234319T=CA1239260269DNMT3Ac.948A=
c.1845A= (n.1845A=)
c.2030A= (p.His677=)
c.2699A= (p.His900=)
c.2132A= (p.His711=)
c.*552A= (n.*552A=)
c.2255A= (p.His752=)
c.2552A= (p.His851=)
c.2534A= (p.His845=)
c.2243A= (p.His748=)
c.2171A= (p.His724=)
n.3236A=
n.2906A=
n.3129A=
2g.25234319_25234320insAACA1555470DNMT3Ac.947_948insTT
c.1844_1845insTT (n.1844_1845insTT)
c.2029_2030insTT (p.His677LeufsTer7)
c.2698_2699insTT (p.His900LeufsTer7)
c.2131_2132insTT (p.His711LeufsTer7)
c.*551_*552insTT (n.*551_*552insTT)
c.2254_2255insTT (p.His752LeufsTer7)
c.2551_2552insTT (p.His851LeufsTer7)
c.2533_2534insTT (p.His845LeufsTer7)
c.2242_2243insTT (p.His748LeufsTer7)
c.2170_2171insTT (p.His724LeufsTer7)
n.3235_3236insTT
n.2905_2906insTT
n.3128_3129insTT
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234319_25234320insCGCCA2658168049DNMT3Ac.947_948insGCG
c.1844_1845insGCG (n.1844_1845insGCG)
c.2029_2030insGCG (p.His677delinsArgAsp)
c.2698_2699insGCG (p.His900delinsArgAsp)
c.2131_2132insGCG (p.His711delinsArgAsp)
c.*551_*552insGCG (n.*551_*552insGCG)
c.2254_2255insGCG (p.His752delinsArgAsp)
c.2551_2552insGCG (p.His851delinsArgAsp)
c.2533_2534insGCG (p.His845delinsArgAsp)
c.2242_2243insGCG (p.His748delinsArgAsp)
c.2170_2171insGCG (p.His724delinsArgAsp)
n.3235_3236insGCG
n.2905_2906insGCG
n.3128_3129insGCG
 gnomAD v4
2g.25234320G>ACA346068072DNMT3Ac.947C>T
c.1844C>T (n.1844C>T)
c.2029C>T (p.His677Tyr)
c.2698C>T (p.His900Tyr)
c.2131C>T (p.His711Tyr)
c.*551C>T (n.*551C>T)
c.2254C>T (p.His752Tyr)
c.2551C>T (p.His851Tyr)
c.2533C>T (p.His845Tyr)
c.2242C>T (p.His748Tyr)
c.2170C>T (p.His724Tyr)
n.3235C>T
n.2905C>T
n.3128C>T
 gnomAD v4
2g.25234320G>CCA346068073DNMT3Ac.947C>G
c.1844C>G (n.1844C>G)
c.2029C>G (p.His677Asp)
c.2698C>G (p.His900Asp)
c.2131C>G (p.His711Asp)
c.*551C>G (n.*551C>G)
c.2254C>G (p.His752Asp)
c.2551C>G (p.His851Asp)
c.2533C>G (p.His845Asp)
c.2242C>G (p.His748Asp)
c.2170C>G (p.His724Asp)
n.3235C>G
n.2905C>G
n.3128C>G
2g.25234320G>TCA346068074DNMT3Ac.947C>A
c.1844C>A (n.1844C>A)
c.2029C>A (p.His677Asn)
c.2698C>A (p.His900Asn)
c.2131C>A (p.His711Asn)
c.*551C>A (n.*551C>A)
c.2254C>A (p.His752Asn)
c.2551C>A (p.His851Asn)
c.2533C>A (p.His845Asn)
c.2242C>A (p.His748Asn)
c.2170C>A (p.His724Asn)
n.3235C>A
n.2905C>A
n.3128C>A
2g.25234321delCA2658168052DNMT3Ac.947del
c.1844del (n.1844del)
c.2029del (p.His677ThrfsTer6)
c.2698del (p.His900ThrfsTer6)
c.2131del (p.His711ThrfsTer6)
c.*551del (n.*551del)
c.2254del (p.His752ThrfsTer6)
c.2551del (p.His851ThrfsTer6)
c.2533del (p.His845ThrfsTer6)
c.2242del (p.His748ThrfsTer6)
c.2170del (p.His724ThrfsTer6)
n.3235del
n.2905del
n.3128del
 gnomAD v4
2g.25234321G>ACA1555471DNMT3Ac.946C>T
c.1843C>T (n.1843C>T)
c.2028C>T (p.Arg676=)
c.2697C>T (p.Arg899=)
c.2130C>T (p.Arg710=)
c.*550C>T (n.*550C>T)
c.2253C>T (p.Arg751=)
c.2550C>T (p.Arg850=)
c.2532C>T (p.Arg844=)
c.2241C>T (p.Arg747=)
c.2169C>T (p.Arg723=)
n.3234C>T
n.2904C>T
n.3127C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234321G>CCA425180846DNMT3Ac.946C>G
c.1843C>G (n.1843C>G)
c.2028C>G (p.Arg676=)
c.2697C>G (p.Arg899=)
c.2130C>G (p.Arg710=)
c.*550C>G (n.*550C>G)
c.2253C>G (p.Arg751=)
c.2550C>G (p.Arg850=)
c.2532C>G (p.Arg844=)
c.2241C>G (p.Arg747=)
c.2169C>G (p.Arg723=)
n.3234C>G
n.2904C>G
n.3127C>G
2g.25234321G=CA1239260270DNMT3Ac.946C=
c.1843C= (n.1843C=)
c.2028C= (p.Arg676=)
c.2697C= (p.Arg899=)
c.2130C= (p.Arg710=)
c.*550C= (n.*550C=)
c.2253C= (p.Arg751=)
c.2550C= (p.Arg850=)
c.2532C= (p.Arg844=)
c.2241C= (p.Arg747=)
c.2169C= (p.Arg723=)
n.3234C=
n.2904C=
n.3127C=
2g.25234321G>TCA425180847DNMT3Ac.946C>A
c.1843C>A (n.1843C>A)
c.2028C>A (p.Arg676=)
c.2697C>A (p.Arg899=)
c.2130C>A (p.Arg710=)
c.*550C>A (n.*550C>A)
c.2253C>A (p.Arg751=)
c.2550C>A (p.Arg850=)
c.2532C>A (p.Arg844=)
c.2241C>A (p.Arg747=)
c.2169C>A (p.Arg723=)
n.3234C>A
n.2904C>A
n.3127C>A
2g.25234322C>ACA346068075DNMT3Ac.945G>T
c.1842G>T (n.1842G>T)
c.2027G>T (p.Arg676Leu)
c.2696G>T (p.Arg899Leu)
c.2129G>T (p.Arg710Leu)
c.*549G>T (n.*549G>T)
c.2252G>T (p.Arg751Leu)
c.2549G>T (p.Arg850Leu)
c.2531G>T (p.Arg844Leu)
c.2240G>T (p.Arg747Leu)
c.2168G>T (p.Arg723Leu)
n.3233G>T
n.2903G>T
n.3126G>T
 gnomAD v4
2g.25234322C=CA1239260271DNMT3Ac.945G=
c.1842G= (n.1842G=)
c.2027G= (p.Arg676=)
c.2696G= (p.Arg899=)
c.2129G= (p.Arg710=)
c.*549G= (n.*549G=)
c.2252G= (p.Arg751=)
c.2549G= (p.Arg850=)
c.2531G= (p.Arg844=)
c.2240G= (p.Arg747=)
c.2168G= (p.Arg723=)
n.3233G=
n.2903G=
n.3126G=
2g.25234322C>GCA346068076DNMT3Ac.945G>C
c.1842G>C (n.1842G>C)
c.2027G>C (p.Arg676Pro)
c.2696G>C (p.Arg899Pro)
c.2129G>C (p.Arg710Pro)
c.*549G>C (n.*549G>C)
c.2252G>C (p.Arg751Pro)
c.2549G>C (p.Arg850Pro)
c.2531G>C (p.Arg844Pro)
c.2240G>C (p.Arg747Pro)
c.2168G>C (p.Arg723Pro)
n.3233G>C
n.2903G>C
n.3126G>C
 dbSNP gnomAD v2 gnomAD v4 COSMIC
2g.25234322C>TCA346068077DNMT3Ac.945G>A
c.1842G>A (n.1842G>A)
c.2027G>A (p.Arg676His)
c.2696G>A (p.Arg899His)
c.2129G>A (p.Arg710His)
c.*549G>A (n.*549G>A)
c.2252G>A (p.Arg751His)
c.2549G>A (p.Arg850His)
c.2531G>A (p.Arg844His)
c.2240G>A (p.Arg747His)
c.2168G>A (p.Arg723His)
n.3233G>A
n.2903G>A
n.3126G>A
 dbSNP gnomAD v4 COSMIC
2g.25234322_25234323delinsCGCA1239260272DNMT3Ac.944_945delinsCG
c.1841_1842delinsCG (n.1841_1842delinsCG)
c.2026_2027delinsCG (p.Arg676=)
c.2695_2696delinsCG (p.Arg899=)
c.2128_2129delinsCG (p.Arg710=)
c.*548_*549delinsCG (n.*548_*549delinsCG)
c.2251_2252delinsCG (p.Arg751=)
c.2548_2549delinsCG (p.Arg850=)
c.2530_2531delinsCG (p.Arg844=)
c.2239_2240delinsCG (p.Arg747=)
c.2167_2168delinsCG (p.Arg723=)
n.3232_3233delinsCG
n.2902_2903delinsCG
n.3125_3126delinsCG
2g.25234325_25234348delCA2658168066DNMT3Ac.922_945del
c.1819_1842del (n.1819_1842del)
c.2004_2027del (p.Ser669_Arg676del)
c.2673_2696del (p.Ser892_Arg899del)
c.2106_2129del (p.Ser703_Arg710del)
c.*526_*549del (n.*526_*549del)
c.2229_2252del (p.Ser744_Arg751del)
c.2526_2549del (p.Ser843_Arg850del)
c.2508_2531del (p.Ser837_Arg844del)
c.2217_2240del (p.Ser740_Arg747del)
c.2145_2168del (p.Ser716_Arg723del)
n.3210_3233del
n.2880_2903del
n.3103_3126del
 gnomAD v4
2g.25234323G>ACA1555472DNMT3Ac.944C>T
c.1841C>T (n.1841C>T)
c.2026C>T (p.Arg676Cys)
c.2695C>T (p.Arg899Cys)
c.2128C>T (p.Arg710Cys)
c.*548C>T (n.*548C>T)
c.2251C>T (p.Arg751Cys)
c.2548C>T (p.Arg850Cys)
c.2530C>T (p.Arg844Cys)
c.2239C>T (p.Arg747Cys)
c.2167C>T (p.Arg723Cys)
n.3232C>T
n.2902C>T
n.3125C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25234323G>CCA346068078DNMT3Ac.944C>G
c.1841C>G (n.1841C>G)
c.2026C>G (p.Arg676Gly)
c.2695C>G (p.Arg899Gly)
c.2128C>G (p.Arg710Gly)
c.*548C>G (n.*548C>G)
c.2251C>G (p.Arg751Gly)
c.2548C>G (p.Arg850Gly)
c.2530C>G (p.Arg844Gly)
c.2239C>G (p.Arg747Gly)
c.2167C>G (p.Arg723Gly)
n.3232C>G
n.2902C>G
n.3125C>G
 gnomAD v4
2g.25234323G=CA1239260273DNMT3Ac.944C=
c.1841C= (n.1841C=)
c.2026C= (p.Arg676=)
c.2695C= (p.Arg899=)
c.2128C= (p.Arg710=)
c.*548C= (n.*548C=)
c.2251C= (p.Arg751=)
c.2548C= (p.Arg850=)
c.2530C= (p.Arg844=)
c.2239C= (p.Arg747=)
c.2167C= (p.Arg723=)
n.3232C=
n.2902C=
n.3125C=
2g.25234323G>TCA346068079DNMT3Ac.944C>A
c.1841C>A (n.1841C>A)
c.2026C>A (p.Arg676Ser)
c.2695C>A (p.Arg899Ser)
c.2128C>A (p.Arg710Ser)
c.*548C>A (n.*548C>A)
c.2251C>A (p.Arg751Ser)
c.2548C>A (p.Arg850Ser)
c.2530C>A (p.Arg844Ser)
c.2239C>A (p.Arg747Ser)
c.2167C>A (p.Arg723Ser)
n.3232C>A
n.2902C>A
n.3125C>A
 gnomAD v4
2g.25234324delCA645515118DNMT3Ac.944del
c.1841del (n.1841del)
c.2026del (p.Arg676AlafsTer7)
c.2695del (p.Arg899AlafsTer7)
c.2128del (p.Arg710AlafsTer7)
c.*548del (n.*548del)
c.2251del (p.Arg751AlafsTer7)
c.2548del (p.Arg850AlafsTer7)
c.2530del (p.Arg844AlafsTer7)
c.2239del (p.Arg747AlafsTer7)
c.2167del (p.Arg723AlafsTer7)
n.3232del
n.2902del
n.3125del
 dbSNP gnomAD v4 COSMIC COSMIC
2g.25234323_25234325delCA2658168082DNMT3Ac.942_944del
c.1839_1841del (n.1839_1841del)
c.2024_2026del (p.Ile675_Arg676delinsSer)
c.2693_2695del (p.Ile898_Arg899delinsSer)
c.2126_2128del (p.Ile709_Arg710delinsSer)
c.*546_*548del (n.*546_*548del)
c.2249_2251del (p.Ile750_Arg751delinsSer)
c.2546_2548del (p.Ile849_Arg850delinsSer)
c.2528_2530del (p.Ile843_Arg844delinsSer)
c.2237_2239del (p.Ile746_Arg747delinsSer)
c.2165_2167del (p.Ile722_Arg723delinsSer)
n.3230_3232del
n.2900_2902del
n.3123_3125del
 gnomAD v4
2g.25234325_25234332dupCA2576693563DNMT3Ac.937_944dup
c.1834_1841dup (n.1834_1841dup)
c.2019_2026dup (p.Arg676GlnfsTer10)
c.2688_2695dup (p.Arg899GlnfsTer10)
c.2121_2128dup (p.Arg710GlnfsTer10)
c.*541_*548dup (n.*541_*548dup)
c.2244_2251dup (p.Arg751GlnfsTer10)
c.2541_2548dup (p.Arg850GlnfsTer10)
c.2523_2530dup (p.Arg844GlnfsTer10)
c.2232_2239dup (p.Arg747GlnfsTer10)
c.2160_2167dup (p.Arg723GlnfsTer10)
n.3225_3232dup
n.2895_2902dup
n.3118_3125dup
2g.25234324G>ACA425180849DNMT3Ac.943C>T
c.1840C>T (n.1840C>T)
c.2025C>T (p.Ile675=)
c.2694C>T (p.Ile898=)
c.2127C>T (p.Ile709=)
c.*547C>T (n.*547C>T)
c.2250C>T (p.Ile750=)
c.2547C>T (p.Ile849=)
c.2529C>T (p.Ile843=)
c.2238C>T (p.Ile746=)
c.2166C>T (p.Ile722=)
n.3231C>T
n.2901C>T
n.3124C>T
 dbSNP gnomAD v2 gnomAD v4
2g.25234324G>CCA346068080DNMT3Ac.943C>G
c.1840C>G (n.1840C>G)
c.2025C>G (p.Ile675Met)
c.2694C>G (p.Ile898Met)
c.2127C>G (p.Ile709Met)
c.*547C>G (n.*547C>G)
c.2250C>G (p.Ile750Met)
c.2547C>G (p.Ile849Met)
c.2529C>G (p.Ile843Met)
c.2238C>G (p.Ile746Met)
c.2166C>G (p.Ile722Met)
n.3231C>G
n.2901C>G
n.3124C>G
 dbSNP
2g.25234324G=CA1239260274DNMT3Ac.943C=
c.1840C= (n.1840C=)
c.2025C= (p.Ile675=)
c.2694C= (p.Ile898=)
c.2127C= (p.Ile709=)
c.*547C= (n.*547C=)
c.2250C= (p.Ile750=)
c.2547C= (p.Ile849=)
c.2529C= (p.Ile843=)
c.2238C= (p.Ile746=)
c.2166C= (p.Ile722=)
n.3231C=
n.2901C=
n.3124C=
2g.25234324G>TCA425180848DNMT3Ac.943C>A
c.1840C>A (n.1840C>A)
c.2025C>A (p.Ile675=)
c.2694C>A (p.Ile898=)
c.2127C>A (p.Ile709=)
c.*547C>A (n.*547C>A)
c.2250C>A (p.Ile750=)
c.2547C>A (p.Ile849=)
c.2529C>A (p.Ile843=)
c.2238C>A (p.Ile746=)
c.2166C>A (p.Ile722=)
n.3231C>A
n.2901C>A
n.3124C>A
2g.25234326_25234328dupCA2576693565DNMT3Ac.941_943dup
c.1838_1840dup (n.1838_1840dup)
c.2023_2025dup (p.Ile675_Arg676insIle)
c.2692_2694dup (p.Ile898_Arg899insIle)
c.2125_2127dup (p.Ile709_Arg710insIle)
c.*545_*547dup (n.*545_*547dup)
c.2248_2250dup (p.Ile750_Arg751insIle)
c.2545_2547dup (p.Ile849_Arg850insIle)
c.2527_2529dup (p.Ile843_Arg844insIle)
c.2236_2238dup (p.Ile746_Arg747insIle)
c.2164_2166dup (p.Ile722_Arg723insIle)
n.3229_3231dup
n.2899_2901dup
n.3122_3124dup
2g.25234324_25234325insTCA1239260275DNMT3Ac.942_943insA
c.1839_1840insA (n.1839_1840insA)
c.2024_2025insA (p.Arg676ProfsTer22)
c.2693_2694insA (p.Arg899ProfsTer22)
c.2126_2127insA (p.Arg710ProfsTer22)
c.*546_*547insA (n.*546_*547insA)
c.2249_2250insA (p.Arg751ProfsTer22)
c.2546_2547insA (p.Arg850ProfsTer22)
c.2528_2529insA (p.Arg844ProfsTer22)
c.2237_2238insA (p.Arg747ProfsTer22)
c.2165_2166insA (p.Arg723ProfsTer22)
n.3230_3231insA
n.2900_2901insA
n.3123_3124insA
 dbSNP
2g.25234325delCA2658168103DNMT3Ac.942del
c.1839del (n.1839del)
c.2024del (p.Ile675ThrfsTer8)
c.2693del (p.Ile898ThrfsTer8)
c.2126del (p.Ile709ThrfsTer8)
c.*546del (n.*546del)
c.2249del (p.Ile750ThrfsTer8)
c.2546del (p.Ile849ThrfsTer8)
c.2528del (p.Ile843ThrfsTer8)
c.2237del (p.Ile746ThrfsTer8)
c.2165del (p.Ile722ThrfsTer8)
n.3230del
n.2900del
n.3123del
 gnomAD v4
2g.25234325A=CA1239260276DNMT3Ac.942T=
c.1839T= (n.1839T=)
c.2024T= (p.Ile675=)
c.2693T= (p.Ile898=)
c.2126T= (p.Ile709=)
c.*546T= (n.*546T=)
c.2249T= (p.Ile750=)
c.2546T= (p.Ile849=)
c.2528T= (p.Ile843=)
c.2237T= (p.Ile746=)
c.2165T= (p.Ile722=)
n.3230T=
n.2900T=
n.3123T=
2g.25234325A>CCA346068081DNMT3Ac.942T>G
c.1839T>G (n.1839T>G)
c.2024T>G (p.Ile675Ser)
c.2693T>G (p.Ile898Ser)
c.2126T>G (p.Ile709Ser)
c.*546T>G (n.*546T>G)
c.2249T>G (p.Ile750Ser)
c.2546T>G (p.Ile849Ser)
c.2528T>G (p.Ile843Ser)
c.2237T>G (p.Ile746Ser)
c.2165T>G (p.Ile722Ser)
n.3230T>G
n.2900T>G
n.3123T>G
 gnomAD v3 gnomAD v4
2g.25234325A>GCA346068082DNMT3Ac.942T>C
c.1839T>C (n.1839T>C)
c.2024T>C (p.Ile675Thr)
c.2693T>C (p.Ile898Thr)
c.2126T>C (p.Ile709Thr)
c.*546T>C (n.*546T>C)
c.2249T>C (p.Ile750Thr)
c.2546T>C (p.Ile849Thr)
c.2528T>C (p.Ile843Thr)
c.2237T>C (p.Ile746Thr)
c.2165T>C (p.Ile722Thr)
n.3230T>C
n.2900T>C
n.3123T>C
 ClinVar dbSNP COSMIC
2g.25234325A>TCA43695906DNMT3Ac.942T>A
c.1839T>A (n.1839T>A)
c.2024T>A (p.Ile675Asn)
c.2693T>A (p.Ile898Asn)
c.2126T>A (p.Ile709Asn)
c.*546T>A (n.*546T>A)
c.2249T>A (p.Ile750Asn)
c.2546T>A (p.Ile849Asn)
c.2528T>A (p.Ile843Asn)
c.2237T>A (p.Ile746Asn)
c.2165T>A (p.Ile722Asn)
n.3230T>A
n.2900T>A
n.3123T>A
 dbSNP
2g.25234325_25234326delinsATCA1239260277DNMT3Ac.941_942delinsAT
c.1838_1839delinsAT (n.1838_1839delinsAT)
c.2023_2024delinsAT (p.Ile675=)
c.2692_2693delinsAT (p.Ile898=)
c.2125_2126delinsAT (p.Ile709=)
c.*545_*546delinsAT (n.*545_*546delinsAT)
c.2248_2249delinsAT (p.Ile750=)
c.2545_2546delinsAT (p.Ile849=)
c.2527_2528delinsAT (p.Ile843=)
c.2236_2237delinsAT (p.Ile746=)
c.2164_2165delinsAT (p.Ile722=)
n.3229_3230delinsAT
n.2899_2900delinsAT
n.3122_3123delinsAT
2g.25234330_25234345dupCA2658168100DNMT3Ac.927_942dup
c.1824_1839dup (n.1824_1839dup)
c.2009_2024dup (p.Ile675MetfsTer28)
c.2678_2693dup (p.Ile898MetfsTer28)
c.2111_2126dup (p.Ile709MetfsTer28)
c.*531_*546dup (n.*531_*546dup)
c.2234_2249dup (p.Ile750MetfsTer28)
c.2531_2546dup (p.Ile849MetfsTer28)
c.2513_2528dup (p.Ile843MetfsTer28)
c.2222_2237dup (p.Ile746MetfsTer28)
c.2150_2165dup (p.Ile722MetfsTer28)
n.3215_3230dup
n.2885_2900dup
n.3108_3123dup
 gnomAD v4
2g.25234330_25234345delCA2576693566DNMT3Ac.927_942del
c.1824_1839del (n.1824_1839del)
c.2009_2024del (p.Trp670SerfsTer8)
c.2678_2693del (p.Trp893SerfsTer8)
c.2111_2126del (p.Trp704SerfsTer8)
c.*531_*546del (n.*531_*546del)
c.2234_2249del (p.Trp745SerfsTer8)
c.2531_2546del (p.Trp844SerfsTer8)
c.2513_2528del (p.Trp838SerfsTer8)
c.2222_2237del (p.Trp741SerfsTer8)
c.2150_2165del (p.Trp717SerfsTer8)
n.3215_3230del
n.2885_2900del
n.3108_3123del
2g.25234326delCA1239260278DNMT3Ac.941del
c.1838del (n.1838del)
c.2023del (p.Ile675SerfsTer8)
c.2692del (p.Ile898SerfsTer8)
c.2125del (p.Ile709SerfsTer8)
c.*545del (n.*545del)
c.2248del (p.Ile750SerfsTer8)
c.2545del (p.Ile849SerfsTer8)
c.2527del (p.Ile843SerfsTer8)
c.2236del (p.Ile746SerfsTer8)
c.2164del (p.Ile722SerfsTer8)
n.3229del
n.2899del
n.3122del
 dbSNP
2g.25234326T>ACA346068083DNMT3Ac.941A>T
c.1838A>T (n.1838A>T)
c.2023A>T (p.Ile675Phe)
c.2692A>T (p.Ile898Phe)
c.2125A>T (p.Ile709Phe)
c.*545A>T (n.*545A>T)
c.2248A>T (p.Ile750Phe)
c.2545A>T (p.Ile849Phe)
c.2527A>T (p.Ile843Phe)
c.2236A>T (p.Ile746Phe)
c.2164A>T (p.Ile722Phe)
n.3229A>T
n.2899A>T
n.3122A>T
2g.25234326T>CCA346068084DNMT3Ac.941A>G
c.1838A>G (n.1838A>G)
c.2023A>G (p.Ile675Val)
c.2692A>G (p.Ile898Val)
c.2125A>G (p.Ile709Val)
c.*545A>G (n.*545A>G)
c.2248A>G (p.Ile750Val)
c.2545A>G (p.Ile849Val)
c.2527A>G (p.Ile843Val)
c.2236A>G (p.Ile746Val)
c.2164A>G (p.Ile722Val)
n.3229A>G
n.2899A>G
n.3122A>G
2g.25234326T>GCA346068085DNMT3Ac.941A>C
c.1838A>C (n.1838A>C)
c.2023A>C (p.Ile675Leu)
c.2692A>C (p.Ile898Leu)
c.2125A>C (p.Ile709Leu)
c.*545A>C (n.*545A>C)
c.2248A>C (p.Ile750Leu)
c.2545A>C (p.Ile849Leu)
c.2527A>C (p.Ile843Leu)
c.2236A>C (p.Ile746Leu)
c.2164A>C (p.Ile722Leu)
n.3229A>C
n.2899A>C
n.3122A>C
2g.25234326_25234327insCCATGCA2658168114DNMT3Ac.940_941insCATGG
c.1837_1838insCATGG (n.1837_1838insCATGG)
c.2022_2023insCATGG (p.Ile675HisfsTer10)
c.2691_2692insCATGG (p.Ile898HisfsTer10)
c.2124_2125insCATGG (p.Ile709HisfsTer10)
c.*544_*545insCATGG (n.*544_*545insCATGG)
c.2247_2248insCATGG (p.Ile750HisfsTer10)
c.2544_2545insCATGG (p.Ile849HisfsTer10)
c.2526_2527insCATGG (p.Ile843HisfsTer10)
c.2235_2236insCATGG (p.Ile746HisfsTer10)
c.2163_2164insCATGG (p.Ile722HisfsTer10)
n.3228_3229insCATGG
n.2898_2899insCATGG
n.3121_3122insCATGG
 gnomAD v4
2g.25234327G>ACA425180850DNMT3Ac.940C>T
c.1837C>T (n.1837C>T)
c.2022C>T (p.Val674=)
c.2691C>T (p.Val897=)
c.2124C>T (p.Val708=)
c.*544C>T (n.*544C>T)
c.2247C>T (p.Val749=)
c.2544C>T (p.Val848=)
c.2526C>T (p.Val842=)
c.2235C>T (p.Val745=)
c.2163C>T (p.Val721=)
n.3228C>T
n.2898C>T
n.3121C>T
 COSMIC COSMIC
2g.25234327G>CCA425180851DNMT3Ac.940C>G
c.1837C>G (n.1837C>G)
c.2022C>G (p.Val674=)
c.2691C>G (p.Val897=)
c.2124C>G (p.Val708=)
c.*544C>G (n.*544C>G)
c.2247C>G (p.Val749=)
c.2544C>G (p.Val848=)
c.2526C>G (p.Val842=)
c.2235C>G (p.Val745=)
c.2163C>G (p.Val721=)
n.3228C>G
n.2898C>G
n.3121C>G
2g.25234327G=CA1239260279DNMT3Ac.940C=
c.1837C= (n.1837C=)
c.2022C= (p.Val674=)
c.2691C= (p.Val897=)
c.2124C= (p.Val708=)
c.*544C= (n.*544C=)
c.2247C= (p.Val749=)
c.2544C= (p.Val848=)
c.2526C= (p.Val842=)
c.2235C= (p.Val745=)
c.2163C= (p.Val721=)
n.3228C=
n.2898C=
n.3121C=
2g.25234327G>TCA425180852DNMT3Ac.940C>A
c.1837C>A (n.1837C>A)
c.2022C>A (p.Val674=)
c.2691C>A (p.Val897=)
c.2124C>A (p.Val708=)
c.*544C>A (n.*544C>A)
c.2247C>A (p.Val749=)
c.2544C>A (p.Val848=)
c.2526C>A (p.Val842=)
c.2235C>A (p.Val745=)
c.2163C>A (p.Val721=)
n.3228C>A
n.2898C>A
n.3121C>A
 dbSNP gnomAD v4
2g.25234327_25234328insCCAACA2749204950DNMT3Ac.939_940insTTGG
c.1836_1837insTTGG (n.1836_1837insTTGG)
c.2021_2022insTTGG (p.Ile675TrpfsTer24)
c.2690_2691insTTGG (p.Ile898TrpfsTer24)
c.2123_2124insTTGG (p.Ile709TrpfsTer24)
c.*543_*544insTTGG (n.*543_*544insTTGG)
c.2246_2247insTTGG (p.Ile750TrpfsTer24)
c.2543_2544insTTGG (p.Ile849TrpfsTer24)
c.2525_2526insTTGG (p.Ile843TrpfsTer24)
c.2234_2235insTTGG (p.Ile746TrpfsTer24)
c.2162_2163insTTGG (p.Ile722TrpfsTer24)
n.3227_3228insTTGG
n.2897_2898insTTGG
n.3120_3121insTTGG
2g.25234328A=CA1239260280DNMT3Ac.939T=
c.1836T= (n.1836T=)
c.2021T= (p.Val674=)
c.2690T= (p.Val897=)
c.2123T= (p.Val708=)
c.*543T= (n.*543T=)
c.2246T= (p.Val749=)
c.2543T= (p.Val848=)
c.2525T= (p.Val842=)
c.2234T= (p.Val745=)
c.2162T= (p.Val721=)
n.3227T=
n.2897T=
n.3120T=
2g.25234328A>CCA346068086DNMT3Ac.939T>G
c.1836T>G (n.1836T>G)
c.2021T>G (p.Val674Gly)
c.2690T>G (p.Val897Gly)
c.2123T>G (p.Val708Gly)
c.*543T>G (n.*543T>G)
c.2246T>G (p.Val749Gly)
c.2543T>G (p.Val848Gly)
c.2525T>G (p.Val842Gly)
c.2234T>G (p.Val745Gly)
c.2162T>G (p.Val721Gly)
n.3227T>G
n.2897T>G
n.3120T>G
 dbSNP gnomAD v3 gnomAD v4
2g.25234328A>GCA346068087DNMT3Ac.939T>C
c.1836T>C (n.1836T>C)
c.2021T>C (p.Val674Ala)
c.2690T>C (p.Val897Ala)
c.2123T>C (p.Val708Ala)
c.*543T>C (n.*543T>C)
c.2246T>C (p.Val749Ala)
c.2543T>C (p.Val848Ala)
c.2525T>C (p.Val842Ala)
c.2234T>C (p.Val745Ala)
c.2162T>C (p.Val721Ala)
n.3227T>C
n.2897T>C
n.3120T>C
2g.25234328A>TCA346068088DNMT3Ac.939T>A
c.1836T>A (n.1836T>A)
c.2021T>A (p.Val674Asp)
c.2690T>A (p.Val897Asp)
c.2123T>A (p.Val708Asp)
c.*543T>A (n.*543T>A)
c.2246T>A (p.Val749Asp)
c.2543T>A (p.Val848Asp)
c.2525T>A (p.Val842Asp)
c.2234T>A (p.Val745Asp)
c.2162T>A (p.Val721Asp)
n.3227T>A
n.2897T>A
n.3120T>A
 dbSNP COSMIC
2g.25234328dupCA2658168126DNMT3Ac.939dup
c.1836dup (n.1836dup)
c.2021dup (p.Ile675HisfsTer23)
c.2690dup (p.Ile898HisfsTer23)
c.2123dup (p.Ile709HisfsTer23)
c.*543dup (n.*543dup)
c.2246dup (p.Ile750HisfsTer23)
c.2543dup (p.Ile849HisfsTer23)
c.2525dup (p.Ile843HisfsTer23)
c.2234dup (p.Ile746HisfsTer23)
c.2162dup (p.Ile722HisfsTer23)
n.3227dup
n.2897dup
n.3120dup
 gnomAD v4
2g.25234329C>ACA346068089DNMT3Ac.938G>T
c.1835G>T (n.1835G>T)
c.2020G>T (p.Val674Phe)
c.2689G>T (p.Val897Phe)
c.2122G>T (p.Val708Phe)
c.*542G>T (n.*542G>T)
c.2245G>T (p.Val749Phe)
c.2542G>T (p.Val848Phe)
c.2524G>T (p.Val842Phe)
c.2233G>T (p.Val745Phe)
c.2161G>T (p.Val721Phe)
n.3226G>T
n.2896G>T
n.3119G>T
2g.25234329C>GCA346068090DNMT3Ac.938G>C
c.1835G>C (n.1835G>C)
c.2020G>C (p.Val674Leu)
c.2689G>C (p.Val897Leu)
c.2122G>C (p.Val708Leu)
c.*542G>C (n.*542G>C)
c.2245G>C (p.Val749Leu)
c.2542G>C (p.Val848Leu)
c.2524G>C (p.Val842Leu)
c.2233G>C (p.Val745Leu)
c.2161G>C (p.Val721Leu)
n.3226G>C
n.2896G>C
n.3119G>C
2g.25234329C>TCA346068091DNMT3Ac.938G>A
c.1835G>A (n.1835G>A)
c.2020G>A (p.Val674Ile)
c.2689G>A (p.Val897Ile)
c.2122G>A (p.Val708Ile)
c.*542G>A (n.*542G>A)
c.2245G>A (p.Val749Ile)
c.2542G>A (p.Val848Ile)
c.2524G>A (p.Val842Ile)
c.2233G>A (p.Val745Ile)
c.2161G>A (p.Val721Ile)
n.3226G>A
n.2896G>A
n.3119G>A
 dbSNP
2g.25234329_25234330insAAACAGAAAACCCCTCTGAAAAGAGCA2749204951DNMT3Ac.937_938insCTCTTTTCAGAGGGGTTTTCTGTTT
c.1834_1835insCTCTTTTCAGAGGGGTTTTCTGTTT (n.1834_1835insCTCTTTTCAGAGGGGTTTTCTGTTT)
c.2019_2020insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val674LeufsTer32)
c.2688_2689insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val897LeufsTer32)
c.2121_2122insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val708LeufsTer32)
c.*541_*542insCTCTTTTCAGAGGGGTTTTCTGTTT (n.*541_*542insCTCTTTTCAGAGGGGTTTTCTGTTT)
c.2244_2245insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val749LeufsTer32)
c.2541_2542insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val848LeufsTer32)
c.2523_2524insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val842LeufsTer32)
c.2232_2233insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val745LeufsTer32)
c.2160_2161insCTCTTTTCAGAGGGGTTTTCTGTTT (p.Val721LeufsTer32)
n.3225_3226insCTCTTTTCAGAGGGGTTTTCTGTTT
n.2895_2896insCTCTTTTCAGAGGGGTTTTCTGTTT
n.3118_3119insCTCTTTTCAGAGGGGTTTTCTGTTT
2g.25234330T>ACA425180854DNMT3Ac.937A>T
c.1834A>T (n.1834A>T)
c.2019A>T (p.Pro673=)
c.2688A>T (p.Pro896=)
c.2121A>T (p.Pro707=)
c.*541A>T (n.*541A>T)
c.2244A>T (p.Pro748=)
c.2541A>T (p.Pro847=)
c.2523A>T (p.Pro841=)
c.2232A>T (p.Pro744=)
c.2160A>T (p.Pro720=)
n.3225A>T
n.2895A>T
n.3118A>T
 dbSNP
2g.25234330T>CCA1555473DNMT3Ac.937A>G
c.1834A>G (n.1834A>G)
c.2019A>G (p.Pro673=)
c.2688A>G (p.Pro896=)
c.2121A>G (p.Pro707=)
c.*541A>G (n.*541A>G)
c.2244A>G (p.Pro748=)
c.2541A>G (p.Pro847=)
c.2523A>G (p.Pro841=)
c.2232A>G (p.Pro744=)
c.2160A>G (p.Pro720=)
n.3225A>G
n.2895A>G
n.3118A>G
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25234330T>GCA425180853DNMT3Ac.937A>C
c.1834A>C (n.1834A>C)
c.2019A>C (p.Pro673=)
c.2688A>C (p.Pro896=)
c.2121A>C (p.Pro707=)
c.*541A>C (n.*541A>C)
c.2244A>C (p.Pro748=)
c.2541A>C (p.Pro847=)
c.2523A>C (p.Pro841=)
c.2232A>C (p.Pro744=)
c.2160A>C (p.Pro720=)
n.3225A>C
n.2895A>C
n.3118A>C
2g.25234330T=CA1239260281DNMT3Ac.937A=
c.1834A= (n.1834A=)
c.2019A= (p.Pro673=)
c.2688A= (p.Pro896=)
c.2121A= (p.Pro707=)
c.*541A= (n.*541A=)
c.2244A= (p.Pro748=)
c.2541A= (p.Pro847=)
c.2523A= (p.Pro841=)
c.2232A= (p.Pro744=)
c.2160A= (p.Pro720=)
n.3225A=
n.2895A=
n.3118A=
2g.25234331G>ACA346068094DNMT3Ac.936C>T
c.1833C>T (n.1833C>T)
c.2018C>T (p.Pro673Leu)
c.2687C>T (p.Pro896Leu)
c.2120C>T (p.Pro707Leu)
c.*540C>T (n.*540C>T)
c.2243C>T (p.Pro748Leu)
c.2540C>T (p.Pro847Leu)
c.2522C>T (p.Pro841Leu)
c.2231C>T (p.Pro744Leu)
c.2159C>T (p.Pro720Leu)
n.3224C>T
n.2894C>T
n.3117C>T
 dbSNP gnomAD v4 COSMIC COSMIC
2g.25234331G>CCA346068093DNMT3Ac.936C>G
c.1833C>G (n.1833C>G)
c.2018C>G (p.Pro673Arg)
c.2687C>G (p.Pro896Arg)
c.2120C>G (p.Pro707Arg)
c.*540C>G (n.*540C>G)
c.2243C>G (p.Pro748Arg)
c.2540C>G (p.Pro847Arg)
c.2522C>G (p.Pro841Arg)
c.2231C>G (p.Pro744Arg)
c.2159C>G (p.Pro720Arg)
n.3224C>G
n.2894C>G
n.3117C>G
2g.25234331G>TCA346068092DNMT3Ac.936C>A
c.1833C>A (n.1833C>A)
c.2018C>A (p.Pro673Gln)
c.2687C>A (p.Pro896Gln)
c.2120C>A (p.Pro707Gln)
c.*540C>A (n.*540C>A)
c.2243C>A (p.Pro748Gln)
c.2540C>A (p.Pro847Gln)
c.2522C>A (p.Pro841Gln)
c.2231C>A (p.Pro744Gln)
c.2159C>A (p.Pro720Gln)
n.3224C>A
n.2894C>A
n.3117C>A
2g.25234332delCA2658168139DNMT3Ac.936del
c.1833del (n.1833del)
c.2018del (p.Pro673GlnfsTer10)
c.2687del (p.Pro896GlnfsTer10)
c.2120del (p.Pro707GlnfsTer10)
c.*540del (n.*540del)
c.2243del (p.Pro748GlnfsTer10)
c.2540del (p.Pro847GlnfsTer10)
c.2522del (p.Pro841GlnfsTer10)
c.2231del (p.Pro744GlnfsTer10)
c.2159del (p.Pro720GlnfsTer10)
n.3224del
n.2894del
n.3117del
 gnomAD v4
2g.25234334_25234349dupCA2658168138DNMT3Ac.921_936dup
c.1818_1833dup (n.1818_1833dup)
c.2003_2018dup (p.Ile675MetfsTer28)
c.2672_2687dup (p.Ile898MetfsTer28)
c.2105_2120dup (p.Ile709MetfsTer28)
c.*525_*540dup (n.*525_*540dup)
c.2228_2243dup (p.Ile750MetfsTer28)
c.2525_2540dup (p.Ile849MetfsTer28)
c.2507_2522dup (p.Ile843MetfsTer28)
c.2216_2231dup (p.Ile746MetfsTer28)
c.2144_2159dup (p.Ile722MetfsTer28)
n.3209_3224dup
n.2879_2894dup
n.3102_3117dup
 gnomAD v4
2g.25234332G>ACA43695916DNMT3Ac.935C>T
c.1832C>T (n.1832C>T)
c.2017C>T (p.Pro673Ser)
c.2686C>T (p.Pro896Ser)
c.2119C>T (p.Pro707Ser)
c.*539C>T (n.*539C>T)
c.2242C>T (p.Pro748Ser)
c.2539C>T (p.Pro847Ser)
c.2521C>T (p.Pro841Ser)
c.2230C>T (p.Pro744Ser)
c.2158C>T (p.Pro720Ser)
n.3223C>T
n.2893C>T
n.3116C>T
 dbSNP
2g.25234332G>CCA346068096DNMT3Ac.935C>G
c.1832C>G (n.1832C>G)
c.2017C>G (p.Pro673Ala)
c.2686C>G (p.Pro896Ala)
c.2119C>G (p.Pro707Ala)
c.*539C>G (n.*539C>G)
c.2242C>G (p.Pro748Ala)
c.2539C>G (p.Pro847Ala)
c.2521C>G (p.Pro841Ala)
c.2230C>G (p.Pro744Ala)
c.2158C>G (p.Pro720Ala)
n.3223C>G
n.2893C>G
n.3116C>G
2g.25234332G=CA1239260282DNMT3Ac.935C=
c.1832C= (n.1832C=)
c.2017C= (p.Pro673=)
c.2686C= (p.Pro896=)
c.2119C= (p.Pro707=)
c.*539C= (n.*539C=)
c.2242C= (p.Pro748=)
c.2539C= (p.Pro847=)
c.2521C= (p.Pro841=)
c.2230C= (p.Pro744=)
c.2158C= (p.Pro720=)
n.3223C=
n.2893C=
n.3116C=
2g.25234332G>TCA346068095DNMT3Ac.935C>A
c.1832C>A (n.1832C>A)
c.2017C>A (p.Pro673Thr)
c.2686C>A (p.Pro896Thr)
c.2119C>A (p.Pro707Thr)
c.*539C>A (n.*539C>A)
c.2242C>A (p.Pro748Thr)
c.2539C>A (p.Pro847Thr)
c.2521C>A (p.Pro841Thr)
c.2230C>A (p.Pro744Thr)
c.2158C>A (p.Pro720Thr)
n.3223C>A
n.2893C>A
n.3116C>A
2g.25234334_25234337delCA2658168145DNMT3Ac.932_935del
c.1829_1832del (n.1829_1832del)
c.2014_2017del (p.Val672GlnfsTer10)
c.2683_2686del (p.Val895GlnfsTer10)
c.2116_2119del (p.Val706GlnfsTer10)
c.*536_*539del (n.*536_*539del)
c.2239_2242del (p.Val747GlnfsTer10)
c.2536_2539del (p.Val846GlnfsTer10)
c.2518_2521del (p.Val840GlnfsTer10)
c.2227_2230del (p.Val743GlnfsTer10)
c.2155_2158del (p.Val719GlnfsTer10)
n.3220_3223del
n.2890_2893del
n.3113_3116del
 gnomAD v4
2g.25234333C>ACA425180855DNMT3Ac.934G>T
c.1831G>T (n.1831G>T)
c.2016G>T (p.Val672=)
c.2685G>T (p.Val895=)
c.2118G>T (p.Val706=)
c.*538G>T (n.*538G>T)
c.2241G>T (p.Val747=)
c.2538G>T (p.Val846=)
c.2520G>T (p.Val840=)
c.2229G>T (p.Val743=)
c.2157G>T (p.Val719=)
n.3222G>T
n.2892G>T
n.3115G>T
2g.25234333C>GCA425180856DNMT3Ac.934G>C
c.1831G>C (n.1831G>C)
c.2016G>C (p.Val672=)
c.2685G>C (p.Val895=)
c.2118G>C (p.Val706=)
c.*538G>C (n.*538G>C)
c.2241G>C (p.Val747=)
c.2538G>C (p.Val846=)
c.2520G>C (p.Val840=)
c.2229G>C (p.Val743=)
c.2157G>C (p.Val719=)
n.3222G>C
n.2892G>C
n.3115G>C
2g.25234333C>TCA425180857DNMT3Ac.934G>A
c.1831G>A (n.1831G>A)
c.2016G>A (p.Val672=)
c.2685G>A (p.Val895=)
c.2118G>A (p.Val706=)
c.*538G>A (n.*538G>A)
c.2241G>A (p.Val747=)
c.2538G>A (p.Val846=)
c.2520G>A (p.Val840=)
c.2229G>A (p.Val743=)
c.2157G>A (p.Val719=)
n.3222G>A
n.2892G>A
n.3115G>A
 dbSNP
2g.25234333_25234337delCA2658168149DNMT3Ac.930_934del
c.1827_1831del (n.1827_1831del)
c.2012_2016del (p.Ser671ThrfsTer25)
c.2681_2685del (p.Ser894ThrfsTer25)
c.2114_2118del (p.Ser705ThrfsTer25)
c.*534_*538del (n.*534_*538del)
c.2237_2241del (p.Ser746ThrfsTer25)
c.2534_2538del (p.Ser845ThrfsTer25)
c.2516_2520del (p.Ser839ThrfsTer25)
c.2225_2229del (p.Ser742ThrfsTer25)
c.2153_2157del (p.Ser718ThrfsTer25)
n.3218_3222del
n.2888_2892del
n.3111_3115del
 gnomAD v4
2g.25234334A>CCA346068097DNMT3Ac.933T>G
c.1830T>G (n.1830T>G)
c.2015T>G (p.Val672Gly)
c.2684T>G (p.Val895Gly)
c.2117T>G (p.Val706Gly)
c.*537T>G (n.*537T>G)
c.2240T>G (p.Val747Gly)
c.2537T>G (p.Val846Gly)
c.2519T>G (p.Val840Gly)
c.2228T>G (p.Val743Gly)
c.2156T>G (p.Val719Gly)
n.3221T>G
n.2891T>G
n.3114T>G
2g.25234334A>GCA346068098DNMT3Ac.933T>C
c.1830T>C (n.1830T>C)
c.2015T>C (p.Val672Ala)
c.2684T>C (p.Val895Ala)
c.2117T>C (p.Val706Ala)
c.*537T>C (n.*537T>C)
c.2240T>C (p.Val747Ala)
c.2537T>C (p.Val846Ala)
c.2519T>C (p.Val840Ala)
c.2228T>C (p.Val743Ala)
c.2156T>C (p.Val719Ala)
n.3221T>C
n.2891T>C
n.3114T>C
2g.25234334A>TCA346068099DNMT3Ac.933T>A
c.1830T>A (n.1830T>A)
c.2015T>A (p.Val672Glu)
c.2684T>A (p.Val895Glu)
c.2117T>A (p.Val706Glu)
c.*537T>A (n.*537T>A)
c.2240T>A (p.Val747Glu)
c.2537T>A (p.Val846Glu)
c.2519T>A (p.Val840Glu)
c.2228T>A (p.Val743Glu)
c.2156T>A (p.Val719Glu)
n.3221T>A
n.2891T>A
n.3114T>A
2g.25234335C>ACA346068100DNMT3Ac.932G>T
c.1829G>T (n.1829G>T)
c.2014G>T (p.Val672Leu)
c.2683G>T (p.Val895Leu)
c.2116G>T (p.Val706Leu)
c.*536G>T (n.*536G>T)
c.2239G>T (p.Val747Leu)
c.2536G>T (p.Val846Leu)
c.2518G>T (p.Val840Leu)
c.2227G>T (p.Val743Leu)
c.2155G>T (p.Val719Leu)
n.3220G>T
n.2890G>T
n.3113G>T
 gnomAD v4
2g.25234335C=CA1239260283DNMT3Ac.932G=
c.1829G= (n.1829G=)
c.2014G= (p.Val672=)
c.2683G= (p.Val895=)
c.2116G= (p.Val706=)
c.*536G= (n.*536G=)
c.2239G= (p.Val747=)
c.2536G= (p.Val846=)
c.2518G= (p.Val840=)
c.2227G= (p.Val743=)
c.2155G= (p.Val719=)
n.3220G=
n.2890G=
n.3113G=
2g.25234335C>GCA346068101DNMT3Ac.932G>C
c.1829G>C (n.1829G>C)
c.2014G>C (p.Val672Leu)
c.2683G>C (p.Val895Leu)
c.2116G>C (p.Val706Leu)
c.*536G>C (n.*536G>C)
c.2239G>C (p.Val747Leu)
c.2536G>C (p.Val846Leu)
c.2518G>C (p.Val840Leu)
c.2227G>C (p.Val743Leu)
c.2155G>C (p.Val719Leu)
n.3220G>C
n.2890G>C
n.3113G>C
2g.25234335C>TCA1555474DNMT3Ac.932G>A
c.1829G>A (n.1829G>A)
c.2014G>A (p.Val672Met)
c.2683G>A (p.Val895Met)
c.2116G>A (p.Val706Met)
c.*536G>A (n.*536G>A)
c.2239G>A (p.Val747Met)
c.2536G>A (p.Val846Met)
c.2518G>A (p.Val840Met)
c.2227G>A (p.Val743Met)
c.2155G>A (p.Val719Met)
n.3220G>A
n.2890G>A
n.3113G>A
 dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC COSMIC
2g.25234336G>ACA1555475DNMT3Ac.931C>T
c.1828C>T (n.1828C>T)
c.2013C>T (p.Ser671=)
c.2682C>T (p.Ser894=)
c.2115C>T (p.Ser705=)
c.*535C>T (n.*535C>T)
c.2238C>T (p.Ser746=)
c.2535C>T (p.Ser845=)
c.2517C>T (p.Ser839=)
c.2226C>T (p.Ser742=)
c.2154C>T (p.Ser718=)
n.3219C>T
n.2889C>T
n.3112C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234336G>CCA346068102DNMT3Ac.931C>G
c.1828C>G (n.1828C>G)
c.2013C>G (p.Ser671Arg)
c.2682C>G (p.Ser894Arg)
c.2115C>G (p.Ser705Arg)
c.*535C>G (n.*535C>G)
c.2238C>G (p.Ser746Arg)
c.2535C>G (p.Ser845Arg)
c.2517C>G (p.Ser839Arg)
c.2226C>G (p.Ser742Arg)
c.2154C>G (p.Ser718Arg)
n.3219C>G
n.2889C>G
n.3112C>G
 gnomAD v4
2g.25234336G=CA1239260284DNMT3Ac.931C=
c.1828C= (n.1828C=)
c.2013C= (p.Ser671=)
c.2682C= (p.Ser894=)
c.2115C= (p.Ser705=)
c.*535C= (n.*535C=)
c.2238C= (p.Ser746=)
c.2535C= (p.Ser845=)
c.2517C= (p.Ser839=)
c.2226C= (p.Ser742=)
c.2154C= (p.Ser718=)
n.3219C=
n.2889C=
n.3112C=
2g.25234336G>TCA346068103DNMT3Ac.931C>A
c.1828C>A (n.1828C>A)
c.2013C>A (p.Ser671Arg)
c.2682C>A (p.Ser894Arg)
c.2115C>A (p.Ser705Arg)
c.*535C>A (n.*535C>A)
c.2238C>A (p.Ser746Arg)
c.2535C>A (p.Ser845Arg)
c.2517C>A (p.Ser839Arg)
c.2226C>A (p.Ser742Arg)
c.2154C>A (p.Ser718Arg)
n.3219C>A
n.2889C>A
n.3112C>A
2g.25234337C>ACA346068104DNMT3Ac.930G>T
c.1827G>T (n.1827G>T)
c.2012G>T (p.Ser671Ile)
c.2681G>T (p.Ser894Ile)
c.2114G>T (p.Ser705Ile)
c.*534G>T (n.*534G>T)
c.2237G>T (p.Ser746Ile)
c.2534G>T (p.Ser845Ile)
c.2516G>T (p.Ser839Ile)
c.2225G>T (p.Ser742Ile)
c.2153G>T (p.Ser718Ile)
n.3218G>T
n.2888G>T
n.3111G>T
2g.25234337C>GCA346068105DNMT3Ac.930G>C
c.1827G>C (n.1827G>C)
c.2012G>C (p.Ser671Thr)
c.2681G>C (p.Ser894Thr)
c.2114G>C (p.Ser705Thr)
c.*534G>C (n.*534G>C)
c.2237G>C (p.Ser746Thr)
c.2534G>C (p.Ser845Thr)
c.2516G>C (p.Ser839Thr)
c.2225G>C (p.Ser742Thr)
c.2153G>C (p.Ser718Thr)
n.3218G>C
n.2888G>C
n.3111G>C
 gnomAD v4
2g.25234337C>TCA346068106DNMT3Ac.930G>A
c.1827G>A (n.1827G>A)
c.2012G>A (p.Ser671Asn)
c.2681G>A (p.Ser894Asn)
c.2114G>A (p.Ser705Asn)
c.*534G>A (n.*534G>A)
c.2237G>A (p.Ser746Asn)
c.2534G>A (p.Ser845Asn)
c.2516G>A (p.Ser839Asn)
c.2225G>A (p.Ser742Asn)
c.2153G>A (p.Ser718Asn)
n.3218G>A
n.2888G>A
n.3111G>A
 gnomAD v4
2g.25234339_25234361delCA2658168166DNMT3Ac.908_930del
c.1805_1827del (n.1805_1827del)
c.1990_2012del (p.Leu665AlafsTer25)
c.2659_2681del (p.Leu888AlafsTer25)
c.2092_2114del (p.Leu699AlafsTer25)
c.*512_*534del (n.*512_*534del)
c.2215_2237del (p.Leu740AlafsTer25)
c.2512_2534del (p.Leu839AlafsTer25)
c.2494_2516del (p.Leu833AlafsTer25)
c.2203_2225del (p.Leu736AlafsTer25)
c.2131_2153del (p.Leu712AlafsTer25)
n.3196_3218del
n.2866_2888del
n.3089_3111del
 gnomAD v4
2g.25234338T>ACA346068109DNMT3Ac.929A>T
c.1826A>T (n.1826A>T)
c.2011A>T (p.Ser671Cys)
c.2680A>T (p.Ser894Cys)
c.2113A>T (p.Ser705Cys)
c.*533A>T (n.*533A>T)
c.2236A>T (p.Ser746Cys)
c.2533A>T (p.Ser845Cys)
c.2515A>T (p.Ser839Cys)
c.2224A>T (p.Ser742Cys)
c.2152A>T (p.Ser718Cys)
n.3217A>T
n.2887A>T
n.3110A>T
2g.25234338T>CCA346068107DNMT3Ac.929A>G
c.1826A>G (n.1826A>G)
c.2011A>G (p.Ser671Gly)
c.2680A>G (p.Ser894Gly)
c.2113A>G (p.Ser705Gly)
c.*533A>G (n.*533A>G)
c.2236A>G (p.Ser746Gly)
c.2533A>G (p.Ser845Gly)
c.2515A>G (p.Ser839Gly)
c.2224A>G (p.Ser742Gly)
c.2152A>G (p.Ser718Gly)
n.3217A>G
n.2887A>G
n.3110A>G
 gnomAD v4
2g.25234338T>GCA346068108DNMT3Ac.929A>C
c.1826A>C (n.1826A>C)
c.2011A>C (p.Ser671Arg)
c.2680A>C (p.Ser894Arg)
c.2113A>C (p.Ser705Arg)
c.*533A>C (n.*533A>C)
c.2236A>C (p.Ser746Arg)
c.2533A>C (p.Ser845Arg)
c.2515A>C (p.Ser839Arg)
c.2224A>C (p.Ser742Arg)
c.2152A>C (p.Ser718Arg)
n.3217A>C
n.2887A>C
n.3110A>C
2g.25234339C>ACA346068110DNMT3Ac.928G>T
c.1825G>T (n.1825G>T)
c.2010G>T (p.Trp670Cys)
c.2679G>T (p.Trp893Cys)
c.2112G>T (p.Trp704Cys)
c.*532G>T (n.*532G>T)
c.2235G>T (p.Trp745Cys)
c.2532G>T (p.Trp844Cys)
c.2514G>T (p.Trp838Cys)
c.2223G>T (p.Trp741Cys)
c.2151G>T (p.Trp717Cys)
n.3216G>T
n.2886G>T
n.3109G>T
 gnomAD v4 COSMIC
2g.25234339C=CA1239260285DNMT3Ac.928G=
c.1825G= (n.1825G=)
c.2010G= (p.Trp670=)
c.2679G= (p.Trp893=)
c.2112G= (p.Trp704=)
c.*532G= (n.*532G=)
c.2235G= (p.Trp745=)
c.2532G= (p.Trp844=)
c.2514G= (p.Trp838=)
c.2223G= (p.Trp741=)
c.2151G= (p.Trp717=)
n.3216G=
n.2886G=
n.3109G=
2g.25234339C>GCA346068111DNMT3Ac.928G>C
c.1825G>C (n.1825G>C)
c.2010G>C (p.Trp670Cys)
c.2679G>C (p.Trp893Cys)
c.2112G>C (p.Trp704Cys)
c.*532G>C (n.*532G>C)
c.2235G>C (p.Trp745Cys)
c.2532G>C (p.Trp844Cys)
c.2514G>C (p.Trp838Cys)
c.2223G>C (p.Trp741Cys)
c.2151G>C (p.Trp717Cys)
n.3216G>C
n.2886G>C
n.3109G>C
 COSMIC
2g.25234339C>TCA346068112DNMT3Ac.928G>A
c.1825G>A (n.1825G>A)
c.2010G>A (p.Trp670Ter)
c.2679G>A (p.Trp893Ter)
c.2112G>A (p.Trp704Ter)
c.*532G>A (n.*532G>A)
c.2235G>A (p.Trp745Ter)
c.2532G>A (p.Trp844Ter)
c.2514G>A (p.Trp838Ter)
c.2223G>A (p.Trp741Ter)
c.2151G>A (p.Trp717Ter)
n.3216G>A
n.2886G>A
n.3109G>A
 dbSNP gnomAD v3 gnomAD v4
2g.25234339_25234340delinsAGCA891841775DNMT3Ac.927_928delinsCT
c.1824_1825delinsCT (n.1824_1825delinsCT)
c.2009_2010delinsCT (p.Trp670Ser)
c.2678_2679delinsCT (p.Trp893Ser)
c.2111_2112delinsCT (p.Trp704Ser)
c.*531_*532delinsCT (n.*531_*532delinsCT)
c.2234_2235delinsCT (p.Trp745Ser)
c.2531_2532delinsCT (p.Trp844Ser)
c.2513_2514delinsCT (p.Trp838Ser)
c.2222_2223delinsCT (p.Trp741Ser)
c.2150_2151delinsCT (p.Trp717Ser)
n.3215_3216delinsCT
n.2885_2886delinsCT
n.3108_3109delinsCT
2g.25234340dupCA2658168177DNMT3Ac.928dup
c.1825dup (n.1825dup)
c.2010dup (p.Ser671GlufsTer27)
c.2679dup (p.Ser894GlufsTer27)
c.2112dup (p.Ser705GlufsTer27)
c.*532dup (n.*532dup)
c.2235dup (p.Ser746GlufsTer27)
c.2532dup (p.Ser845GlufsTer27)
c.2514dup (p.Ser839GlufsTer27)
c.2223dup (p.Ser742GlufsTer27)
c.2151dup (p.Ser718GlufsTer27)
n.3216dup
n.2886dup
n.3109dup
 gnomAD v4
2g.25234340delCA2658168175DNMT3Ac.928del
c.1825del (n.1825del)
c.2010del (p.Trp670Ter)
c.2679del (p.Trp893Ter)
c.2112del (p.Trp704Ter)
c.*532del (n.*532del)
c.2235del (p.Trp745Ter)
c.2532del (p.Trp844Ter)
c.2514del (p.Trp838Ter)
c.2223del (p.Trp741Ter)
c.2151del (p.Trp717Ter)
n.3216del
n.2886del
n.3109del
 gnomAD v4
2g.25234340C>ACA346068113DNMT3Ac.927G>T
c.1824G>T (n.1824G>T)
c.2009G>T (p.Trp670Leu)
c.2678G>T (p.Trp893Leu)
c.2111G>T (p.Trp704Leu)
c.*531G>T (n.*531G>T)
c.2234G>T (p.Trp745Leu)
c.2531G>T (p.Trp844Leu)
c.2513G>T (p.Trp838Leu)
c.2222G>T (p.Trp741Leu)
c.2150G>T (p.Trp717Leu)
n.3215G>T
n.2885G>T
n.3108G>T
 COSMIC COSMIC
2g.25234340C=CA1239260286DNMT3Ac.927G=
c.1824G= (n.1824G=)
c.2009G= (p.Trp670=)
c.2678G= (p.Trp893=)
c.2111G= (p.Trp704=)
c.*531G= (n.*531G=)
c.2234G= (p.Trp745=)
c.2531G= (p.Trp844=)
c.2513G= (p.Trp838=)
c.2222G= (p.Trp741=)
c.2150G= (p.Trp717=)
n.3215G=
n.2885G=
n.3108G=
2g.25234340C>GCA346068114DNMT3Ac.927G>C
c.1824G>C (n.1824G>C)
c.2009G>C (p.Trp670Ser)
c.2678G>C (p.Trp893Ser)
c.2111G>C (p.Trp704Ser)
c.*531G>C (n.*531G>C)
c.2234G>C (p.Trp745Ser)
c.2531G>C (p.Trp844Ser)
c.2513G>C (p.Trp838Ser)
c.2222G>C (p.Trp741Ser)
c.2150G>C (p.Trp717Ser)
n.3215G>C
n.2885G>C
n.3108G>C
 dbSNP gnomAD v4 COSMIC COSMIC
2g.25234340C>TCA1555476DNMT3Ac.927G>A
c.1824G>A (n.1824G>A)
c.2009G>A (p.Trp670Ter)
c.2678G>A (p.Trp893Ter)
c.2111G>A (p.Trp704Ter)
c.*531G>A (n.*531G>A)
c.2234G>A (p.Trp745Ter)
c.2531G>A (p.Trp844Ter)
c.2513G>A (p.Trp838Ter)
c.2222G>A (p.Trp741Ter)
c.2150G>A (p.Trp717Ter)
n.3215G>A
n.2885G>A
n.3108G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234340_25234347delCA2658168185DNMT3Ac.920_927del
c.1817_1824del (n.1817_1824del)
c.2002_2009del (p.Arg668GlufsTer27)
c.2671_2678del (p.Arg891GlufsTer27)
c.2104_2111del (p.Arg702GlufsTer27)
c.*524_*531del (n.*524_*531del)
c.2227_2234del (p.Arg743GlufsTer27)
c.2524_2531del (p.Arg842GlufsTer27)
c.2506_2513del (p.Arg836GlufsTer27)
c.2215_2222del (p.Arg739GlufsTer27)
c.2143_2150del (p.Arg715GlufsTer27)
n.3208_3215del
n.2878_2885del
n.3101_3108del
 gnomAD v4
2g.25234341A>CCA346068115DNMT3Ac.926T>G
c.1823T>G (n.1823T>G)
c.2008T>G (p.Trp670Gly)
c.2677T>G (p.Trp893Gly)
c.2110T>G (p.Trp704Gly)
c.*530T>G (n.*530T>G)
c.2233T>G (p.Trp745Gly)
c.2530T>G (p.Trp844Gly)
c.2512T>G (p.Trp838Gly)
c.2221T>G (p.Trp741Gly)
c.2149T>G (p.Trp717Gly)
n.3214T>G
n.2884T>G
n.3107T>G
2g.25234341A>GCA346068116DNMT3Ac.926T>C
c.1823T>C (n.1823T>C)
c.2008T>C (p.Trp670Arg)
c.2677T>C (p.Trp893Arg)
c.2110T>C (p.Trp704Arg)
c.*530T>C (n.*530T>C)
c.2233T>C (p.Trp745Arg)
c.2530T>C (p.Trp844Arg)
c.2512T>C (p.Trp838Arg)
c.2221T>C (p.Trp741Arg)
c.2149T>C (p.Trp717Arg)
n.3214T>C
n.2884T>C
n.3107T>C
 gnomAD v4
2g.25234341A>TCA346068117DNMT3Ac.926T>A
c.1823T>A (n.1823T>A)
c.2008T>A (p.Trp670Arg)
c.2677T>A (p.Trp893Arg)
c.2110T>A (p.Trp704Arg)
c.*530T>A (n.*530T>A)
c.2233T>A (p.Trp745Arg)
c.2530T>A (p.Trp844Arg)
c.2512T>A (p.Trp838Arg)
c.2221T>A (p.Trp741Arg)
c.2149T>A (p.Trp717Arg)
n.3214T>A
n.2884T>A
n.3107T>A
 COSMIC
2g.25234342T>ACA425180858DNMT3Ac.925A>T
c.1822A>T (n.1822A>T)
c.2007A>T (p.Ser669=)
c.2676A>T (p.Ser892=)
c.2109A>T (p.Ser703=)
c.*529A>T (n.*529A>T)
c.2232A>T (p.Ser744=)
c.2529A>T (p.Ser843=)
c.2511A>T (p.Ser837=)
c.2220A>T (p.Ser740=)
c.2148A>T (p.Ser716=)
n.3213A>T
n.2883A>T
n.3106A>T
 dbSNP gnomAD v3 gnomAD v4
2g.25234342T>CCA1555477DNMT3Ac.925A>G
c.1822A>G (n.1822A>G)
c.2007A>G (p.Ser669=)
c.2676A>G (p.Ser892=)
c.2109A>G (p.Ser703=)
c.*529A>G (n.*529A>G)
c.2232A>G (p.Ser744=)
c.2529A>G (p.Ser843=)
c.2511A>G (p.Ser837=)
c.2220A>G (p.Ser740=)
c.2148A>G (p.Ser716=)
n.3213A>G
n.2883A>G
n.3106A>G
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234342T>GCA425180859DNMT3Ac.925A>C
c.1822A>C (n.1822A>C)
c.2007A>C (p.Ser669=)
c.2676A>C (p.Ser892=)
c.2109A>C (p.Ser703=)
c.*529A>C (n.*529A>C)
c.2232A>C (p.Ser744=)
c.2529A>C (p.Ser843=)
c.2511A>C (p.Ser837=)
c.2220A>C (p.Ser740=)
c.2148A>C (p.Ser716=)
n.3213A>C
n.2883A>C
n.3106A>C
2g.25234342T=CA1239254482DNMT3Ac.925A=
c.1822A= (n.1822A=)
c.2007A= (p.Ser669=)
c.2676A= (p.Ser892=)
c.2109A= (p.Ser703=)
c.*529A= (n.*529A=)
c.2232A= (p.Ser744=)
c.2529A= (p.Ser843=)
c.2511A= (p.Ser837=)
c.2220A= (p.Ser740=)
c.2148A= (p.Ser716=)
n.3213A=
n.2883A=
n.3106A=
2g.25234342_25234355delinsTGACCGGCCCAGCACA1239254488DNMT3Ac.912_925delinsTGCTGGGCCGGTCA
c.1809_1822delinsTGCTGGGCCGGTCA (n.1809_1822delinsTGCTGGGCCGGTCA)
c.1994_2007delinsTGCTGGGCCGGTCA (p.Leu665=)
c.2663_2676delinsTGCTGGGCCGGTCA (p.Leu888=)
c.2096_2109delinsTGCTGGGCCGGTCA (p.Leu699=)
c.*516_*529delinsTGCTGGGCCGGTCA (n.*516_*529delinsTGCTGGGCCGGTCA)
c.2219_2232delinsTGCTGGGCCGGTCA (p.Leu740=)
c.2516_2529delinsTGCTGGGCCGGTCA (p.Leu839=)
c.2498_2511delinsTGCTGGGCCGGTCA (p.Leu833=)
c.2207_2220delinsTGCTGGGCCGGTCA (p.Leu736=)
c.2135_2148delinsTGCTGGGCCGGTCA (p.Leu712=)
n.3200_3213delinsTGCTGGGCCGGTCA
n.2870_2883delinsTGCTGGGCCGGTCA
n.3093_3106delinsTGCTGGGCCGGTCA
2g.25234343delCA2658168208DNMT3Ac.924del
c.1821del (n.1821del)
c.2006del (p.Ser669TyrfsTer14)
c.2675del (p.Ser892TyrfsTer14)
c.2108del (p.Ser703TyrfsTer14)
c.*528del (n.*528del)
c.2231del (p.Ser744TyrfsTer14)
c.2528del (p.Ser843TyrfsTer14)
c.2510del (p.Ser837TyrfsTer14)
c.2219del (p.Ser740TyrfsTer14)
c.2147del (p.Ser716TyrfsTer14)
n.3212del
n.2882del
n.3105del
 gnomAD v4
2g.25234343G>ACA346068120DNMT3Ac.924C>T
c.1821C>T (n.1821C>T)
c.2006C>T (p.Ser669Leu)
c.2675C>T (p.Ser892Leu)
c.2108C>T (p.Ser703Leu)
c.*528C>T (n.*528C>T)
c.2231C>T (p.Ser744Leu)
c.2528C>T (p.Ser843Leu)
c.2510C>T (p.Ser837Leu)
c.2219C>T (p.Ser740Leu)
c.2147C>T (p.Ser716Leu)
n.3212C>T
n.2882C>T
n.3105C>T
 dbSNP gnomAD v2 gnomAD v4
2g.25234343G>CCA346068119DNMT3Ac.924C>G
c.1821C>G (n.1821C>G)
c.2006C>G (p.Ser669Ter)
c.2675C>G (p.Ser892Ter)
c.2108C>G (p.Ser703Ter)
c.*528C>G (n.*528C>G)
c.2231C>G (p.Ser744Ter)
c.2528C>G (p.Ser843Ter)
c.2510C>G (p.Ser837Ter)
c.2219C>G (p.Ser740Ter)
c.2147C>G (p.Ser716Ter)
n.3212C>G
n.2882C>G
n.3105C>G
 dbSNP gnomAD v4
2g.25234343G=CA1239254495DNMT3Ac.924C=
c.1821C= (n.1821C=)
c.2006C= (p.Ser669=)
c.2675C= (p.Ser892=)
c.2108C= (p.Ser703=)
c.*528C= (n.*528C=)
c.2231C= (p.Ser744=)
c.2528C= (p.Ser843=)
c.2510C= (p.Ser837=)
c.2219C= (p.Ser740=)
c.2147C= (p.Ser716=)
n.3212C=
n.2882C=
n.3105C=
2g.25234343G>TCA346068118DNMT3Ac.924C>A
c.1821C>A (n.1821C>A)
c.2006C>A (p.Ser669Ter)
c.2675C>A (p.Ser892Ter)
c.2108C>A (p.Ser703Ter)
c.*528C>A (n.*528C>A)
c.2231C>A (p.Ser744Ter)
c.2528C>A (p.Ser843Ter)
c.2510C>A (p.Ser837Ter)
c.2219C>A (p.Ser740Ter)
c.2147C>A (p.Ser716Ter)
n.3212C>A
n.2882C>A
n.3105C>A
 gnomAD v4
2g.25234343_25234344insGAGCA2658168207DNMT3Ac.924_925insTCC
c.1821_1822insTCC (n.1821_1822insTCC)
c.2006_2007insTCC (p.Ser669_Trp670insPro)
c.2675_2676insTCC (p.Ser892_Trp893insPro)
c.2108_2109insTCC (p.Ser703_Trp704insPro)
c.*528_*529insTCC (n.*528_*529insTCC)
c.2231_2232insTCC (p.Ser744_Trp745insPro)
c.2528_2529insTCC (p.Ser843_Trp844insPro)
c.2510_2511insTCC (p.Ser837_Trp838insPro)
c.2219_2220insTCC (p.Ser740_Trp741insPro)
c.2147_2148insTCC (p.Ser716_Trp717insPro)
n.3212_3213insTCC
n.2882_2883insTCC
n.3105_3106insTCC
 gnomAD v4
2g.25234344_25234347delCA2658168210DNMT3Ac.921_924del
c.1818_1821del (n.1818_1821del)
c.2003_2006del (p.Arg668HisfsTer14)
c.2672_2675del (p.Arg891HisfsTer14)
c.2105_2108del (p.Arg702HisfsTer14)
c.*525_*528del (n.*525_*528del)
c.2228_2231del (p.Arg743HisfsTer14)
c.2525_2528del (p.Arg842HisfsTer14)
c.2507_2510del (p.Arg836HisfsTer14)
c.2216_2219del (p.Arg739HisfsTer14)
c.2144_2147del (p.Arg715HisfsTer14)
n.3209_3212del
n.2879_2882del
n.3102_3105del
 gnomAD v4
2g.25234344_25234356delCA531368320DNMT3Ac.912_924del
c.1809_1821del (n.1809_1821del)
c.1994_2006del (p.Leu665HisfsTer14)
c.2663_2675del (p.Leu888HisfsTer14)
c.2096_2108del (p.Leu699HisfsTer14)
c.*516_*528del (n.*516_*528del)
c.2219_2231del (p.Leu740HisfsTer14)
c.2516_2528del (p.Leu839HisfsTer14)
c.2498_2510del (p.Leu833HisfsTer14)
c.2207_2219del (p.Leu736HisfsTer14)
c.2135_2147del (p.Leu712HisfsTer14)
n.3200_3212del
n.2870_2882del
n.3093_3105del
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25234344A>CCA346068121DNMT3Ac.923T>G
c.1820T>G (n.1820T>G)
c.2005T>G (p.Ser669Ala)
c.2674T>G (p.Ser892Ala)
c.2107T>G (p.Ser703Ala)
c.*527T>G (n.*527T>G)
c.2230T>G (p.Ser744Ala)
c.2527T>G (p.Ser843Ala)
c.2509T>G (p.Ser837Ala)
c.2218T>G (p.Ser740Ala)
c.2146T>G (p.Ser716Ala)
n.3211T>G
n.2881T>G
n.3104T>G
2g.25234344A>GCA346068122DNMT3Ac.923T>C
c.1820T>C (n.1820T>C)
c.2005T>C (p.Ser669Pro)
c.2674T>C (p.Ser892Pro)
c.2107T>C (p.Ser703Pro)
c.*527T>C (n.*527T>C)
c.2230T>C (p.Ser744Pro)
c.2527T>C (p.Ser843Pro)
c.2509T>C (p.Ser837Pro)
c.2218T>C (p.Ser740Pro)
c.2146T>C (p.Ser716Pro)
n.3211T>C
n.2881T>C
n.3104T>C
2g.25234344A>TCA346068123DNMT3Ac.923T>A
c.1820T>A (n.1820T>A)
c.2005T>A (p.Ser669Thr)
c.2674T>A (p.Ser892Thr)
c.2107T>A (p.Ser703Thr)
c.*527T>A (n.*527T>A)
c.2230T>A (p.Ser744Thr)
c.2527T>A (p.Ser843Thr)
c.2509T>A (p.Ser837Thr)
c.2218T>A (p.Ser740Thr)
c.2146T>A (p.Ser716Thr)
n.3211T>A
n.2881T>A
n.3104T>A
2g.25234345C>ACA1555478DNMT3Ac.922G>T
c.1819G>T (n.1819G>T)
c.2004G>T (p.Arg668=)
c.2673G>T (p.Arg891=)
c.2106G>T (p.Arg702=)
c.*526G>T (n.*526G>T)
c.2229G>T (p.Arg743=)
c.2526G>T (p.Arg842=)
c.2508G>T (p.Arg836=)
c.2217G>T (p.Arg739=)
c.2145G>T (p.Arg715=)
n.3210G>T
n.2880G>T
n.3103G>T
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234345C=CA1239254498DNMT3Ac.922G=
c.1819G= (n.1819G=)
c.2004G= (p.Arg668=)
c.2673G= (p.Arg891=)
c.2106G= (p.Arg702=)
c.*526G= (n.*526G=)
c.2229G= (p.Arg743=)
c.2526G= (p.Arg842=)
c.2508G= (p.Arg836=)
c.2217G= (p.Arg739=)
c.2145G= (p.Arg715=)
n.3210G=
n.2880G=
n.3103G=
2g.25234345C>GCA425180860DNMT3Ac.922G>C
c.1819G>C (n.1819G>C)
c.2004G>C (p.Arg668=)
c.2673G>C (p.Arg891=)
c.2106G>C (p.Arg702=)
c.*526G>C (n.*526G>C)
c.2229G>C (p.Arg743=)
c.2526G>C (p.Arg842=)
c.2508G>C (p.Arg836=)
c.2217G>C (p.Arg739=)
c.2145G>C (p.Arg715=)
n.3210G>C
n.2880G>C
n.3103G>C
 gnomAD v4
2g.25234345C>TCA425180861DNMT3Ac.922G>A
c.1819G>A (n.1819G>A)
c.2004G>A (p.Arg668=)
c.2673G>A (p.Arg891=)
c.2106G>A (p.Arg702=)
c.*526G>A (n.*526G>A)
c.2229G>A (p.Arg743=)
c.2526G>A (p.Arg842=)
c.2508G>A (p.Arg836=)
c.2217G>A (p.Arg739=)
c.2145G>A (p.Arg715=)
n.3210G>A
n.2880G>A
n.3103G>A
2g.25234345_25234358delCA2658168221DNMT3Ac.909_922del
c.1806_1819del (n.1806_1819del)
c.1991_2004del (p.Arg664IlefsTer29)
c.2660_2673del (p.Arg887IlefsTer29)
c.2093_2106del (p.Arg698IlefsTer29)
c.*513_*526del (n.*513_*526del)
c.2216_2229del (p.Arg739IlefsTer29)
c.2513_2526del (p.Arg838IlefsTer29)
c.2495_2508del (p.Arg832IlefsTer29)
c.2204_2217del (p.Arg735IlefsTer29)
c.2132_2145del (p.Arg711IlefsTer29)
n.3197_3210del
n.2867_2880del
n.3090_3103del
 gnomAD v4
2g.25234346C>ACA346068124DNMT3Ac.921G>T
c.1818G>T (n.1818G>T)
c.2003G>T (p.Arg668Leu)
c.2672G>T (p.Arg891Leu)
c.2105G>T (p.Arg702Leu)
c.*525G>T (n.*525G>T)
c.2228G>T (p.Arg743Leu)
c.2525G>T (p.Arg842Leu)
c.2507G>T (p.Arg836Leu)
c.2216G>T (p.Arg739Leu)
c.2144G>T (p.Arg715Leu)
n.3209G>T
n.2879G>T
n.3102G>T
 dbSNP
2g.25234346C=CA1239254503DNMT3Ac.921G=
c.1818G= (n.1818G=)
c.2003G= (p.Arg668=)
c.2672G= (p.Arg891=)
c.2105G= (p.Arg702=)
c.*525G= (n.*525G=)
c.2228G= (p.Arg743=)
c.2525G= (p.Arg842=)
c.2507G= (p.Arg836=)
c.2216G= (p.Arg739=)
c.2144G= (p.Arg715=)
n.3209G=
n.2879G=
n.3102G=
2g.25234346C>GCA346068125DNMT3Ac.921G>C
c.1818G>C (n.1818G>C)
c.2003G>C (p.Arg668Pro)
c.2672G>C (p.Arg891Pro)
c.2105G>C (p.Arg702Pro)
c.*525G>C (n.*525G>C)
c.2228G>C (p.Arg743Pro)
c.2525G>C (p.Arg842Pro)
c.2507G>C (p.Arg836Pro)
c.2216G>C (p.Arg739Pro)
c.2144G>C (p.Arg715Pro)
n.3209G>C
n.2879G>C
n.3102G>C
2g.25234346C>TCA346068126DNMT3Ac.921G>A
c.1818G>A (n.1818G>A)
c.2003G>A (p.Arg668Gln)
c.2672G>A (p.Arg891Gln)
c.2105G>A (p.Arg702Gln)
c.*525G>A (n.*525G>A)
c.2228G>A (p.Arg743Gln)
c.2525G>A (p.Arg842Gln)
c.2507G>A (p.Arg836Gln)
c.2216G>A (p.Arg739Gln)
c.2144G>A (p.Arg715Gln)
n.3209G>A
n.2879G>A
n.3102G>A
 dbSNP gnomAD v4 COSMIC
2g.25234346_25234347delinsCGCA1239254502DNMT3Ac.920_921delinsCG
c.1817_1818delinsCG (n.1817_1818delinsCG)
c.2002_2003delinsCG (p.Arg668=)
c.2671_2672delinsCG (p.Arg891=)
c.2104_2105delinsCG (p.Arg702=)
c.*524_*525delinsCG (n.*524_*525delinsCG)
c.2227_2228delinsCG (p.Arg743=)
c.2524_2525delinsCG (p.Arg842=)
c.2506_2507delinsCG (p.Arg836=)
c.2215_2216delinsCG (p.Arg739=)
c.2143_2144delinsCG (p.Arg715=)
n.3208_3209delinsCG
n.2878_2879delinsCG
n.3101_3102delinsCG
2g.25234347G>ACA346068127DNMT3Ac.920C>T
c.1817C>T (n.1817C>T)
c.2002C>T (p.Arg668Trp)
c.2671C>T (p.Arg891Trp)
c.2104C>T (p.Arg702Trp)
c.*524C>T (n.*524C>T)
c.2227C>T (p.Arg743Trp)
c.2524C>T (p.Arg842Trp)
c.2506C>T (p.Arg836Trp)
c.2215C>T (p.Arg739Trp)
c.2143C>T (p.Arg715Trp)
n.3208C>T
n.2878C>T
n.3101C>T
 dbSNP gnomAD v4
2g.25234347G>CCA346068128DNMT3Ac.920C>G
c.1817C>G (n.1817C>G)
c.2002C>G (p.Arg668Gly)
c.2671C>G (p.Arg891Gly)
c.2104C>G (p.Arg702Gly)
c.*524C>G (n.*524C>G)
c.2227C>G (p.Arg743Gly)
c.2524C>G (p.Arg842Gly)
c.2506C>G (p.Arg836Gly)
c.2215C>G (p.Arg739Gly)
c.2143C>G (p.Arg715Gly)
n.3208C>G
n.2878C>G
n.3101C>G
 dbSNP
2g.25234347G=CA1239254506DNMT3Ac.920C=
c.1817C= (n.1817C=)
c.2002C= (p.Arg668=)
c.2671C= (p.Arg891=)
c.2104C= (p.Arg702=)
c.*524C= (n.*524C=)
c.2227C= (p.Arg743=)
c.2524C= (p.Arg842=)
c.2506C= (p.Arg836=)
c.2215C= (p.Arg739=)
c.2143C= (p.Arg715=)
n.3208C=
n.2878C=
n.3101C=
2g.25234347G>TCA43695928DNMT3Ac.920C>A
c.1817C>A (n.1817C>A)
c.2002C>A (p.Arg668=)
c.2671C>A (p.Arg891=)
c.2104C>A (p.Arg702=)
c.*524C>A (n.*524C>A)
c.2227C>A (p.Arg743=)
c.2524C>A (p.Arg842=)
c.2506C>A (p.Arg836=)
c.2215C>A (p.Arg739=)
c.2143C>A (p.Arg715=)
n.3208C>A
n.2878C>A
n.3101C>A
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25234348delCA1555479DNMT3Ac.920del
c.1817del (n.1817del)
c.2002del (p.Arg668GlyfsTer15)
c.2671del (p.Arg891GlyfsTer15)
c.2104del (p.Arg702GlyfsTer15)
c.*524del (n.*524del)
c.2227del (p.Arg743GlyfsTer15)
c.2524del (p.Arg842GlyfsTer15)
c.2506del (p.Arg836GlyfsTer15)
c.2215del (p.Arg739GlyfsTer15)
c.2143del (p.Arg715GlyfsTer15)
n.3208del
n.2878del
n.3101del
 dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC
2g.25234348G>ACA425180862DNMT3Ac.919C>T
c.1816C>T (n.1816C>T)
c.2001C>T (p.Gly667=)
c.2670C>T (p.Gly890=)
c.2103C>T (p.Gly701=)
c.*523C>T (n.*523C>T)
c.2226C>T (p.Gly742=)
c.2523C>T (p.Gly841=)
c.2505C>T (p.Gly835=)
c.2214C>T (p.Gly738=)
c.2142C>T (p.Gly714=)
n.3207C>T
n.2877C>T
n.3100C>T
 dbSNP gnomAD v4
2g.25234348G>CCA425180863DNMT3Ac.919C>G
c.1816C>G (n.1816C>G)
c.2001C>G (p.Gly667=)
c.2670C>G (p.Gly890=)
c.2103C>G (p.Gly701=)
c.*523C>G (n.*523C>G)
c.2226C>G (p.Gly742=)
c.2523C>G (p.Gly841=)
c.2505C>G (p.Gly835=)
c.2214C>G (p.Gly738=)
c.2142C>G (p.Gly714=)
n.3207C>G
n.2877C>G
n.3100C>G
2g.25234348G=CA1239254510DNMT3Ac.919C=
c.1816C= (n.1816C=)
c.2001C= (p.Gly667=)
c.2670C= (p.Gly890=)
c.2103C= (p.Gly701=)
c.*523C= (n.*523C=)
c.2226C= (p.Gly742=)
c.2523C= (p.Gly841=)
c.2505C= (p.Gly835=)
c.2214C= (p.Gly738=)
c.2142C= (p.Gly714=)
n.3207C=
n.2877C=
n.3100C=
2g.25234348G>TCA425180864DNMT3Ac.919C>A
c.1816C>A (n.1816C>A)
c.2001C>A (p.Gly667=)
c.2670C>A (p.Gly890=)
c.2103C>A (p.Gly701=)
c.*523C>A (n.*523C>A)
c.2226C>A (p.Gly742=)
c.2523C>A (p.Gly841=)
c.2505C>A (p.Gly835=)
c.2214C>A (p.Gly738=)
c.2142C>A (p.Gly714=)
n.3207C>A
n.2877C>A
n.3100C>A
2g.25234351_25234364dupCA2658168241DNMT3Ac.906_919dup
c.1803_1816dup (n.1803_1816dup)
c.1988_2001dup (p.Ser669AspfsTer19)
c.2657_2670dup (p.Ser892AspfsTer19)
c.2090_2103dup (p.Ser703AspfsTer19)
c.*510_*523dup (n.*510_*523dup)
c.2213_2226dup (p.Ser744AspfsTer19)
c.2510_2523dup (p.Ser843AspfsTer19)
c.2492_2505dup (p.Ser837AspfsTer19)
c.2201_2214dup (p.Ser740AspfsTer19)
c.2129_2142dup (p.Ser716AspfsTer19)
n.3194_3207dup
n.2864_2877dup
n.3087_3100dup
 gnomAD v4
2g.25234349C>ACA346068130DNMT3Ac.918G>T
c.1815G>T (n.1815G>T)
c.2000G>T (p.Gly667Val)
c.2669G>T (p.Gly890Val)
c.2102G>T (p.Gly701Val)
c.*522G>T (n.*522G>T)
c.2225G>T (p.Gly742Val)
c.2522G>T (p.Gly841Val)
c.2504G>T (p.Gly835Val)
c.2213G>T (p.Gly738Val)
c.2141G>T (p.Gly714Val)
n.3206G>T
n.2876G>T
n.3099G>T
2g.25234349C=CA1239254515DNMT3Ac.918G=
c.1815G= (n.1815G=)
c.2000G= (p.Gly667=)
c.2669G= (p.Gly890=)
c.2102G= (p.Gly701=)
c.*522G= (n.*522G=)
c.2225G= (p.Gly742=)
c.2522G= (p.Gly841=)
c.2504G= (p.Gly835=)
c.2213G= (p.Gly738=)
c.2141G= (p.Gly714=)
n.3206G=
n.2876G=
n.3099G=
2g.25234349C>GCA346068129DNMT3Ac.918G>C
c.1815G>C (n.1815G>C)
c.2000G>C (p.Gly667Ala)
c.2669G>C (p.Gly890Ala)
c.2102G>C (p.Gly701Ala)
c.*522G>C (n.*522G>C)
c.2225G>C (p.Gly742Ala)
c.2522G>C (p.Gly841Ala)
c.2504G>C (p.Gly835Ala)
c.2213G>C (p.Gly738Ala)
c.2141G>C (p.Gly714Ala)
n.3206G>C
n.2876G>C
n.3099G>C
2g.25234349C>TCA1555481DNMT3Ac.918G>A
c.1815G>A (n.1815G>A)
c.2000G>A (p.Gly667Asp)
c.2669G>A (p.Gly890Asp)
c.2102G>A (p.Gly701Asp)
c.*522G>A (n.*522G>A)
c.2225G>A (p.Gly742Asp)
c.2522G>A (p.Gly841Asp)
c.2504G>A (p.Gly835Asp)
c.2213G>A (p.Gly738Asp)
c.2141G>A (p.Gly714Asp)
n.3206G>A
n.2876G>A
n.3099G>A
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234351dupCA1555480DNMT3Ac.918dup
c.1815dup (n.1815dup)
c.2000dup (p.Arg668ProfsTer30)
c.2669dup (p.Arg891ProfsTer30)
c.2102dup (p.Arg702ProfsTer30)
c.*522dup (n.*522dup)
c.2225dup (p.Arg743ProfsTer30)
c.2522dup (p.Arg842ProfsTer30)
c.2504dup (p.Arg836ProfsTer30)
c.2213dup (p.Arg739ProfsTer30)
c.2141dup (p.Arg715ProfsTer30)
n.3206dup
n.2876dup
n.3099dup
 dbSNP ExAC gnomAD v2
2g.25234351delCA2576693581DNMT3Ac.918del
c.1815del (n.1815del)
c.2000del (p.Gly667AlafsTer16)
c.2669del (p.Gly890AlafsTer16)
c.2102del (p.Gly701AlafsTer16)
c.*522del (n.*522del)
c.2225del (p.Gly742AlafsTer16)
c.2522del (p.Gly841AlafsTer16)
c.2504del (p.Gly835AlafsTer16)
c.2213del (p.Gly738AlafsTer16)
c.2141del (p.Gly714AlafsTer16)
n.3206del
n.2876del
n.3099del
 gnomAD v4
2g.25234350_25234351delCA645515119DNMT3Ac.917_918del
c.1814_1815del (n.1814_1815del)
c.1999_2000del (p.Gly667ProfsTer30)
c.2668_2669del (p.Gly890ProfsTer30)
c.2101_2102del (p.Gly701ProfsTer30)
c.*521_*522del (n.*521_*522del)
c.2224_2225del (p.Gly742ProfsTer30)
c.2521_2522del (p.Gly841ProfsTer30)
c.2503_2504del (p.Gly835ProfsTer30)
c.2212_2213del (p.Gly738ProfsTer30)
c.2140_2141del (p.Gly714ProfsTer30)
n.3205_3206del
n.2875_2876del
n.3098_3099del
 COSMIC
2g.25234349_25234352dupCA531368322DNMT3Ac.915_918dup
c.1812_1815dup (n.1812_1815dup)
c.1997_2000dup (p.Arg668GlyfsTer31)
c.2666_2669dup (p.Arg891GlyfsTer31)
c.2099_2102dup (p.Arg702GlyfsTer31)
c.*519_*522dup (n.*519_*522dup)
c.2222_2225dup (p.Arg743GlyfsTer31)
c.2519_2522dup (p.Arg842GlyfsTer31)
c.2501_2504dup (p.Arg836GlyfsTer31)
c.2210_2213dup (p.Arg739GlyfsTer31)
c.2138_2141dup (p.Arg715GlyfsTer31)
n.3203_3206dup
n.2873_2876dup
n.3096_3099dup
 dbSNP gnomAD v2 gnomAD v4
2g.25234350C>ACA346068131DNMT3Ac.917G>T
c.1814G>T (n.1814G>T)
c.1999G>T (p.Gly667Cys)
c.2668G>T (p.Gly890Cys)
c.2101G>T (p.Gly701Cys)
c.*521G>T (n.*521G>T)
c.2224G>T (p.Gly742Cys)
c.2521G>T (p.Gly841Cys)
c.2503G>T (p.Gly835Cys)
c.2212G>T (p.Gly738Cys)
c.2140G>T (p.Gly714Cys)
n.3205G>T
n.2875G>T
n.3098G>T
 dbSNP
2g.25234350C=CA1239254521DNMT3Ac.917G=
c.1814G= (n.1814G=)
c.1999G= (p.Gly667=)
c.2668G= (p.Gly890=)
c.2101G= (p.Gly701=)
c.*521G= (n.*521G=)
c.2224G= (p.Gly742=)
c.2521G= (p.Gly841=)
c.2503G= (p.Gly835=)
c.2212G= (p.Gly738=)
c.2140G= (p.Gly714=)
n.3205G=
n.2875G=
n.3098G=
2g.25234350C>GCA346068132DNMT3Ac.917G>C
c.1814G>C (n.1814G>C)
c.1999G>C (p.Gly667Arg)
c.2668G>C (p.Gly890Arg)
c.2101G>C (p.Gly701Arg)
c.*521G>C (n.*521G>C)
c.2224G>C (p.Gly742Arg)
c.2521G>C (p.Gly841Arg)
c.2503G>C (p.Gly835Arg)
c.2212G>C (p.Gly738Arg)
c.2140G>C (p.Gly714Arg)
n.3205G>C
n.2875G>C
n.3098G>C
2g.25234350C>TCA346068133DNMT3Ac.917G>A
c.1814G>A (n.1814G>A)
c.1999G>A (p.Gly667Ser)
c.2668G>A (p.Gly890Ser)
c.2101G>A (p.Gly701Ser)
c.*521G>A (n.*521G>A)
c.2224G>A (p.Gly742Ser)
c.2521G>A (p.Gly841Ser)
c.2503G>A (p.Gly835Ser)
c.2212G>A (p.Gly738Ser)
c.2140G>A (p.Gly714Ser)
n.3205G>A
n.2875G>A
n.3098G>A
 dbSNP
2g.25234351C>ACA425180867DNMT3Ac.916G>T
c.1813G>T (n.1813G>T)
c.1998G>T (p.Leu666=)
c.2667G>T (p.Leu889=)
c.2100G>T (p.Leu700=)
c.*520G>T (n.*520G>T)
c.2223G>T (p.Leu741=)
c.2520G>T (p.Leu840=)
c.2502G>T (p.Leu834=)
c.2211G>T (p.Leu737=)
c.2139G>T (p.Leu713=)
n.3204G>T
n.2874G>T
n.3097G>T
 COSMIC COSMIC
2g.25234351C>GCA425180866DNMT3Ac.916G>C
c.1813G>C (n.1813G>C)
c.1998G>C (p.Leu666=)
c.2667G>C (p.Leu889=)
c.2100G>C (p.Leu700=)
c.*520G>C (n.*520G>C)
c.2223G>C (p.Leu741=)
c.2520G>C (p.Leu840=)
c.2502G>C (p.Leu834=)
c.2211G>C (p.Leu737=)
c.2139G>C (p.Leu713=)
n.3204G>C
n.2874G>C
n.3097G>C
2g.25234351C>TCA425180865DNMT3Ac.916G>A
c.1813G>A (n.1813G>A)
c.1998G>A (p.Leu666=)
c.2667G>A (p.Leu889=)
c.2100G>A (p.Leu700=)
c.*520G>A (n.*520G>A)
c.2223G>A (p.Leu741=)
c.2520G>A (p.Leu840=)
c.2502G>A (p.Leu834=)
c.2211G>A (p.Leu737=)
c.2139G>A (p.Leu713=)
n.3204G>A
n.2874G>A
n.3097G>A
 dbSNP
2g.25234352A=CA1239254524DNMT3Ac.915T=
c.1812T= (n.1812T=)
c.1997T= (p.Leu666=)
c.2666T= (p.Leu889=)
c.2099T= (p.Leu700=)
c.*519T= (n.*519T=)
c.2222T= (p.Leu741=)
c.2519T= (p.Leu840=)
c.2501T= (p.Leu834=)
c.2210T= (p.Leu737=)
c.2138T= (p.Leu713=)
n.3203T=
n.2873T=
n.3096T=
2g.25234352A>CCA346068134DNMT3Ac.915T>G
c.1812T>G (n.1812T>G)
c.1997T>G (p.Leu666Arg)
c.2666T>G (p.Leu889Arg)
c.2099T>G (p.Leu700Arg)
c.*519T>G (n.*519T>G)
c.2222T>G (p.Leu741Arg)
c.2519T>G (p.Leu840Arg)
c.2501T>G (p.Leu834Arg)
c.2210T>G (p.Leu737Arg)
c.2138T>G (p.Leu713Arg)
n.3203T>G
n.2873T>G
n.3096T>G
 ClinVar gnomAD v4
2g.25234352A>GCA346068135DNMT3Ac.915T>C
c.1812T>C (n.1812T>C)
c.1997T>C (p.Leu666Pro)
c.2666T>C (p.Leu889Pro)
c.2099T>C (p.Leu700Pro)
c.*519T>C (n.*519T>C)
c.2222T>C (p.Leu741Pro)
c.2519T>C (p.Leu840Pro)
c.2501T>C (p.Leu834Pro)
c.2210T>C (p.Leu737Pro)
c.2138T>C (p.Leu713Pro)
n.3203T>C
n.2873T>C
n.3096T>C
 dbSNP gnomAD v4 COSMIC
2g.25234352A>TCA346068136DNMT3Ac.915T>A
c.1812T>A (n.1812T>A)
c.1997T>A (p.Leu666Gln)
c.2666T>A (p.Leu889Gln)
c.2099T>A (p.Leu700Gln)
c.*519T>A (n.*519T>A)
c.2222T>A (p.Leu741Gln)
c.2519T>A (p.Leu840Gln)
c.2501T>A (p.Leu834Gln)
c.2210T>A (p.Leu737Gln)
c.2138T>A (p.Leu713Gln)
n.3203T>A
n.2873T>A
n.3096T>A
 gnomAD v4
2g.25234353G>ACA425180868DNMT3Ac.914C>T
c.1811C>T (n.1811C>T)
c.1996C>T (p.Leu666=)
c.2665C>T (p.Leu889=)
c.2098C>T (p.Leu700=)
c.*518C>T (n.*518C>T)
c.2221C>T (p.Leu741=)
c.2518C>T (p.Leu840=)
c.2500C>T (p.Leu834=)
c.2209C>T (p.Leu737=)
c.2137C>T (p.Leu713=)
n.3202C>T
n.2872C>T
n.3095C>T
 dbSNP
2g.25234353G>CCA346068137DNMT3Ac.914C>G
c.1811C>G (n.1811C>G)
c.1996C>G (p.Leu666Val)
c.2665C>G (p.Leu889Val)
c.2098C>G (p.Leu700Val)
c.*518C>G (n.*518C>G)
c.2221C>G (p.Leu741Val)
c.2518C>G (p.Leu840Val)
c.2500C>G (p.Leu834Val)
c.2209C>G (p.Leu737Val)
c.2137C>G (p.Leu713Val)
n.3202C>G
n.2872C>G
n.3095C>G
2g.25234353G>TCA346068138DNMT3Ac.914C>A
c.1811C>A (n.1811C>A)
c.1996C>A (p.Leu666Met)
c.2665C>A (p.Leu889Met)
c.2098C>A (p.Leu700Met)
c.*518C>A (n.*518C>A)
c.2221C>A (p.Leu741Met)
c.2518C>A (p.Leu840Met)
c.2500C>A (p.Leu834Met)
c.2209C>A (p.Leu737Met)
c.2137C>A (p.Leu713Met)
n.3202C>A
n.2872C>A
n.3095C>A
 gnomAD v4
2g.25234355_25234368delCA2749204952DNMT3Ac.901_914del
c.1798_1811del (n.1798_1811del)
c.1983_1996del (p.Arg662GlyfsTer?)
c.2652_2665del (p.Arg885GlyfsTer?)
c.2085_2098del (p.Arg696GlyfsTer?)
c.*505_*518del (n.*505_*518del)
c.2208_2221del (p.Arg737GlyfsTer?)
c.2505_2518del (p.Arg836GlyfsTer?)
c.2487_2500del (p.Arg830GlyfsTer?)
c.2196_2209del (p.Arg733GlyfsTer?)
c.2124_2137del (p.Arg709GlyfsTer?)
n.3189_3202del
n.2859_2872del
n.3082_3095del
2g.25234354C>ACA425180869DNMT3Ac.913G>T
c.1810G>T (n.1810G>T)
c.1995G>T (p.Leu665=)
c.2664G>T (p.Leu888=)
c.2097G>T (p.Leu699=)
c.*517G>T (n.*517G>T)
c.2220G>T (p.Leu740=)
c.2517G>T (p.Leu839=)
c.2499G>T (p.Leu833=)
c.2208G>T (p.Leu736=)
c.2136G>T (p.Leu712=)
n.3201G>T
n.2871G>T
n.3094G>T
2g.25234354C>GCA425180870DNMT3Ac.913G>C
c.1810G>C (n.1810G>C)
c.1995G>C (p.Leu665=)
c.2664G>C (p.Leu888=)
c.2097G>C (p.Leu699=)
c.*517G>C (n.*517G>C)
c.2220G>C (p.Leu740=)
c.2517G>C (p.Leu839=)
c.2499G>C (p.Leu833=)
c.2208G>C (p.Leu736=)
c.2136G>C (p.Leu712=)
n.3201G>C
n.2871G>C
n.3094G>C
2g.25234354C>TCA425180871DNMT3Ac.913G>A
c.1810G>A (n.1810G>A)
c.1995G>A (p.Leu665=)
c.2664G>A (p.Leu888=)
c.2097G>A (p.Leu699=)
c.*517G>A (n.*517G>A)
c.2220G>A (p.Leu740=)
c.2517G>A (p.Leu839=)
c.2499G>A (p.Leu833=)
c.2208G>A (p.Leu736=)
c.2136G>A (p.Leu712=)
n.3201G>A
n.2871G>A
n.3094G>A
 dbSNP
2g.25234355A>CCA346068139DNMT3Ac.912T>G
c.1809T>G (n.1809T>G)
c.1994T>G (p.Leu665Arg)
c.2663T>G (p.Leu888Arg)
c.2096T>G (p.Leu699Arg)
c.*516T>G (n.*516T>G)
c.2219T>G (p.Leu740Arg)
c.2516T>G (p.Leu839Arg)
c.2498T>G (p.Leu833Arg)
c.2207T>G (p.Leu736Arg)
c.2135T>G (p.Leu712Arg)
n.3200T>G
n.2870T>G
n.3093T>G
2g.25234355A>GCA346068140DNMT3Ac.912T>C
c.1809T>C (n.1809T>C)
c.1994T>C (p.Leu665Pro)
c.2663T>C (p.Leu888Pro)
c.2096T>C (p.Leu699Pro)
c.*516T>C (n.*516T>C)
c.2219T>C (p.Leu740Pro)
c.2516T>C (p.Leu839Pro)
c.2498T>C (p.Leu833Pro)
c.2207T>C (p.Leu736Pro)
c.2135T>C (p.Leu712Pro)
n.3200T>C
n.2870T>C
n.3093T>C
 gnomAD v4
2g.25234355A>TCA346068141DNMT3Ac.912T>A
c.1809T>A (n.1809T>A)
c.1994T>A (p.Leu665Gln)
c.2663T>A (p.Leu888Gln)
c.2096T>A (p.Leu699Gln)
c.*516T>A (n.*516T>A)
c.2219T>A (p.Leu740Gln)
c.2516T>A (p.Leu839Gln)
c.2498T>A (p.Leu833Gln)
c.2207T>A (p.Leu736Gln)
c.2135T>A (p.Leu712Gln)
n.3200T>A
n.2870T>A
n.3093T>A
2g.25234355_25234356delCA2658168273DNMT3Ac.911_912del
c.1808_1809del (n.1808_1809del)
c.1993_1994del (p.Leu665AlafsTer?)
c.2662_2663del (p.Leu888AlafsTer?)
c.2095_2096del (p.Leu699AlafsTer?)
c.*515_*516del (n.*515_*516del)
c.2218_2219del (p.Leu740AlafsTer?)
c.2515_2516del (p.Leu839AlafsTer?)
c.2497_2498del (p.Leu833AlafsTer?)
c.2206_2207del (p.Leu736AlafsTer?)
c.2134_2135del (p.Leu712AlafsTer?)
n.3199_3200del
n.2869_2870del
n.3092_3093del
 gnomAD v4
2g.25234355_25234356dupCA2658168272DNMT3Ac.911_912dup
c.1808_1809dup (n.1808_1809dup)
c.1993_1994dup (p.Leu666CysfsTer18)
c.2662_2663dup (p.Leu889CysfsTer18)
c.2095_2096dup (p.Leu700CysfsTer18)
c.*515_*516dup (n.*515_*516dup)
c.2218_2219dup (p.Leu741CysfsTer18)
c.2515_2516dup (p.Leu840CysfsTer18)
c.2497_2498dup (p.Leu834CysfsTer18)
c.2206_2207dup (p.Leu737CysfsTer18)
c.2134_2135dup (p.Leu713CysfsTer18)
n.3199_3200dup
n.2869_2870dup
n.3092_3093dup
 gnomAD v4
2g.25234356G>ACA425180872DNMT3Ac.911C>T
c.1808C>T (n.1808C>T)
c.1993C>T (p.Leu665=)
c.2662C>T (p.Leu888=)
c.2095C>T (p.Leu699=)
c.*515C>T (n.*515C>T)
c.2218C>T (p.Leu740=)
c.2515C>T (p.Leu839=)
c.2497C>T (p.Leu833=)
c.2206C>T (p.Leu736=)
c.2134C>T (p.Leu712=)
n.3199C>T
n.2869C>T
n.3092C>T
2g.25234356G>CCA346068142DNMT3Ac.911C>G
c.1808C>G (n.1808C>G)
c.1993C>G (p.Leu665Val)
c.2662C>G (p.Leu888Val)
c.2095C>G (p.Leu699Val)
c.*515C>G (n.*515C>G)
c.2218C>G (p.Leu740Val)
c.2515C>G (p.Leu839Val)
c.2497C>G (p.Leu833Val)
c.2206C>G (p.Leu736Val)
c.2134C>G (p.Leu712Val)
n.3199C>G
n.2869C>G
n.3092C>G
2g.25234356G>TCA346068143DNMT3Ac.911C>A
c.1808C>A (n.1808C>A)
c.1993C>A (p.Leu665Met)
c.2662C>A (p.Leu888Met)
c.2095C>A (p.Leu699Met)
c.*515C>A (n.*515C>A)
c.2218C>A (p.Leu740Met)
c.2515C>A (p.Leu839Met)
c.2497C>A (p.Leu833Met)
c.2206C>A (p.Leu736Met)
c.2134C>A (p.Leu712Met)
n.3199C>A
n.2869C>A
n.3092C>A
2g.25234356_25234358delinsGTCCA1239254526DNMT3Ac.909_911delinsGAC
c.1806_1808delinsGAC (n.1806_1808delinsGAC)
c.1991_1993delinsGAC (p.Arg664=)
c.2660_2662delinsGAC (p.Arg887=)
c.2093_2095delinsGAC (p.Arg698=)
c.*513_*515delinsGAC (n.*513_*515delinsGAC)
c.2216_2218delinsGAC (p.Arg739=)
c.2513_2515delinsGAC (p.Arg838=)
c.2495_2497delinsGAC (p.Arg832=)
c.2204_2206delinsGAC (p.Arg735=)
c.2132_2134delinsGAC (p.Arg711=)
n.3197_3199delinsGAC
n.2867_2869delinsGAC
n.3090_3092delinsGAC
2g.25234357_25234375delCA2658168277DNMT3Ac.893_911del
c.1790_1808del (n.1790_1808del)
c.1975_1993del (p.Arg659CysfsTer18)
c.2644_2662del (p.Arg882CysfsTer18)
c.2077_2095del (p.Arg693CysfsTer18)
c.*497_*515del (n.*497_*515del)
c.2200_2218del (p.Arg734CysfsTer18)
c.2497_2515del (p.Arg833CysfsTer18)
c.2479_2497del (p.Arg827CysfsTer18)
c.2188_2206del (p.Arg730CysfsTer18)
c.2116_2134del (p.Arg706CysfsTer18)
n.3181_3199del
n.2851_2869del
n.3074_3092del
 gnomAD v4
2g.25234357T>ACA346068144DNMT3Ac.910A>T
c.1807A>T (n.1807A>T)
c.1992A>T (p.Arg664Ser)
c.2661A>T (p.Arg887Ser)
c.2094A>T (p.Arg698Ser)
c.*514A>T (n.*514A>T)
c.2217A>T (p.Arg739Ser)
c.2514A>T (p.Arg838Ser)
c.2496A>T (p.Arg832Ser)
c.2205A>T (p.Arg735Ser)
c.2133A>T (p.Arg711Ser)
n.3198A>T
n.2868A>T
n.3091A>T
2g.25234357T>CCA425180873DNMT3Ac.910A>G
c.1807A>G (n.1807A>G)
c.1992A>G (p.Arg664=)
c.2661A>G (p.Arg887=)
c.2094A>G (p.Arg698=)
c.*514A>G (n.*514A>G)
c.2217A>G (p.Arg739=)
c.2514A>G (p.Arg838=)
c.2496A>G (p.Arg832=)
c.2205A>G (p.Arg735=)
c.2133A>G (p.Arg711=)
n.3198A>G
n.2868A>G
n.3091A>G
2g.25234357T>GCA346068145DNMT3Ac.910A>C
c.1807A>C (n.1807A>C)
c.1992A>C (p.Arg664Ser)
c.2661A>C (p.Arg887Ser)
c.2094A>C (p.Arg698Ser)
c.*514A>C (n.*514A>C)
c.2217A>C (p.Arg739Ser)
c.2514A>C (p.Arg838Ser)
c.2496A>C (p.Arg832Ser)
c.2205A>C (p.Arg735Ser)
c.2133A>C (p.Arg711Ser)
n.3198A>C
n.2868A>C
n.3091A>C
2g.25234360_25234361delCA1028525366DNMT3Ac.909_910del
c.1806_1807del (n.1806_1807del)
c.1991_1992del (p.Arg664ThrfsTer?)
c.2660_2661del (p.Arg887ThrfsTer?)
c.2093_2094del (p.Arg698ThrfsTer?)
c.*513_*514del (n.*513_*514del)
c.2216_2217del (p.Arg739ThrfsTer?)
c.2513_2514del (p.Arg838ThrfsTer?)
c.2495_2496del (p.Arg832ThrfsTer?)
c.2204_2205del (p.Arg735ThrfsTer?)
c.2132_2133del (p.Arg711ThrfsTer?)
n.3197_3198del
n.2867_2868del
n.3090_3091del
 dbSNP gnomAD v4
2g.25234358C>ACA346068146DNMT3Ac.909G>T
c.1806G>T (n.1806G>T)
c.1991G>T (p.Arg664Ile)
c.2660G>T (p.Arg887Ile)
c.2093G>T (p.Arg698Ile)
c.*513G>T (n.*513G>T)
c.2216G>T (p.Arg739Ile)
c.2513G>T (p.Arg838Ile)
c.2495G>T (p.Arg832Ile)
c.2204G>T (p.Arg735Ile)
c.2132G>T (p.Arg711Ile)
n.3197G>T
n.2867G>T
n.3090G>T
 dbSNP
2g.25234358C>GCA346068148DNMT3Ac.909G>C
c.1806G>C (n.1806G>C)
c.1991G>C (p.Arg664Thr)
c.2660G>C (p.Arg887Thr)
c.2093G>C (p.Arg698Thr)
c.*513G>C (n.*513G>C)
c.2216G>C (p.Arg739Thr)
c.2513G>C (p.Arg838Thr)
c.2495G>C (p.Arg832Thr)
c.2204G>C (p.Arg735Thr)
c.2132G>C (p.Arg711Thr)
n.3197G>C
n.2867G>C
n.3090G>C
 dbSNP
2g.25234358C>TCA346068147DNMT3Ac.909G>A
c.1806G>A (n.1806G>A)
c.1991G>A (p.Arg664Lys)
c.2660G>A (p.Arg887Lys)
c.2093G>A (p.Arg698Lys)
c.*513G>A (n.*513G>A)
c.2216G>A (p.Arg739Lys)
c.2513G>A (p.Arg838Lys)
c.2495G>A (p.Arg832Lys)
c.2204G>A (p.Arg735Lys)
c.2132G>A (p.Arg711Lys)
n.3197G>A
n.2867G>A
n.3090G>A
2g.25234359T>ACA346068149DNMT3Ac.908A>T
c.1805A>T (n.1805A>T)
c.1990A>T (p.Arg664Ter)
c.2659A>T (p.Arg887Ter)
c.2092A>T (p.Arg698Ter)
c.*512A>T (n.*512A>T)
c.2215A>T (p.Arg739Ter)
c.2512A>T (p.Arg838Ter)
c.2494A>T (p.Arg832Ter)
c.2203A>T (p.Arg735Ter)
c.2131A>T (p.Arg711Ter)
n.3196A>T
n.2866A>T
n.3089A>T
 dbSNP gnomAD v3 gnomAD v4
2g.25234359T>CCA346068150DNMT3Ac.908A>G
c.1805A>G (n.1805A>G)
c.1990A>G (p.Arg664Gly)
c.2659A>G (p.Arg887Gly)
c.2092A>G (p.Arg698Gly)
c.*512A>G (n.*512A>G)
c.2215A>G (p.Arg739Gly)
c.2512A>G (p.Arg838Gly)
c.2494A>G (p.Arg832Gly)
c.2203A>G (p.Arg735Gly)
c.2131A>G (p.Arg711Gly)
n.3196A>G
n.2866A>G
n.3089A>G
2g.25234359T>GCA1555482DNMT3Ac.908A>C
c.1805A>C (n.1805A>C)
c.1990A>C (p.Arg664=)
c.2659A>C (p.Arg887=)
c.2092A>C (p.Arg698=)
c.*512A>C (n.*512A>C)
c.2215A>C (p.Arg739=)
c.2512A>C (p.Arg838=)
c.2494A>C (p.Arg832=)
c.2203A>C (p.Arg735=)
c.2131A>C (p.Arg711=)
n.3196A>C
n.2866A>C
n.3089A>C
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234359T=CA1239254531DNMT3Ac.908A=
c.1805A= (n.1805A=)
c.1990A= (p.Arg664=)
c.2659A= (p.Arg887=)
c.2092A= (p.Arg698=)
c.*512A= (n.*512A=)
c.2215A= (p.Arg739=)
c.2512A= (p.Arg838=)
c.2494A= (p.Arg832=)
c.2203A= (p.Arg735=)
c.2131A= (p.Arg711=)
n.3196A=
n.2866A=
n.3089A=
2g.25234360C>ACA346068151DNMT3Ac.907G>T
c.1804G>T (n.1804G>T)
c.1989G>T (p.Gln663His)
c.2658G>T (p.Gln886His)
c.2091G>T (p.Gln697His)
c.*511G>T (n.*511G>T)
c.2214G>T (p.Gln738His)
c.2511G>T (p.Gln837His)
c.2493G>T (p.Gln831His)
c.2202G>T (p.Gln734His)
c.2130G>T (p.Gln710His)
n.3195G>T
n.2865G>T
n.3088G>T
2g.25234360C=CA1239254535DNMT3Ac.907G=
c.1804G= (n.1804G=)
c.1989G= (p.Gln663=)
c.2658G= (p.Gln886=)
c.2091G= (p.Gln697=)
c.*511G= (n.*511G=)
c.2214G= (p.Gln738=)
c.2511G= (p.Gln837=)
c.2493G= (p.Gln831=)
c.2202G= (p.Gln734=)
c.2130G= (p.Gln710=)
n.3195G=
n.2865G=
n.3088G=
2g.25234360C>GCA346068152DNMT3Ac.907G>C
c.1804G>C (n.1804G>C)
c.1989G>C (p.Gln663His)
c.2658G>C (p.Gln886His)
c.2091G>C (p.Gln697His)
c.*511G>C (n.*511G>C)
c.2214G>C (p.Gln738His)
c.2511G>C (p.Gln837His)
c.2493G>C (p.Gln831His)
c.2202G>C (p.Gln734His)
c.2130G>C (p.Gln710His)
n.3195G>C
n.2865G>C
n.3088G>C
2g.25234360C>TCA1555483DNMT3Ac.907G>A
c.1804G>A (n.1804G>A)
c.1989G>A (p.Gln663=)
c.2658G>A (p.Gln886=)
c.2091G>A (p.Gln697=)
c.*511G>A (n.*511G>A)
c.2214G>A (p.Gln738=)
c.2511G>A (p.Gln837=)
c.2493G>A (p.Gln831=)
c.2202G>A (p.Gln734=)
c.2130G>A (p.Gln710=)
n.3195G>A
n.2865G>A
n.3088G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234360_25234361delinsCTCA1239254536DNMT3Ac.906_907delinsAG
c.1803_1804delinsAG (n.1803_1804delinsAG)
c.1988_1989delinsAG (p.Gln663=)
c.2657_2658delinsAG (p.Gln886=)
c.2090_2091delinsAG (p.Gln697=)
c.*510_*511delinsAG (n.*510_*511delinsAG)
c.2213_2214delinsAG (p.Gln738=)
c.2510_2511delinsAG (p.Gln837=)
c.2492_2493delinsAG (p.Gln831=)
c.2201_2202delinsAG (p.Gln734=)
c.2129_2130delinsAG (p.Gln710=)
n.3194_3195delinsAG
n.2864_2865delinsAG
n.3087_3088delinsAG
2g.25234360_25234361insGCA2658168300DNMT3Ac.906_907insC
c.1803_1804insC (n.1803_1804insC)
c.1988_1989insC (p.Gln663HisfsTer?)
c.2657_2658insC (p.Gln886HisfsTer?)
c.2090_2091insC (p.Gln697HisfsTer?)
c.*510_*511insC (n.*510_*511insC)
c.2213_2214insC (p.Gln738HisfsTer?)
c.2510_2511insC (p.Gln837HisfsTer?)
c.2492_2493insC (p.Gln831HisfsTer?)
c.2201_2202insC (p.Gln734HisfsTer?)
c.2129_2130insC (p.Gln710HisfsTer?)
n.3194_3195insC
n.2864_2865insC
n.3087_3088insC
 gnomAD v4
2g.25234361delCA915943704DNMT3Ac.906del
c.1803del (n.1803del)
c.1988del (p.Gln663ArgfsTer20)
c.2657del (p.Gln886ArgfsTer20)
c.2090del (p.Gln697ArgfsTer20)
c.*510del (n.*510del)
c.2213del (p.Gln738ArgfsTer20)
c.2510del (p.Gln837ArgfsTer20)
c.2492del (p.Gln831ArgfsTer20)
c.2201del (p.Gln734ArgfsTer20)
c.2129del (p.Gln710ArgfsTer20)
n.3194del
n.2864del
n.3087del
 ClinVar dbSNP gnomAD v4
2g.25234361T>ACA346068153DNMT3Ac.906A>T
c.1803A>T (n.1803A>T)
c.1988A>T (p.Gln663Leu)
c.2657A>T (p.Gln886Leu)
c.2090A>T (p.Gln697Leu)
c.*510A>T (n.*510A>T)
c.2213A>T (p.Gln738Leu)
c.2510A>T (p.Gln837Leu)
c.2492A>T (p.Gln831Leu)
c.2201A>T (p.Gln734Leu)
c.2129A>T (p.Gln710Leu)
n.3194A>T
n.2864A>T
n.3087A>T
2g.25234361T>CCA346068154DNMT3Ac.906A>G
c.1803A>G (n.1803A>G)
c.1988A>G (p.Gln663Arg)
c.2657A>G (p.Gln886Arg)
c.2090A>G (p.Gln697Arg)
c.*510A>G (n.*510A>G)
c.2213A>G (p.Gln738Arg)
c.2510A>G (p.Gln837Arg)
c.2492A>G (p.Gln831Arg)
c.2201A>G (p.Gln734Arg)
c.2129A>G (p.Gln710Arg)
n.3194A>G
n.2864A>G
n.3087A>G
 dbSNP COSMIC COSMIC
2g.25234361T>GCA346068155DNMT3Ac.906A>C
c.1803A>C (n.1803A>C)
c.1988A>C (p.Gln663Pro)
c.2657A>C (p.Gln886Pro)
c.2090A>C (p.Gln697Pro)
c.*510A>C (n.*510A>C)
c.2213A>C (p.Gln738Pro)
c.2510A>C (p.Gln837Pro)
c.2492A>C (p.Gln831Pro)
c.2201A>C (p.Gln734Pro)
c.2129A>C (p.Gln710Pro)
n.3194A>C
n.2864A>C
n.3087A>C
2g.25234361T=CA1239254541DNMT3Ac.906A=
c.1803A= (n.1803A=)
c.1988A= (p.Gln663=)
c.2657A= (p.Gln886=)
c.2090A= (p.Gln697=)
c.*510A= (n.*510A=)
c.2213A= (p.Gln738=)
c.2510A= (p.Gln837=)
c.2492A= (p.Gln831=)
c.2201A= (p.Gln734=)
c.2129A= (p.Gln710=)
n.3194A=
n.2864A=
n.3087A=
2g.25234361dupCA2699055465DNMT3Ac.906dup
c.1803dup (n.1803dup)
c.1988dup (p.Arg664GlufsTer?)
c.2657dup (p.Arg887GlufsTer?)
c.2090dup (p.Arg698GlufsTer?)
c.*510dup (n.*510dup)
c.2213dup (p.Arg739GlufsTer?)
c.2510dup (p.Arg838GlufsTer?)
c.2492dup (p.Arg832GlufsTer?)
c.2201dup (p.Arg735GlufsTer?)
c.2129dup (p.Arg711GlufsTer?)
n.3194dup
n.2864dup
n.3087dup
 dbSNP
2g.25234362G>ACA1555484DNMT3Ac.905C>T
c.1802C>T (n.1802C>T)
c.1987C>T (p.Gln663Ter)
c.2656C>T (p.Gln886Ter)
c.2089C>T (p.Gln697Ter)
c.*509C>T (n.*509C>T)
c.2212C>T (p.Gln738Ter)
c.2509C>T (p.Gln837Ter)
c.2491C>T (p.Gln831Ter)
c.2200C>T (p.Gln734Ter)
c.2128C>T (p.Gln710Ter)
n.3193C>T
n.2863C>T
n.3086C>T
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25234362G>CCA346068156DNMT3Ac.905C>G
c.1802C>G (n.1802C>G)
c.1987C>G (p.Gln663Glu)
c.2656C>G (p.Gln886Glu)
c.2089C>G (p.Gln697Glu)
c.*509C>G (n.*509C>G)
c.2212C>G (p.Gln738Glu)
c.2509C>G (p.Gln837Glu)
c.2491C>G (p.Gln831Glu)
c.2200C>G (p.Gln734Glu)
c.2128C>G (p.Gln710Glu)
n.3193C>G
n.2863C>G
n.3086C>G
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25234362G=CA1239254546DNMT3Ac.905C=
c.1802C= (n.1802C=)
c.1987C= (p.Gln663=)
c.2656C= (p.Gln886=)
c.2089C= (p.Gln697=)
c.*509C= (n.*509C=)
c.2212C= (p.Gln738=)
c.2509C= (p.Gln837=)
c.2491C= (p.Gln831=)
c.2200C= (p.Gln734=)
c.2128C= (p.Gln710=)
n.3193C=
n.2863C=
n.3086C=
2g.25234362G>TCA346068157DNMT3Ac.905C>A
c.1802C>A (n.1802C>A)
c.1987C>A (p.Gln663Lys)
c.2656C>A (p.Gln886Lys)
c.2089C>A (p.Gln697Lys)
c.*509C>A (n.*509C>A)
c.2212C>A (p.Gln738Lys)
c.2509C>A (p.Gln837Lys)
c.2491C>A (p.Gln831Lys)
c.2200C>A (p.Gln734Lys)
c.2128C>A (p.Gln710Lys)
n.3193C>A
n.2863C>A
n.3086C>A
2g.25234363C>ACA346068158DNMT3Ac.904G>T
c.1801G>T (n.1801G>T)
c.1986G>T (p.Arg662Ser)
c.2655G>T (p.Arg885Ser)
c.2088G>T (p.Arg696Ser)
c.*508G>T (n.*508G>T)
c.2211G>T (p.Arg737Ser)
c.2508G>T (p.Arg836Ser)
c.2490G>T (p.Arg830Ser)
c.2199G>T (p.Arg733Ser)
c.2127G>T (p.Arg709Ser)
n.3192G>T
n.2862G>T
n.3085G>T
2g.25234363C>GCA346068159DNMT3Ac.904G>C
c.1801G>C (n.1801G>C)
c.1986G>C (p.Arg662Ser)
c.2655G>C (p.Arg885Ser)
c.2088G>C (p.Arg696Ser)
c.*508G>C (n.*508G>C)
c.2211G>C (p.Arg737Ser)
c.2508G>C (p.Arg836Ser)
c.2490G>C (p.Arg830Ser)
c.2199G>C (p.Arg733Ser)
c.2127G>C (p.Arg709Ser)
n.3192G>C
n.2862G>C
n.3085G>C
2g.25234363C>TCA425180874DNMT3Ac.904G>A
c.1801G>A (n.1801G>A)
c.1986G>A (p.Arg662=)
c.2655G>A (p.Arg885=)
c.2088G>A (p.Arg696=)
c.*508G>A (n.*508G>A)
c.2211G>A (p.Arg737=)
c.2508G>A (p.Arg836=)
c.2490G>A (p.Arg830=)
c.2199G>A (p.Arg733=)
c.2127G>A (p.Arg709=)
n.3192G>A
n.2862G>A
n.3085G>A
2g.25234364C>ACA346068162DNMT3Ac.903G>T
c.1800G>T (n.1800G>T)
c.1985G>T (p.Arg662Met)
c.2654G>T (p.Arg885Met)
c.2087G>T (p.Arg696Met)
c.*507G>T (n.*507G>T)
c.2210G>T (p.Arg737Met)
c.2507G>T (p.Arg836Met)
c.2489G>T (p.Arg830Met)
c.2198G>T (p.Arg733Met)
c.2126G>T (p.Arg709Met)
n.3191G>T
n.2861G>T
n.3084G>T
2g.25234364C>GCA346068160DNMT3Ac.903G>C
c.1800G>C (n.1800G>C)
c.1985G>C (p.Arg662Thr)
c.2654G>C (p.Arg885Thr)
c.2087G>C (p.Arg696Thr)
c.*507G>C (n.*507G>C)
c.2210G>C (p.Arg737Thr)
c.2507G>C (p.Arg836Thr)
c.2489G>C (p.Arg830Thr)
c.2198G>C (p.Arg733Thr)
c.2126G>C (p.Arg709Thr)
n.3191G>C
n.2861G>C
n.3084G>C
2g.25234364C>TCA346068161DNMT3Ac.903G>A
c.1800G>A (n.1800G>A)
c.1985G>A (p.Arg662Lys)
c.2654G>A (p.Arg885Lys)
c.2087G>A (p.Arg696Lys)
c.*507G>A (n.*507G>A)
c.2210G>A (p.Arg737Lys)
c.2507G>A (p.Arg836Lys)
c.2489G>A (p.Arg830Lys)
c.2198G>A (p.Arg733Lys)
c.2126G>A (p.Arg709Lys)
n.3191G>A
n.2861G>A
n.3084G>A
 COSMIC
2g.25234365_25234366delCA2658168313DNMT3Ac.902_903del
c.1799_1800del (n.1799_1800del)
c.1984_1985del (p.Arg662AlafsTer?)
c.2653_2654del (p.Arg885AlafsTer?)
c.2086_2087del (p.Arg696AlafsTer?)
c.*506_*507del (n.*506_*507del)
c.2209_2210del (p.Arg737AlafsTer?)
c.2506_2507del (p.Arg836AlafsTer?)
c.2488_2489del (p.Arg830AlafsTer?)
c.2197_2198del (p.Arg733AlafsTer?)
c.2125_2126del (p.Arg709AlafsTer?)
n.3190_3191del
n.2860_2861del
n.3083_3084del
 gnomAD v4
2g.25234365delCA2576693584DNMT3Ac.902del
c.1799del (n.1799del)
c.1984del (p.Arg662GlyfsTer21)
c.2653del (p.Arg885GlyfsTer21)
c.2086del (p.Arg696GlyfsTer21)
c.*506del (n.*506del)
c.2209del (p.Arg737GlyfsTer21)
c.2506del (p.Arg836GlyfsTer21)
c.2488del (p.Arg830GlyfsTer21)
c.2197del (p.Arg733GlyfsTer21)
c.2125del (p.Arg709GlyfsTer21)
n.3190del
n.2860del
n.3083del
2g.25234365T>ACA346068163DNMT3Ac.902A>T
c.1799A>T (n.1799A>T)
c.1984A>T (p.Arg662Trp)
c.2653A>T (p.Arg885Trp)
c.2086A>T (p.Arg696Trp)
c.*506A>T (n.*506A>T)
c.2209A>T (p.Arg737Trp)
c.2506A>T (p.Arg836Trp)
c.2488A>T (p.Arg830Trp)
c.2197A>T (p.Arg733Trp)
c.2125A>T (p.Arg709Trp)
n.3190A>T
n.2860A>T
n.3083A>T
 dbSNP
2g.25234365T>CCA346068164DNMT3Ac.902A>G
c.1799A>G (n.1799A>G)
c.1984A>G (p.Arg662Gly)
c.2653A>G (p.Arg885Gly)
c.2086A>G (p.Arg696Gly)
c.*506A>G (n.*506A>G)
c.2209A>G (p.Arg737Gly)
c.2506A>G (p.Arg836Gly)
c.2488A>G (p.Arg830Gly)
c.2197A>G (p.Arg733Gly)
c.2125A>G (p.Arg709Gly)
n.3190A>G
n.2860A>G
n.3083A>G
2g.25234365T>GCA425180875DNMT3Ac.902A>C
c.1799A>C (n.1799A>C)
c.1984A>C (p.Arg662=)
c.2653A>C (p.Arg885=)
c.2086A>C (p.Arg696=)
c.*506A>C (n.*506A>C)
c.2209A>C (p.Arg737=)
c.2506A>C (p.Arg836=)
c.2488A>C (p.Arg830=)
c.2197A>C (p.Arg733=)
c.2125A>C (p.Arg709=)
n.3190A>C
n.2860A>C
n.3083A>C
2g.25234366delCA2658168325DNMT3Ac.901del
c.1798del (n.1798del)
c.1983del (p.Arg662GlyfsTer21)
c.2652del (p.Arg885GlyfsTer21)
c.2085del (p.Arg696GlyfsTer21)
c.*505del (n.*505del)
c.2208del (p.Arg737GlyfsTer21)
c.2505del (p.Arg836GlyfsTer21)
c.2487del (p.Arg830GlyfsTer21)
c.2196del (p.Arg733GlyfsTer21)
c.2124del (p.Arg709GlyfsTer21)
n.3189del
n.2859del
n.3082del
 gnomAD v4
2g.25234366C>ACA425180876DNMT3Ac.901G>T
c.1798G>T (n.1798G>T)
c.1983G>T (p.Ala661=)
c.2652G>T (p.Ala884=)
c.2085G>T (p.Ala695=)
c.*505G>T (n.*505G>T)
c.2208G>T (p.Ala736=)
c.2505G>T (p.Ala835=)
c.2487G>T (p.Ala829=)
c.2196G>T (p.Ala732=)
c.2124G>T (p.Ala708=)
n.3189G>T
n.2859G>T
n.3082G>T
 dbSNP
2g.25234366C=CA1239254555DNMT3Ac.901G=
c.1798G= (n.1798G=)
c.1983G= (p.Ala661=)
c.2652G= (p.Ala884=)
c.2085G= (p.Ala695=)
c.*505G= (n.*505G=)
c.2208G= (p.Ala736=)
c.2505G= (p.Ala835=)
c.2487G= (p.Ala829=)
c.2196G= (p.Ala732=)
c.2124G= (p.Ala708=)
n.3189G=
n.2859G=
n.3082G=
2g.25234366C>GCA1555486DNMT3Ac.901G>C
c.1798G>C (n.1798G>C)
c.1983G>C (p.Ala661=)
c.2652G>C (p.Ala884=)
c.2085G>C (p.Ala695=)
c.*505G>C (n.*505G>C)
c.2208G>C (p.Ala736=)
c.2505G>C (p.Ala835=)
c.2487G>C (p.Ala829=)
c.2196G>C (p.Ala732=)
c.2124G>C (p.Ala708=)
n.3189G>C
n.2859G>C
n.3082G>C
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25234366C>TCA1555485DNMT3Ac.901G>A
c.1798G>A (n.1798G>A)
c.1983G>A (p.Ala661=)
c.2652G>A (p.Ala884=)
c.2085G>A (p.Ala695=)
c.*505G>A (n.*505G>A)
c.2208G>A (p.Ala736=)
c.2505G>A (p.Ala835=)
c.2487G>A (p.Ala829=)
c.2196G>A (p.Ala732=)
c.2124G>A (p.Ala708=)
n.3189G>A
n.2859G>A
n.3082G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25234367_25234368delCA2658168348DNMT3Ac.900_901del
c.1797_1798del (n.1797_1798del)
c.1982_1983del (p.Ala661GlufsTer?)
c.2651_2652del (p.Ala884GlufsTer?)
c.2084_2085del (p.Ala695GlufsTer?)
c.*504_*505del (n.*504_*505del)
c.2207_2208del (p.Ala736GlufsTer?)
c.2504_2505del (p.Ala835GlufsTer?)
c.2486_2487del (p.Ala829GlufsTer?)
c.2195_2196del (p.Ala732GlufsTer?)
c.2123_2124del (p.Ala708GlufsTer?)
n.3188_3189del
n.2858_2859del
n.3081_3082del
 gnomAD v4
2g.25234367G>ACA1555487DNMT3Ac.900C>T
c.1797C>T (n.1797C>T)
c.1982C>T (p.Ala661Val)
c.2651C>T (p.Ala884Val)
c.2084C>T (p.Ala695Val)
c.*504C>T (n.*504C>T)
c.2207C>T (p.Ala736Val)
c.2504C>T (p.Ala835Val)
c.2486C>T (p.Ala829Val)
c.2195C>T (p.Ala732Val)
c.2123C>T (p.Ala708Val)
n.3188C>T
n.2858C>T
n.3081C>T
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25234367G>CCA346068165DNMT3Ac.900C>G
c.1797C>G (n.1797C>G)
c.1982C>G (p.Ala661Gly)
c.2651C>G (p.Ala884Gly)
c.2084C>G (p.Ala695Gly)
c.*504C>G (n.*504C>G)
c.2207C>G (p.Ala736Gly)
c.2504C>G (p.Ala835Gly)
c.2486C>G (p.Ala829Gly)
c.2195C>G (p.Ala732Gly)
c.2123C>G (p.Ala708Gly)
n.3188C>G
n.2858C>G
n.3081C>G
 dbSNP
2g.25234367G=CA1239254569DNMT3Ac.900C=
c.1797C= (n.1797C=)
c.1982C= (p.Ala661=)
c.2651C= (p.Ala884=)
c.2084C= (p.Ala695=)
c.*504C= (n.*504C=)
c.2207C= (p.Ala736=)
c.2504C= (p.Ala835=)
c.2486C= (p.Ala829=)
c.2195C= (p.Ala732=)
c.2123C= (p.Ala708=)
n.3188C=
n.2858C=
n.3081C=
2g.25234367G>TCA346068166DNMT3Ac.900C>A
c.1797C>A (n.1797C>A)
c.1982C>A (p.Ala661Glu)
c.2651C>A (p.Ala884Glu)
c.2084C>A (p.Ala695Glu)
c.*504C>A (n.*504C>A)
c.2207C>A (p.Ala736Glu)
c.2504C>A (p.Ala835Glu)
c.2486C>A (p.Ala829Glu)
c.2195C>A (p.Ala732Glu)
c.2123C>A (p.Ala708Glu)
n.3188C>A
n.2858C>A
n.3081C>A
2g.25234368C>ACA346068167DNMT3Ac.899G>T
c.1796G>T (n.1796G>T)
c.1981G>T (p.Ala661Ser)
c.2650G>T (p.Ala884Ser)
c.2083G>T (p.Ala695Ser)
c.*503G>T (n.*503G>T)
c.2206G>T (p.Ala736Ser)
c.2503G>T (p.Ala835Ser)
c.2485G>T (p.Ala829Ser)
c.2194G>T (p.Ala732Ser)
c.2122G>T (p.Ala708Ser)
n.3187G>T
n.2857G>T
n.3080G>T
 dbSNP
2g.25234368C>GCA346068168DNMT3Ac.899G>C
c.1796G>C (n.1796G>C)
c.1981G>C (p.Ala661Pro)
c.2650G>C (p.Ala884Pro)
c.2083G>C (p.Ala695Pro)
c.*503G>C (n.*503G>C)
c.2206G>C (p.Ala736Pro)
c.2503G>C (p.Ala835Pro)
c.2485G>C (p.Ala829Pro)
c.2194G>C (p.Ala732Pro)
c.2122G>C (p.Ala708Pro)
n.3187G>C
n.2857G>C
n.3080G>C
2g.25234368C>TCA346068169DNMT3Ac.899G>A
c.1796G>A (n.1796G>A)
c.1981G>A (p.Ala661Thr)
c.2650G>A (p.Ala884Thr)
c.2083G>A (p.Ala695Thr)
c.*503G>A (n.*503G>A)
c.2206G>A (p.Ala736Thr)
c.2503G>A (p.Ala835Thr)
c.2485G>A (p.Ala829Thr)
c.2194G>A (p.Ala732Thr)
c.2122G>A (p.Ala708Thr)
n.3187G>A
n.2857G>A
n.3080G>A
2g.25234369delCA531368329DNMT3Ac.899del
c.1796del (n.1796del)
c.1981del (p.Ala661ArgfsTer22)
c.2650del (p.Ala884ArgfsTer22)
c.2083del (p.Ala695ArgfsTer22)
c.*503del (n.*503del)
c.2206del (p.Ala736ArgfsTer22)
c.2503del (p.Ala835ArgfsTer22)
c.2485del (p.Ala829ArgfsTer22)
c.2194del (p.Ala732ArgfsTer22)
c.2122del (p.Ala708ArgfsTer22)
n.3187del
n.2857del
n.3080del
 gnomAD v2
2g.25234369C>ACA346068171DNMT3Ac.898G>T
c.1795G>T (n.1795G>T)
c.1980G>T (p.Leu660Phe)
c.2649G>T (p.Leu883Phe)
c.2082G>T (p.Leu694Phe)
c.*502G>T (n.*502G>T)
c.2205G>T (p.Leu735Phe)
c.2502G>T (p.Leu834Phe)
c.2484G>T (p.Leu828Phe)
c.2193G>T (p.Leu731Phe)
c.2121G>T (p.Leu707Phe)
n.3186G>T
n.2856G>T
n.3079G>T
 gnomAD v4
2g.25234369C>GCA346068170DNMT3Ac.898G>C
c.1795G>C (n.1795G>C)
c.1980G>C (p.Leu660Phe)
c.2649G>C (p.Leu883Phe)
c.2082G>C (p.Leu694Phe)
c.*502G>C (n.*502G>C)
c.2205G>C (p.Leu735Phe)
c.2502G>C (p.Leu834Phe)
c.2484G>C (p.Leu828Phe)
c.2193G>C (p.Leu731Phe)
c.2121G>C (p.Leu707Phe)
n.3186G>C
n.2856G>C
n.3079G>C
2g.25234369C>TCA425180877DNMT3Ac.898G>A
c.1795G>A (n.1795G>A)
c.1980G>A (p.Leu660=)
c.2649G>A (p.Leu883=)
c.2082G>A (p.Leu694=)
c.*502G>A (n.*502G>A)
c.2205G>A (p.Leu735=)
c.2502G>A (p.Leu834=)
c.2484G>A (p.Leu828=)
c.2193G>A (p.Leu731=)
c.2121G>A (p.Leu707=)
n.3186G>A
n.2856G>A
n.3079G>A
2g.25234370A=CA1239254577DNMT3Ac.897T=
c.1794T= (n.1794T=)
c.1979T= (p.Leu660=)
c.2648T= (p.Leu883=)
c.2081T= (p.Leu694=)
c.*501T= (n.*501T=)
c.2204T= (p.Leu735=)
c.2501T= (p.Leu834=)
c.2483T= (p.Leu828=)
c.2192T= (p.Leu731=)
c.2120T= (p.Leu707=)
n.3185T=
n.2855T=
n.3078T=
2g.25234370A>CCA346068172DNMT3Ac.897T>G
c.1794T>G (n.1794T>G)
c.1979T>G (p.Leu660Trp)
c.2648T>G (p.Leu883Trp)
c.2081T>G (p.Leu694Trp)
c.*501T>G (n.*501T>G)
c.2204T>G (p.Leu735Trp)
c.2501T>G (p.Leu834Trp)
c.2483T>G (p.Leu828Trp)
c.2192T>G (p.Leu731Trp)
c.2120T>G (p.Leu707Trp)
n.3185T>G
n.2855T>G
n.3078T>G
2g.25234370A>GCA346068173DNMT3Ac.897T>C
c.1794T>C (n.1794T>C)
c.1979T>C (p.Leu660Ser)
c.2648T>C (p.Leu883Ser)
c.2081T>C (p.Leu694Ser)
c.*501T>C (n.*501T>C)
c.2204T>C (p.Leu735Ser)
c.2501T>C (p.Leu834Ser)
c.2483T>C (p.Leu828Ser)
c.2192T>C (p.Leu731Ser)
c.2120T>C (p.Leu707Ser)
n.3185T>C
n.2855T>C
n.3078T>C
2g.25234370A>TCA346068174DNMT3Ac.897T>A
c.1794T>A (n.1794T>A)
c.1979T>A (p.Leu660Ter)
c.2648T>A (p.Leu883Ter)
c.2081T>A (p.Leu694Ter)
c.*501T>A (n.*501T>A)
c.2204T>A (p.Leu735Ter)
c.2501T>A (p.Leu834Ter)
c.2483T>A (p.Leu828Ter)
c.2192T>A (p.Leu731Ter)
c.2120T>A (p.Leu707Ter)
n.3185T>A
n.2855T>A
n.3078T>A
 dbSNP gnomAD v2 gnomAD v4
2g.25234371delCA2594345190DNMT3Ac.897del
c.1794del (n.1794del)
c.1979del (p.Leu660TrpfsTer23)
c.2648del (p.Leu883TrpfsTer23)
c.2081del (p.Leu694TrpfsTer23)
c.*501del (n.*501del)
c.2204del (p.Leu735TrpfsTer23)
c.2501del (p.Leu834TrpfsTer23)
c.2483del (p.Leu828TrpfsTer23)
c.2192del (p.Leu731TrpfsTer23)
c.2120del (p.Leu707TrpfsTer23)
n.3185del
n.2855del
n.3078del
 gnomAD v3 gnomAD v4
2g.25234370_25234371insCCA2658168363DNMT3Ac.896_897insG
c.1793_1794insG (n.1793_1794insG)
c.1978_1979insG (p.Leu660CysfsTer?)
c.2647_2648insG (p.Leu883CysfsTer?)
c.2080_2081insG (p.Leu694CysfsTer?)
c.*500_*501insG (n.*500_*501insG)
c.2203_2204insG (p.Leu735CysfsTer?)
c.2500_2501insG (p.Leu834CysfsTer?)
c.2482_2483insG (p.Leu828CysfsTer?)
c.2191_2192insG (p.Leu731CysfsTer?)
c.2119_2120insG (p.Leu707CysfsTer?)
n.3184_3185insG
n.2854_2855insG
n.3077_3078insG
 gnomAD v4
2g.25234371A=CA1239254579DNMT3Ac.896T=
c.1793T= (n.1793T=)
c.1978T= (p.Leu660=)
c.2647T= (p.Leu883=)
c.2080T= (p.Leu694=)
c.*500T= (n.*500T=)
c.2203T= (p.Leu735=)
c.2500T= (p.Leu834=)
c.2482T= (p.Leu828=)
c.2191T= (p.Leu731=)
c.2119T= (p.Leu707=)
n.3184T=
n.2854T=
n.3077T=
2g.25234371A>CCA346068175DNMT3Ac.896T>G
c.1793T>G (n.1793T>G)
c.1978T>G (p.Leu660Val)
c.2647T>G (p.Leu883Val)
c.2080T>G (p.Leu694Val)
c.*500T>G (n.*500T>G)
c.2203T>G (p.Leu735Val)
c.2500T>G (p.Leu834Val)
c.2482T>G (p.Leu828Val)
c.2191T>G (p.Leu731Val)
c.2119T>G (p.Leu707Val)
n.3184T>G
n.2854T>G
n.3077T>G
2g.25234371A>GCA425180878DNMT3Ac.896T>C
c.1793T>C (n.1793T>C)
c.1978T>C (p.Leu660=)
c.2647T>C (p.Leu883=)
c.2080T>C (p.Leu694=)
c.*500T>C (n.*500T>C)
c.2203T>C (p.Leu735=)
c.2500T>C (p.Leu834=)
c.2482T>C (p.Leu828=)
c.2191T>C (p.Leu731=)
c.2119T>C (p.Leu707=)
n.3184T>C
n.2854T>C
n.3077T>C
 ClinVar dbSNP gnomAD v4
2g.25234371A>TCA346068176DNMT3Ac.896T>A
c.1793T>A (n.1793T>A)
c.1978T>A (p.Leu660Met)
c.2647T>A (p.Leu883Met)
c.2080T>A (p.Leu694Met)
c.*500T>A (n.*500T>A)
c.2203T>A (p.Leu735Met)
c.2500T>A (p.Leu834Met)
c.2482T>A (p.Leu828Met)
c.2191T>A (p.Leu731Met)
c.2119T>A (p.Leu707Met)
n.3184T>A
n.2854T>A
n.3077T>A
 dbSNP
2g.25234372G>ACA425180879DNMT3Ac.895C>T
c.1792C>T (n.1792C>T)
c.1977C>T (p.Arg659=)
c.2646C>T (p.Arg882=)
c.2079C>T (p.Arg693=)
c.*499C>T (n.*499C>T)
c.2202C>T (p.Arg734=)
c.2499C>T (p.Arg833=)
c.2481C>T (p.Arg827=)
c.2190C>T (p.Arg730=)
c.2118C>T (p.Arg706=)
n.3183C>T
n.2853C>T
n.3076C>T
 gnomAD v4
2g.25234372G>CCA425180880DNMT3Ac.895C>G
c.1792C>G (n.1792C>G)
c.1977C>G (p.Arg659=)
c.2646C>G (p.Arg882=)
c.2079C>G (p.Arg693=)
c.*499C>G (n.*499C>G)
c.2202C>G (p.Arg734=)
c.2499C>G (p.Arg833=)
c.2481C>G (p.Arg827=)
c.2190C>G (p.Arg730=)
c.2118C>G (p.Arg706=)
n.3183C>G
n.2853C>G
n.3076C>G
2g.25234372G>TCA425180881DNMT3Ac.895C>A
c.1792C>A (n.1792C>A)
c.1977C>A (p.Arg659=)
c.2646C>A (p.Arg882=)
c.2079C>A (p.Arg693=)
c.*499C>A (n.*499C>A)
c.2202C>A (p.Arg734=)
c.2499C>A (p.Arg833=)
c.2481C>A (p.Arg827=)
c.2190C>A (p.Arg730=)
c.2118C>A (p.Arg706=)
n.3183C>A
n.2853C>A
n.3076C>A
2g.25234373C>ACA1555490DNMT3Ac.894G>T
c.1791G>T (n.1791G>T)
c.1976G>T (p.Arg659Leu)
c.2645G>T (p.Arg882Leu)
c.2078G>T (p.Arg693Leu)
c.*498G>T (n.*498G>T)
c.2201G>T (p.Arg734Leu)
c.2498G>T (p.Arg833Leu)
c.2480G>T (p.Arg827Leu)
c.2189G>T (p.Arg730Leu)
c.2117G>T (p.Arg706Leu)
n.3182G>T
n.2852G>T
n.3075G>T
 ClinVar dbSNP ExAC gnomAD v3 gnomAD v4 COSMIC
2g.25234373C=CA1239254590DNMT3Ac.894G=
c.1791G= (n.1791G=)
c.1976G= (p.Arg659=)
c.2645G= (p.Arg882=)
c.2078G= (p.Arg693=)
c.*498G= (n.*498G=)
c.2201G= (p.Arg734=)
c.2498G= (p.Arg833=)
c.2480G= (p.Arg827=)
c.2189G= (p.Arg730=)
c.2117G= (p.Arg706=)
n.3182G=
n.2852G=
n.3075G=
2g.25234373C>GCA1555489DNMT3Ac.894G>C
c.1791G>C (n.1791G>C)
c.1976G>C (p.Arg659Pro)
c.2645G>C (p.Arg882Pro)
c.2078G>C (p.Arg693Pro)
c.*498G>C (n.*498G>C)
c.2201G>C (p.Arg734Pro)
c.2498G>C (p.Arg833Pro)
c.2480G>C (p.Arg827Pro)
c.2189G>C (p.Arg730Pro)
c.2117G>C (p.Arg706Pro)
n.3182G>C
n.2852G>C
n.3075G>C
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234373C>TCA1555488DNMT3Ac.894G>A
c.1791G>A (n.1791G>A)
c.1976G>A (p.Arg659His)
c.2645G>A (p.Arg882His)
c.2078G>A (p.Arg693His)
c.*498G>A (n.*498G>A)
c.2201G>A (p.Arg734His)
c.2498G>A (p.Arg833His)
c.2480G>A (p.Arg827His)
c.2189G>A (p.Arg730His)
c.2117G>A (p.Arg706His)
n.3182G>A
n.2852G>A
n.3075G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234374G>ACA1555491DNMT3Ac.893C>T
c.1790C>T (n.1790C>T)
c.1975C>T (p.Arg659Cys)
c.2644C>T (p.Arg882Cys)
c.2077C>T (p.Arg693Cys)
c.*497C>T (n.*497C>T)
c.2200C>T (p.Arg734Cys)
c.2497C>T (p.Arg833Cys)
c.2479C>T (p.Arg827Cys)
c.2188C>T (p.Arg730Cys)
c.2116C>T (p.Arg706Cys)
n.3181C>T
n.2851C>T
n.3074C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234374G>CCA16602366DNMT3Ac.893C>G
c.1790C>G (n.1790C>G)
c.1975C>G (p.Arg659Gly)
c.2644C>G (p.Arg882Gly)
c.2077C>G (p.Arg693Gly)
c.*497C>G (n.*497C>G)
c.2200C>G (p.Arg734Gly)
c.2497C>G (p.Arg833Gly)
c.2479C>G (p.Arg827Gly)
c.2188C>G (p.Arg730Gly)
c.2116C>G (p.Arg706Gly)
n.3181C>G
n.2851C>G
n.3074C>G
 ClinVar dbSNP gnomAD v4 COSMIC
2g.25234374G=CA1239254614DNMT3Ac.893C=
c.1790C= (n.1790C=)
c.1975C= (p.Arg659=)
c.2644C= (p.Arg882=)
c.2077C= (p.Arg693=)
c.*497C= (n.*497C=)
c.2200C= (p.Arg734=)
c.2497C= (p.Arg833=)
c.2479C= (p.Arg827=)
c.2188C= (p.Arg730=)
c.2116C= (p.Arg706=)
n.3181C=
n.2851C=
n.3074C=
2g.25234374G>TCA16602367DNMT3Ac.893C>A
c.1790C>A (n.1790C>A)
c.1975C>A (p.Arg659Ser)
c.2644C>A (p.Arg882Ser)
c.2077C>A (p.Arg693Ser)
c.*497C>A (n.*497C>A)
c.2200C>A (p.Arg734Ser)
c.2497C>A (p.Arg833Ser)
c.2479C>A (p.Arg827Ser)
c.2188C>A (p.Arg730Ser)
c.2116C>A (p.Arg706Ser)
n.3181C>A
n.2851C>A
n.3074C>A
 ClinVar dbSNP gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234375G>ACA43695968DNMT3Ac.892C>T
c.1789C>T (n.1789C>T)
c.1974C>T (p.Ser658=)
c.2643C>T (p.Ser881=)
c.2076C>T (p.Ser692=)
c.*496C>T (n.*496C>T)
c.2199C>T (p.Ser733=)
c.2496C>T (p.Ser832=)
c.2478C>T (p.Ser826=)
c.2187C>T (p.Ser729=)
c.2115C>T (p.Ser705=)
n.3180C>T
n.2850C>T
n.3073C>T
 ClinVar dbSNP gnomAD v3 gnomAD v4
2g.25234375G>CCA346068177DNMT3Ac.892C>G
c.1789C>G (n.1789C>G)
c.1974C>G (p.Ser658Arg)
c.2643C>G (p.Ser881Arg)
c.2076C>G (p.Ser692Arg)
c.*496C>G (n.*496C>G)
c.2199C>G (p.Ser733Arg)
c.2496C>G (p.Ser832Arg)
c.2478C>G (p.Ser826Arg)
c.2187C>G (p.Ser729Arg)
c.2115C>G (p.Ser705Arg)
n.3180C>G
n.2850C>G
n.3073C>G
2g.25234375G=CA1239254618DNMT3Ac.892C=
c.1789C= (n.1789C=)
c.1974C= (p.Ser658=)
c.2643C= (p.Ser881=)
c.2076C= (p.Ser692=)
c.*496C= (n.*496C=)
c.2199C= (p.Ser733=)
c.2496C= (p.Ser832=)
c.2478C= (p.Ser826=)
c.2187C= (p.Ser729=)
c.2115C= (p.Ser705=)
n.3180C=
n.2850C=
n.3073C=
2g.25234375G>TCA346068178DNMT3Ac.892C>A
c.1789C>A (n.1789C>A)
c.1974C>A (p.Ser658Arg)
c.2643C>A (p.Ser881Arg)
c.2076C>A (p.Ser692Arg)
c.*496C>A (n.*496C>A)
c.2199C>A (p.Ser733Arg)
c.2496C>A (p.Ser832Arg)
c.2478C>A (p.Ser826Arg)
c.2187C>A (p.Ser729Arg)
c.2115C>A (p.Ser705Arg)
n.3180C>A
n.2850C>A
n.3073C>A
2g.25234376C>ACA346068181DNMT3Ac.891G>T
c.1788G>T (n.1788G>T)
c.1973G>T (p.Ser658Ile)
c.2642G>T (p.Ser881Ile)
c.2075G>T (p.Ser692Ile)
c.*495G>T (n.*495G>T)
c.2198G>T (p.Ser733Ile)
c.2495G>T (p.Ser832Ile)
c.2477G>T (p.Ser826Ile)
c.2186G>T (p.Ser729Ile)
c.2114G>T (p.Ser705Ile)
n.3179G>T
n.2849G>T
n.3072G>T
2g.25234376C>GCA346068179DNMT3Ac.891G>C
c.1788G>C (n.1788G>C)
c.1973G>C (p.Ser658Thr)
c.2642G>C (p.Ser881Thr)
c.2075G>C (p.Ser692Thr)
c.*495G>C (n.*495G>C)
c.2198G>C (p.Ser733Thr)
c.2495G>C (p.Ser832Thr)
c.2477G>C (p.Ser826Thr)
c.2186G>C (p.Ser729Thr)
c.2114G>C (p.Ser705Thr)
n.3179G>C
n.2849G>C
n.3072G>C
 dbSNP
2g.25234376C>TCA346068180DNMT3Ac.891G>A
c.1788G>A (n.1788G>A)
c.1973G>A (p.Ser658Asn)
c.2642G>A (p.Ser881Asn)
c.2075G>A (p.Ser692Asn)
c.*495G>A (n.*495G>A)
c.2198G>A (p.Ser733Asn)
c.2495G>A (p.Ser832Asn)
c.2477G>A (p.Ser826Asn)
c.2186G>A (p.Ser729Asn)
c.2114G>A (p.Ser705Asn)
n.3179G>A
n.2849G>A
n.3072G>A
 COSMIC
2g.25234377T>ACA346068182DNMT3Ac.890A>T
c.1787A>T (n.1787A>T)
c.1972A>T (p.Ser658Cys)
c.2641A>T (p.Ser881Cys)
c.2074A>T (p.Ser692Cys)
c.*494A>T (n.*494A>T)
c.2197A>T (p.Ser733Cys)
c.2494A>T (p.Ser832Cys)
c.2476A>T (p.Ser826Cys)
c.2185A>T (p.Ser729Cys)
c.2113A>T (p.Ser705Cys)
n.3178A>T
n.2848A>T
n.3071A>T
2g.25234377T>CCA346068183DNMT3Ac.890A>G
c.1787A>G (n.1787A>G)
c.1972A>G (p.Ser658Gly)
c.2641A>G (p.Ser881Gly)
c.2074A>G (p.Ser692Gly)
c.*494A>G (n.*494A>G)
c.2197A>G (p.Ser733Gly)
c.2494A>G (p.Ser832Gly)
c.2476A>G (p.Ser826Gly)
c.2185A>G (p.Ser729Gly)
c.2113A>G (p.Ser705Gly)
n.3178A>G
n.2848A>G
n.3071A>G
2g.25234377T>GCA346068184DNMT3Ac.890A>C
c.1787A>C (n.1787A>C)
c.1972A>C (p.Ser658Arg)
c.2641A>C (p.Ser881Arg)
c.2074A>C (p.Ser692Arg)
c.*494A>C (n.*494A>C)
c.2197A>C (p.Ser733Arg)
c.2494A>C (p.Ser832Arg)
c.2476A>C (p.Ser826Arg)
c.2185A>C (p.Ser729Arg)
c.2113A>C (p.Ser705Arg)
n.3178A>C
n.2848A>C
n.3071A>C
2g.25234378C>ACA346068185DNMT3Ac.889G>T
c.1786G>T (n.1786G>T)
c.1971G>T (p.Met657Ile)
c.2640G>T (p.Met880Ile)
c.2073G>T (p.Met691Ile)
c.*493G>T (n.*493G>T)
c.2196G>T (p.Met732Ile)
c.2493G>T (p.Met831Ile)
c.2475G>T (p.Met825Ile)
c.2184G>T (p.Met728Ile)
c.2112G>T (p.Met704Ile)
n.3177G>T
n.2847G>T
n.3070G>T
 gnomAD v4 COSMIC COSMIC
2g.25234378C=CA1239254620DNMT3Ac.889G=
c.1786G= (n.1786G=)
c.1971G= (p.Met657=)
c.2640G= (p.Met880=)
c.2073G= (p.Met691=)
c.*493G= (n.*493G=)
c.2196G= (p.Met732=)
c.2493G= (p.Met831=)
c.2475G= (p.Met825=)
c.2184G= (p.Met728=)
c.2112G= (p.Met704=)
n.3177G=
n.2847G=
n.3070G=
2g.25234378C>GCA346068186DNMT3Ac.889G>C
c.1786G>C (n.1786G>C)
c.1971G>C (p.Met657Ile)
c.2640G>C (p.Met880Ile)
c.2073G>C (p.Met691Ile)
c.*493G>C (n.*493G>C)
c.2196G>C (p.Met732Ile)
c.2493G>C (p.Met831Ile)
c.2475G>C (p.Met825Ile)
c.2184G>C (p.Met728Ile)
c.2112G>C (p.Met704Ile)
n.3177G>C
n.2847G>C
n.3070G>C
 dbSNP gnomAD v4 COSMIC
2g.25234378C>TCA346068187DNMT3Ac.889G>A
c.1786G>A (n.1786G>A)
c.1971G>A (p.Met657Ile)
c.2640G>A (p.Met880Ile)
c.2073G>A (p.Met691Ile)
c.*493G>A (n.*493G>A)
c.2196G>A (p.Met732Ile)
c.2493G>A (p.Met831Ile)
c.2475G>A (p.Met825Ile)
c.2184G>A (p.Met728Ile)
c.2112G>A (p.Met704Ile)
n.3177G>A
n.2847G>A
n.3070G>A
 dbSNP gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234378_25234380delinsCATCA1239254621DNMT3Ac.887_889delinsATG
c.1784_1786delinsATG (n.1784_1786delinsATG)
c.1969_1971delinsATG (p.Met657=)
c.2638_2640delinsATG (p.Met880=)
c.2071_2073delinsATG (p.Met691=)
c.*491_*493delinsATG (n.*491_*493delinsATG)
c.2194_2196delinsATG (p.Met732=)
c.2491_2493delinsATG (p.Met831=)
c.2473_2475delinsATG (p.Met825=)
c.2182_2184delinsATG (p.Met728=)
c.2110_2112delinsATG (p.Met704=)
n.3175_3177delinsATG
n.2845_2847delinsATG
n.3068_3070delinsATG
2g.25234379delCA2576693588DNMT3Ac.888del
c.1785del (n.1785del)
c.1970del (p.Met657ArgfsTer26)
c.2639del (p.Met880ArgfsTer26)
c.2072del (p.Met691ArgfsTer26)
c.*492del (n.*492del)
c.2195del (p.Met732ArgfsTer26)
c.2492del (p.Met831ArgfsTer26)
c.2474del (p.Met825ArgfsTer26)
c.2183del (p.Met728ArgfsTer26)
c.2111del (p.Met704ArgfsTer26)
n.3176del
n.2846del
n.3069del
2g.25234379A>CCA346068188DNMT3Ac.888T>G
c.1785T>G (n.1785T>G)
c.1970T>G (p.Met657Arg)
c.2639T>G (p.Met880Arg)
c.2072T>G (p.Met691Arg)
c.*492T>G (n.*492T>G)
c.2195T>G (p.Met732Arg)
c.2492T>G (p.Met831Arg)
c.2474T>G (p.Met825Arg)
c.2183T>G (p.Met728Arg)
c.2111T>G (p.Met704Arg)
n.3176T>G
n.2846T>G
n.3069T>G
2g.25234379A>GCA346068189DNMT3Ac.888T>C
c.1785T>C (n.1785T>C)
c.1970T>C (p.Met657Thr)
c.2639T>C (p.Met880Thr)
c.2072T>C (p.Met691Thr)
c.*492T>C (n.*492T>C)
c.2195T>C (p.Met732Thr)
c.2492T>C (p.Met831Thr)
c.2474T>C (p.Met825Thr)
c.2183T>C (p.Met728Thr)
c.2111T>C (p.Met704Thr)
n.3176T>C
n.2846T>C
n.3069T>C
2g.25234379A>TCA346068190DNMT3Ac.888T>A
c.1785T>A (n.1785T>A)
c.1970T>A (p.Met657Lys)
c.2639T>A (p.Met880Lys)
c.2072T>A (p.Met691Lys)
c.*492T>A (n.*492T>A)
c.2195T>A (p.Met732Lys)
c.2492T>A (p.Met831Lys)
c.2474T>A (p.Met825Lys)
c.2183T>A (p.Met728Lys)
c.2111T>A (p.Met704Lys)
n.3176T>A
n.2846T>A
n.3069T>A
2g.25234379dupCA2658168399DNMT3Ac.888dup
c.1785dup (n.1785dup)
c.1970dup (p.Met657IlefsTer?)
c.2639dup (p.Met880IlefsTer?)
c.2072dup (p.Met691IlefsTer?)
c.*492dup (n.*492dup)
c.2195dup (p.Met732IlefsTer?)
c.2492dup (p.Met831IlefsTer?)
c.2474dup (p.Met825IlefsTer?)
c.2183dup (p.Met728IlefsTer?)
c.2111dup (p.Met704IlefsTer?)
n.3176dup
n.2846dup
n.3069dup
 gnomAD v4
2g.25234379_25234380delCA1239254623DNMT3Ac.887_888del
c.1784_1785del (n.1784_1785del)
c.1969_1970del (p.Met657GlufsTer?)
c.2638_2639del (p.Met880GlufsTer?)
c.2071_2072del (p.Met691GlufsTer?)
c.*491_*492del (n.*491_*492del)
c.2194_2195del (p.Met732GlufsTer?)
c.2491_2492del (p.Met831GlufsTer?)
c.2473_2474del (p.Met825GlufsTer?)
c.2182_2183del (p.Met728GlufsTer?)
c.2110_2111del (p.Met704GlufsTer?)
n.3175_3176del
n.2845_2846del
n.3068_3069del
 dbSNP
2g.25234380T>ACA346068191DNMT3Ac.887A>T
c.1784A>T (n.1784A>T)
c.1969A>T (p.Met657Leu)
c.2638A>T (p.Met880Leu)
c.2071A>T (p.Met691Leu)
c.*491A>T (n.*491A>T)
c.2194A>T (p.Met732Leu)
c.2491A>T (p.Met831Leu)
c.2473A>T (p.Met825Leu)
c.2182A>T (p.Met728Leu)
c.2110A>T (p.Met704Leu)
n.3175A>T
n.2845A>T
n.3068A>T
2g.25234380T>CCA1555492DNMT3Ac.887A>G
c.1784A>G (n.1784A>G)
c.1969A>G (p.Met657Val)
c.2638A>G (p.Met880Val)
c.2071A>G (p.Met691Val)
c.*491A>G (n.*491A>G)
c.2194A>G (p.Met732Val)
c.2491A>G (p.Met831Val)
c.2473A>G (p.Met825Val)
c.2182A>G (p.Met728Val)
c.2110A>G (p.Met704Val)
n.3175A>G
n.2845A>G
n.3068A>G
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25234380T>GCA346068192DNMT3Ac.887A>C
c.1784A>C (n.1784A>C)
c.1969A>C (p.Met657Leu)
c.2638A>C (p.Met880Leu)
c.2071A>C (p.Met691Leu)
c.*491A>C (n.*491A>C)
c.2194A>C (p.Met732Leu)
c.2491A>C (p.Met831Leu)
c.2473A>C (p.Met825Leu)
c.2182A>C (p.Met728Leu)
c.2110A>C (p.Met704Leu)
n.3175A>C
n.2845A>C
n.3068A>C
2g.25234380T=CA1239254626DNMT3Ac.887A=
c.1784A= (n.1784A=)
c.1969A= (p.Met657=)
c.2638A= (p.Met880=)
c.2071A= (p.Met691=)
c.*491A= (n.*491A=)
c.2194A= (p.Met732=)
c.2491A= (p.Met831=)
c.2473A= (p.Met825=)
c.2182A= (p.Met728=)
c.2110A= (p.Met704=)
n.3175A=
n.2845A=
n.3068A=
2g.25234381delCA2576693590DNMT3Ac.886del
c.1783del (n.1783del)
c.1968del (p.Asn656LysfsTer2)
c.2637del (p.Asn879LysfsTer2)
c.2070del (p.Asn690LysfsTer2)
c.*490del (n.*490del)
c.2193del (p.Asn731LysfsTer2)
c.2490del (p.Asn830LysfsTer2)
c.2472del (p.Asn824LysfsTer2)
c.2181del (p.Asn727LysfsTer2)
c.2109del (p.Asn703LysfsTer2)
n.3174del
n.2844del
n.3067del
2g.25234381G>ACA425180883DNMT3Ac.886C>T
c.1783C>T (n.1783C>T)
c.1968C>T (p.Asn656=)
c.2637C>T (p.Asn879=)
c.2070C>T (p.Asn690=)
c.*490C>T (n.*490C>T)
c.2193C>T (p.Asn731=)
c.2490C>T (p.Asn830=)
c.2472C>T (p.Asn824=)
c.2181C>T (p.Asn727=)
c.2109C>T (p.Asn703=)
n.3174C>T
n.2844C>T
n.3067C>T
 dbSNP gnomAD v4
2g.25234381G>CCA346068194DNMT3Ac.886C>G
c.1783C>G (n.1783C>G)
c.1968C>G (p.Asn656Lys)
c.2637C>G (p.Asn879Lys)
c.2070C>G (p.Asn690Lys)
c.*490C>G (n.*490C>G)
c.2193C>G (p.Asn731Lys)
c.2490C>G (p.Asn830Lys)
c.2472C>G (p.Asn824Lys)
c.2181C>G (p.Asn727Lys)
c.2109C>G (p.Asn703Lys)
n.3174C>G
n.2844C>G
n.3067C>G
2g.25234381G>TCA346068193DNMT3Ac.886C>A
c.1783C>A (n.1783C>A)
c.1968C>A (p.Asn656Lys)
c.2637C>A (p.Asn879Lys)
c.2070C>A (p.Asn690Lys)
c.*490C>A (n.*490C>A)
c.2193C>A (p.Asn731Lys)
c.2490C>A (p.Asn830Lys)
c.2472C>A (p.Asn824Lys)
c.2181C>A (p.Asn727Lys)
c.2109C>A (p.Asn703Lys)
n.3174C>A
n.2844C>A
n.3067C>A
2g.25234383_25234391delCA2749204953DNMT3Ac.878_886del
c.1775_1783del (n.1775_1783del)
c.1960_1968del (p.Val654_Asn656del)
c.2629_2637del (p.Val877_Asn879del)
c.2062_2070del (p.Val688_Asn690del)
c.*482_*490del (n.*482_*490del)
c.2185_2193del (p.Val729_Asn731del)
c.2482_2490del (p.Val828_Asn830del)
c.2464_2472del (p.Val822_Asn824del)
c.2173_2181del (p.Val725_Asn727del)
c.2101_2109del (p.Val701_Asn703del)
n.3166_3174del
n.2836_2844del
n.3059_3067del
2g.25234382T>ACA346068195DNMT3Ac.885A>T
c.1782A>T (n.1782A>T)
c.1967A>T (p.Asn656Ile)
c.2636A>T (p.Asn879Ile)
c.2069A>T (p.Asn690Ile)
c.*489A>T (n.*489A>T)
c.2192A>T (p.Asn731Ile)
c.2489A>T (p.Asn830Ile)
c.2471A>T (p.Asn824Ile)
c.2180A>T (p.Asn727Ile)
c.2108A>T (p.Asn703Ile)
n.3173A>T
n.2843A>T
n.3066A>T
2g.25234382T>CCA346068197DNMT3Ac.885A>G
c.1782A>G (n.1782A>G)
c.1967A>G (p.Asn656Ser)
c.2636A>G (p.Asn879Ser)
c.2069A>G (p.Asn690Ser)
c.*489A>G (n.*489A>G)
c.2192A>G (p.Asn731Ser)
c.2489A>G (p.Asn830Ser)
c.2471A>G (p.Asn824Ser)
c.2180A>G (p.Asn727Ser)
c.2108A>G (p.Asn703Ser)
n.3173A>G
n.2843A>G
n.3066A>G
 COSMIC COSMIC
2g.25234382T>GCA346068196DNMT3Ac.885A>C
c.1782A>C (n.1782A>C)
c.1967A>C (p.Asn656Thr)
c.2636A>C (p.Asn879Thr)
c.2069A>C (p.Asn690Thr)
c.*489A>C (n.*489A>C)
c.2192A>C (p.Asn731Thr)
c.2489A>C (p.Asn830Thr)
c.2471A>C (p.Asn824Thr)
c.2180A>C (p.Asn727Thr)
c.2108A>C (p.Asn703Thr)
n.3173A>C
n.2843A>C
n.3066A>C
2g.25234382_25234383delCA2658168407DNMT3Ac.884_885del
c.1781_1782del (n.1781_1782del)
c.1966_1967del (p.Asn656HisfsTer?)
c.2635_2636del (p.Asn879HisfsTer?)
c.2068_2069del (p.Asn690HisfsTer?)
c.*488_*489del (n.*488_*489del)
c.2191_2192del (p.Asn731HisfsTer?)
c.2488_2489del (p.Asn830HisfsTer?)
c.2470_2471del (p.Asn824HisfsTer?)
c.2179_2180del (p.Asn727HisfsTer?)
c.2107_2108del (p.Asn703HisfsTer?)
n.3172_3173del
n.2842_2843del
n.3065_3066del
 gnomAD v4
2g.25234383delCA2576693591DNMT3Ac.885del
c.1782del (n.1782del)
c.1967del (p.Asn656ThrfsTer2)
c.2636del (p.Asn879ThrfsTer2)
c.2069del (p.Asn690ThrfsTer2)
c.*489del (n.*489del)
c.2192del (p.Asn731ThrfsTer2)
c.2489del (p.Asn830ThrfsTer2)
c.2471del (p.Asn824ThrfsTer2)
c.2180del (p.Asn727ThrfsTer2)
c.2108del (p.Asn703ThrfsTer2)
n.3173del
n.2843del
n.3066del
2g.25234382_25234398delinsTTGGAGACGTCAGTATACA1239254630DNMT3Ac.869_885delinsTATACTGACGTCTCCAA
c.1766_1782delinsTATACTGACGTCTCCAA (n.1766_1782delinsTATACTGACGTCTCCAA)
c.1951_1967delinsTATACTGACGTCTCCAA (p.Tyr651=)
c.2620_2636delinsTATACTGACGTCTCCAA (p.Tyr874=)
c.2053_2069delinsTATACTGACGTCTCCAA (p.Tyr685=)
c.*473_*489delinsTATACTGACGTCTCCAA (n.*473_*489delinsTATACTGACGTCTCCAA)
c.2176_2192delinsTATACTGACGTCTCCAA (p.Tyr726=)
c.2473_2489delinsTATACTGACGTCTCCAA (p.Tyr825=)
c.2455_2471delinsTATACTGACGTCTCCAA (p.Tyr819=)
c.2164_2180delinsTATACTGACGTCTCCAA (p.Tyr722=)
c.2092_2108delinsTATACTGACGTCTCCAA (p.Tyr698=)
n.3157_3173delinsTATACTGACGTCTCCAA
n.2827_2843delinsTATACTGACGTCTCCAA
n.3050_3066delinsTATACTGACGTCTCCAA
2g.25234383T>ACA346068198DNMT3Ac.884A>T
c.1781A>T (n.1781A>T)
c.1966A>T (p.Asn656Tyr)
c.2635A>T (p.Asn879Tyr)
c.2068A>T (p.Asn690Tyr)
c.*488A>T (n.*488A>T)
c.2191A>T (p.Asn731Tyr)
c.2488A>T (p.Asn830Tyr)
c.2470A>T (p.Asn824Tyr)
c.2179A>T (p.Asn727Tyr)
c.2107A>T (p.Asn703Tyr)
n.3172A>T
n.2842A>T
n.3065A>T
 gnomAD v4
2g.25234383T>CCA346068199DNMT3Ac.884A>G
c.1781A>G (n.1781A>G)
c.1966A>G (p.Asn656Asp)
c.2635A>G (p.Asn879Asp)
c.2068A>G (p.Asn690Asp)
c.*488A>G (n.*488A>G)
c.2191A>G (p.Asn731Asp)
c.2488A>G (p.Asn830Asp)
c.2470A>G (p.Asn824Asp)
c.2179A>G (p.Asn727Asp)
c.2107A>G (p.Asn703Asp)
n.3172A>G
n.2842A>G
n.3065A>G
 dbSNP gnomAD v2 gnomAD v4 COSMIC COSMIC
2g.25234383T>GCA346068200DNMT3Ac.884A>C
c.1781A>C (n.1781A>C)
c.1966A>C (p.Asn656His)
c.2635A>C (p.Asn879His)
c.2068A>C (p.Asn690His)
c.*488A>C (n.*488A>C)
c.2191A>C (p.Asn731His)
c.2488A>C (p.Asn830His)
c.2470A>C (p.Asn824His)
c.2179A>C (p.Asn727His)
c.2107A>C (p.Asn703His)
n.3172A>C
n.2842A>C
n.3065A>C
2g.25234383T=CA1239254632DNMT3Ac.884A=
c.1781A= (n.1781A=)
c.1966A= (p.Asn656=)
c.2635A= (p.Asn879=)
c.2068A= (p.Asn690=)
c.*488A= (n.*488A=)
c.2191A= (p.Asn731=)
c.2488A= (p.Asn830=)
c.2470A= (p.Asn824=)
c.2179A= (p.Asn727=)
c.2107A= (p.Asn703=)
n.3172A=
n.2842A=
n.3065A=
2g.25234383_25234398delCA1239254634DNMT3Ac.869_884del
c.1766_1781del (n.1766_1781del)
c.1951_1966del (p.Tyr651ThrfsTer2)
c.2620_2635del (p.Tyr874ThrfsTer2)
c.2053_2068del (p.Tyr685ThrfsTer2)
c.*473_*488del (n.*473_*488del)
c.2176_2191del (p.Tyr726ThrfsTer2)
c.2473_2488del (p.Tyr825ThrfsTer2)
c.2455_2470del (p.Tyr819ThrfsTer2)
c.2164_2179del (p.Tyr722ThrfsTer2)
c.2092_2107del (p.Tyr698ThrfsTer2)
n.3157_3172del
n.2827_2842del
n.3050_3065del
 dbSNP

Number of alleles fetched