Chr Mutation (hg38) CAid Gene Transcript Linkouts
2g.25244179_25244194delCA2658168411DNMT3Ac.134_149del
c.961_976del (n.961_976del)
c.1146_1161del (p.Gln383IlefsTer?)
c.1815_1830del (p.Gln606IlefsTer?)
c.1248_1263del (p.Gln417IlefsTer?)
n.134_149del
c.1371_1386del (p.Gln458IlefsTer?)
c.1668_1683del (p.Gln557IlefsTer?)
c.1650_1665del (p.Gln551IlefsTer?)
c.1359_1374del (p.Gln454IlefsTer?)
c.1287_1302del (p.Gln430IlefsTer?)
n.2153_2168del
n.2092_2107del
n.2046_2061del
 gnomAD v4
2g.25244181_25244223dupCA2658168426DNMT3Ac.102_144dup
c.929_971dup (n.929_971dup)
c.1114_1156dup (p.Phe386SerfsTer17)
c.1783_1825dup (p.Phe609SerfsTer17)
c.1216_1258dup (p.Phe420SerfsTer17)
n.102_144dup
c.1339_1381dup (p.Phe461SerfsTer17)
c.1636_1678dup (p.Phe560SerfsTer17)
c.1618_1660dup (p.Phe554SerfsTer17)
c.1327_1369dup (p.Phe457SerfsTer17)
c.1255_1297dup (p.Phe433SerfsTer17)
n.2121_2163dup
n.2060_2102dup
n.2014_2056dup
 gnomAD v4
2g.25244193G>ACA346071736DNMT3Ac.132C>T
c.959C>T (n.959C>T)
c.1144C>T (p.Leu382Phe)
c.1813C>T (p.Leu605Phe)
c.1246C>T (p.Leu416Phe)
n.132C>T
c.1369C>T (p.Leu457Phe)
c.1666C>T (p.Leu556Phe)
c.1648C>T (p.Leu550Phe)
c.1357C>T (p.Leu453Phe)
c.1285C>T (p.Leu429Phe)
n.2151C>T
n.2090C>T
n.2044C>T
2g.25244193G>CCA346071735DNMT3Ac.132C>G
c.959C>G (n.959C>G)
c.1144C>G (p.Leu382Val)
c.1813C>G (p.Leu605Val)
c.1246C>G (p.Leu416Val)
n.132C>G
c.1369C>G (p.Leu457Val)
c.1666C>G (p.Leu556Val)
c.1648C>G (p.Leu550Val)
c.1357C>G (p.Leu453Val)
c.1285C>G (p.Leu429Val)
n.2151C>G
n.2090C>G
n.2044C>G
2g.25244193G>TCA346071734DNMT3Ac.132C>A
c.959C>A (n.959C>A)
c.1144C>A (p.Leu382Ile)
c.1813C>A (p.Leu605Ile)
c.1246C>A (p.Leu416Ile)
n.132C>A
c.1369C>A (p.Leu457Ile)
c.1666C>A (p.Leu556Ile)
c.1648C>A (p.Leu550Ile)
c.1357C>A (p.Leu453Ile)
c.1285C>A (p.Leu429Ile)
n.2151C>A
n.2090C>A
n.2044C>A
2g.25244194_25244198dupCA2658168456DNMT3Ac.128_132dup
c.955_959dup (n.955_959dup)
c.1140_1144dup (p.Leu382ProfsTer?)
c.1809_1813dup (p.Leu605ProfsTer?)
c.1242_1246dup (p.Leu416ProfsTer?)
n.128_132dup
c.1365_1369dup (p.Leu457ProfsTer?)
c.1662_1666dup (p.Leu556ProfsTer?)
c.1644_1648dup (p.Leu550ProfsTer?)
c.1353_1357dup (p.Leu453ProfsTer?)
c.1281_1285dup (p.Leu429ProfsTer?)
n.2147_2151dup
n.2086_2090dup
n.2040_2044dup
 gnomAD v4
2g.25244194C>ACA425182237DNMT3Ac.131G>T
c.958G>T (n.958G>T)
c.1143G>T (p.Arg381=)
c.1812G>T (p.Arg604=)
c.1245G>T (p.Arg415=)
n.131G>T
c.1368G>T (p.Arg456=)
c.1665G>T (p.Arg555=)
c.1647G>T (p.Arg549=)
c.1356G>T (p.Arg452=)
c.1284G>T (p.Arg428=)
n.2150G>T
n.2089G>T
n.2043G>T
2g.25244194C>GCA425182238DNMT3Ac.131G>C
c.958G>C (n.958G>C)
c.1143G>C (p.Arg381=)
c.1812G>C (p.Arg604=)
c.1245G>C (p.Arg415=)
n.131G>C
c.1368G>C (p.Arg456=)
c.1665G>C (p.Arg555=)
c.1647G>C (p.Arg549=)
c.1356G>C (p.Arg452=)
c.1284G>C (p.Arg428=)
n.2150G>C
n.2089G>C
n.2043G>C
2g.25244194C>TCA425182239DNMT3Ac.131G>A
c.958G>A (n.958G>A)
c.1143G>A (p.Arg381=)
c.1812G>A (p.Arg604=)
c.1245G>A (p.Arg415=)
n.131G>A
c.1368G>A (p.Arg456=)
c.1665G>A (p.Arg555=)
c.1647G>A (p.Arg549=)
c.1356G>A (p.Arg452=)
c.1284G>A (p.Arg428=)
n.2150G>A
n.2089G>A
n.2043G>A
 dbSNP gnomAD v4
2g.25244195delCA2658168457DNMT3Ac.131del
c.958del (n.958del)
c.1143del (p.Leu382SerfsTer?)
c.1812del (p.Leu605SerfsTer?)
c.1245del (p.Leu416SerfsTer?)
n.131del
c.1368del (p.Leu457SerfsTer?)
c.1665del (p.Leu556SerfsTer?)
c.1647del (p.Leu550SerfsTer?)
c.1356del (p.Leu453SerfsTer?)
c.1284del (p.Leu429SerfsTer?)
n.2150del
n.2089del
n.2043del
 gnomAD v4
2g.25244195C>ACA346071737DNMT3Ac.130G>T
c.957G>T (n.957G>T)
c.1142G>T (p.Arg381Leu)
c.1811G>T (p.Arg604Leu)
c.1244G>T (p.Arg415Leu)
n.130G>T
c.1367G>T (p.Arg456Leu)
c.1664G>T (p.Arg555Leu)
c.1646G>T (p.Arg549Leu)
c.1355G>T (p.Arg452Leu)
c.1283G>T (p.Arg428Leu)
n.2149G>T
n.2088G>T
n.2042G>T
2g.25244195C=CA1239262760DNMT3Ac.130G=
c.957G= (n.957G=)
c.1142G= (p.Arg381=)
c.1811G= (p.Arg604=)
c.1244G= (p.Arg415=)
n.130G=
c.1367G= (p.Arg456=)
c.1664G= (p.Arg555=)
c.1646G= (p.Arg549=)
c.1355G= (p.Arg452=)
c.1283G= (p.Arg428=)
n.2149G=
n.2088G=
n.2042G=
2g.25244195C>GCA346071738DNMT3Ac.130G>C
c.957G>C (n.957G>C)
c.1142G>C (p.Arg381Pro)
c.1811G>C (p.Arg604Pro)
c.1244G>C (p.Arg415Pro)
n.130G>C
c.1367G>C (p.Arg456Pro)
c.1664G>C (p.Arg555Pro)
c.1646G>C (p.Arg549Pro)
c.1355G>C (p.Arg452Pro)
c.1283G>C (p.Arg428Pro)
n.2149G>C
n.2088G>C
n.2042G>C
 gnomAD v4
2g.25244195C>TCA1555868DNMT3Ac.130G>A
c.957G>A (n.957G>A)
c.1142G>A (p.Arg381Gln)
c.1811G>A (p.Arg604Gln)
c.1244G>A (p.Arg415Gln)
n.130G>A
c.1367G>A (p.Arg456Gln)
c.1664G>A (p.Arg555Gln)
c.1646G>A (p.Arg549Gln)
c.1355G>A (p.Arg452Gln)
c.1283G>A (p.Arg428Gln)
n.2149G>A
n.2088G>A
n.2042G>A
 dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC COSMIC
2g.25244195_25244196delinsCGCA1239262761DNMT3Ac.129_130delinsCG
c.956_957delinsCG (n.956_957delinsCG)
c.1141_1142delinsCG (p.Arg381=)
c.1810_1811delinsCG (p.Arg604=)
c.1243_1244delinsCG (p.Arg415=)
n.129_130delinsCG
c.1366_1367delinsCG (p.Arg456=)
c.1663_1664delinsCG (p.Arg555=)
c.1645_1646delinsCG (p.Arg549=)
c.1354_1355delinsCG (p.Arg452=)
c.1282_1283delinsCG (p.Arg428=)
n.2148_2149delinsCG
n.2087_2088delinsCG
n.2041_2042delinsCG
2g.25244196G>ACA346071739DNMT3Ac.129C>T
c.956C>T (n.956C>T)
c.1141C>T (p.Arg381Trp)
c.1810C>T (p.Arg604Trp)
c.1243C>T (p.Arg415Trp)
n.129C>T
c.1366C>T (p.Arg456Trp)
c.1663C>T (p.Arg555Trp)
c.1645C>T (p.Arg549Trp)
c.1354C>T (p.Arg452Trp)
c.1282C>T (p.Arg428Trp)
n.2148C>T
n.2087C>T
n.2041C>T
 ClinVar dbSNP gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25244196G>CCA346071740DNMT3Ac.129C>G
c.956C>G (n.956C>G)
c.1141C>G (p.Arg381Gly)
c.1810C>G (p.Arg604Gly)
c.1243C>G (p.Arg415Gly)
n.129C>G
c.1366C>G (p.Arg456Gly)
c.1663C>G (p.Arg555Gly)
c.1645C>G (p.Arg549Gly)
c.1354C>G (p.Arg452Gly)
c.1282C>G (p.Arg428Gly)
n.2148C>G
n.2087C>G
n.2041C>G
2g.25244196G=CA1239262766DNMT3Ac.129C=
c.956C= (n.956C=)
c.1141C= (p.Arg381=)
c.1810C= (p.Arg604=)
c.1243C= (p.Arg415=)
n.129C=
c.1366C= (p.Arg456=)
c.1663C= (p.Arg555=)
c.1645C= (p.Arg549=)
c.1354C= (p.Arg452=)
c.1282C= (p.Arg428=)
n.2148C=
n.2087C=
n.2041C=
2g.25244196G>TCA425182243DNMT3Ac.129C>A
c.956C>A (n.956C>A)
c.1141C>A (p.Arg381=)
c.1810C>A (p.Arg604=)
c.1243C>A (p.Arg415=)
n.129C>A
c.1366C>A (p.Arg456=)
c.1663C>A (p.Arg555=)
c.1645C>A (p.Arg549=)
c.1354C>A (p.Arg452=)
c.1282C>A (p.Arg428=)
n.2148C>A
n.2087C>A
n.2041C>A
2g.25244198delCA1555867DNMT3Ac.129del
c.956del (n.956del)
c.1141del (p.Arg381GlyfsTer?)
c.1810del (p.Arg604GlyfsTer?)
c.1243del (p.Arg415GlyfsTer?)
n.129del
c.1366del (p.Arg456GlyfsTer?)
c.1663del (p.Arg555GlyfsTer?)
c.1645del (p.Arg549GlyfsTer?)
c.1354del (p.Arg452GlyfsTer?)
c.1282del (p.Arg428GlyfsTer?)
n.2148del
n.2087del
n.2041del
 dbSNP ExAC gnomAD v3 gnomAD v4
2g.25244197G>ACA425182244DNMT3Ac.128C>T
c.955C>T (n.955C>T)
c.1140C>T (p.Ser380=)
c.1809C>T (p.Ser603=)
c.1242C>T (p.Ser414=)
n.128C>T
c.1365C>T (p.Ser455=)
c.1662C>T (p.Ser554=)
c.1644C>T (p.Ser548=)
c.1353C>T (p.Ser451=)
c.1281C>T (p.Ser427=)
n.2147C>T
n.2086C>T
n.2040C>T
 dbSNP
2g.25244197G>CCA425182245DNMT3Ac.128C>G
c.955C>G (n.955C>G)
c.1140C>G (p.Ser380=)
c.1809C>G (p.Ser603=)
c.1242C>G (p.Ser414=)
n.128C>G
c.1365C>G (p.Ser455=)
c.1662C>G (p.Ser554=)
c.1644C>G (p.Ser548=)
c.1353C>G (p.Ser451=)
c.1281C>G (p.Ser427=)
n.2147C>G
n.2086C>G
n.2040C>G
2g.25244197G>TCA425182246DNMT3Ac.128C>A
c.955C>A (n.955C>A)
c.1140C>A (p.Ser380=)
c.1809C>A (p.Ser603=)
c.1242C>A (p.Ser414=)
n.128C>A
c.1365C>A (p.Ser455=)
c.1662C>A (p.Ser554=)
c.1644C>A (p.Ser548=)
c.1353C>A (p.Ser451=)
c.1281C>A (p.Ser427=)
n.2147C>A
n.2086C>A
n.2040C>A
 gnomAD v4
2g.25244198G>ACA346071743DNMT3Ac.127C>T
c.954C>T (n.954C>T)
c.1139C>T (p.Ser380Phe)
c.1808C>T (p.Ser603Phe)
c.1241C>T (p.Ser414Phe)
n.127C>T
c.1364C>T (p.Ser455Phe)
c.1661C>T (p.Ser554Phe)
c.1643C>T (p.Ser548Phe)
c.1352C>T (p.Ser451Phe)
c.1280C>T (p.Ser427Phe)
n.2146C>T
n.2085C>T
n.2039C>T
2g.25244198G>CCA346071742DNMT3Ac.127C>G
c.954C>G (n.954C>G)
c.1139C>G (p.Ser380Cys)
c.1808C>G (p.Ser603Cys)
c.1241C>G (p.Ser414Cys)
n.127C>G
c.1364C>G (p.Ser455Cys)
c.1661C>G (p.Ser554Cys)
c.1643C>G (p.Ser548Cys)
c.1352C>G (p.Ser451Cys)
c.1280C>G (p.Ser427Cys)
n.2146C>G
n.2085C>G
n.2039C>G
2g.25244198G>TCA346071741DNMT3Ac.127C>A
c.954C>A (n.954C>A)
c.1139C>A (p.Ser380Tyr)
c.1808C>A (p.Ser603Tyr)
c.1241C>A (p.Ser414Tyr)
n.127C>A
c.1364C>A (p.Ser455Tyr)
c.1661C>A (p.Ser554Tyr)
c.1643C>A (p.Ser548Tyr)
c.1352C>A (p.Ser451Tyr)
c.1280C>A (p.Ser427Tyr)
n.2146C>A
n.2085C>A
n.2039C>A
2g.25244199A>CCA346071744DNMT3Ac.126T>G
c.953T>G (n.953T>G)
c.1138T>G (p.Ser380Ala)
c.1807T>G (p.Ser603Ala)
c.1240T>G (p.Ser414Ala)
n.126T>G
c.1363T>G (p.Ser455Ala)
c.1660T>G (p.Ser554Ala)
c.1642T>G (p.Ser548Ala)
c.1351T>G (p.Ser451Ala)
c.1279T>G (p.Ser427Ala)
n.2145T>G
n.2084T>G
n.2038T>G
2g.25244199A>GCA346071745DNMT3Ac.126T>C
c.953T>C (n.953T>C)
c.1138T>C (p.Ser380Pro)
c.1807T>C (p.Ser603Pro)
c.1240T>C (p.Ser414Pro)
n.126T>C
c.1363T>C (p.Ser455Pro)
c.1660T>C (p.Ser554Pro)
c.1642T>C (p.Ser548Pro)
c.1351T>C (p.Ser451Pro)
c.1279T>C (p.Ser427Pro)
n.2145T>C
n.2084T>C
n.2038T>C
 dbSNP
2g.25244199A>TCA346071746DNMT3Ac.126T>A
c.953T>A (n.953T>A)
c.1138T>A (p.Ser380Thr)
c.1807T>A (p.Ser603Thr)
c.1240T>A (p.Ser414Thr)
n.126T>A
c.1363T>A (p.Ser455Thr)
c.1660T>A (p.Ser554Thr)
c.1642T>A (p.Ser548Thr)
c.1351T>A (p.Ser451Thr)
c.1279T>A (p.Ser427Thr)
n.2145T>A
n.2084T>A
n.2038T>A
2g.25244200G>ACA425182252DNMT3Ac.125C>T
c.952C>T (n.952C>T)
c.1137C>T (p.Pro379=)
c.1806C>T (p.Pro602=)
c.1239C>T (p.Pro413=)
n.125C>T
c.1362C>T (p.Pro454=)
c.1659C>T (p.Pro553=)
c.1641C>T (p.Pro547=)
c.1350C>T (p.Pro450=)
c.1278C>T (p.Pro426=)
n.2144C>T
n.2083C>T
n.2037C>T
 dbSNP
2g.25244200G>CCA425182251DNMT3Ac.125C>G
c.952C>G (n.952C>G)
c.1137C>G (p.Pro379=)
c.1806C>G (p.Pro602=)
c.1239C>G (p.Pro413=)
n.125C>G
c.1362C>G (p.Pro454=)
c.1659C>G (p.Pro553=)
c.1641C>G (p.Pro547=)
c.1350C>G (p.Pro450=)
c.1278C>G (p.Pro426=)
n.2144C>G
n.2083C>G
n.2037C>G
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244200G=CA1239262771DNMT3Ac.125C=
c.952C= (n.952C=)
c.1137C= (p.Pro379=)
c.1806C= (p.Pro602=)
c.1239C= (p.Pro413=)
n.125C=
c.1362C= (p.Pro454=)
c.1659C= (p.Pro553=)
c.1641C= (p.Pro547=)
c.1350C= (p.Pro450=)
c.1278C= (p.Pro426=)
n.2144C=
n.2083C=
n.2037C=
2g.25244200G>TCA425182250DNMT3Ac.125C>A
c.952C>A (n.952C>A)
c.1137C>A (p.Pro379=)
c.1806C>A (p.Pro602=)
c.1239C>A (p.Pro413=)
n.125C>A
c.1362C>A (p.Pro454=)
c.1659C>A (p.Pro553=)
c.1641C>A (p.Pro547=)
c.1350C>A (p.Pro450=)
c.1278C>A (p.Pro426=)
n.2144C>A
n.2083C>A
n.2037C>A
2g.25244202delCA2658168459DNMT3Ac.125del
c.952del (n.952del)
c.1137del (p.Ser380ProfsTer?)
c.1806del (p.Ser603ProfsTer?)
c.1239del (p.Ser414ProfsTer?)
n.125del
c.1362del (p.Ser455ProfsTer?)
c.1659del (p.Ser554ProfsTer?)
c.1641del (p.Ser548ProfsTer?)
c.1350del (p.Ser451ProfsTer?)
c.1278del (p.Ser427ProfsTer?)
n.2144del
n.2083del
n.2037del
 gnomAD v4
2g.25244201_25244202delCA2658168458DNMT3Ac.124_125del
c.951_952del (n.951_952del)
c.1136_1137del (p.Pro379LeufsTer9)
c.1805_1806del (p.Pro602LeufsTer9)
c.1238_1239del (p.Pro413LeufsTer9)
n.124_125del
c.1361_1362del (p.Pro454LeufsTer9)
c.1658_1659del (p.Pro553LeufsTer9)
c.1640_1641del (p.Pro547LeufsTer9)
c.1349_1350del (p.Pro450LeufsTer9)
c.1277_1278del (p.Pro426LeufsTer9)
n.2143_2144del
n.2082_2083del
n.2036_2037del
 gnomAD v4
2g.25244200_25244203delCA2658168462DNMT3Ac.122_125del
c.949_952del (n.949_952del)
c.1134_1137del (p.Trp378CysfsTer?)
c.1803_1806del (p.Trp601CysfsTer?)
c.1236_1239del (p.Trp412CysfsTer?)
n.122_125del
c.1359_1362del (p.Trp453CysfsTer?)
c.1656_1659del (p.Trp552CysfsTer?)
c.1638_1641del (p.Trp546CysfsTer?)
c.1347_1350del (p.Trp449CysfsTer?)
c.1275_1278del (p.Trp425CysfsTer?)
n.2141_2144del
n.2080_2083del
n.2034_2037del
 gnomAD v4
2g.25244200_25244206delCA2658168463DNMT3Ac.119_125del
c.946_952del (n.946_952del)
c.1131_1137del (p.Trp378ProfsTer?)
c.1800_1806del (p.Trp601ProfsTer?)
c.1233_1239del (p.Trp412ProfsTer?)
n.119_125del
c.1356_1362del (p.Trp453ProfsTer?)
c.1653_1659del (p.Trp552ProfsTer?)
c.1635_1641del (p.Trp546ProfsTer?)
c.1344_1350del (p.Trp449ProfsTer?)
c.1272_1278del (p.Trp425ProfsTer?)
n.2138_2144del
n.2077_2083del
n.2031_2037del
 gnomAD v4
2g.25244201G>ACA346071747DNMT3Ac.124C>T
c.951C>T (n.951C>T)
c.1136C>T (p.Pro379Leu)
c.1805C>T (p.Pro602Leu)
c.1238C>T (p.Pro413Leu)
n.124C>T
c.1361C>T (p.Pro454Leu)
c.1658C>T (p.Pro553Leu)
c.1640C>T (p.Pro547Leu)
c.1349C>T (p.Pro450Leu)
c.1277C>T (p.Pro426Leu)
n.2143C>T
n.2082C>T
n.2036C>T
2g.25244201G>CCA346071748DNMT3Ac.124C>G
c.951C>G (n.951C>G)
c.1136C>G (p.Pro379Arg)
c.1805C>G (p.Pro602Arg)
c.1238C>G (p.Pro413Arg)
n.124C>G
c.1361C>G (p.Pro454Arg)
c.1658C>G (p.Pro553Arg)
c.1640C>G (p.Pro547Arg)
c.1349C>G (p.Pro450Arg)
c.1277C>G (p.Pro426Arg)
n.2143C>G
n.2082C>G
n.2036C>G
2g.25244201G>TCA346071749DNMT3Ac.124C>A
c.951C>A (n.951C>A)
c.1136C>A (p.Pro379His)
c.1805C>A (p.Pro602His)
c.1238C>A (p.Pro413His)
n.124C>A
c.1361C>A (p.Pro454His)
c.1658C>A (p.Pro553His)
c.1640C>A (p.Pro547His)
c.1349C>A (p.Pro450His)
c.1277C>A (p.Pro426His)
n.2143C>A
n.2082C>A
n.2036C>A
2g.25244202G>ACA346071750DNMT3Ac.123C>T
c.950C>T (n.950C>T)
c.1135C>T (p.Pro379Ser)
c.1804C>T (p.Pro602Ser)
c.1237C>T (p.Pro413Ser)
n.123C>T
c.1360C>T (p.Pro454Ser)
c.1657C>T (p.Pro553Ser)
c.1639C>T (p.Pro547Ser)
c.1348C>T (p.Pro450Ser)
c.1276C>T (p.Pro426Ser)
n.2142C>T
n.2081C>T
n.2035C>T
 dbSNP
2g.25244202G>CCA346071752DNMT3Ac.123C>G
c.950C>G (n.950C>G)
c.1135C>G (p.Pro379Ala)
c.1804C>G (p.Pro602Ala)
c.1237C>G (p.Pro413Ala)
n.123C>G
c.1360C>G (p.Pro454Ala)
c.1657C>G (p.Pro553Ala)
c.1639C>G (p.Pro547Ala)
c.1348C>G (p.Pro450Ala)
c.1276C>G (p.Pro426Ala)
n.2142C>G
n.2081C>G
n.2035C>G
2g.25244202G>TCA346071751DNMT3Ac.123C>A
c.950C>A (n.950C>A)
c.1135C>A (p.Pro379Thr)
c.1804C>A (p.Pro602Thr)
c.1237C>A (p.Pro413Thr)
n.123C>A
c.1360C>A (p.Pro454Thr)
c.1657C>A (p.Pro553Thr)
c.1639C>A (p.Pro547Thr)
c.1348C>A (p.Pro450Thr)
c.1276C>A (p.Pro426Thr)
n.2142C>A
n.2081C>A
n.2035C>A
2g.25244202_25244208delCA2699060369DNMT3Ac.117_123del
c.944_950del (n.944_950del)
c.1129_1135del (p.Asp377ProfsTer?)
c.1798_1804del (p.Asp600ProfsTer?)
c.1231_1237del (p.Asp411ProfsTer?)
n.117_123del
c.1354_1360del (p.Asp452ProfsTer?)
c.1651_1657del (p.Asp551ProfsTer?)
c.1633_1639del (p.Asp545ProfsTer?)
c.1342_1348del (p.Asp448ProfsTer?)
c.1270_1276del (p.Asp424ProfsTer?)
n.2136_2142del
n.2075_2081del
n.2029_2035del
 dbSNP
2g.25244203C>ACA346071753DNMT3Ac.122G>T
c.949G>T (n.949G>T)
c.1134G>T (p.Trp378Cys)
c.1803G>T (p.Trp601Cys)
c.1236G>T (p.Trp412Cys)
n.122G>T
c.1359G>T (p.Trp453Cys)
c.1656G>T (p.Trp552Cys)
c.1638G>T (p.Trp546Cys)
c.1347G>T (p.Trp449Cys)
c.1275G>T (p.Trp425Cys)
n.2141G>T
n.2080G>T
n.2034G>T
2g.25244203C=CA1239262778DNMT3Ac.122G=
c.949G= (n.949G=)
c.1134G= (p.Trp378=)
c.1803G= (p.Trp601=)
c.1236G= (p.Trp412=)
n.122G=
c.1359G= (p.Trp453=)
c.1656G= (p.Trp552=)
c.1638G= (p.Trp546=)
c.1347G= (p.Trp449=)
c.1275G= (p.Trp425=)
n.2141G=
n.2080G=
n.2034G=
2g.25244203C>GCA346071754DNMT3Ac.122G>C
c.949G>C (n.949G>C)
c.1134G>C (p.Trp378Cys)
c.1803G>C (p.Trp601Cys)
c.1236G>C (p.Trp412Cys)
n.122G>C
c.1359G>C (p.Trp453Cys)
c.1656G>C (p.Trp552Cys)
c.1638G>C (p.Trp546Cys)
c.1347G>C (p.Trp449Cys)
c.1275G>C (p.Trp425Cys)
n.2141G>C
n.2080G>C
n.2034G>C
2g.25244203C>TCA1555869DNMT3Ac.122G>A
c.949G>A (n.949G>A)
c.1134G>A (p.Trp378Ter)
c.1803G>A (p.Trp601Ter)
c.1236G>A (p.Trp412Ter)
n.122G>A
c.1359G>A (p.Trp453Ter)
c.1656G>A (p.Trp552Ter)
c.1638G>A (p.Trp546Ter)
c.1347G>A (p.Trp449Ter)
c.1275G>A (p.Trp425Ter)
n.2141G>A
n.2080G>A
n.2034G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC
2g.25244205_25244209delCA2658168467DNMT3Ac.118_122del
c.945_949del (n.945_949del)
c.1130_1134del (p.Asp377AlafsTer10)
c.1799_1803del (p.Asp600AlafsTer10)
c.1232_1236del (p.Asp411AlafsTer10)
n.118_122del
c.1355_1359del (p.Asp452AlafsTer10)
c.1652_1656del (p.Asp551AlafsTer10)
c.1634_1638del (p.Asp545AlafsTer10)
c.1343_1347del (p.Asp448AlafsTer10)
c.1271_1275del (p.Asp424AlafsTer10)
n.2137_2141del
n.2076_2080del
n.2030_2034del
 gnomAD v4
2g.25244204C>ACA346071755DNMT3Ac.121G>T
c.948G>T (n.948G>T)
c.1133G>T (p.Trp378Leu)
c.1802G>T (p.Trp601Leu)
c.1235G>T (p.Trp412Leu)
n.121G>T
c.1358G>T (p.Trp453Leu)
c.1655G>T (p.Trp552Leu)
c.1637G>T (p.Trp546Leu)
c.1346G>T (p.Trp449Leu)
c.1274G>T (p.Trp425Leu)
n.2140G>T
n.2079G>T
n.2033G>T
2g.25244204C=CA1239262782DNMT3Ac.121G=
c.948G= (n.948G=)
c.1133G= (p.Trp378=)
c.1802G= (p.Trp601=)
c.1235G= (p.Trp412=)
n.121G=
c.1358G= (p.Trp453=)
c.1655G= (p.Trp552=)
c.1637G= (p.Trp546=)
c.1346G= (p.Trp449=)
c.1274G= (p.Trp425=)
n.2140G=
n.2079G=
n.2033G=
2g.25244204C>GCA346071756DNMT3Ac.121G>C
c.948G>C (n.948G>C)
c.1133G>C (p.Trp378Ser)
c.1802G>C (p.Trp601Ser)
c.1235G>C (p.Trp412Ser)
n.121G>C
c.1358G>C (p.Trp453Ser)
c.1655G>C (p.Trp552Ser)
c.1637G>C (p.Trp546Ser)
c.1346G>C (p.Trp449Ser)
c.1274G>C (p.Trp425Ser)
n.2140G>C
n.2079G>C
n.2033G>C
2g.25244204C>TCA43703281DNMT3Ac.121G>A
c.948G>A (n.948G>A)
c.1133G>A (p.Trp378Ter)
c.1802G>A (p.Trp601Ter)
c.1235G>A (p.Trp412Ter)
n.121G>A
c.1358G>A (p.Trp453Ter)
c.1655G>A (p.Trp552Ter)
c.1637G>A (p.Trp546Ter)
c.1346G>A (p.Trp449Ter)
c.1274G>A (p.Trp425Ter)
n.2140G>A
n.2079G>A
n.2033G>A
 ClinVar dbSNP gnomAD v2 gnomAD v4
2g.25244205A>CCA346071757DNMT3Ac.120T>G
c.947T>G (n.947T>G)
c.1132T>G (p.Trp378Gly)
c.1801T>G (p.Trp601Gly)
c.1234T>G (p.Trp412Gly)
n.120T>G
c.1357T>G (p.Trp453Gly)
c.1654T>G (p.Trp552Gly)
c.1636T>G (p.Trp546Gly)
c.1345T>G (p.Trp449Gly)
c.1273T>G (p.Trp425Gly)
n.2139T>G
n.2078T>G
n.2032T>G
2g.25244205A>GCA346071758DNMT3Ac.120T>C
c.947T>C (n.947T>C)
c.1132T>C (p.Trp378Arg)
c.1801T>C (p.Trp601Arg)
c.1234T>C (p.Trp412Arg)
n.120T>C
c.1357T>C (p.Trp453Arg)
c.1654T>C (p.Trp552Arg)
c.1636T>C (p.Trp546Arg)
c.1345T>C (p.Trp449Arg)
c.1273T>C (p.Trp425Arg)
n.2139T>C
n.2078T>C
n.2032T>C
2g.25244205A>TCA346071759DNMT3Ac.120T>A
c.947T>A (n.947T>A)
c.1132T>A (p.Trp378Arg)
c.1801T>A (p.Trp601Arg)
c.1234T>A (p.Trp412Arg)
n.120T>A
c.1357T>A (p.Trp453Arg)
c.1654T>A (p.Trp552Arg)
c.1636T>A (p.Trp546Arg)
c.1345T>A (p.Trp449Arg)
c.1273T>A (p.Trp425Arg)
n.2139T>A
n.2078T>A
n.2032T>A
2g.25244206G>ACA425182257DNMT3Ac.119C>T
c.946C>T (n.946C>T)
c.1131C>T (p.Asp377=)
c.1800C>T (p.Asp600=)
c.1233C>T (p.Asp411=)
n.119C>T
c.1356C>T (p.Asp452=)
c.1653C>T (p.Asp551=)
c.1635C>T (p.Asp545=)
c.1344C>T (p.Asp448=)
c.1272C>T (p.Asp424=)
n.2138C>T
n.2077C>T
n.2031C>T
 dbSNP
2g.25244206G>CCA346071760DNMT3Ac.119C>G
c.946C>G (n.946C>G)
c.1131C>G (p.Asp377Glu)
c.1800C>G (p.Asp600Glu)
c.1233C>G (p.Asp411Glu)
n.119C>G
c.1356C>G (p.Asp452Glu)
c.1653C>G (p.Asp551Glu)
c.1635C>G (p.Asp545Glu)
c.1344C>G (p.Asp448Glu)
c.1272C>G (p.Asp424Glu)
n.2138C>G
n.2077C>G
n.2031C>G
 dbSNP
2g.25244206G>TCA346071761DNMT3Ac.119C>A
c.946C>A (n.946C>A)
c.1131C>A (p.Asp377Glu)
c.1800C>A (p.Asp600Glu)
c.1233C>A (p.Asp411Glu)
n.119C>A
c.1356C>A (p.Asp452Glu)
c.1653C>A (p.Asp551Glu)
c.1635C>A (p.Asp545Glu)
c.1344C>A (p.Asp448Glu)
c.1272C>A (p.Asp424Glu)
n.2138C>A
n.2077C>A
n.2031C>A
2g.25244207T>ACA346071762DNMT3Ac.118A>T
c.945A>T (n.945A>T)
c.1130A>T (p.Asp377Val)
c.1799A>T (p.Asp600Val)
c.1232A>T (p.Asp411Val)
n.118A>T
c.1355A>T (p.Asp452Val)
c.1652A>T (p.Asp551Val)
c.1634A>T (p.Asp545Val)
c.1343A>T (p.Asp448Val)
c.1271A>T (p.Asp424Val)
n.2137A>T
n.2076A>T
n.2030A>T
2g.25244207T>CCA346071764DNMT3Ac.118A>G
c.945A>G (n.945A>G)
c.1130A>G (p.Asp377Gly)
c.1799A>G (p.Asp600Gly)
c.1232A>G (p.Asp411Gly)
n.118A>G
c.1355A>G (p.Asp452Gly)
c.1652A>G (p.Asp551Gly)
c.1634A>G (p.Asp545Gly)
c.1343A>G (p.Asp448Gly)
c.1271A>G (p.Asp424Gly)
n.2137A>G
n.2076A>G
n.2030A>G
 dbSNP
2g.25244207T>GCA346071763DNMT3Ac.118A>C
c.945A>C (n.945A>C)
c.1130A>C (p.Asp377Ala)
c.1799A>C (p.Asp600Ala)
c.1232A>C (p.Asp411Ala)
n.118A>C
c.1355A>C (p.Asp452Ala)
c.1652A>C (p.Asp551Ala)
c.1634A>C (p.Asp545Ala)
c.1343A>C (p.Asp448Ala)
c.1271A>C (p.Asp424Ala)
n.2137A>C
n.2076A>C
n.2030A>C
2g.25244209_25244213dupCA2658168474DNMT3Ac.114_118dup
c.941_945dup (n.941_945dup)
c.1126_1130dup (p.Asp377GlufsTer?)
c.1795_1799dup (p.Asp600GlufsTer?)
c.1228_1232dup (p.Asp411GlufsTer?)
n.114_118dup
c.1351_1355dup (p.Asp452GlufsTer?)
c.1648_1652dup (p.Asp551GlufsTer?)
c.1630_1634dup (p.Asp545GlufsTer?)
c.1339_1343dup (p.Asp448GlufsTer?)
c.1267_1271dup (p.Asp424GlufsTer?)
n.2133_2137dup
n.2072_2076dup
n.2026_2030dup
 gnomAD v4
2g.25244208C>ACA346071765DNMT3Ac.117G>T
c.944G>T (n.944G>T)
c.1129G>T (p.Asp377Tyr)
c.1798G>T (p.Asp600Tyr)
c.1231G>T (p.Asp411Tyr)
n.117G>T
c.1354G>T (p.Asp452Tyr)
c.1651G>T (p.Asp551Tyr)
c.1633G>T (p.Asp545Tyr)
c.1342G>T (p.Asp448Tyr)
c.1270G>T (p.Asp424Tyr)
n.2136G>T
n.2075G>T
n.2029G>T
2g.25244208C=CA1239262787DNMT3Ac.117G=
c.944G= (n.944G=)
c.1129G= (p.Asp377=)
c.1798G= (p.Asp600=)
c.1231G= (p.Asp411=)
n.117G=
c.1354G= (p.Asp452=)
c.1651G= (p.Asp551=)
c.1633G= (p.Asp545=)
c.1342G= (p.Asp448=)
c.1270G= (p.Asp424=)
n.2136G=
n.2075G=
n.2029G=
2g.25244208C>GCA346071766DNMT3Ac.117G>C
c.944G>C (n.944G>C)
c.1129G>C (p.Asp377His)
c.1798G>C (p.Asp600His)
c.1231G>C (p.Asp411His)
n.117G>C
c.1354G>C (p.Asp452His)
c.1651G>C (p.Asp551His)
c.1633G>C (p.Asp545His)
c.1342G>C (p.Asp448His)
c.1270G>C (p.Asp424His)
n.2136G>C
n.2075G>C
n.2029G>C
2g.25244208C>TCA1555870DNMT3Ac.117G>A
c.944G>A (n.944G>A)
c.1129G>A (p.Asp377Asn)
c.1798G>A (p.Asp600Asn)
c.1231G>A (p.Asp411Asn)
n.117G>A
c.1354G>A (p.Asp452Asn)
c.1651G>A (p.Asp551Asn)
c.1633G>A (p.Asp545Asn)
c.1342G>A (p.Asp448Asn)
c.1270G>A (p.Asp424Asn)
n.2136G>A
n.2075G>A
n.2029G>A
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244208_25244211delCA2658168479DNMT3Ac.114_117del
c.941_944del (n.941_944del)
c.1126_1129del (p.Glu376ThrfsTer?)
c.1795_1798del (p.Glu599ThrfsTer?)
c.1228_1231del (p.Glu410ThrfsTer?)
n.114_117del
c.1351_1354del (p.Glu451ThrfsTer?)
c.1648_1651del (p.Glu550ThrfsTer?)
c.1630_1633del (p.Glu544ThrfsTer?)
c.1339_1342del (p.Glu447ThrfsTer?)
c.1267_1270del (p.Glu423ThrfsTer?)
n.2133_2136del
n.2072_2075del
n.2026_2029del
 gnomAD v4
2g.25244209C>ACA1555871DNMT3Ac.116G>T
c.943G>T (n.943G>T)
c.1128G>T (p.Glu376Asp)
c.1797G>T (p.Glu599Asp)
c.1230G>T (p.Glu410Asp)
n.116G>T
c.1353G>T (p.Glu451Asp)
c.1650G>T (p.Glu550Asp)
c.1632G>T (p.Glu544Asp)
c.1341G>T (p.Glu447Asp)
c.1269G>T (p.Glu423Asp)
n.2135G>T
n.2074G>T
n.2028G>T
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244209C=CA1239262790DNMT3Ac.116G=
c.943G= (n.943G=)
c.1128G= (p.Glu376=)
c.1797G= (p.Glu599=)
c.1230G= (p.Glu410=)
n.116G=
c.1353G= (p.Glu451=)
c.1650G= (p.Glu550=)
c.1632G= (p.Glu544=)
c.1341G= (p.Glu447=)
c.1269G= (p.Glu423=)
n.2135G=
n.2074G=
n.2028G=
2g.25244209C>GCA346071767DNMT3Ac.116G>C
c.943G>C (n.943G>C)
c.1128G>C (p.Glu376Asp)
c.1797G>C (p.Glu599Asp)
c.1230G>C (p.Glu410Asp)
n.116G>C
c.1353G>C (p.Glu451Asp)
c.1650G>C (p.Glu550Asp)
c.1632G>C (p.Glu544Asp)
c.1341G>C (p.Glu447Asp)
c.1269G>C (p.Glu423Asp)
n.2135G>C
n.2074G>C
n.2028G>C
2g.25244209C>TCA425182261DNMT3Ac.116G>A
c.943G>A (n.943G>A)
c.1128G>A (p.Glu376=)
c.1797G>A (p.Glu599=)
c.1230G>A (p.Glu410=)
n.116G>A
c.1353G>A (p.Glu451=)
c.1650G>A (p.Glu550=)
c.1632G>A (p.Glu544=)
c.1341G>A (p.Glu447=)
c.1269G>A (p.Glu423=)
n.2135G>A
n.2074G>A
n.2028G>A
 dbSNP
2g.25244210delCA2576694284DNMT3Ac.115del
c.942del (n.942del)
c.1127del (p.Glu376GlyfsTer?)
c.1796del (p.Glu599GlyfsTer?)
c.1229del (p.Glu410GlyfsTer?)
n.115del
c.1352del (p.Glu451GlyfsTer?)
c.1649del (p.Glu550GlyfsTer?)
c.1631del (p.Glu544GlyfsTer?)
c.1340del (p.Glu447GlyfsTer?)
c.1268del (p.Glu423GlyfsTer?)
n.2134del
n.2073del
n.2027del
2g.25244210T>ACA346071768DNMT3Ac.115A>T
c.942A>T (n.942A>T)
c.1127A>T (p.Glu376Val)
c.1796A>T (p.Glu599Val)
c.1229A>T (p.Glu410Val)
n.115A>T
c.1352A>T (p.Glu451Val)
c.1649A>T (p.Glu550Val)
c.1631A>T (p.Glu544Val)
c.1340A>T (p.Glu447Val)
c.1268A>T (p.Glu423Val)
n.2134A>T
n.2073A>T
n.2027A>T
2g.25244210T>CCA346071769DNMT3Ac.115A>G
c.942A>G (n.942A>G)
c.1127A>G (p.Glu376Gly)
c.1796A>G (p.Glu599Gly)
c.1229A>G (p.Glu410Gly)
n.115A>G
c.1352A>G (p.Glu451Gly)
c.1649A>G (p.Glu550Gly)
c.1631A>G (p.Glu544Gly)
c.1340A>G (p.Glu447Gly)
c.1268A>G (p.Glu423Gly)
n.2134A>G
n.2073A>G
n.2027A>G
 dbSNP
2g.25244210T>GCA346071770DNMT3Ac.115A>C
c.942A>C (n.942A>C)
c.1127A>C (p.Glu376Ala)
c.1796A>C (p.Glu599Ala)
c.1229A>C (p.Glu410Ala)
n.115A>C
c.1352A>C (p.Glu451Ala)
c.1649A>C (p.Glu550Ala)
c.1631A>C (p.Glu544Ala)
c.1340A>C (p.Glu447Ala)
c.1268A>C (p.Glu423Ala)
n.2134A>C
n.2073A>C
n.2027A>C
2g.25244211C>ACA346071771DNMT3Ac.114G>T
c.941G>T (n.941G>T)
c.1126G>T (p.Glu376Ter)
c.1795G>T (p.Glu599Ter)
c.1228G>T (p.Glu410Ter)
n.114G>T
c.1351G>T (p.Glu451Ter)
c.1648G>T (p.Glu550Ter)
c.1630G>T (p.Glu544Ter)
c.1339G>T (p.Glu447Ter)
c.1267G>T (p.Glu423Ter)
n.2133G>T
n.2072G>T
n.2026G>T
 gnomAD v4
2g.25244211C>GCA346071772DNMT3Ac.114G>C
c.941G>C (n.941G>C)
c.1126G>C (p.Glu376Gln)
c.1795G>C (p.Glu599Gln)
c.1228G>C (p.Glu410Gln)
n.114G>C
c.1351G>C (p.Glu451Gln)
c.1648G>C (p.Glu550Gln)
c.1630G>C (p.Glu544Gln)
c.1339G>C (p.Glu447Gln)
c.1267G>C (p.Glu423Gln)
n.2133G>C
n.2072G>C
n.2026G>C
2g.25244211C>TCA346071773DNMT3Ac.114G>A
c.941G>A (n.941G>A)
c.1126G>A (p.Glu376Lys)
c.1795G>A (p.Glu599Lys)
c.1228G>A (p.Glu410Lys)
n.114G>A
c.1351G>A (p.Glu451Lys)
c.1648G>A (p.Glu550Lys)
c.1630G>A (p.Glu544Lys)
c.1339G>A (p.Glu447Lys)
c.1267G>A (p.Glu423Lys)
n.2133G>A
n.2072G>A
n.2026G>A
2g.25244212delCA2739317457DNMT3Ac.113del
c.940del (n.940del)
c.1125del (p.Glu376ArgfsTer?)
c.1794del (p.Glu599ArgfsTer?)
c.1227del (p.Glu410ArgfsTer?)
n.113del
c.1350del (p.Glu451ArgfsTer?)
c.1647del (p.Glu550ArgfsTer?)
c.1629del (p.Glu544ArgfsTer?)
c.1338del (p.Glu447ArgfsTer?)
c.1266del (p.Glu423ArgfsTer?)
n.2132del
n.2071del
n.2025del
2g.25244212T>ACA425182262DNMT3Ac.113A>T
c.940A>T (n.940A>T)
c.1125A>T (p.Arg375=)
c.1794A>T (p.Arg598=)
c.1227A>T (p.Arg409=)
n.113A>T
c.1350A>T (p.Arg450=)
c.1647A>T (p.Arg549=)
c.1629A>T (p.Arg543=)
c.1338A>T (p.Arg446=)
c.1266A>T (p.Arg422=)
n.2132A>T
n.2071A>T
n.2025A>T
2g.25244212T>CCA425182263DNMT3Ac.113A>G
c.940A>G (n.940A>G)
c.1125A>G (p.Arg375=)
c.1794A>G (p.Arg598=)
c.1227A>G (p.Arg409=)
n.113A>G
c.1350A>G (p.Arg450=)
c.1647A>G (p.Arg549=)
c.1629A>G (p.Arg543=)
c.1338A>G (p.Arg446=)
c.1266A>G (p.Arg422=)
n.2132A>G
n.2071A>G
n.2025A>G
2g.25244212T>GCA425182264DNMT3Ac.113A>C
c.940A>C (n.940A>C)
c.1125A>C (p.Arg375=)
c.1794A>C (p.Arg598=)
c.1227A>C (p.Arg409=)
n.113A>C
c.1350A>C (p.Arg450=)
c.1647A>C (p.Arg549=)
c.1629A>C (p.Arg543=)
c.1338A>C (p.Arg446=)
c.1266A>C (p.Arg422=)
n.2132A>C
n.2071A>C
n.2025A>C
2g.25244212_25244213delinsTCCA1239262795DNMT3Ac.112_113delinsGA
c.939_940delinsGA (n.939_940delinsGA)
c.1124_1125delinsGA (p.Arg375=)
c.1793_1794delinsGA (p.Arg598=)
c.1226_1227delinsGA (p.Arg409=)
n.112_113delinsGA
c.1349_1350delinsGA (p.Arg450=)
c.1646_1647delinsGA (p.Arg549=)
c.1628_1629delinsGA (p.Arg543=)
c.1337_1338delinsGA (p.Arg446=)
c.1265_1266delinsGA (p.Arg422=)
n.2131_2132delinsGA
n.2070_2071delinsGA
n.2024_2025delinsGA
2g.25244213delCA43703299DNMT3Ac.112del
c.939del (n.939del)
c.1124del (p.Arg375GlnfsTer?)
c.1793del (p.Arg598GlnfsTer?)
c.1226del (p.Arg409GlnfsTer?)
n.112del
c.1349del (p.Arg450GlnfsTer?)
c.1646del (p.Arg549GlnfsTer?)
c.1628del (p.Arg543GlnfsTer?)
c.1337del (p.Arg446GlnfsTer?)
c.1265del (p.Arg422GlnfsTer?)
n.2131del
n.2070del
n.2024del
 dbSNP
2g.25244213C>ACA346071774DNMT3Ac.112G>T
c.939G>T (n.939G>T)
c.1124G>T (p.Arg375Leu)
c.1793G>T (p.Arg598Leu)
c.1226G>T (p.Arg409Leu)
n.112G>T
c.1349G>T (p.Arg450Leu)
c.1646G>T (p.Arg549Leu)
c.1628G>T (p.Arg543Leu)
c.1337G>T (p.Arg446Leu)
c.1265G>T (p.Arg422Leu)
n.2131G>T
n.2070G>T
n.2024G>T
 dbSNP
2g.25244213C=CA1239262800DNMT3Ac.112G=
c.939G= (n.939G=)
c.1124G= (p.Arg375=)
c.1793G= (p.Arg598=)
c.1226G= (p.Arg409=)
n.112G=
c.1349G= (p.Arg450=)
c.1646G= (p.Arg549=)
c.1628G= (p.Arg543=)
c.1337G= (p.Arg446=)
c.1265G= (p.Arg422=)
n.2131G=
n.2070G=
n.2024G=
2g.25244213C>GCA346071775DNMT3Ac.112G>C
c.939G>C (n.939G>C)
c.1124G>C (p.Arg375Pro)
c.1793G>C (p.Arg598Pro)
c.1226G>C (p.Arg409Pro)
n.112G>C
c.1349G>C (p.Arg450Pro)
c.1646G>C (p.Arg549Pro)
c.1628G>C (p.Arg543Pro)
c.1337G>C (p.Arg446Pro)
c.1265G>C (p.Arg422Pro)
n.2131G>C
n.2070G>C
n.2024G>C
2g.25244213C>TCA1555872DNMT3Ac.112G>A
c.939G>A (n.939G>A)
c.1124G>A (p.Arg375Gln)
c.1793G>A (p.Arg598Gln)
c.1226G>A (p.Arg409Gln)
n.112G>A
c.1349G>A (p.Arg450Gln)
c.1646G>A (p.Arg549Gln)
c.1628G>A (p.Arg543Gln)
c.1337G>A (p.Arg446Gln)
c.1265G>A (p.Arg422Gln)
n.2131G>A
n.2070G>A
n.2024G>A
 dbSNP ExAC gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25244213dupCA2658168493DNMT3Ac.112dup
c.939dup (n.939dup)
c.1124dup (p.Glu376ArgfsTer13)
c.1793dup (p.Glu599ArgfsTer13)
c.1226dup (p.Glu410ArgfsTer13)
n.112dup
c.1349dup (p.Glu451ArgfsTer13)
c.1646dup (p.Glu550ArgfsTer13)
c.1628dup (p.Glu544ArgfsTer13)
c.1337dup (p.Glu447ArgfsTer13)
c.1265dup (p.Glu423ArgfsTer13)
n.2131dup
n.2070dup
n.2024dup
 gnomAD v4
2g.25244214G>ACA1555873DNMT3Ac.111C>T
c.938C>T (n.938C>T)
c.1123C>T (p.Arg375Ter)
c.1792C>T (p.Arg598Ter)
c.1225C>T (p.Arg409Ter)
n.111C>T
c.1348C>T (p.Arg450Ter)
c.1645C>T (p.Arg549Ter)
c.1627C>T (p.Arg543Ter)
c.1336C>T (p.Arg446Ter)
c.1264C>T (p.Arg422Ter)
n.2130C>T
n.2069C>T
n.2023C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25244214G>CCA346071776DNMT3Ac.111C>G
c.938C>G (n.938C>G)
c.1123C>G (p.Arg375Gly)
c.1792C>G (p.Arg598Gly)
c.1225C>G (p.Arg409Gly)
n.111C>G
c.1348C>G (p.Arg450Gly)
c.1645C>G (p.Arg549Gly)
c.1627C>G (p.Arg543Gly)
c.1336C>G (p.Arg446Gly)
c.1264C>G (p.Arg422Gly)
n.2130C>G
n.2069C>G
n.2023C>G
 dbSNP gnomAD v4
2g.25244214G=CA1239262805DNMT3Ac.111C=
c.938C= (n.938C=)
c.1123C= (p.Arg375=)
c.1792C= (p.Arg598=)
c.1225C= (p.Arg409=)
n.111C=
c.1348C= (p.Arg450=)
c.1645C= (p.Arg549=)
c.1627C= (p.Arg543=)
c.1336C= (p.Arg446=)
c.1264C= (p.Arg422=)
n.2130C=
n.2069C=
n.2023C=
2g.25244214G>TCA425182265DNMT3Ac.111C>A
c.938C>A (n.938C>A)
c.1123C>A (p.Arg375=)
c.1792C>A (p.Arg598=)
c.1225C>A (p.Arg409=)
n.111C>A
c.1348C>A (p.Arg450=)
c.1645C>A (p.Arg549=)
c.1627C>A (p.Arg543=)
c.1336C>A (p.Arg446=)
c.1264C>A (p.Arg422=)
n.2130C>A
n.2069C>A
n.2023C>A
 dbSNP
2g.25244214dupCA2697547836DNMT3Ac.111dup
c.938dup (n.938dup)
c.1123dup (p.Arg375ProfsTer14)
c.1792dup (p.Arg598ProfsTer14)
c.1225dup (p.Arg409ProfsTer14)
n.111dup
c.1348dup (p.Arg450ProfsTer14)
c.1645dup (p.Arg549ProfsTer14)
c.1627dup (p.Arg543ProfsTer14)
c.1336dup (p.Arg446ProfsTer14)
c.1264dup (p.Arg422ProfsTer14)
n.2130dup
n.2069dup
n.2023dup
 ClinVar
2g.25244215_25244254dupCA2658168498DNMT3Ac.72_111dup
c.899_938dup (n.899_938dup)
c.1084_1123dup (p.Arg375HisfsTer27)
c.1753_1792dup (p.Arg598HisfsTer27)
c.1186_1225dup (p.Arg409HisfsTer27)
n.72_111dup
c.1309_1348dup (p.Arg450HisfsTer27)
c.1606_1645dup (p.Arg549HisfsTer27)
c.1588_1627dup (p.Arg543HisfsTer27)
c.1297_1336dup (p.Arg446HisfsTer27)
c.1225_1264dup (p.Arg422HisfsTer27)
n.2091_2130dup
n.2030_2069dup
n.1984_2023dup
 gnomAD v4
2g.25244215C>ACA425182266DNMT3Ac.110G>T
c.937G>T (n.937G>T)
c.1122G>T (p.Arg374=)
c.1791G>T (p.Arg597=)
c.1224G>T (p.Arg408=)
n.110G>T
c.1347G>T (p.Arg449=)
c.1644G>T (p.Arg548=)
c.1626G>T (p.Arg542=)
c.1335G>T (p.Arg445=)
c.1263G>T (p.Arg421=)
n.2129G>T
n.2068G>T
n.2022G>T
 gnomAD v4
2g.25244215C=CA1239262809DNMT3Ac.110G=
c.937G= (n.937G=)
c.1122G= (p.Arg374=)
c.1791G= (p.Arg597=)
c.1224G= (p.Arg408=)
n.110G=
c.1347G= (p.Arg449=)
c.1644G= (p.Arg548=)
c.1626G= (p.Arg542=)
c.1335G= (p.Arg445=)
c.1263G= (p.Arg421=)
n.2129G=
n.2068G=
n.2022G=
2g.25244215C>GCA425182268DNMT3Ac.110G>C
c.937G>C (n.937G>C)
c.1122G>C (p.Arg374=)
c.1791G>C (p.Arg597=)
c.1224G>C (p.Arg408=)
n.110G>C
c.1347G>C (p.Arg449=)
c.1644G>C (p.Arg548=)
c.1626G>C (p.Arg542=)
c.1335G>C (p.Arg445=)
c.1263G>C (p.Arg421=)
n.2129G>C
n.2068G>C
n.2022G>C
2g.25244215C>TCA425182269DNMT3Ac.110G>A
c.937G>A (n.937G>A)
c.1122G>A (p.Arg374=)
c.1791G>A (p.Arg597=)
c.1224G>A (p.Arg408=)
n.110G>A
c.1347G>A (p.Arg449=)
c.1644G>A (p.Arg548=)
c.1626G>A (p.Arg542=)
c.1335G>A (p.Arg445=)
c.1263G>A (p.Arg421=)
n.2129G>A
n.2068G>A
n.2022G>A
 dbSNP
2g.25244216delCA2573050554DNMT3Ac.110del
c.937del (n.937del)
c.1122del (p.Arg375GlufsTer?)
c.1791del (p.Arg598GlufsTer?)
c.1224del (p.Arg409GlufsTer?)
n.110del
c.1347del (p.Arg450GlufsTer?)
c.1644del (p.Arg549GlufsTer?)
c.1626del (p.Arg543GlufsTer?)
c.1335del (p.Arg446GlufsTer?)
c.1263del (p.Arg422GlufsTer?)
n.2129del
n.2068del
n.2022del
 ClinVar dbSNP
2g.25244216C>ACA346071777DNMT3Ac.109G>T
c.936G>T (n.936G>T)
c.1121G>T (p.Arg374Leu)
c.1790G>T (p.Arg597Leu)
c.1223G>T (p.Arg408Leu)
n.109G>T
c.1346G>T (p.Arg449Leu)
c.1643G>T (p.Arg548Leu)
c.1625G>T (p.Arg542Leu)
c.1334G>T (p.Arg445Leu)
c.1262G>T (p.Arg421Leu)
n.2128G>T
n.2067G>T
n.2021G>T
2g.25244216C>GCA346071779DNMT3Ac.109G>C
c.936G>C (n.936G>C)
c.1121G>C (p.Arg374Pro)
c.1790G>C (p.Arg597Pro)
c.1223G>C (p.Arg408Pro)
n.109G>C
c.1346G>C (p.Arg449Pro)
c.1643G>C (p.Arg548Pro)
c.1625G>C (p.Arg542Pro)
c.1334G>C (p.Arg445Pro)
c.1262G>C (p.Arg421Pro)
n.2128G>C
n.2067G>C
n.2021G>C
2g.25244216C>TCA346071778DNMT3Ac.109G>A
c.936G>A (n.936G>A)
c.1121G>A (p.Arg374Gln)
c.1790G>A (p.Arg597Gln)
c.1223G>A (p.Arg408Gln)
n.109G>A
c.1346G>A (p.Arg449Gln)
c.1643G>A (p.Arg548Gln)
c.1625G>A (p.Arg542Gln)
c.1334G>A (p.Arg445Gln)
c.1262G>A (p.Arg421Gln)
n.2128G>A
n.2067G>A
n.2021G>A
 ClinVar gnomAD v4 COSMIC COSMIC
2g.25244217_25244218dupCA2658168512DNMT3Ac.108_109dup
c.935_936dup (n.935_936dup)
c.1120_1121dup (p.Arg375GlyfsTer?)
c.1789_1790dup (p.Arg598GlyfsTer?)
c.1222_1223dup (p.Arg409GlyfsTer?)
n.108_109dup
c.1345_1346dup (p.Arg450GlyfsTer?)
c.1642_1643dup (p.Arg549GlyfsTer?)
c.1624_1625dup (p.Arg543GlyfsTer?)
c.1333_1334dup (p.Arg446GlyfsTer?)
c.1261_1262dup (p.Arg422GlyfsTer?)
n.2127_2128dup
n.2066_2067dup
n.2020_2021dup
 gnomAD v4
2g.25244217G>ACA1555874DNMT3Ac.108C>T
c.935C>T (n.935C>T)
c.1120C>T (p.Arg374Trp)
c.1789C>T (p.Arg597Trp)
c.1222C>T (p.Arg408Trp)
n.108C>T
c.1345C>T (p.Arg449Trp)
c.1642C>T (p.Arg548Trp)
c.1624C>T (p.Arg542Trp)
c.1333C>T (p.Arg445Trp)
c.1261C>T (p.Arg421Trp)
n.2127C>T
n.2066C>T
n.2020C>T
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25244217G>CCA346071780DNMT3Ac.108C>G
c.935C>G (n.935C>G)
c.1120C>G (p.Arg374Gly)
c.1789C>G (p.Arg597Gly)
c.1222C>G (p.Arg408Gly)
n.108C>G
c.1345C>G (p.Arg449Gly)
c.1642C>G (p.Arg548Gly)
c.1624C>G (p.Arg542Gly)
c.1333C>G (p.Arg445Gly)
c.1261C>G (p.Arg421Gly)
n.2127C>G
n.2066C>G
n.2020C>G
2g.25244217G=CA1239262811DNMT3Ac.108C=
c.935C= (n.935C=)
c.1120C= (p.Arg374=)
c.1789C= (p.Arg597=)
c.1222C= (p.Arg408=)
n.108C=
c.1345C= (p.Arg449=)
c.1642C= (p.Arg548=)
c.1624C= (p.Arg542=)
c.1333C= (p.Arg445=)
c.1261C= (p.Arg421=)
n.2127C=
n.2066C=
n.2020C=
2g.25244217G>TCA425182271DNMT3Ac.108C>A
c.935C>A (n.935C>A)
c.1120C>A (p.Arg374=)
c.1789C>A (p.Arg597=)
c.1222C>A (p.Arg408=)
n.108C>A
c.1345C>A (p.Arg449=)
c.1642C>A (p.Arg548=)
c.1624C>A (p.Arg542=)
c.1333C>A (p.Arg445=)
c.1261C>A (p.Arg421=)
n.2127C>A
n.2066C>A
n.2020C>A
2g.25244218C>ACA425182272DNMT3Ac.107G>T
c.934G>T (n.934G>T)
c.1119G>T (p.Arg373=)
c.1788G>T (p.Arg596=)
c.1221G>T (p.Arg407=)
n.107G>T
c.1344G>T (p.Arg448=)
c.1641G>T (p.Arg547=)
c.1623G>T (p.Arg541=)
c.1332G>T (p.Arg444=)
c.1260G>T (p.Arg420=)
n.2126G>T
n.2065G>T
n.2019G>T
2g.25244218C>GCA425182273DNMT3Ac.107G>C
c.934G>C (n.934G>C)
c.1119G>C (p.Arg373=)
c.1788G>C (p.Arg596=)
c.1221G>C (p.Arg407=)
n.107G>C
c.1344G>C (p.Arg448=)
c.1641G>C (p.Arg547=)
c.1623G>C (p.Arg541=)
c.1332G>C (p.Arg444=)
c.1260G>C (p.Arg420=)
n.2126G>C
n.2065G>C
n.2019G>C
2g.25244218C>TCA425182274DNMT3Ac.107G>A
c.934G>A (n.934G>A)
c.1119G>A (p.Arg373=)
c.1788G>A (p.Arg596=)
c.1221G>A (p.Arg407=)
n.107G>A
c.1344G>A (p.Arg448=)
c.1641G>A (p.Arg547=)
c.1623G>A (p.Arg541=)
c.1332G>A (p.Arg444=)
c.1260G>A (p.Arg420=)
n.2126G>A
n.2065G>A
n.2019G>A
2g.25244219delCA2576694289DNMT3Ac.107del
c.934del (n.934del)
c.1119del (p.Arg374GlyfsTer?)
c.1788del (p.Arg597GlyfsTer?)
c.1221del (p.Arg408GlyfsTer?)
n.107del
c.1344del (p.Arg449GlyfsTer?)
c.1641del (p.Arg548GlyfsTer?)
c.1623del (p.Arg542GlyfsTer?)
c.1332del (p.Arg445GlyfsTer?)
c.1260del (p.Arg421GlyfsTer?)
n.2126del
n.2065del
n.2019del
 gnomAD v4
2g.25244219C>ACA346071781DNMT3Ac.106G>T
c.933G>T (n.933G>T)
c.1118G>T (p.Arg373Leu)
c.1787G>T (p.Arg596Leu)
c.1220G>T (p.Arg407Leu)
n.106G>T
c.1343G>T (p.Arg448Leu)
c.1640G>T (p.Arg547Leu)
c.1622G>T (p.Arg541Leu)
c.1331G>T (p.Arg444Leu)
c.1259G>T (p.Arg420Leu)
n.2125G>T
n.2064G>T
n.2018G>T
 ClinVar
2g.25244219C=CA1239262814DNMT3Ac.106G=
c.933G= (n.933G=)
c.1118G= (p.Arg373=)
c.1787G= (p.Arg596=)
c.1220G= (p.Arg407=)
n.106G=
c.1343G= (p.Arg448=)
c.1640G= (p.Arg547=)
c.1622G= (p.Arg541=)
c.1331G= (p.Arg444=)
c.1259G= (p.Arg420=)
n.2125G=
n.2064G=
n.2018G=
2g.25244219C>GCA346071782DNMT3Ac.106G>C
c.933G>C (n.933G>C)
c.1118G>C (p.Arg373Pro)
c.1787G>C (p.Arg596Pro)
c.1220G>C (p.Arg407Pro)
n.106G>C
c.1343G>C (p.Arg448Pro)
c.1640G>C (p.Arg547Pro)
c.1622G>C (p.Arg541Pro)
c.1331G>C (p.Arg444Pro)
c.1259G>C (p.Arg420Pro)
n.2125G>C
n.2064G>C
n.2018G>C
2g.25244219C>TCA43703315DNMT3Ac.106G>A
c.933G>A (n.933G>A)
c.1118G>A (p.Arg373Gln)
c.1787G>A (p.Arg596Gln)
c.1220G>A (p.Arg407Gln)
n.106G>A
c.1343G>A (p.Arg448Gln)
c.1640G>A (p.Arg547Gln)
c.1622G>A (p.Arg541Gln)
c.1331G>A (p.Arg444Gln)
c.1259G>A (p.Arg420Gln)
n.2125G>A
n.2064G>A
n.2018G>A
 ClinVar dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244220G>ACA346071783DNMT3Ac.105C>T
c.932C>T (n.932C>T)
c.1117C>T (p.Arg373Trp)
c.1786C>T (p.Arg596Trp)
c.1219C>T (p.Arg407Trp)
n.105C>T
c.1342C>T (p.Arg448Trp)
c.1639C>T (p.Arg547Trp)
c.1621C>T (p.Arg541Trp)
c.1330C>T (p.Arg444Trp)
c.1258C>T (p.Arg420Trp)
n.2124C>T
n.2063C>T
n.2017C>T
 dbSNP gnomAD v3 gnomAD v4
2g.25244220G>CCA346071784DNMT3Ac.105C>G
c.932C>G (n.932C>G)
c.1117C>G (p.Arg373Gly)
c.1786C>G (p.Arg596Gly)
c.1219C>G (p.Arg407Gly)
n.105C>G
c.1342C>G (p.Arg448Gly)
c.1639C>G (p.Arg547Gly)
c.1621C>G (p.Arg541Gly)
c.1330C>G (p.Arg444Gly)
c.1258C>G (p.Arg420Gly)
n.2124C>G
n.2063C>G
n.2017C>G
2g.25244220G=CA1239262817DNMT3Ac.105C=
c.932C= (n.932C=)
c.1117C= (p.Arg373=)
c.1786C= (p.Arg596=)
c.1219C= (p.Arg407=)
n.105C=
c.1342C= (p.Arg448=)
c.1639C= (p.Arg547=)
c.1621C= (p.Arg541=)
c.1330C= (p.Arg444=)
c.1258C= (p.Arg420=)
n.2124C=
n.2063C=
n.2017C=
2g.25244220G>TCA425182276DNMT3Ac.105C>A
c.932C>A (n.932C>A)
c.1117C>A (p.Arg373=)
c.1786C>A (p.Arg596=)
c.1219C>A (p.Arg407=)
n.105C>A
c.1342C>A (p.Arg448=)
c.1639C>A (p.Arg547=)
c.1621C>A (p.Arg541=)
c.1330C>A (p.Arg444=)
c.1258C>A (p.Arg420=)
n.2124C>A
n.2063C>A
n.2017C>A
 dbSNP gnomAD v3 gnomAD v4
2g.25244221C>ACA425182277DNMT3Ac.104G>T
c.931G>T (n.931G>T)
c.1116G>T (p.Leu372=)
c.1785G>T (p.Leu595=)
c.1218G>T (p.Leu406=)
n.104G>T
c.1341G>T (p.Leu447=)
c.1638G>T (p.Leu546=)
c.1620G>T (p.Leu540=)
c.1329G>T (p.Leu443=)
c.1257G>T (p.Leu419=)
n.2123G>T
n.2062G>T
n.2016G>T
2g.25244221C=CA1239262821DNMT3Ac.104G=
c.931G= (n.931G=)
c.1116G= (p.Leu372=)
c.1785G= (p.Leu595=)
c.1218G= (p.Leu406=)
n.104G=
c.1341G= (p.Leu447=)
c.1638G= (p.Leu546=)
c.1620G= (p.Leu540=)
c.1329G= (p.Leu443=)
c.1257G= (p.Leu419=)
n.2123G=
n.2062G=
n.2016G=
2g.25244221C>GCA425182279DNMT3Ac.104G>C
c.931G>C (n.931G>C)
c.1116G>C (p.Leu372=)
c.1785G>C (p.Leu595=)
c.1218G>C (p.Leu406=)
n.104G>C
c.1341G>C (p.Leu447=)
c.1638G>C (p.Leu546=)
c.1620G>C (p.Leu540=)
c.1329G>C (p.Leu443=)
c.1257G>C (p.Leu419=)
n.2123G>C
n.2062G>C
n.2016G>C
2g.25244221C>TCA425182278DNMT3Ac.104G>A
c.931G>A (n.931G>A)
c.1116G>A (p.Leu372=)
c.1785G>A (p.Leu595=)
c.1218G>A (p.Leu406=)
n.104G>A
c.1341G>A (p.Leu447=)
c.1638G>A (p.Leu546=)
c.1620G>A (p.Leu540=)
c.1329G>A (p.Leu443=)
c.1257G>A (p.Leu419=)
n.2123G>A
n.2062G>A
n.2016G>A
 dbSNP gnomAD v2 gnomAD v4
2g.25244221dupCA2658168519DNMT3Ac.104dup
c.931dup (n.931dup)
c.1116dup (p.Arg373AlafsTer16)
c.1785dup (p.Arg596AlafsTer16)
c.1218dup (p.Arg407AlafsTer16)
n.104dup
c.1341dup (p.Arg448AlafsTer16)
c.1638dup (p.Arg547AlafsTer16)
c.1620dup (p.Arg541AlafsTer16)
c.1329dup (p.Arg444AlafsTer16)
c.1257dup (p.Arg420AlafsTer16)
n.2123dup
n.2062dup
n.2016dup
 gnomAD v4
2g.25244221_25244222delinsCACA1239262820DNMT3Ac.103_104delinsTG
c.930_931delinsTG (n.930_931delinsTG)
c.1115_1116delinsTG (p.Leu372=)
c.1784_1785delinsTG (p.Leu595=)
c.1217_1218delinsTG (p.Leu406=)
n.103_104delinsTG
c.1340_1341delinsTG (p.Leu447=)
c.1637_1638delinsTG (p.Leu546=)
c.1619_1620delinsTG (p.Leu540=)
c.1328_1329delinsTG (p.Leu443=)
c.1256_1257delinsTG (p.Leu419=)
n.2122_2123delinsTG
n.2061_2062delinsTG
n.2015_2016delinsTG
2g.25244222delCA1028509725DNMT3Ac.103del
c.930del (n.930del)
c.1115del (p.Leu372ArgfsTer?)
c.1784del (p.Leu595ArgfsTer?)
c.1217del (p.Leu406ArgfsTer?)
n.103del
c.1340del (p.Leu447ArgfsTer?)
c.1637del (p.Leu546ArgfsTer?)
c.1619del (p.Leu540ArgfsTer?)
c.1328del (p.Leu443ArgfsTer?)
c.1256del (p.Leu419ArgfsTer?)
n.2122del
n.2061del
n.2015del
 dbSNP gnomAD v3 gnomAD v4
2g.25244222A=CA1239262825DNMT3Ac.103T=
c.930T= (n.930T=)
c.1115T= (p.Leu372=)
c.1784T= (p.Leu595=)
c.1217T= (p.Leu406=)
n.103T=
c.1340T= (p.Leu447=)
c.1637T= (p.Leu546=)
c.1619T= (p.Leu540=)
c.1328T= (p.Leu443=)
c.1256T= (p.Leu419=)
n.2122T=
n.2061T=
n.2015T=
2g.25244222A>CCA346071785DNMT3Ac.103T>G
c.930T>G (n.930T>G)
c.1115T>G (p.Leu372Arg)
c.1784T>G (p.Leu595Arg)
c.1217T>G (p.Leu406Arg)
n.103T>G
c.1340T>G (p.Leu447Arg)
c.1637T>G (p.Leu546Arg)
c.1619T>G (p.Leu540Arg)
c.1328T>G (p.Leu443Arg)
c.1256T>G (p.Leu419Arg)
n.2122T>G
n.2061T>G
n.2015T>G
 gnomAD v3 gnomAD v4
2g.25244222A>GCA346071786DNMT3Ac.103T>C
c.930T>C (n.930T>C)
c.1115T>C (p.Leu372Pro)
c.1784T>C (p.Leu595Pro)
c.1217T>C (p.Leu406Pro)
n.103T>C
c.1340T>C (p.Leu447Pro)
c.1637T>C (p.Leu546Pro)
c.1619T>C (p.Leu540Pro)
c.1328T>C (p.Leu443Pro)
c.1256T>C (p.Leu419Pro)
n.2122T>C
n.2061T>C
n.2015T>C
 dbSNP gnomAD v2 gnomAD v4 COSMIC
2g.25244222A>TCA346071787DNMT3Ac.103T>A
c.930T>A (n.930T>A)
c.1115T>A (p.Leu372Gln)
c.1784T>A (p.Leu595Gln)
c.1217T>A (p.Leu406Gln)
n.103T>A
c.1340T>A (p.Leu447Gln)
c.1637T>A (p.Leu546Gln)
c.1619T>A (p.Leu540Gln)
c.1328T>A (p.Leu443Gln)
c.1256T>A (p.Leu419Gln)
n.2122T>A
n.2061T>A
n.2015T>A
2g.25244222dupCA2658168522DNMT3Ac.103dup
c.930dup (n.930dup)
c.1115dup (p.Arg373AlafsTer16)
c.1784dup (p.Arg596AlafsTer16)
c.1217dup (p.Arg407AlafsTer16)
n.103dup
c.1340dup (p.Arg448AlafsTer16)
c.1637dup (p.Arg547AlafsTer16)
c.1619dup (p.Arg541AlafsTer16)
c.1328dup (p.Arg444AlafsTer16)
c.1256dup (p.Arg420AlafsTer16)
n.2122dup
n.2061dup
n.2015dup
 gnomAD v4
2g.25244223G>ACA425182281DNMT3Ac.102C>T
c.929C>T (n.929C>T)
c.1114C>T (p.Leu372=)
c.1783C>T (p.Leu595=)
c.1216C>T (p.Leu406=)
n.102C>T
c.1339C>T (p.Leu447=)
c.1636C>T (p.Leu546=)
c.1618C>T (p.Leu540=)
c.1327C>T (p.Leu443=)
c.1255C>T (p.Leu419=)
n.2121C>T
n.2060C>T
n.2014C>T
 dbSNP
2g.25244223G>CCA346071789DNMT3Ac.102C>G
c.929C>G (n.929C>G)
c.1114C>G (p.Leu372Val)
c.1783C>G (p.Leu595Val)
c.1216C>G (p.Leu406Val)
n.102C>G
c.1339C>G (p.Leu447Val)
c.1636C>G (p.Leu546Val)
c.1618C>G (p.Leu540Val)
c.1327C>G (p.Leu443Val)
c.1255C>G (p.Leu419Val)
n.2121C>G
n.2060C>G
n.2014C>G
 dbSNP
2g.25244223G>TCA346071788DNMT3Ac.102C>A
c.929C>A (n.929C>A)
c.1114C>A (p.Leu372Met)
c.1783C>A (p.Leu595Met)
c.1216C>A (p.Leu406Met)
n.102C>A
c.1339C>A (p.Leu447Met)
c.1636C>A (p.Leu546Met)
c.1618C>A (p.Leu540Met)
c.1327C>A (p.Leu443Met)
c.1255C>A (p.Leu419Met)
n.2121C>A
n.2060C>A
n.2014C>A
2g.25244224C>ACA425182282DNMT3Ac.101G>T
c.928G>T (n.928G>T)
c.1113G>T (p.Leu371=)
c.1782G>T (p.Leu594=)
c.1215G>T (p.Leu405=)
n.101G>T
c.1338G>T (p.Leu446=)
c.1635G>T (p.Leu545=)
c.1617G>T (p.Leu539=)
c.1326G>T (p.Leu442=)
c.1254G>T (p.Leu418=)
n.2120G>T
n.2059G>T
n.2013G>T
2g.25244224C>GCA425182283DNMT3Ac.101G>C
c.928G>C (n.928G>C)
c.1113G>C (p.Leu371=)
c.1782G>C (p.Leu594=)
c.1215G>C (p.Leu405=)
n.101G>C
c.1338G>C (p.Leu446=)
c.1635G>C (p.Leu545=)
c.1617G>C (p.Leu539=)
c.1326G>C (p.Leu442=)
c.1254G>C (p.Leu418=)
n.2120G>C
n.2059G>C
n.2013G>C
2g.25244224C>TCA425182284DNMT3Ac.101G>A
c.928G>A (n.928G>A)
c.1113G>A (p.Leu371=)
c.1782G>A (p.Leu594=)
c.1215G>A (p.Leu405=)
n.101G>A
c.1338G>A (p.Leu446=)
c.1635G>A (p.Leu545=)
c.1617G>A (p.Leu539=)
c.1326G>A (p.Leu442=)
c.1254G>A (p.Leu418=)
n.2120G>A
n.2059G>A
n.2013G>A
 dbSNP
2g.25244225A>CCA346071790DNMT3Ac.100T>G
c.927T>G (n.927T>G)
c.1112T>G (p.Leu371Arg)
c.1781T>G (p.Leu594Arg)
c.1214T>G (p.Leu405Arg)
n.100T>G
c.1337T>G (p.Leu446Arg)
c.1634T>G (p.Leu545Arg)
c.1616T>G (p.Leu539Arg)
c.1325T>G (p.Leu442Arg)
c.1253T>G (p.Leu418Arg)
n.2119T>G
n.2058T>G
n.2012T>G
2g.25244225A>GCA346071792DNMT3Ac.100T>C
c.927T>C (n.927T>C)
c.1112T>C (p.Leu371Pro)
c.1781T>C (p.Leu594Pro)
c.1214T>C (p.Leu405Pro)
n.100T>C
c.1337T>C (p.Leu446Pro)
c.1634T>C (p.Leu545Pro)
c.1616T>C (p.Leu539Pro)
c.1325T>C (p.Leu442Pro)
c.1253T>C (p.Leu418Pro)
n.2119T>C
n.2058T>C
n.2012T>C
2g.25244225A>TCA346071791DNMT3Ac.100T>A
c.927T>A (n.927T>A)
c.1112T>A (p.Leu371Gln)
c.1781T>A (p.Leu594Gln)
c.1214T>A (p.Leu405Gln)
n.100T>A
c.1337T>A (p.Leu446Gln)
c.1634T>A (p.Leu545Gln)
c.1616T>A (p.Leu539Gln)
c.1325T>A (p.Leu442Gln)
c.1253T>A (p.Leu418Gln)
n.2119T>A
n.2058T>A
n.2012T>A
2g.25244225_25244226delCA2658168527DNMT3Ac.99_100del
c.926_927del (n.926_927del)
c.1111_1112del (p.Leu371AlafsTer17)
c.1780_1781del (p.Leu594AlafsTer17)
c.1213_1214del (p.Leu405AlafsTer17)
n.99_100del
c.1336_1337del (p.Leu446AlafsTer17)
c.1633_1634del (p.Leu545AlafsTer17)
c.1615_1616del (p.Leu539AlafsTer17)
c.1324_1325del (p.Leu442AlafsTer17)
c.1252_1253del (p.Leu418AlafsTer17)
n.2118_2119del
n.2057_2058del
n.2011_2012del
 gnomAD v4
2g.25244226G>ACA1555875DNMT3Ac.99C>T
c.926C>T (n.926C>T)
c.1111C>T (p.Leu371=)
c.1780C>T (p.Leu594=)
c.1213C>T (p.Leu405=)
n.99C>T
c.1336C>T (p.Leu446=)
c.1633C>T (p.Leu545=)
c.1615C>T (p.Leu539=)
c.1324C>T (p.Leu442=)
c.1252C>T (p.Leu418=)
n.2118C>T
n.2057C>T
n.2011C>T
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244226G>CCA346071793DNMT3Ac.99C>G
c.926C>G (n.926C>G)
c.1111C>G (p.Leu371Val)
c.1780C>G (p.Leu594Val)
c.1213C>G (p.Leu405Val)
n.99C>G
c.1336C>G (p.Leu446Val)
c.1633C>G (p.Leu545Val)
c.1615C>G (p.Leu539Val)
c.1324C>G (p.Leu442Val)
c.1252C>G (p.Leu418Val)
n.2118C>G
n.2057C>G
n.2011C>G
2g.25244226G=CA1239262828DNMT3Ac.99C=
c.926C= (n.926C=)
c.1111C= (p.Leu371=)
c.1780C= (p.Leu594=)
c.1213C= (p.Leu405=)
n.99C=
c.1336C= (p.Leu446=)
c.1633C= (p.Leu545=)
c.1615C= (p.Leu539=)
c.1324C= (p.Leu442=)
c.1252C= (p.Leu418=)
n.2118C=
n.2057C=
n.2011C=
2g.25244226G>TCA346071794DNMT3Ac.99C>A
c.926C>A (n.926C>A)
c.1111C>A (p.Leu371Met)
c.1780C>A (p.Leu594Met)
c.1213C>A (p.Leu405Met)
n.99C>A
c.1336C>A (p.Leu446Met)
c.1633C>A (p.Leu545Met)
c.1615C>A (p.Leu539Met)
c.1324C>A (p.Leu442Met)
c.1252C>A (p.Leu418Met)
n.2118C>A
n.2057C>A
n.2011C>A
2g.25244227_25244230dupCA2658168531DNMT3Ac.96_99dup
c.923_926dup (n.923_926dup)
c.1108_1111dup (p.Leu371ArgfsTer19)
c.1777_1780dup (p.Leu594ArgfsTer19)
c.1210_1213dup (p.Leu405ArgfsTer19)
n.96_99dup
c.1333_1336dup (p.Leu446ArgfsTer19)
c.1630_1633dup (p.Leu545ArgfsTer19)
c.1612_1615dup (p.Leu539ArgfsTer19)
c.1321_1324dup (p.Leu442ArgfsTer19)
c.1249_1252dup (p.Leu418ArgfsTer19)
n.2115_2118dup
n.2054_2057dup
n.2008_2011dup
 gnomAD v4
2g.25244227C>ACA425182285DNMT3Ac.98G>T
c.925G>T (n.925G>T)
c.1110G>T (p.Gly370=)
c.1779G>T (p.Gly593=)
c.1212G>T (p.Gly404=)
n.98G>T
c.1335G>T (p.Gly445=)
c.1632G>T (p.Gly544=)
c.1614G>T (p.Gly538=)
c.1323G>T (p.Gly441=)
c.1251G>T (p.Gly417=)
n.2117G>T
n.2056G>T
n.2010G>T
2g.25244227C>GCA425182286DNMT3Ac.98G>C
c.925G>C (n.925G>C)
c.1110G>C (p.Gly370=)
c.1779G>C (p.Gly593=)
c.1212G>C (p.Gly404=)
n.98G>C
c.1335G>C (p.Gly445=)
c.1632G>C (p.Gly544=)
c.1614G>C (p.Gly538=)
c.1323G>C (p.Gly441=)
c.1251G>C (p.Gly417=)
n.2117G>C
n.2056G>C
n.2010G>C
2g.25244227C>TCA425182288DNMT3Ac.98G>A
c.925G>A (n.925G>A)
c.1110G>A (p.Gly370=)
c.1779G>A (p.Gly593=)
c.1212G>A (p.Gly404=)
n.98G>A
c.1335G>A (p.Gly445=)
c.1632G>A (p.Gly544=)
c.1614G>A (p.Gly538=)
c.1323G>A (p.Gly441=)
c.1251G>A (p.Gly417=)
n.2117G>A
n.2056G>A
n.2010G>A
2g.25244229delCA425182289DNMT3Ac.98del
c.925del (n.925del)
c.1110del (p.Leu371CysfsTer?)
c.1779del (p.Leu594CysfsTer?)
c.1212del (p.Leu405CysfsTer?)
n.98del
c.1335del (p.Leu446CysfsTer?)
c.1632del (p.Leu545CysfsTer?)
c.1614del (p.Leu539CysfsTer?)
c.1323del (p.Leu442CysfsTer?)
c.1251del (p.Leu418CysfsTer?)
n.2117del
n.2056del
n.2010del
 gnomAD v4 COSMIC COSMIC
2g.25244228C>ACA346071795DNMT3Ac.97G>T
c.924G>T (n.924G>T)
c.1109G>T (p.Gly370Val)
c.1778G>T (p.Gly593Val)
c.1211G>T (p.Gly404Val)
n.97G>T
c.1334G>T (p.Gly445Val)
c.1631G>T (p.Gly544Val)
c.1613G>T (p.Gly538Val)
c.1322G>T (p.Gly441Val)
c.1250G>T (p.Gly417Val)
n.2116G>T
n.2055G>T
n.2009G>T
 dbSNP
2g.25244228C>GCA346071796DNMT3Ac.97G>C
c.924G>C (n.924G>C)
c.1109G>C (p.Gly370Ala)
c.1778G>C (p.Gly593Ala)
c.1211G>C (p.Gly404Ala)
n.97G>C
c.1334G>C (p.Gly445Ala)
c.1631G>C (p.Gly544Ala)
c.1613G>C (p.Gly538Ala)
c.1322G>C (p.Gly441Ala)
c.1250G>C (p.Gly417Ala)
n.2116G>C
n.2055G>C
n.2009G>C
2g.25244228C>TCA346071797DNMT3Ac.97G>A
c.924G>A (n.924G>A)
c.1109G>A (p.Gly370Glu)
c.1778G>A (p.Gly593Glu)
c.1211G>A (p.Gly404Glu)
n.97G>A
c.1334G>A (p.Gly445Glu)
c.1631G>A (p.Gly544Glu)
c.1613G>A (p.Gly538Glu)
c.1322G>A (p.Gly441Glu)
c.1250G>A (p.Gly417Glu)
n.2116G>A
n.2055G>A
n.2009G>A
 ClinVar
2g.25244229C>ACA346071798DNMT3Ac.96G>T
c.923G>T (n.923G>T)
c.1108G>T (p.Gly370Trp)
c.1777G>T (p.Gly593Trp)
c.1210G>T (p.Gly404Trp)
n.96G>T
c.1333G>T (p.Gly445Trp)
c.1630G>T (p.Gly544Trp)
c.1612G>T (p.Gly538Trp)
c.1321G>T (p.Gly441Trp)
c.1249G>T (p.Gly417Trp)
n.2115G>T
n.2054G>T
n.2008G>T
2g.25244229C=CA1239262832DNMT3Ac.96G=
c.923G= (n.923G=)
c.1108G= (p.Gly370=)
c.1777G= (p.Gly593=)
c.1210G= (p.Gly404=)
n.96G=
c.1333G= (p.Gly445=)
c.1630G= (p.Gly544=)
c.1612G= (p.Gly538=)
c.1321G= (p.Gly441=)
c.1249G= (p.Gly417=)
n.2115G=
n.2054G=
n.2008G=
2g.25244229C>GCA346071799DNMT3Ac.96G>C
c.923G>C (n.923G>C)
c.1108G>C (p.Gly370Arg)
c.1777G>C (p.Gly593Arg)
c.1210G>C (p.Gly404Arg)
n.96G>C
c.1333G>C (p.Gly445Arg)
c.1630G>C (p.Gly544Arg)
c.1612G>C (p.Gly538Arg)
c.1321G>C (p.Gly441Arg)
c.1249G>C (p.Gly417Arg)
n.2115G>C
n.2054G>C
n.2008G>C
2g.25244229C>TCA1555876DNMT3Ac.96G>A
c.923G>A (n.923G>A)
c.1108G>A (p.Gly370Arg)
c.1777G>A (p.Gly593Arg)
c.1210G>A (p.Gly404Arg)
n.96G>A
c.1333G>A (p.Gly445Arg)
c.1630G>A (p.Gly544Arg)
c.1612G>A (p.Gly538Arg)
c.1321G>A (p.Gly441Arg)
c.1249G>A (p.Gly417Arg)
n.2115G>A
n.2054G>A
n.2008G>A
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244229_25244230insTTCA2658168546DNMT3Ac.95_96insAA
c.922_923insAA (n.922_923insAA)
c.1107_1108insAA (p.Gly370LysfsTer?)
c.1776_1777insAA (p.Gly593LysfsTer?)
c.1209_1210insAA (p.Gly404LysfsTer?)
n.95_96insAA
c.1332_1333insAA (p.Gly445LysfsTer?)
c.1629_1630insAA (p.Gly544LysfsTer?)
c.1611_1612insAA (p.Gly538LysfsTer?)
c.1320_1321insAA (p.Gly441LysfsTer?)
c.1248_1249insAA (p.Gly417LysfsTer?)
n.2114_2115insAA
n.2053_2054insAA
n.2007_2008insAA
 gnomAD v4
2g.25244230G>ACA43703328DNMT3Ac.95C>T
c.922C>T (n.922C>T)
c.1107C>T (p.Tyr369=)
c.1776C>T (p.Tyr592=)
c.1209C>T (p.Tyr403=)
n.95C>T
c.1332C>T (p.Tyr444=)
c.1629C>T (p.Tyr543=)
c.1611C>T (p.Tyr537=)
c.1320C>T (p.Tyr440=)
c.1248C>T (p.Tyr416=)
n.2114C>T
n.2053C>T
n.2007C>T
 ClinVar dbSNP gnomAD v2 gnomAD v4 COSMIC COSMIC
2g.25244230G>CCA346071800DNMT3Ac.95C>G
c.922C>G (n.922C>G)
c.1107C>G (p.Tyr369Ter)
c.1776C>G (p.Tyr592Ter)
c.1209C>G (p.Tyr403Ter)
n.95C>G
c.1332C>G (p.Tyr444Ter)
c.1629C>G (p.Tyr543Ter)
c.1611C>G (p.Tyr537Ter)
c.1320C>G (p.Tyr440Ter)
c.1248C>G (p.Tyr416Ter)
n.2114C>G
n.2053C>G
n.2007C>G
 dbSNP gnomAD v2 gnomAD v4 COSMIC
2g.25244230G=CA1239262837DNMT3Ac.95C=
c.922C= (n.922C=)
c.1107C= (p.Tyr369=)
c.1776C= (p.Tyr592=)
c.1209C= (p.Tyr403=)
n.95C=
c.1332C= (p.Tyr444=)
c.1629C= (p.Tyr543=)
c.1611C= (p.Tyr537=)
c.1320C= (p.Tyr440=)
c.1248C= (p.Tyr416=)
n.2114C=
n.2053C=
n.2007C=
2g.25244230G>TCA1555877DNMT3Ac.95C>A
c.922C>A (n.922C>A)
c.1107C>A (p.Tyr369Ter)
c.1776C>A (p.Tyr592Ter)
c.1209C>A (p.Tyr403Ter)
n.95C>A
c.1332C>A (p.Tyr444Ter)
c.1629C>A (p.Tyr543Ter)
c.1611C>A (p.Tyr537Ter)
c.1320C>A (p.Tyr440Ter)
c.1248C>A (p.Tyr416Ter)
n.2114C>A
n.2053C>A
n.2007C>A
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25244231T>ACA346071803DNMT3Ac.94A>T
c.921A>T (n.921A>T)
c.1106A>T (p.Tyr369Phe)
c.1775A>T (p.Tyr592Phe)
c.1208A>T (p.Tyr403Phe)
n.94A>T
c.1331A>T (p.Tyr444Phe)
c.1628A>T (p.Tyr543Phe)
c.1610A>T (p.Tyr537Phe)
c.1319A>T (p.Tyr440Phe)
c.1247A>T (p.Tyr416Phe)
n.2113A>T
n.2052A>T
n.2006A>T
2g.25244231T>CCA346071802DNMT3Ac.94A>G
c.921A>G (n.921A>G)
c.1106A>G (p.Tyr369Cys)
c.1775A>G (p.Tyr592Cys)
c.1208A>G (p.Tyr403Cys)
n.94A>G
c.1331A>G (p.Tyr444Cys)
c.1628A>G (p.Tyr543Cys)
c.1610A>G (p.Tyr537Cys)
c.1319A>G (p.Tyr440Cys)
c.1247A>G (p.Tyr416Cys)
n.2113A>G
n.2052A>G
n.2006A>G
 dbSNP gnomAD v2 gnomAD v4
2g.25244231T>GCA346071801DNMT3Ac.94A>C
c.921A>C (n.921A>C)
c.1106A>C (p.Tyr369Ser)
c.1775A>C (p.Tyr592Ser)
c.1208A>C (p.Tyr403Ser)
n.94A>C
c.1331A>C (p.Tyr444Ser)
c.1628A>C (p.Tyr543Ser)
c.1610A>C (p.Tyr537Ser)
c.1319A>C (p.Tyr440Ser)
c.1247A>C (p.Tyr416Ser)
n.2113A>C
n.2052A>C
n.2006A>C
 dbSNP
2g.25244231T=CA1239262844DNMT3Ac.94A=
c.921A= (n.921A=)
c.1106A= (p.Tyr369=)
c.1775A= (p.Tyr592=)
c.1208A= (p.Tyr403=)
n.94A=
c.1331A= (p.Tyr444=)
c.1628A= (p.Tyr543=)
c.1610A= (p.Tyr537=)
c.1319A= (p.Tyr440=)
c.1247A= (p.Tyr416=)
n.2113A=
n.2052A=
n.2006A=
2g.25244231_25244232insCTCA2576694298DNMT3Ac.94_95insGA
c.921_922insGA (n.921_922insGA)
c.1106_1107insGA (p.Tyr369Ter)
c.1775_1776insGA (p.Tyr592Ter)
c.1208_1209insGA (p.Tyr403Ter)
n.94_95insGA
c.1331_1332insGA (p.Tyr444Ter)
c.1628_1629insGA (p.Tyr543Ter)
c.1610_1611insGA (p.Tyr537Ter)
c.1319_1320insGA (p.Tyr440Ter)
c.1247_1248insGA (p.Tyr416Ter)
n.2113_2114insGA
n.2052_2053insGA
n.2006_2007insGA
2g.25244231_25244232insGCCCGCACCA2658168552DNMT3Ac.93_94insGTGCGGGC
c.920_921insGTGCGGGC (n.920_921insGTGCGGGC)
c.1105_1106insGTGCGGGC (p.Tyr369CysfsTer?)
c.1774_1775insGTGCGGGC (p.Tyr592CysfsTer?)
c.1207_1208insGTGCGGGC (p.Tyr403CysfsTer?)
n.93_94insGTGCGGGC
c.1330_1331insGTGCGGGC (p.Tyr444CysfsTer?)
c.1627_1628insGTGCGGGC (p.Tyr543CysfsTer?)
c.1609_1610insGTGCGGGC (p.Tyr537CysfsTer?)
c.1318_1319insGTGCGGGC (p.Tyr440CysfsTer?)
c.1246_1247insGTGCGGGC (p.Tyr416CysfsTer?)
n.2112_2113insGTGCGGGC
n.2051_2052insGTGCGGGC
n.2005_2006insGTGCGGGC
 gnomAD v4
2g.25244232delCA2658168553DNMT3Ac.93del
c.920del (n.920del)
c.1105del (p.Tyr369ThrfsTer?)
c.1774del (p.Tyr592ThrfsTer?)
c.1207del (p.Tyr403ThrfsTer?)
n.93del
c.1330del (p.Tyr444ThrfsTer?)
c.1627del (p.Tyr543ThrfsTer?)
c.1609del (p.Tyr537ThrfsTer?)
c.1318del (p.Tyr440ThrfsTer?)
c.1246del (p.Tyr416ThrfsTer?)
n.2112del
n.2051del
n.2005del
 gnomAD v4
2g.25244232A>CCA346071804DNMT3Ac.93T>G
c.920T>G (n.920T>G)
c.1105T>G (p.Tyr369Asp)
c.1774T>G (p.Tyr592Asp)
c.1207T>G (p.Tyr403Asp)
n.93T>G
c.1330T>G (p.Tyr444Asp)
c.1627T>G (p.Tyr543Asp)
c.1609T>G (p.Tyr537Asp)
c.1318T>G (p.Tyr440Asp)
c.1246T>G (p.Tyr416Asp)
n.2112T>G
n.2051T>G
n.2005T>G
2g.25244232A>GCA346071805DNMT3Ac.93T>C
c.920T>C (n.920T>C)
c.1105T>C (p.Tyr369His)
c.1774T>C (p.Tyr592His)
c.1207T>C (p.Tyr403His)
n.93T>C
c.1330T>C (p.Tyr444His)
c.1627T>C (p.Tyr543His)
c.1609T>C (p.Tyr537His)
c.1318T>C (p.Tyr440His)
c.1246T>C (p.Tyr416His)
n.2112T>C
n.2051T>C
n.2005T>C
2g.25244232A>TCA346071806DNMT3Ac.93T>A
c.920T>A (n.920T>A)
c.1105T>A (p.Tyr369Asn)
c.1774T>A (p.Tyr592Asn)
c.1207T>A (p.Tyr403Asn)
n.93T>A
c.1330T>A (p.Tyr444Asn)
c.1627T>A (p.Tyr543Asn)
c.1609T>A (p.Tyr537Asn)
c.1318T>A (p.Tyr440Asn)
c.1246T>A (p.Tyr416Asn)
n.2112T>A
n.2051T>A
n.2005T>A
2g.25244232_25244233delinsAGCA1239262847DNMT3Ac.92_93delinsCT
c.919_920delinsCT (n.919_920delinsCT)
c.1104_1105delinsCT (p.Thr368=)
c.1773_1774delinsCT (p.Thr591=)
c.1206_1207delinsCT (p.Thr402=)
n.92_93delinsCT
c.1329_1330delinsCT (p.Thr443=)
c.1626_1627delinsCT (p.Thr542=)
c.1608_1609delinsCT (p.Thr536=)
c.1317_1318delinsCT (p.Thr439=)
c.1245_1246delinsCT (p.Thr415=)
n.2111_2112delinsCT
n.2050_2051delinsCT
n.2004_2005delinsCT
2g.25244233_25244252delCA2658168554DNMT3Ac.74_93del
c.901_920del (n.901_920del)
c.1086_1105del (p.Met362IlefsTer20)
c.1755_1774del (p.Met585IlefsTer20)
c.1188_1207del (p.Met396IlefsTer20)
n.74_93del
c.1311_1330del (p.Met437IlefsTer20)
c.1608_1627del (p.Met536IlefsTer20)
c.1590_1609del (p.Met530IlefsTer20)
c.1299_1318del (p.Met433IlefsTer20)
c.1227_1246del (p.Met409IlefsTer20)
n.2093_2112del
n.2032_2051del
n.1986_2005del
 gnomAD v4
2g.25244233G>ACA425182293DNMT3Ac.92C>T
c.919C>T (n.919C>T)
c.1104C>T (p.Thr368=)
c.1773C>T (p.Thr591=)
c.1206C>T (p.Thr402=)
n.92C>T
c.1329C>T (p.Thr443=)
c.1626C>T (p.Thr542=)
c.1608C>T (p.Thr536=)
c.1317C>T (p.Thr439=)
c.1245C>T (p.Thr415=)
n.2111C>T
n.2050C>T
n.2004C>T
 dbSNP gnomAD v2 gnomAD v4
2g.25244233G>CCA425182294DNMT3Ac.92C>G
c.919C>G (n.919C>G)
c.1104C>G (p.Thr368=)
c.1773C>G (p.Thr591=)
c.1206C>G (p.Thr402=)
n.92C>G
c.1329C>G (p.Thr443=)
c.1626C>G (p.Thr542=)
c.1608C>G (p.Thr536=)
c.1317C>G (p.Thr439=)
c.1245C>G (p.Thr415=)
n.2111C>G
n.2050C>G
n.2004C>G
2g.25244233G=CA1239262849DNMT3Ac.92C=
c.919C= (n.919C=)
c.1104C= (p.Thr368=)
c.1773C= (p.Thr591=)
c.1206C= (p.Thr402=)
n.92C=
c.1329C= (p.Thr443=)
c.1626C= (p.Thr542=)
c.1608C= (p.Thr536=)
c.1317C= (p.Thr439=)
c.1245C= (p.Thr415=)
n.2111C=
n.2050C=
n.2004C=
2g.25244233G>TCA425182298DNMT3Ac.92C>A
c.919C>A (n.919C>A)
c.1104C>A (p.Thr368=)
c.1773C>A (p.Thr591=)
c.1206C>A (p.Thr402=)
n.92C>A
c.1329C>A (p.Thr443=)
c.1626C>A (p.Thr542=)
c.1608C>A (p.Thr536=)
c.1317C>A (p.Thr439=)
c.1245C>A (p.Thr415=)
n.2111C>A
n.2050C>A
n.2004C>A
 gnomAD v4
2g.25244234dupCA2576694300DNMT3Ac.92dup
c.919dup (n.919dup)
c.1104dup (p.Tyr369LeufsTer20)
c.1773dup (p.Tyr592LeufsTer20)
c.1206dup (p.Tyr403LeufsTer20)
n.92dup
c.1329dup (p.Tyr444LeufsTer20)
c.1626dup (p.Tyr543LeufsTer20)
c.1608dup (p.Tyr537LeufsTer20)
c.1317dup (p.Tyr440LeufsTer20)
c.1245dup (p.Tyr416LeufsTer20)
n.2111dup
n.2050dup
n.2004dup
 gnomAD v4
2g.25244234delCA531760991DNMT3Ac.92del
c.919del (n.919del)
c.1104del (p.Tyr369ThrfsTer?)
c.1773del (p.Tyr592ThrfsTer?)
c.1206del (p.Tyr403ThrfsTer?)
n.92del
c.1329del (p.Tyr444ThrfsTer?)
c.1626del (p.Tyr543ThrfsTer?)
c.1608del (p.Tyr537ThrfsTer?)
c.1317del (p.Tyr440ThrfsTer?)
c.1245del (p.Tyr416ThrfsTer?)
n.2111del
n.2050del
n.2004del
 dbSNP gnomAD v2 gnomAD v4
2g.25244233_25244240delCA2573051230DNMT3Ac.85_92del
c.912_919del (n.912_919del)
c.1097_1104del (p.Lys366IlefsTer20)
c.1766_1773del (p.Lys589IlefsTer20)
c.1199_1206del (p.Lys400IlefsTer20)
n.85_92del
c.1322_1329del (p.Lys441IlefsTer20)
c.1619_1626del (p.Lys540IlefsTer20)
c.1601_1608del (p.Lys534IlefsTer20)
c.1310_1317del (p.Lys437IlefsTer20)
c.1238_1245del (p.Lys413IlefsTer20)
n.2104_2111del
n.2043_2050del
n.1997_2004del
2g.25244234_25244248delCA2576694301DNMT3Ac.78_92del
c.905_919del (n.905_919del)
c.1090_1104del (p.Gly364_Thr368del)
c.1759_1773del (p.Gly587_Thr591del)
c.1192_1206del (p.Gly398_Thr402del)
n.78_92del
c.1315_1329del (p.Gly439_Thr443del)
c.1612_1626del (p.Gly538_Thr542del)
c.1594_1608del (p.Gly532_Thr536del)
c.1303_1317del (p.Gly435_Thr439del)
c.1231_1245del (p.Gly411_Thr415del)
n.2097_2111del
n.2036_2050del
n.1990_2004del
2g.25244234G>ACA346071807DNMT3Ac.91C>T
c.918C>T (n.918C>T)
c.1103C>T (p.Thr368Ile)
c.1772C>T (p.Thr591Ile)
c.1205C>T (p.Thr402Ile)
n.91C>T
c.1328C>T (p.Thr443Ile)
c.1625C>T (p.Thr542Ile)
c.1607C>T (p.Thr536Ile)
c.1316C>T (p.Thr439Ile)
c.1244C>T (p.Thr415Ile)
n.2110C>T
n.2049C>T
n.2003C>T
 dbSNP
2g.25244234G>CCA346071808DNMT3Ac.91C>G
c.918C>G (n.918C>G)
c.1103C>G (p.Thr368Ser)
c.1772C>G (p.Thr591Ser)
c.1205C>G (p.Thr402Ser)
n.91C>G
c.1328C>G (p.Thr443Ser)
c.1625C>G (p.Thr542Ser)
c.1607C>G (p.Thr536Ser)
c.1316C>G (p.Thr439Ser)
c.1244C>G (p.Thr415Ser)
n.2110C>G
n.2049C>G
n.2003C>G
 dbSNP
2g.25244234G>TCA346071809DNMT3Ac.91C>A
c.918C>A (n.918C>A)
c.1103C>A (p.Thr368Asn)
c.1772C>A (p.Thr591Asn)
c.1205C>A (p.Thr402Asn)
n.91C>A
c.1328C>A (p.Thr443Asn)
c.1625C>A (p.Thr542Asn)
c.1607C>A (p.Thr536Asn)
c.1316C>A (p.Thr439Asn)
c.1244C>A (p.Thr415Asn)
n.2110C>A
n.2049C>A
n.2003C>A
2g.25244234_25244240delCA2658168561DNMT3Ac.85_91del
c.912_918del (n.912_918del)
c.1097_1103del (p.Lys366ThrfsTer?)
c.1766_1772del (p.Lys589ThrfsTer?)
c.1199_1205del (p.Lys400ThrfsTer?)
n.85_91del
c.1322_1328del (p.Lys441ThrfsTer?)
c.1619_1625del (p.Lys540ThrfsTer?)
c.1601_1607del (p.Lys534ThrfsTer?)
c.1310_1316del (p.Lys437ThrfsTer?)
c.1238_1244del (p.Lys413ThrfsTer?)
n.2104_2110del
n.2043_2049del
n.1997_2003del
 gnomAD v4
2g.25244235delCA2658168563DNMT3Ac.90del
c.917del (n.917del)
c.1102del (p.Thr368ProfsTer?)
c.1771del (p.Thr591ProfsTer?)
c.1204del (p.Thr402ProfsTer?)
n.90del
c.1327del (p.Thr443ProfsTer?)
c.1624del (p.Thr542ProfsTer?)
c.1606del (p.Thr536ProfsTer?)
c.1315del (p.Thr439ProfsTer?)
c.1243del (p.Thr415ProfsTer?)
n.2109del
n.2048del
n.2002del
 gnomAD v4
2g.25244235T>ACA1555878DNMT3Ac.90A>T
c.917A>T (n.917A>T)
c.1102A>T (p.Thr368Ser)
c.1771A>T (p.Thr591Ser)
c.1204A>T (p.Thr402Ser)
n.90A>T
c.1327A>T (p.Thr443Ser)
c.1624A>T (p.Thr542Ser)
c.1606A>T (p.Thr536Ser)
c.1315A>T (p.Thr439Ser)
c.1243A>T (p.Thr415Ser)
n.2109A>T
n.2048A>T
n.2002A>T
 dbSNP ExAC gnomAD v2
2g.25244235T>CCA346071810DNMT3Ac.90A>G
c.917A>G (n.917A>G)
c.1102A>G (p.Thr368Ala)
c.1771A>G (p.Thr591Ala)
c.1204A>G (p.Thr402Ala)
n.90A>G
c.1327A>G (p.Thr443Ala)
c.1624A>G (p.Thr542Ala)
c.1606A>G (p.Thr536Ala)
c.1315A>G (p.Thr439Ala)
c.1243A>G (p.Thr415Ala)
n.2109A>G
n.2048A>G
n.2002A>G
 dbSNP gnomAD v2 gnomAD v4
2g.25244235T>GCA346071811DNMT3Ac.90A>C
c.917A>C (n.917A>C)
c.1102A>C (p.Thr368Pro)
c.1771A>C (p.Thr591Pro)
c.1204A>C (p.Thr402Pro)
n.90A>C
c.1327A>C (p.Thr443Pro)
c.1624A>C (p.Thr542Pro)
c.1606A>C (p.Thr536Pro)
c.1315A>C (p.Thr439Pro)
c.1243A>C (p.Thr415Pro)
n.2109A>C
n.2048A>C
n.2002A>C
2g.25244235T=CA1239262855DNMT3Ac.90A=
c.917A= (n.917A=)
c.1102A= (p.Thr368=)
c.1771A= (p.Thr591=)
c.1204A= (p.Thr402=)
n.90A=
c.1327A= (p.Thr443=)
c.1624A= (p.Thr542=)
c.1606A= (p.Thr536=)
c.1315A= (p.Thr439=)
c.1243A= (p.Thr415=)
n.2109A=
n.2048A=
n.2002A=
2g.25244236A>CCA425182301DNMT3Ac.89T>G
c.916T>G (n.916T>G)
c.1101T>G (p.Gly367=)
c.1770T>G (p.Gly590=)
c.1203T>G (p.Gly401=)
n.89T>G
c.1326T>G (p.Gly442=)
c.1623T>G (p.Gly541=)
c.1605T>G (p.Gly535=)
c.1314T>G (p.Gly438=)
c.1242T>G (p.Gly414=)
n.2108T>G
n.2047T>G
n.2001T>G
2g.25244236A>GCA425182303DNMT3Ac.89T>C
c.916T>C (n.916T>C)
c.1101T>C (p.Gly367=)
c.1770T>C (p.Gly590=)
c.1203T>C (p.Gly401=)
n.89T>C
c.1326T>C (p.Gly442=)
c.1623T>C (p.Gly541=)
c.1605T>C (p.Gly535=)
c.1314T>C (p.Gly438=)
c.1242T>C (p.Gly414=)
n.2108T>C
n.2047T>C
n.2001T>C
2g.25244236A>TCA425182304DNMT3Ac.89T>A
c.916T>A (n.916T>A)
c.1101T>A (p.Gly367=)
c.1770T>A (p.Gly590=)
c.1203T>A (p.Gly401=)
n.89T>A
c.1326T>A (p.Gly442=)
c.1623T>A (p.Gly541=)
c.1605T>A (p.Gly535=)
c.1314T>A (p.Gly438=)
c.1242T>A (p.Gly414=)
n.2108T>A
n.2047T>A
n.2001T>A
 dbSNP
2g.25244236_25244242delCA2576694302DNMT3Ac.83_89del
c.910_916del (n.910_916del)
c.1095_1101del (p.His365GlnfsTer?)
c.1764_1770del (p.His588GlnfsTer?)
c.1197_1203del (p.His399GlnfsTer?)
n.83_89del
c.1320_1326del (p.His440GlnfsTer?)
c.1617_1623del (p.His539GlnfsTer?)
c.1599_1605del (p.His533GlnfsTer?)
c.1308_1314del (p.His436GlnfsTer?)
c.1236_1242del (p.His412GlnfsTer?)
n.2102_2108del
n.2041_2047del
n.1995_2001del
2g.25244237C>ACA346071812DNMT3Ac.88G>T
c.915G>T (n.915G>T)
c.1100G>T (p.Gly367Val)
c.1769G>T (p.Gly590Val)
c.1202G>T (p.Gly401Val)
n.88G>T
c.1325G>T (p.Gly442Val)
c.1622G>T (p.Gly541Val)
c.1604G>T (p.Gly535Val)
c.1313G>T (p.Gly438Val)
c.1241G>T (p.Gly414Val)
n.2107G>T
n.2046G>T
n.2000G>T
2g.25244237C>GCA346071813DNMT3Ac.88G>C
c.915G>C (n.915G>C)
c.1100G>C (p.Gly367Ala)
c.1769G>C (p.Gly590Ala)
c.1202G>C (p.Gly401Ala)
n.88G>C
c.1325G>C (p.Gly442Ala)
c.1622G>C (p.Gly541Ala)
c.1604G>C (p.Gly535Ala)
c.1313G>C (p.Gly438Ala)
c.1241G>C (p.Gly414Ala)
n.2107G>C
n.2046G>C
n.2000G>C
2g.25244237C>TCA346071814DNMT3Ac.88G>A
c.915G>A (n.915G>A)
c.1100G>A (p.Gly367Asp)
c.1769G>A (p.Gly590Asp)
c.1202G>A (p.Gly401Asp)
n.88G>A
c.1325G>A (p.Gly442Asp)
c.1622G>A (p.Gly541Asp)
c.1604G>A (p.Gly535Asp)
c.1313G>A (p.Gly438Asp)
c.1241G>A (p.Gly414Asp)
n.2107G>A
n.2046G>A
n.2000G>A
 dbSNP
2g.25244239dupCA2658168568DNMT3Ac.88dup
c.915dup (n.915dup)
c.1100dup (p.Thr368TyrfsTer21)
c.1769dup (p.Thr591TyrfsTer21)
c.1202dup (p.Thr402TyrfsTer21)
n.88dup
c.1325dup (p.Thr443TyrfsTer21)
c.1622dup (p.Thr542TyrfsTer21)
c.1604dup (p.Thr536TyrfsTer21)
c.1313dup (p.Thr439TyrfsTer21)
c.1241dup (p.Thr415TyrfsTer21)
n.2107dup
n.2046dup
n.2000dup
 gnomAD v4
2g.25244239delCA425182311DNMT3Ac.88del
c.915del (n.915del)
c.1100del (p.Gly367ValfsTer?)
c.1769del (p.Gly590ValfsTer?)
c.1202del (p.Gly401ValfsTer?)
n.88del
c.1325del (p.Gly442ValfsTer?)
c.1622del (p.Gly541ValfsTer?)
c.1604del (p.Gly535ValfsTer?)
c.1313del (p.Gly438ValfsTer?)
c.1241del (p.Gly414ValfsTer?)
n.2107del
n.2046del
n.2000del
 gnomAD v3 gnomAD v4 COSMIC COSMIC COSMIC
2g.25244238C>ACA346071817DNMT3Ac.87G>T
c.914G>T (n.914G>T)
c.1099G>T (p.Gly367Cys)
c.1768G>T (p.Gly590Cys)
c.1201G>T (p.Gly401Cys)
n.87G>T
c.1324G>T (p.Gly442Cys)
c.1621G>T (p.Gly541Cys)
c.1603G>T (p.Gly535Cys)
c.1312G>T (p.Gly438Cys)
c.1240G>T (p.Gly414Cys)
n.2106G>T
n.2045G>T
n.1999G>T
2g.25244238C>GCA346071815DNMT3Ac.87G>C
c.914G>C (n.914G>C)
c.1099G>C (p.Gly367Arg)
c.1768G>C (p.Gly590Arg)
c.1201G>C (p.Gly401Arg)
n.87G>C
c.1324G>C (p.Gly442Arg)
c.1621G>C (p.Gly541Arg)
c.1603G>C (p.Gly535Arg)
c.1312G>C (p.Gly438Arg)
c.1240G>C (p.Gly414Arg)
n.2106G>C
n.2045G>C
n.1999G>C
2g.25244238C>TCA346071816DNMT3Ac.87G>A
c.914G>A (n.914G>A)
c.1099G>A (p.Gly367Ser)
c.1768G>A (p.Gly590Ser)
c.1201G>A (p.Gly401Ser)
n.87G>A
c.1324G>A (p.Gly442Ser)
c.1621G>A (p.Gly541Ser)
c.1603G>A (p.Gly535Ser)
c.1312G>A (p.Gly438Ser)
c.1240G>A (p.Gly414Ser)
n.2106G>A
n.2045G>A
n.1999G>A
 gnomAD v4
2g.25244239C>ACA346071818DNMT3Ac.86G>T
c.913G>T (n.913G>T)
c.1098G>T (p.Lys366Asn)
c.1767G>T (p.Lys589Asn)
c.1200G>T (p.Lys400Asn)
n.86G>T
c.1323G>T (p.Lys441Asn)
c.1620G>T (p.Lys540Asn)
c.1602G>T (p.Lys534Asn)
c.1311G>T (p.Lys437Asn)
c.1239G>T (p.Lys413Asn)
n.2105G>T
n.2044G>T
n.1998G>T
 dbSNP
2g.25244239C>GCA346071819DNMT3Ac.86G>C
c.913G>C (n.913G>C)
c.1098G>C (p.Lys366Asn)
c.1767G>C (p.Lys589Asn)
c.1200G>C (p.Lys400Asn)
n.86G>C
c.1323G>C (p.Lys441Asn)
c.1620G>C (p.Lys540Asn)
c.1602G>C (p.Lys534Asn)
c.1311G>C (p.Lys437Asn)
c.1239G>C (p.Lys413Asn)
n.2105G>C
n.2044G>C
n.1998G>C
2g.25244239C>TCA425182320DNMT3Ac.86G>A
c.913G>A (n.913G>A)
c.1098G>A (p.Lys366=)
c.1767G>A (p.Lys589=)
c.1200G>A (p.Lys400=)
n.86G>A
c.1323G>A (p.Lys441=)
c.1620G>A (p.Lys540=)
c.1602G>A (p.Lys534=)
c.1311G>A (p.Lys437=)
c.1239G>A (p.Lys413=)
n.2105G>A
n.2044G>A
n.1998G>A
2g.25244240T>ACA346071820DNMT3Ac.85A>T
c.912A>T (n.912A>T)
c.1097A>T (p.Lys366Met)
c.1766A>T (p.Lys589Met)
c.1199A>T (p.Lys400Met)
n.85A>T
c.1322A>T (p.Lys441Met)
c.1619A>T (p.Lys540Met)
c.1601A>T (p.Lys534Met)
c.1310A>T (p.Lys437Met)
c.1238A>T (p.Lys413Met)
n.2104A>T
n.2043A>T
n.1997A>T
 gnomAD v4
2g.25244240T>CCA346071821DNMT3Ac.85A>G
c.912A>G (n.912A>G)
c.1097A>G (p.Lys366Arg)
c.1766A>G (p.Lys589Arg)
c.1199A>G (p.Lys400Arg)
n.85A>G
c.1322A>G (p.Lys441Arg)
c.1619A>G (p.Lys540Arg)
c.1601A>G (p.Lys534Arg)
c.1310A>G (p.Lys437Arg)
c.1238A>G (p.Lys413Arg)
n.2104A>G
n.2043A>G
n.1997A>G
 ClinVar dbSNP gnomAD v4
2g.25244240T>GCA346071822DNMT3Ac.85A>C
c.912A>C (n.912A>C)
c.1097A>C (p.Lys366Thr)
c.1766A>C (p.Lys589Thr)
c.1199A>C (p.Lys400Thr)
n.85A>C
c.1322A>C (p.Lys441Thr)
c.1619A>C (p.Lys540Thr)
c.1601A>C (p.Lys534Thr)
c.1310A>C (p.Lys437Thr)
c.1238A>C (p.Lys413Thr)
n.2104A>C
n.2043A>C
n.1997A>C
2g.25244240T=CA1239262860DNMT3Ac.85A=
c.912A= (n.912A=)
c.1097A= (p.Lys366=)
c.1766A= (p.Lys589=)
c.1199A= (p.Lys400=)
n.85A=
c.1322A= (p.Lys441=)
c.1619A= (p.Lys540=)
c.1601A= (p.Lys534=)
c.1310A= (p.Lys437=)
c.1238A= (p.Lys413=)
n.2104A=
n.2043A=
n.1997A=
2g.25244241delCA2576694303DNMT3Ac.85del
c.912del (n.912del)
c.1097del (p.Lys366ArgfsTer?)
c.1766del (p.Lys589ArgfsTer?)
c.1199del (p.Lys400ArgfsTer?)
n.85del
c.1322del (p.Lys441ArgfsTer?)
c.1619del (p.Lys540ArgfsTer?)
c.1601del (p.Lys534ArgfsTer?)
c.1310del (p.Lys437ArgfsTer?)
c.1238del (p.Lys413ArgfsTer?)
n.2104del
n.2043del
n.1997del
 gnomAD v4
2g.25244240_25244241insGCA2658168575DNMT3Ac.84_85insC
c.911_912insC (n.911_912insC)
c.1096_1097insC (p.Lys366ThrfsTer23)
c.1765_1766insC (p.Lys589ThrfsTer23)
c.1198_1199insC (p.Lys400ThrfsTer23)
n.84_85insC
c.1321_1322insC (p.Lys441ThrfsTer23)
c.1618_1619insC (p.Lys540ThrfsTer23)
c.1600_1601insC (p.Lys534ThrfsTer23)
c.1309_1310insC (p.Lys437ThrfsTer23)
c.1237_1238insC (p.Lys413ThrfsTer23)
n.2103_2104insC
n.2042_2043insC
n.1996_1997insC
 gnomAD v4
2g.25244241T>ACA346071823DNMT3Ac.84A>T
c.911A>T (n.911A>T)
c.1096A>T (p.Lys366Ter)
c.1765A>T (p.Lys589Ter)
c.1198A>T (p.Lys400Ter)
n.84A>T
c.1321A>T (p.Lys441Ter)
c.1618A>T (p.Lys540Ter)
c.1600A>T (p.Lys534Ter)
c.1309A>T (p.Lys437Ter)
c.1237A>T (p.Lys413Ter)
n.2103A>T
n.2042A>T
n.1996A>T
 gnomAD v4
2g.25244241T>CCA346071824DNMT3Ac.84A>G
c.911A>G (n.911A>G)
c.1096A>G (p.Lys366Glu)
c.1765A>G (p.Lys589Glu)
c.1198A>G (p.Lys400Glu)
n.84A>G
c.1321A>G (p.Lys441Glu)
c.1618A>G (p.Lys540Glu)
c.1600A>G (p.Lys534Glu)
c.1309A>G (p.Lys437Glu)
c.1237A>G (p.Lys413Glu)
n.2103A>G
n.2042A>G
n.1996A>G
 gnomAD v4
2g.25244241T>GCA346071825DNMT3Ac.84A>C
c.911A>C (n.911A>C)
c.1096A>C (p.Lys366Gln)
c.1765A>C (p.Lys589Gln)
c.1198A>C (p.Lys400Gln)
n.84A>C
c.1321A>C (p.Lys441Gln)
c.1618A>C (p.Lys540Gln)
c.1600A>C (p.Lys534Gln)
c.1309A>C (p.Lys437Gln)
c.1237A>C (p.Lys413Gln)
n.2103A>C
n.2042A>C
n.1996A>C
2g.25244241_25244242delinsTGCA1239262862DNMT3Ac.83_84delinsCA
c.910_911delinsCA (n.910_911delinsCA)
c.1095_1096delinsCA (p.His365=)
c.1764_1765delinsCA (p.His588=)
c.1197_1198delinsCA (p.His399=)
n.83_84delinsCA
c.1320_1321delinsCA (p.His440=)
c.1617_1618delinsCA (p.His539=)
c.1599_1600delinsCA (p.His533=)
c.1308_1309delinsCA (p.His436=)
c.1236_1237delinsCA (p.His412=)
n.2102_2103delinsCA
n.2041_2042delinsCA
n.1995_1996delinsCA
2g.25244242delCA1555879DNMT3Ac.83del
c.910del (n.910del)
c.1095del (p.His365GlnfsTer?)
c.1764del (p.His588GlnfsTer?)
c.1197del (p.His399GlnfsTer?)
n.83del
c.1320del (p.His440GlnfsTer?)
c.1617del (p.His539GlnfsTer?)
c.1599del (p.His533GlnfsTer?)
c.1308del (p.His436GlnfsTer?)
c.1236del (p.His412GlnfsTer?)
n.2102del
n.2041del
n.1995del
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244242G>ACA425182329DNMT3Ac.83C>T
c.910C>T (n.910C>T)
c.1095C>T (p.His365=)
c.1764C>T (p.His588=)
c.1197C>T (p.His399=)
n.83C>T
c.1320C>T (p.His440=)
c.1617C>T (p.His539=)
c.1599C>T (p.His533=)
c.1308C>T (p.His436=)
c.1236C>T (p.His412=)
n.2102C>T
n.2041C>T
n.1995C>T
 dbSNP gnomAD v4
2g.25244242G>CCA346071826DNMT3Ac.83C>G
c.910C>G (n.910C>G)
c.1095C>G (p.His365Gln)
c.1764C>G (p.His588Gln)
c.1197C>G (p.His399Gln)
n.83C>G
c.1320C>G (p.His440Gln)
c.1617C>G (p.His539Gln)
c.1599C>G (p.His533Gln)
c.1308C>G (p.His436Gln)
c.1236C>G (p.His412Gln)
n.2102C>G
n.2041C>G
n.1995C>G
 gnomAD v4
2g.25244242G>TCA346071827DNMT3Ac.83C>A
c.910C>A (n.910C>A)
c.1095C>A (p.His365Gln)
c.1764C>A (p.His588Gln)
c.1197C>A (p.His399Gln)
n.83C>A
c.1320C>A (p.His440Gln)
c.1617C>A (p.His539Gln)
c.1599C>A (p.His533Gln)
c.1308C>A (p.His436Gln)
c.1236C>A (p.His412Gln)
n.2102C>A
n.2041C>A
n.1995C>A
2g.25244243T>ACA346071828DNMT3Ac.82A>T
c.909A>T (n.909A>T)
c.1094A>T (p.His365Leu)
c.1763A>T (p.His588Leu)
c.1196A>T (p.His399Leu)
n.82A>T
c.1319A>T (p.His440Leu)
c.1616A>T (p.His539Leu)
c.1598A>T (p.His533Leu)
c.1307A>T (p.His436Leu)
c.1235A>T (p.His412Leu)
n.2101A>T
n.2040A>T
n.1994A>T
2g.25244243T>CCA346071829DNMT3Ac.82A>G
c.909A>G (n.909A>G)
c.1094A>G (p.His365Arg)
c.1763A>G (p.His588Arg)
c.1196A>G (p.His399Arg)
n.82A>G
c.1319A>G (p.His440Arg)
c.1616A>G (p.His539Arg)
c.1598A>G (p.His533Arg)
c.1307A>G (p.His436Arg)
c.1235A>G (p.His412Arg)
n.2101A>G
n.2040A>G
n.1994A>G
2g.25244243T>GCA346071830DNMT3Ac.82A>C
c.909A>C (n.909A>C)
c.1094A>C (p.His365Pro)
c.1763A>C (p.His588Pro)
c.1196A>C (p.His399Pro)
n.82A>C
c.1319A>C (p.His440Pro)
c.1616A>C (p.His539Pro)
c.1598A>C (p.His533Pro)
c.1307A>C (p.His436Pro)
c.1235A>C (p.His412Pro)
n.2101A>C
n.2040A>C
n.1994A>C
2g.25244243_25244253delCA2576694304DNMT3Ac.72_82del
c.899_909del (n.899_909del)
c.1084_1094del (p.Met362GlnfsTer23)
c.1753_1763del (p.Met585GlnfsTer23)
c.1186_1196del (p.Met396GlnfsTer23)
n.72_82del
c.1309_1319del (p.Met437GlnfsTer23)
c.1606_1616del (p.Met536GlnfsTer23)
c.1588_1598del (p.Met530GlnfsTer23)
c.1297_1307del (p.Met433GlnfsTer23)
c.1225_1235del (p.Met409GlnfsTer23)
n.2091_2101del
n.2030_2040del
n.1984_1994del
2g.25244244G>ACA346071833DNMT3Ac.81C>T
c.908C>T (n.908C>T)
c.1093C>T (p.His365Tyr)
c.1762C>T (p.His588Tyr)
c.1195C>T (p.His399Tyr)
n.81C>T
c.1318C>T (p.His440Tyr)
c.1615C>T (p.His539Tyr)
c.1597C>T (p.His533Tyr)
c.1306C>T (p.His436Tyr)
c.1234C>T (p.His412Tyr)
n.2100C>T
n.2039C>T
n.1993C>T
2g.25244244G>CCA346071832DNMT3Ac.81C>G
c.908C>G (n.908C>G)
c.1093C>G (p.His365Asp)
c.1762C>G (p.His588Asp)
c.1195C>G (p.His399Asp)
n.81C>G
c.1318C>G (p.His440Asp)
c.1615C>G (p.His539Asp)
c.1597C>G (p.His533Asp)
c.1306C>G (p.His436Asp)
c.1234C>G (p.His412Asp)
n.2100C>G
n.2039C>G
n.1993C>G
2g.25244244G>TCA346071831DNMT3Ac.81C>A
c.908C>A (n.908C>A)
c.1093C>A (p.His365Asn)
c.1762C>A (p.His588Asn)
c.1195C>A (p.His399Asn)
n.81C>A
c.1318C>A (p.His440Asn)
c.1615C>A (p.His539Asn)
c.1597C>A (p.His533Asn)
c.1306C>A (p.His436Asn)
c.1234C>A (p.His412Asn)
n.2100C>A
n.2039C>A
n.1993C>A
 gnomAD v4
2g.25244244_25244245delCA2658168591DNMT3Ac.80_81del
c.907_908del (n.907_908del)
c.1092_1093del (p.His365GlnfsTer23)
c.1761_1762del (p.His588GlnfsTer23)
c.1194_1195del (p.His399GlnfsTer23)
n.80_81del
c.1317_1318del (p.His440GlnfsTer23)
c.1614_1615del (p.His539GlnfsTer23)
c.1596_1597del (p.His533GlnfsTer23)
c.1305_1306del (p.His436GlnfsTer23)
c.1233_1234del (p.His412GlnfsTer23)
n.2099_2100del
n.2038_2039del
n.1992_1993del
 gnomAD v4
2g.25244244_25244245delinsGCCA1239262866DNMT3Ac.80_81delinsGC
c.907_908delinsGC (n.907_908delinsGC)
c.1092_1093delinsGC (p.Gly364=)
c.1761_1762delinsGC (p.Gly587=)
c.1194_1195delinsGC (p.Gly398=)
n.80_81delinsGC
c.1317_1318delinsGC (p.Gly439=)
c.1614_1615delinsGC (p.Gly538=)
c.1596_1597delinsGC (p.Gly532=)
c.1305_1306delinsGC (p.Gly435=)
c.1233_1234delinsGC (p.Gly411=)
n.2099_2100delinsGC
n.2038_2039delinsGC
n.1992_1993delinsGC
2g.25244246_25244249dupCA2658168586DNMT3Ac.78_81dup
c.905_908dup (n.905_908dup)
c.1090_1093dup (p.His365ArgfsTer25)
c.1759_1762dup (p.His588ArgfsTer25)
c.1192_1195dup (p.His399ArgfsTer25)
n.78_81dup
c.1315_1318dup (p.His440ArgfsTer25)
c.1612_1615dup (p.His539ArgfsTer25)
c.1594_1597dup (p.His533ArgfsTer25)
c.1303_1306dup (p.His436ArgfsTer25)
c.1231_1234dup (p.His412ArgfsTer25)
n.2097_2100dup
n.2036_2039dup
n.1990_1993dup
 gnomAD v4
2g.25244245C>ACA425182342DNMT3Ac.80G>T
c.907G>T (n.907G>T)
c.1092G>T (p.Gly364=)
c.1761G>T (p.Gly587=)
c.1194G>T (p.Gly398=)
n.80G>T
c.1317G>T (p.Gly439=)
c.1614G>T (p.Gly538=)
c.1596G>T (p.Gly532=)
c.1305G>T (p.Gly435=)
c.1233G>T (p.Gly411=)
n.2099G>T
n.2038G>T
n.1992G>T
 gnomAD v4
2g.25244245C>GCA425182343DNMT3Ac.80G>C
c.907G>C (n.907G>C)
c.1092G>C (p.Gly364=)
c.1761G>C (p.Gly587=)
c.1194G>C (p.Gly398=)
n.80G>C
c.1317G>C (p.Gly439=)
c.1614G>C (p.Gly538=)
c.1596G>C (p.Gly532=)
c.1305G>C (p.Gly435=)
c.1233G>C (p.Gly411=)
n.2099G>C
n.2038G>C
n.1992G>C
2g.25244245C>TCA425182345DNMT3Ac.80G>A
c.907G>A (n.907G>A)
c.1092G>A (p.Gly364=)
c.1761G>A (p.Gly587=)
c.1194G>A (p.Gly398=)
n.80G>A
c.1317G>A (p.Gly439=)
c.1614G>A (p.Gly538=)
c.1596G>A (p.Gly532=)
c.1305G>A (p.Gly435=)
c.1233G>A (p.Gly411=)
n.2099G>A
n.2038G>A
n.1992G>A
 dbSNP
2g.25244247delCA767176377DNMT3Ac.80del
c.907del (n.907del)
c.1092del (p.His365ThrfsTer?)
c.1761del (p.His588ThrfsTer?)
c.1194del (p.His399ThrfsTer?)
n.80del
c.1317del (p.His440ThrfsTer?)
c.1614del (p.His539ThrfsTer?)
c.1596del (p.His533ThrfsTer?)
c.1305del (p.His436ThrfsTer?)
c.1233del (p.His412ThrfsTer?)
n.2099del
n.2038del
n.1992del
 dbSNP gnomAD v3 gnomAD v4
2g.25244246C>ACA346071834DNMT3Ac.79G>T
c.906G>T (n.906G>T)
c.1091G>T (p.Gly364Val)
c.1760G>T (p.Gly587Val)
c.1193G>T (p.Gly398Val)
n.79G>T
c.1316G>T (p.Gly439Val)
c.1613G>T (p.Gly538Val)
c.1595G>T (p.Gly532Val)
c.1304G>T (p.Gly435Val)
c.1232G>T (p.Gly411Val)
n.2098G>T
n.2037G>T
n.1991G>T
 gnomAD v4
2g.25244246C>GCA346071835DNMT3Ac.79G>C
c.906G>C (n.906G>C)
c.1091G>C (p.Gly364Ala)
c.1760G>C (p.Gly587Ala)
c.1193G>C (p.Gly398Ala)
n.79G>C
c.1316G>C (p.Gly439Ala)
c.1613G>C (p.Gly538Ala)
c.1595G>C (p.Gly532Ala)
c.1304G>C (p.Gly435Ala)
c.1232G>C (p.Gly411Ala)
n.2098G>C
n.2037G>C
n.1991G>C
2g.25244246C>TCA346071836DNMT3Ac.79G>A
c.906G>A (n.906G>A)
c.1091G>A (p.Gly364Glu)
c.1760G>A (p.Gly587Glu)
c.1193G>A (p.Gly398Glu)
n.79G>A
c.1316G>A (p.Gly439Glu)
c.1613G>A (p.Gly538Glu)
c.1595G>A (p.Gly532Glu)
c.1304G>A (p.Gly435Glu)
c.1232G>A (p.Gly411Glu)
n.2098G>A
n.2037G>A
n.1991G>A
 gnomAD v4
2g.25244247C>ACA346071837DNMT3Ac.78G>T
c.905G>T (n.905G>T)
c.1090G>T (p.Gly364Trp)
c.1759G>T (p.Gly587Trp)
c.1192G>T (p.Gly398Trp)
n.78G>T
c.1315G>T (p.Gly439Trp)
c.1612G>T (p.Gly538Trp)
c.1594G>T (p.Gly532Trp)
c.1303G>T (p.Gly435Trp)
c.1231G>T (p.Gly411Trp)
n.2097G>T
n.2036G>T
n.1990G>T
 ClinVar dbSNP
2g.25244247C=CA1239262869DNMT3Ac.78G=
c.905G= (n.905G=)
c.1090G= (p.Gly364=)
c.1759G= (p.Gly587=)
c.1192G= (p.Gly398=)
n.78G=
c.1315G= (p.Gly439=)
c.1612G= (p.Gly538=)
c.1594G= (p.Gly532=)
c.1303G= (p.Gly435=)
c.1231G= (p.Gly411=)
n.2097G=
n.2036G=
n.1990G=
2g.25244247C>GCA346071838DNMT3Ac.78G>C
c.905G>C (n.905G>C)
c.1090G>C (p.Gly364Arg)
c.1759G>C (p.Gly587Arg)
c.1192G>C (p.Gly398Arg)
n.78G>C
c.1315G>C (p.Gly439Arg)
c.1612G>C (p.Gly538Arg)
c.1594G>C (p.Gly532Arg)
c.1303G>C (p.Gly435Arg)
c.1231G>C (p.Gly411Arg)
n.2097G>C
n.2036G>C
n.1990G>C
2g.25244247C>TCA346071839DNMT3Ac.78G>A
c.905G>A (n.905G>A)
c.1090G>A (p.Gly364Arg)
c.1759G>A (p.Gly587Arg)
c.1192G>A (p.Gly398Arg)
n.78G>A
c.1315G>A (p.Gly439Arg)
c.1612G>A (p.Gly538Arg)
c.1594G>A (p.Gly532Arg)
c.1303G>A (p.Gly435Arg)
c.1231G>A (p.Gly411Arg)
n.2097G>A
n.2036G>A
n.1990G>A
 dbSNP gnomAD v4
2g.25244248delCA2658168606DNMT3Ac.77del
c.904del (n.904del)
c.1089del (p.Cys363TrpfsTer?)
c.1758del (p.Cys586TrpfsTer?)
c.1191del (p.Cys397TrpfsTer?)
n.77del
c.1314del (p.Cys438TrpfsTer?)
c.1611del (p.Cys537TrpfsTer?)
c.1593del (p.Cys531TrpfsTer?)
c.1302del (p.Cys434TrpfsTer?)
c.1230del (p.Cys410TrpfsTer?)
n.2096del
n.2035del
n.1989del
 gnomAD v4
2g.25244248G>ACA1555880DNMT3Ac.77C>T
c.904C>T (n.904C>T)
c.1089C>T (p.Cys363=)
c.1758C>T (p.Cys586=)
c.1191C>T (p.Cys397=)
n.77C>T
c.1314C>T (p.Cys438=)
c.1611C>T (p.Cys537=)
c.1593C>T (p.Cys531=)
c.1302C>T (p.Cys434=)
c.1230C>T (p.Cys410=)
n.2096C>T
n.2035C>T
n.1989C>T
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC COSMIC
2g.25244248G>CCA346071840DNMT3Ac.77C>G
c.904C>G (n.904C>G)
c.1089C>G (p.Cys363Trp)
c.1758C>G (p.Cys586Trp)
c.1191C>G (p.Cys397Trp)
n.77C>G
c.1314C>G (p.Cys438Trp)
c.1611C>G (p.Cys537Trp)
c.1593C>G (p.Cys531Trp)
c.1302C>G (p.Cys434Trp)
c.1230C>G (p.Cys410Trp)
n.2096C>G
n.2035C>G
n.1989C>G
 gnomAD v4
2g.25244248G=CA1239262872DNMT3Ac.77C=
c.904C= (n.904C=)
c.1089C= (p.Cys363=)
c.1758C= (p.Cys586=)
c.1191C= (p.Cys397=)
n.77C=
c.1314C= (p.Cys438=)
c.1611C= (p.Cys537=)
c.1593C= (p.Cys531=)
c.1302C= (p.Cys434=)
c.1230C= (p.Cys410=)
n.2096C=
n.2035C=
n.1989C=
2g.25244248G>TCA346071841DNMT3Ac.77C>A
c.904C>A (n.904C>A)
c.1089C>A (p.Cys363Ter)
c.1758C>A (p.Cys586Ter)
c.1191C>A (p.Cys397Ter)
n.77C>A
c.1314C>A (p.Cys438Ter)
c.1611C>A (p.Cys537Ter)
c.1593C>A (p.Cys531Ter)
c.1302C>A (p.Cys434Ter)
c.1230C>A (p.Cys410Ter)
n.2096C>A
n.2035C>A
n.1989C>A
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244249C>ACA346071842DNMT3Ac.76G>T
c.903G>T (n.903G>T)
c.1088G>T (p.Cys363Phe)
c.1757G>T (p.Cys586Phe)
c.1190G>T (p.Cys397Phe)
n.76G>T
c.1313G>T (p.Cys438Phe)
c.1610G>T (p.Cys537Phe)
c.1592G>T (p.Cys531Phe)
c.1301G>T (p.Cys434Phe)
c.1229G>T (p.Cys410Phe)
n.2095G>T
n.2034G>T
n.1988G>T
 ClinVar dbSNP
2g.25244249C=CA1239262875DNMT3Ac.76G=
c.903G= (n.903G=)
c.1088G= (p.Cys363=)
c.1757G= (p.Cys586=)
c.1190G= (p.Cys397=)
n.76G=
c.1313G= (p.Cys438=)
c.1610G= (p.Cys537=)
c.1592G= (p.Cys531=)
c.1301G= (p.Cys434=)
c.1229G= (p.Cys410=)
n.2095G=
n.2034G=
n.1988G=
2g.25244249C>GCA346071843DNMT3Ac.76G>C
c.903G>C (n.903G>C)
c.1088G>C (p.Cys363Ser)
c.1757G>C (p.Cys586Ser)
c.1190G>C (p.Cys397Ser)
n.76G>C
c.1313G>C (p.Cys438Ser)
c.1610G>C (p.Cys537Ser)
c.1592G>C (p.Cys531Ser)
c.1301G>C (p.Cys434Ser)
c.1229G>C (p.Cys410Ser)
n.2095G>C
n.2034G>C
n.1988G>C
2g.25244249C>TCA1555881DNMT3Ac.76G>A
c.903G>A (n.903G>A)
c.1088G>A (p.Cys363Tyr)
c.1757G>A (p.Cys586Tyr)
c.1190G>A (p.Cys397Tyr)
n.76G>A
c.1313G>A (p.Cys438Tyr)
c.1610G>A (p.Cys537Tyr)
c.1592G>A (p.Cys531Tyr)
c.1301G>A (p.Cys434Tyr)
c.1229G>A (p.Cys410Tyr)
n.2095G>A
n.2034G>A
n.1988G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4
2g.25244251_25244252dupCA2576694308DNMT3Ac.75_76dup
c.902_903dup (n.902_903dup)
c.1087_1088dup (p.Gly364AlafsTer?)
c.1756_1757dup (p.Gly587AlafsTer?)
c.1189_1190dup (p.Gly398AlafsTer?)
n.75_76dup
c.1312_1313dup (p.Gly439AlafsTer?)
c.1609_1610dup (p.Gly538AlafsTer?)
c.1591_1592dup (p.Gly532AlafsTer?)
c.1300_1301dup (p.Gly435AlafsTer?)
c.1228_1229dup (p.Gly411AlafsTer?)
n.2094_2095dup
n.2033_2034dup
n.1987_1988dup
2g.25244251_25244252delCA2658168624DNMT3Ac.75_76del
c.902_903del (n.902_903del)
c.1087_1088del (p.Cys363ArgfsTer25)
c.1756_1757del (p.Cys586ArgfsTer25)
c.1189_1190del (p.Cys397ArgfsTer25)
n.75_76del
c.1312_1313del (p.Cys438ArgfsTer25)
c.1609_1610del (p.Cys537ArgfsTer25)
c.1591_1592del (p.Cys531ArgfsTer25)
c.1300_1301del (p.Cys434ArgfsTer25)
c.1228_1229del (p.Cys410ArgfsTer25)
n.2094_2095del
n.2033_2034del
n.1987_1988del
 gnomAD v4
2g.25244249_25244260delinsCACATGTAGCAGCA1239262878DNMT3Ac.65_76delinsCTGCTACATGTG
c.892_903delinsCTGCTACATGTG (n.892_903delinsCTGCTACATGTG)
c.1077_1088delinsCTGCTACATGTG (p.Asn359=)
c.1746_1757delinsCTGCTACATGTG (p.Asn582=)
c.1179_1190delinsCTGCTACATGTG (p.Asn393=)
n.65_76delinsCTGCTACATGTG
c.1302_1313delinsCTGCTACATGTG (p.Asn434=)
c.1599_1610delinsCTGCTACATGTG (p.Asn533=)
c.1581_1592delinsCTGCTACATGTG (p.Asn527=)
c.1290_1301delinsCTGCTACATGTG (p.Asn430=)
c.1218_1229delinsCTGCTACATGTG (p.Asn406=)
n.2084_2095delinsCTGCTACATGTG
n.2023_2034delinsCTGCTACATGTG
n.1977_1988delinsCTGCTACATGTG
2g.25244250A=CA1239262882DNMT3Ac.75T=
c.902T= (n.902T=)
c.1087T= (p.Cys363=)
c.1756T= (p.Cys586=)
c.1189T= (p.Cys397=)
n.75T=
c.1312T= (p.Cys438=)
c.1609T= (p.Cys537=)
c.1591T= (p.Cys531=)
c.1300T= (p.Cys434=)
c.1228T= (p.Cys410=)
n.2094T=
n.2033T=
n.1987T=
2g.25244250A>CCA346071844DNMT3Ac.75T>G
c.902T>G (n.902T>G)
c.1087T>G (p.Cys363Gly)
c.1756T>G (p.Cys586Gly)
c.1189T>G (p.Cys397Gly)
n.75T>G
c.1312T>G (p.Cys438Gly)
c.1609T>G (p.Cys537Gly)
c.1591T>G (p.Cys531Gly)
c.1300T>G (p.Cys434Gly)
c.1228T>G (p.Cys410Gly)
n.2094T>G
n.2033T>G
n.1987T>G
2g.25244250A>GCA346071845DNMT3Ac.75T>C
c.902T>C (n.902T>C)
c.1087T>C (p.Cys363Arg)
c.1756T>C (p.Cys586Arg)
c.1189T>C (p.Cys397Arg)
n.75T>C
c.1312T>C (p.Cys438Arg)
c.1609T>C (p.Cys537Arg)
c.1591T>C (p.Cys531Arg)
c.1300T>C (p.Cys434Arg)
c.1228T>C (p.Cys410Arg)
n.2094T>C
n.2033T>C
n.1987T>C
2g.25244250A>TCA346071846DNMT3Ac.75T>A
c.902T>A (n.902T>A)
c.1087T>A (p.Cys363Ser)
c.1756T>A (p.Cys586Ser)
c.1189T>A (p.Cys397Ser)
n.75T>A
c.1312T>A (p.Cys438Ser)
c.1609T>A (p.Cys537Ser)
c.1591T>A (p.Cys531Ser)
c.1300T>A (p.Cys434Ser)
c.1228T>A (p.Cys410Ser)
n.2094T>A
n.2033T>A
n.1987T>A
2g.25244250dupCA1239262884DNMT3Ac.75dup
c.902dup (n.902dup)
c.1087dup (p.Cys363LeufsTer26)
c.1756dup (p.Cys586LeufsTer26)
c.1189dup (p.Cys397LeufsTer26)
n.75dup
c.1312dup (p.Cys438LeufsTer26)
c.1609dup (p.Cys537LeufsTer26)
c.1591dup (p.Cys531LeufsTer26)
c.1300dup (p.Cys434LeufsTer26)
c.1228dup (p.Cys410LeufsTer26)
n.2094dup
n.2033dup
n.1987dup
 dbSNP
2g.25244250_25244251delinsACCA1239262880DNMT3Ac.74_75delinsGT
c.901_902delinsGT (n.901_902delinsGT)
c.1086_1087delinsGT (p.Met362=)
c.1755_1756delinsGT (p.Met585=)
c.1188_1189delinsGT (p.Met396=)
n.74_75delinsGT
c.1311_1312delinsGT (p.Met437=)
c.1608_1609delinsGT (p.Met536=)
c.1590_1591delinsGT (p.Met530=)
c.1299_1300delinsGT (p.Met433=)
c.1227_1228delinsGT (p.Met409=)
n.2093_2094delinsGT
n.2032_2033delinsGT
n.1986_1987delinsGT
2g.25244250_25244260delCA1028509745DNMT3Ac.65_75del
c.892_902del (n.892_902del)
c.1077_1087del (p.Asn359LysfsTer26)
c.1746_1756del (p.Asn582LysfsTer26)
c.1179_1189del (p.Asn393LysfsTer26)
n.65_75del
c.1302_1312del (p.Asn434LysfsTer26)
c.1599_1609del (p.Asn533LysfsTer26)
c.1581_1591del (p.Asn527LysfsTer26)
c.1290_1300del (p.Asn430LysfsTer26)
c.1218_1228del (p.Asn406LysfsTer26)
n.2084_2094del
n.2023_2033del
n.1977_1987del
 dbSNP gnomAD v3 gnomAD v4
2g.25244251delCA531760992DNMT3Ac.74del
c.901del (n.901del)
c.1086del (p.Met362IlefsTer?)
c.1755del (p.Met585IlefsTer?)
c.1188del (p.Met396IlefsTer?)
n.74del
c.1311del (p.Met437IlefsTer?)
c.1608del (p.Met536IlefsTer?)
c.1590del (p.Met530IlefsTer?)
c.1299del (p.Met433IlefsTer?)
c.1227del (p.Met409IlefsTer?)
n.2093del
n.2032del
n.1986del
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244251C>ACA346071848DNMT3Ac.74G>T
c.901G>T (n.901G>T)
c.1086G>T (p.Met362Ile)
c.1755G>T (p.Met585Ile)
c.1188G>T (p.Met396Ile)
n.74G>T
c.1311G>T (p.Met437Ile)
c.1608G>T (p.Met536Ile)
c.1590G>T (p.Met530Ile)
c.1299G>T (p.Met433Ile)
c.1227G>T (p.Met409Ile)
n.2093G>T
n.2032G>T
n.1986G>T
2g.25244251C>GCA346071849DNMT3Ac.74G>C
c.901G>C (n.901G>C)
c.1086G>C (p.Met362Ile)
c.1755G>C (p.Met585Ile)
c.1188G>C (p.Met396Ile)
n.74G>C
c.1311G>C (p.Met437Ile)
c.1608G>C (p.Met536Ile)
c.1590G>C (p.Met530Ile)
c.1299G>C (p.Met433Ile)
c.1227G>C (p.Met409Ile)
n.2093G>C
n.2032G>C
n.1986G>C
2g.25244251C>TCA346071847DNMT3Ac.74G>A
c.901G>A (n.901G>A)
c.1086G>A (p.Met362Ile)
c.1755G>A (p.Met585Ile)
c.1188G>A (p.Met396Ile)
n.74G>A
c.1311G>A (p.Met437Ile)
c.1608G>A (p.Met536Ile)
c.1590G>A (p.Met530Ile)
c.1299G>A (p.Met433Ile)
c.1227G>A (p.Met409Ile)
n.2093G>A
n.2032G>A
n.1986G>A
2g.25244251dupCA767176399DNMT3Ac.74dup
c.901dup (n.901dup)
c.1086dup (p.Cys363ValfsTer26)
c.1755dup (p.Cys586ValfsTer26)
c.1188dup (p.Cys397ValfsTer26)
n.74dup
c.1311dup (p.Cys438ValfsTer26)
c.1608dup (p.Cys537ValfsTer26)
c.1590dup (p.Cys531ValfsTer26)
c.1299dup (p.Cys434ValfsTer26)
c.1227dup (p.Cys410ValfsTer26)
n.2093dup
n.2032dup
n.1986dup
 dbSNP gnomAD v3 gnomAD v4
2g.25244252delCA2658168635DNMT3Ac.73del
c.900del (n.900del)
c.1085del (p.Met362SerfsTer?)
c.1754del (p.Met585SerfsTer?)
c.1187del (p.Met396SerfsTer?)
n.73del
c.1310del (p.Met437SerfsTer?)
c.1607del (p.Met536SerfsTer?)
c.1589del (p.Met530SerfsTer?)
c.1298del (p.Met433SerfsTer?)
c.1226del (p.Met409SerfsTer?)
n.2092del
n.2031del
n.1985del
 gnomAD v4
2g.25244252A>CCA346071850DNMT3Ac.73T>G
c.900T>G (n.900T>G)
c.1085T>G (p.Met362Arg)
c.1754T>G (p.Met585Arg)
c.1187T>G (p.Met396Arg)
n.73T>G
c.1310T>G (p.Met437Arg)
c.1607T>G (p.Met536Arg)
c.1589T>G (p.Met530Arg)
c.1298T>G (p.Met433Arg)
c.1226T>G (p.Met409Arg)
n.2092T>G
n.2031T>G
n.1985T>G
2g.25244252A>GCA346071851DNMT3Ac.73T>C
c.900T>C (n.900T>C)
c.1085T>C (p.Met362Thr)
c.1754T>C (p.Met585Thr)
c.1187T>C (p.Met396Thr)
n.73T>C
c.1310T>C (p.Met437Thr)
c.1607T>C (p.Met536Thr)
c.1589T>C (p.Met530Thr)
c.1298T>C (p.Met433Thr)
c.1226T>C (p.Met409Thr)
n.2092T>C
n.2031T>C
n.1985T>C
2g.25244252A>TCA346071852DNMT3Ac.73T>A
c.900T>A (n.900T>A)
c.1085T>A (p.Met362Lys)
c.1754T>A (p.Met585Lys)
c.1187T>A (p.Met396Lys)
n.73T>A
c.1310T>A (p.Met437Lys)
c.1607T>A (p.Met536Lys)
c.1589T>A (p.Met530Lys)
c.1298T>A (p.Met433Lys)
c.1226T>A (p.Met409Lys)
n.2092T>A
n.2031T>A
n.1985T>A
2g.25244253delCA2576694310DNMT3Ac.72del
c.899del (n.899del)
c.1084del (p.Met362CysfsTer?)
c.1753del (p.Met585CysfsTer?)
c.1186del (p.Met396CysfsTer?)
n.72del
c.1309del (p.Met437CysfsTer?)
c.1606del (p.Met536CysfsTer?)
c.1588del (p.Met530CysfsTer?)
c.1297del (p.Met433CysfsTer?)
c.1225del (p.Met409CysfsTer?)
n.2091del
n.2030del
n.1984del
 gnomAD v4
2g.25244253T>ACA346071853DNMT3Ac.72A>T
c.899A>T (n.899A>T)
c.1084A>T (p.Met362Leu)
c.1753A>T (p.Met585Leu)
c.1186A>T (p.Met396Leu)
n.72A>T
c.1309A>T (p.Met437Leu)
c.1606A>T (p.Met536Leu)
c.1588A>T (p.Met530Leu)
c.1297A>T (p.Met433Leu)
c.1225A>T (p.Met409Leu)
n.2091A>T
n.2030A>T
n.1984A>T
 COSMIC COSMIC
2g.25244253T>CCA346071854DNMT3Ac.72A>G
c.899A>G (n.899A>G)
c.1084A>G (p.Met362Val)
c.1753A>G (p.Met585Val)
c.1186A>G (p.Met396Val)
n.72A>G
c.1309A>G (p.Met437Val)
c.1606A>G (p.Met536Val)
c.1588A>G (p.Met530Val)
c.1297A>G (p.Met433Val)
c.1225A>G (p.Met409Val)
n.2091A>G
n.2030A>G
n.1984A>G
 dbSNP
2g.25244253T>GCA346071855DNMT3Ac.72A>C
c.899A>C (n.899A>C)
c.1084A>C (p.Met362Leu)
c.1753A>C (p.Met585Leu)
c.1186A>C (p.Met396Leu)
n.72A>C
c.1309A>C (p.Met437Leu)
c.1606A>C (p.Met536Leu)
c.1588A>C (p.Met530Leu)
c.1297A>C (p.Met433Leu)
c.1225A>C (p.Met409Leu)
n.2091A>C
n.2030A>C
n.1984A>C
 COSMIC COSMIC
2g.25244254_25244255delCA2658168644DNMT3Ac.71_72del
c.898_899del (n.898_899del)
c.1083_1084del (p.Met362ValfsTer26)
c.1752_1753del (p.Met585ValfsTer26)
c.1185_1186del (p.Met396ValfsTer26)
n.71_72del
c.1308_1309del (p.Met437ValfsTer26)
c.1605_1606del (p.Met536ValfsTer26)
c.1587_1588del (p.Met530ValfsTer26)
c.1296_1297del (p.Met433ValfsTer26)
c.1224_1225del (p.Met409ValfsTer26)
n.2090_2091del
n.2029_2030del
n.1983_1984del
 gnomAD v4
2g.25244253_25244260delinsTGTAGCAGCA1239262893DNMT3Ac.65_72delinsCTGCTACA
c.892_899delinsCTGCTACA (n.892_899delinsCTGCTACA)
c.1077_1084delinsCTGCTACA (p.Asn359=)
c.1746_1753delinsCTGCTACA (p.Asn582=)
c.1179_1186delinsCTGCTACA (p.Asn393=)
n.65_72delinsCTGCTACA
c.1302_1309delinsCTGCTACA (p.Asn434=)
c.1599_1606delinsCTGCTACA (p.Asn533=)
c.1581_1588delinsCTGCTACA (p.Asn527=)
c.1290_1297delinsCTGCTACA (p.Asn430=)
c.1218_1225delinsCTGCTACA (p.Asn406=)
n.2084_2091delinsCTGCTACA
n.2023_2030delinsCTGCTACA
n.1977_1984delinsCTGCTACA
2g.25244254_25244261delCA2576694311DNMT3Ac.65_72del
c.892_899del (n.892_899del)
c.1077_1084del (p.Cys360ValfsTer26)
c.1746_1753del (p.Cys583ValfsTer26)
c.1179_1186del (p.Cys394ValfsTer26)
n.65_72del
c.1302_1309del (p.Cys435ValfsTer26)
c.1599_1606del (p.Cys534ValfsTer26)
c.1581_1588del (p.Cys528ValfsTer26)
c.1290_1297del (p.Cys431ValfsTer26)
c.1218_1225del (p.Cys407ValfsTer26)
n.2084_2091del
n.2023_2030del
n.1977_1984del
2g.25244254G>ACA425182377DNMT3Ac.71C>T
c.898C>T (n.898C>T)
c.1083C>T (p.Tyr361=)
c.1752C>T (p.Tyr584=)
c.1185C>T (p.Tyr395=)
n.71C>T
c.1308C>T (p.Tyr436=)
c.1605C>T (p.Tyr535=)
c.1587C>T (p.Tyr529=)
c.1296C>T (p.Tyr432=)
c.1224C>T (p.Tyr408=)
n.2090C>T
n.2029C>T
n.1983C>T
2g.25244254G>CCA346071856DNMT3Ac.71C>G
c.898C>G (n.898C>G)
c.1083C>G (p.Tyr361Ter)
c.1752C>G (p.Tyr584Ter)
c.1185C>G (p.Tyr395Ter)
n.71C>G
c.1308C>G (p.Tyr436Ter)
c.1605C>G (p.Tyr535Ter)
c.1587C>G (p.Tyr529Ter)
c.1296C>G (p.Tyr432Ter)
c.1224C>G (p.Tyr408Ter)
n.2090C>G
n.2029C>G
n.1983C>G
2g.25244254G>TCA346071857DNMT3Ac.71C>A
c.898C>A (n.898C>A)
c.1083C>A (p.Tyr361Ter)
c.1752C>A (p.Tyr584Ter)
c.1185C>A (p.Tyr395Ter)
n.71C>A
c.1308C>A (p.Tyr436Ter)
c.1605C>A (p.Tyr535Ter)
c.1587C>A (p.Tyr529Ter)
c.1296C>A (p.Tyr432Ter)
c.1224C>A (p.Tyr408Ter)
n.2090C>A
n.2029C>A
n.1983C>A
 gnomAD v4 COSMIC COSMIC
2g.25244254_25244260delCA767176406DNMT3Ac.65_71del
c.892_898del (n.892_898del)
c.1077_1083del (p.Asn359LysfsTer?)
c.1746_1752del (p.Asn582LysfsTer?)
c.1179_1185del (p.Asn393LysfsTer?)
n.65_71del
c.1302_1308del (p.Asn434LysfsTer?)
c.1599_1605del (p.Asn533LysfsTer?)
c.1581_1587del (p.Asn527LysfsTer?)
c.1290_1296del (p.Asn430LysfsTer?)
c.1218_1224del (p.Asn406LysfsTer?)
n.2084_2090del
n.2023_2029del
n.1977_1983del
 dbSNP gnomAD v3 gnomAD v4
2g.25244255delCA2658168653DNMT3Ac.70del
c.897del (n.897del)
c.1082del (p.Tyr361SerfsTer?)
c.1751del (p.Tyr584SerfsTer?)
c.1184del (p.Tyr395SerfsTer?)
n.70del
c.1307del (p.Tyr436SerfsTer?)
c.1604del (p.Tyr535SerfsTer?)
c.1586del (p.Tyr529SerfsTer?)
c.1295del (p.Tyr432SerfsTer?)
c.1223del (p.Tyr408SerfsTer?)
n.2089del
n.2028del
n.1982del
 gnomAD v4
2g.25244255T>ACA346071858DNMT3Ac.70A>T
c.897A>T (n.897A>T)
c.1082A>T (p.Tyr361Phe)
c.1751A>T (p.Tyr584Phe)
c.1184A>T (p.Tyr395Phe)
n.70A>T
c.1307A>T (p.Tyr436Phe)
c.1604A>T (p.Tyr535Phe)
c.1586A>T (p.Tyr529Phe)
c.1295A>T (p.Tyr432Phe)
c.1223A>T (p.Tyr408Phe)
n.2089A>T
n.2028A>T
n.1982A>T
2g.25244255T>CCA346071859DNMT3Ac.70A>G
c.897A>G (n.897A>G)
c.1082A>G (p.Tyr361Cys)
c.1751A>G (p.Tyr584Cys)
c.1184A>G (p.Tyr395Cys)
n.70A>G
c.1307A>G (p.Tyr436Cys)
c.1604A>G (p.Tyr535Cys)
c.1586A>G (p.Tyr529Cys)
c.1295A>G (p.Tyr432Cys)
c.1223A>G (p.Tyr408Cys)
n.2089A>G
n.2028A>G
n.1982A>G
2g.25244255T>GCA346071860DNMT3Ac.70A>C
c.897A>C (n.897A>C)
c.1082A>C (p.Tyr361Ser)
c.1751A>C (p.Tyr584Ser)
c.1184A>C (p.Tyr395Ser)
n.70A>C
c.1307A>C (p.Tyr436Ser)
c.1604A>C (p.Tyr535Ser)
c.1586A>C (p.Tyr529Ser)
c.1295A>C (p.Tyr432Ser)
c.1223A>C (p.Tyr408Ser)
n.2089A>C
n.2028A>C
n.1982A>C
2g.25244255_25244256delinsTACA1239262897DNMT3Ac.69_70delinsTA
c.896_897delinsTA (n.896_897delinsTA)
c.1081_1082delinsTA (p.Tyr361=)
c.1750_1751delinsTA (p.Tyr584=)
c.1183_1184delinsTA (p.Tyr395=)
n.69_70delinsTA
c.1306_1307delinsTA (p.Tyr436=)
c.1603_1604delinsTA (p.Tyr535=)
c.1585_1586delinsTA (p.Tyr529=)
c.1294_1295delinsTA (p.Tyr432=)
c.1222_1223delinsTA (p.Tyr408=)
n.2088_2089delinsTA
n.2027_2028delinsTA
n.1981_1982delinsTA
2g.25244256delCA1555882DNMT3Ac.69del
c.896del (n.896del)
c.1081del (p.Tyr361ThrfsTer?)
c.1750del (p.Tyr584ThrfsTer?)
c.1183del (p.Tyr395ThrfsTer?)
n.69del
c.1306del (p.Tyr436ThrfsTer?)
c.1603del (p.Tyr535ThrfsTer?)
c.1585del (p.Tyr529ThrfsTer?)
c.1294del (p.Tyr432ThrfsTer?)
c.1222del (p.Tyr408ThrfsTer?)
n.2088del
n.2027del
n.1981del
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244256A=CA1239262899DNMT3Ac.69T=
c.896T= (n.896T=)
c.1081T= (p.Tyr361=)
c.1750T= (p.Tyr584=)
c.1183T= (p.Tyr395=)
n.69T=
c.1306T= (p.Tyr436=)
c.1603T= (p.Tyr535=)
c.1585T= (p.Tyr529=)
c.1294T= (p.Tyr432=)
c.1222T= (p.Tyr408=)
n.2088T=
n.2027T=
n.1981T=
2g.25244256A>CCA346071861DNMT3Ac.69T>G
c.896T>G (n.896T>G)
c.1081T>G (p.Tyr361Asp)
c.1750T>G (p.Tyr584Asp)
c.1183T>G (p.Tyr395Asp)
n.69T>G
c.1306T>G (p.Tyr436Asp)
c.1603T>G (p.Tyr535Asp)
c.1585T>G (p.Tyr529Asp)
c.1294T>G (p.Tyr432Asp)
c.1222T>G (p.Tyr408Asp)
n.2088T>G
n.2027T>G
n.1981T>G
2g.25244256A>GCA346071862DNMT3Ac.69T>C
c.896T>C (n.896T>C)
c.1081T>C (p.Tyr361His)
c.1750T>C (p.Tyr584His)
c.1183T>C (p.Tyr395His)
n.69T>C
c.1306T>C (p.Tyr436His)
c.1603T>C (p.Tyr535His)
c.1585T>C (p.Tyr529His)
c.1294T>C (p.Tyr432His)
c.1222T>C (p.Tyr408His)
n.2088T>C
n.2027T>C
n.1981T>C
 gnomAD v4
2g.25244256A>TCA1555883DNMT3Ac.69T>A
c.896T>A (n.896T>A)
c.1081T>A (p.Tyr361Asn)
c.1750T>A (p.Tyr584Asn)
c.1183T>A (p.Tyr395Asn)
n.69T>A
c.1306T>A (p.Tyr436Asn)
c.1603T>A (p.Tyr535Asn)
c.1585T>A (p.Tyr529Asn)
c.1294T>A (p.Tyr432Asn)
c.1222T>A (p.Tyr408Asn)
n.2088T>A
n.2027T>A
n.1981T>A
 dbSNP ExAC gnomAD v2
2g.25244257G>ACA425182388DNMT3Ac.68C>T
c.895C>T (n.895C>T)
c.1080C>T (p.Cys360=)
c.1749C>T (p.Cys583=)
c.1182C>T (p.Cys394=)
n.68C>T
c.1305C>T (p.Cys435=)
c.1602C>T (p.Cys534=)
c.1584C>T (p.Cys528=)
c.1293C>T (p.Cys431=)
c.1221C>T (p.Cys407=)
n.2087C>T
n.2026C>T
n.1980C>T
 gnomAD v4
2g.25244257G>CCA346071863DNMT3Ac.68C>G
c.895C>G (n.895C>G)
c.1080C>G (p.Cys360Trp)
c.1749C>G (p.Cys583Trp)
c.1182C>G (p.Cys394Trp)
n.68C>G
c.1305C>G (p.Cys435Trp)
c.1602C>G (p.Cys534Trp)
c.1584C>G (p.Cys528Trp)
c.1293C>G (p.Cys431Trp)
c.1221C>G (p.Cys407Trp)
n.2087C>G
n.2026C>G
n.1980C>G
2g.25244257G>TCA346071864DNMT3Ac.68C>A
c.895C>A (n.895C>A)
c.1080C>A (p.Cys360Ter)
c.1749C>A (p.Cys583Ter)
c.1182C>A (p.Cys394Ter)
n.68C>A
c.1305C>A (p.Cys435Ter)
c.1602C>A (p.Cys534Ter)
c.1584C>A (p.Cys528Ter)
c.1293C>A (p.Cys431Ter)
c.1221C>A (p.Cys407Ter)
n.2087C>A
n.2026C>A
n.1980C>A
 gnomAD v3 gnomAD v4
2g.25244257_25244263delCA2658168662DNMT3Ac.62_68del
c.889_895del (n.889_895del)
c.1074_1080del (p.Trp358CysfsTer?)
c.1743_1749del (p.Trp581CysfsTer?)
c.1176_1182del (p.Trp392CysfsTer?)
n.62_68del
c.1299_1305del (p.Trp433CysfsTer?)
c.1596_1602del (p.Trp532CysfsTer?)
c.1578_1584del (p.Trp526CysfsTer?)
c.1287_1293del (p.Trp429CysfsTer?)
c.1215_1221del (p.Trp405CysfsTer?)
n.2081_2087del
n.2020_2026del
n.1974_1980del
 gnomAD v4
2g.25244258delCA2576694314DNMT3Ac.67del
c.894del (n.894del)
c.1079del (p.Cys360SerfsTer?)
c.1748del (p.Cys583SerfsTer?)
c.1181del (p.Cys394SerfsTer?)
n.67del
c.1304del (p.Cys435SerfsTer?)
c.1601del (p.Cys534SerfsTer?)
c.1583del (p.Cys528SerfsTer?)
c.1292del (p.Cys431SerfsTer?)
c.1220del (p.Cys407SerfsTer?)
n.2086del
n.2025del
n.1979del
2g.25244258C>ACA346071865DNMT3Ac.67G>T
c.894G>T (n.894G>T)
c.1079G>T (p.Cys360Phe)
c.1748G>T (p.Cys583Phe)
c.1181G>T (p.Cys394Phe)
n.67G>T
c.1304G>T (p.Cys435Phe)
c.1601G>T (p.Cys534Phe)
c.1583G>T (p.Cys528Phe)
c.1292G>T (p.Cys431Phe)
c.1220G>T (p.Cys407Phe)
n.2086G>T
n.2025G>T
n.1979G>T
2g.25244258C=CA1239262905DNMT3Ac.67G=
c.894G= (n.894G=)
c.1079G= (p.Cys360=)
c.1748G= (p.Cys583=)
c.1181G= (p.Cys394=)
n.67G=
c.1304G= (p.Cys435=)
c.1601G= (p.Cys534=)
c.1583G= (p.Cys528=)
c.1292G= (p.Cys431=)
c.1220G= (p.Cys407=)
n.2086G=
n.2025G=
n.1979G=
2g.25244258C>GCA346071866DNMT3Ac.67G>C
c.894G>C (n.894G>C)
c.1079G>C (p.Cys360Ser)
c.1748G>C (p.Cys583Ser)
c.1181G>C (p.Cys394Ser)
n.67G>C
c.1304G>C (p.Cys435Ser)
c.1601G>C (p.Cys534Ser)
c.1583G>C (p.Cys528Ser)
c.1292G>C (p.Cys431Ser)
c.1220G>C (p.Cys407Ser)
n.2086G>C
n.2025G>C
n.1979G>C
 gnomAD v4
2g.25244258C>TCA1555884DNMT3Ac.67G>A
c.894G>A (n.894G>A)
c.1079G>A (p.Cys360Tyr)
c.1748G>A (p.Cys583Tyr)
c.1181G>A (p.Cys394Tyr)
n.67G>A
c.1304G>A (p.Cys435Tyr)
c.1601G>A (p.Cys534Tyr)
c.1583G>A (p.Cys528Tyr)
c.1292G>A (p.Cys431Tyr)
c.1220G>A (p.Cys407Tyr)
n.2086G>A
n.2025G>A
n.1979G>A
 ClinVar dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC
2g.25244259A=CA1239262909DNMT3Ac.66T=
c.893T= (n.893T=)
c.1078T= (p.Cys360=)
c.1747T= (p.Cys583=)
c.1180T= (p.Cys394=)
n.66T=
c.1303T= (p.Cys435=)
c.1600T= (p.Cys534=)
c.1582T= (p.Cys528=)
c.1291T= (p.Cys431=)
c.1219T= (p.Cys407=)
n.2085T=
n.2024T=
n.1978T=
2g.25244259A>CCA346071869DNMT3Ac.66T>G
c.893T>G (n.893T>G)
c.1078T>G (p.Cys360Gly)
c.1747T>G (p.Cys583Gly)
c.1180T>G (p.Cys394Gly)
n.66T>G
c.1303T>G (p.Cys435Gly)
c.1600T>G (p.Cys534Gly)
c.1582T>G (p.Cys528Gly)
c.1291T>G (p.Cys431Gly)
c.1219T>G (p.Cys407Gly)
n.2085T>G
n.2024T>G
n.1978T>G
2g.25244259A>GCA346071867DNMT3Ac.66T>C
c.893T>C (n.893T>C)
c.1078T>C (p.Cys360Arg)
c.1747T>C (p.Cys583Arg)
c.1180T>C (p.Cys394Arg)
n.66T>C
c.1303T>C (p.Cys435Arg)
c.1600T>C (p.Cys534Arg)
c.1582T>C (p.Cys528Arg)
c.1291T>C (p.Cys431Arg)
c.1219T>C (p.Cys407Arg)
n.2085T>C
n.2024T>C
n.1978T>C
 gnomAD v4
2g.25244259A>TCA346071868DNMT3Ac.66T>A
c.893T>A (n.893T>A)
c.1078T>A (p.Cys360Ser)
c.1747T>A (p.Cys583Ser)
c.1180T>A (p.Cys394Ser)
n.66T>A
c.1303T>A (p.Cys435Ser)
c.1600T>A (p.Cys534Ser)
c.1582T>A (p.Cys528Ser)
c.1291T>A (p.Cys431Ser)
c.1219T>A (p.Cys407Ser)
n.2085T>A
n.2024T>A
n.1978T>A
 dbSNP gnomAD v4
2g.25244260G>ACA425182398DNMT3Ac.65C>T
c.892C>T (n.892C>T)
c.1077C>T (p.Asn359=)
c.1746C>T (p.Asn582=)
c.1179C>T (p.Asn393=)
n.65C>T
c.1302C>T (p.Asn434=)
c.1599C>T (p.Asn533=)
c.1581C>T (p.Asn527=)
c.1290C>T (p.Asn430=)
c.1218C>T (p.Asn406=)
n.2084C>T
n.2023C>T
n.1977C>T
 dbSNP
2g.25244260G>CCA346071870DNMT3Ac.65C>G
c.892C>G (n.892C>G)
c.1077C>G (p.Asn359Lys)
c.1746C>G (p.Asn582Lys)
c.1179C>G (p.Asn393Lys)
n.65C>G
c.1302C>G (p.Asn434Lys)
c.1599C>G (p.Asn533Lys)
c.1581C>G (p.Asn527Lys)
c.1290C>G (p.Asn430Lys)
c.1218C>G (p.Asn406Lys)
n.2084C>G
n.2023C>G
n.1977C>G
2g.25244260G>TCA346071871DNMT3Ac.65C>A
c.892C>A (n.892C>A)
c.1077C>A (p.Asn359Lys)
c.1746C>A (p.Asn582Lys)
c.1179C>A (p.Asn393Lys)
n.65C>A
c.1302C>A (p.Asn434Lys)
c.1599C>A (p.Asn533Lys)
c.1581C>A (p.Asn527Lys)
c.1290C>A (p.Asn430Lys)
c.1218C>A (p.Asn406Lys)
n.2084C>A
n.2023C>A
n.1977C>A
2g.25244262_25244270delCA2658168683DNMT3Ac.57_65del
c.884_892del (n.884_892del)
c.1069_1077del (p.Pro357_Asn359del)
c.1738_1746del (p.Pro580_Asn582del)
c.1171_1179del (p.Pro391_Asn393del)
n.57_65del
c.1294_1302del (p.Pro432_Asn434del)
c.1591_1599del (p.Pro531_Asn533del)
c.1573_1581del (p.Pro525_Asn527del)
c.1282_1290del (p.Pro428_Asn430del)
c.1210_1218del (p.Pro404_Asn406del)
n.2076_2084del
n.2015_2023del
n.1969_1977del
 gnomAD v4
2g.25244261T>ACA346071872DNMT3Ac.64A>T
c.891A>T (n.891A>T)
c.1076A>T (p.Asn359Ile)
c.1745A>T (p.Asn582Ile)
c.1178A>T (p.Asn393Ile)
n.64A>T
c.1301A>T (p.Asn434Ile)
c.1598A>T (p.Asn533Ile)
c.1580A>T (p.Asn527Ile)
c.1289A>T (p.Asn430Ile)
c.1217A>T (p.Asn406Ile)
n.2083A>T
n.2022A>T
n.1976A>T
2g.25244261T>CCA346071873DNMT3Ac.64A>G
c.891A>G (n.891A>G)
c.1076A>G (p.Asn359Ser)
c.1745A>G (p.Asn582Ser)
c.1178A>G (p.Asn393Ser)
n.64A>G
c.1301A>G (p.Asn434Ser)
c.1598A>G (p.Asn533Ser)
c.1580A>G (p.Asn527Ser)
c.1289A>G (p.Asn430Ser)
c.1217A>G (p.Asn406Ser)
n.2083A>G
n.2022A>G
n.1976A>G
 gnomAD v4
2g.25244261T>GCA346071874DNMT3Ac.64A>C
c.891A>C (n.891A>C)
c.1076A>C (p.Asn359Thr)
c.1745A>C (p.Asn582Thr)
c.1178A>C (p.Asn393Thr)
n.64A>C
c.1301A>C (p.Asn434Thr)
c.1598A>C (p.Asn533Thr)
c.1580A>C (p.Asn527Thr)
c.1289A>C (p.Asn430Thr)
c.1217A>C (p.Asn406Thr)
n.2083A>C
n.2022A>C
n.1976A>C
2g.25244262T>ACA346071875DNMT3Ac.63A>T
c.890A>T (n.890A>T)
c.1075A>T (p.Asn359Tyr)
c.1744A>T (p.Asn582Tyr)
c.1177A>T (p.Asn393Tyr)
n.63A>T
c.1300A>T (p.Asn434Tyr)
c.1597A>T (p.Asn533Tyr)
c.1579A>T (p.Asn527Tyr)
c.1288A>T (p.Asn430Tyr)
c.1216A>T (p.Asn406Tyr)
n.2082A>T
n.2021A>T
n.1975A>T
2g.25244262T>CCA346071877DNMT3Ac.63A>G
c.890A>G (n.890A>G)
c.1075A>G (p.Asn359Asp)
c.1744A>G (p.Asn582Asp)
c.1177A>G (p.Asn393Asp)
n.63A>G
c.1300A>G (p.Asn434Asp)
c.1597A>G (p.Asn533Asp)
c.1579A>G (p.Asn527Asp)
c.1288A>G (p.Asn430Asp)
c.1216A>G (p.Asn406Asp)
n.2082A>G
n.2021A>G
n.1975A>G
2g.25244262T>GCA346071876DNMT3Ac.63A>C
c.890A>C (n.890A>C)
c.1075A>C (p.Asn359His)
c.1744A>C (p.Asn582His)
c.1177A>C (p.Asn393His)
n.63A>C
c.1300A>C (p.Asn434His)
c.1597A>C (p.Asn533His)
c.1579A>C (p.Asn527His)
c.1288A>C (p.Asn430His)
c.1216A>C (p.Asn406His)
n.2082A>C
n.2021A>C
n.1975A>C
2g.25244263C>ACA16604180DNMT3Ac.62G>T
c.889G>T (n.889G>T)
c.1074G>T (p.Trp358Cys)
c.1743G>T (p.Trp581Cys)
c.1176G>T (p.Trp392Cys)
n.62G>T
c.1299G>T (p.Trp433Cys)
c.1596G>T (p.Trp532Cys)
c.1578G>T (p.Trp526Cys)
c.1287G>T (p.Trp429Cys)
c.1215G>T (p.Trp405Cys)
n.2081G>T
n.2020G>T
n.1974G>T
 ClinVar dbSNP gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25244263C=CA1239262912DNMT3Ac.62G=
c.889G= (n.889G=)
c.1074G= (p.Trp358=)
c.1743G= (p.Trp581=)
c.1176G= (p.Trp392=)
n.62G=
c.1299G= (p.Trp433=)
c.1596G= (p.Trp532=)
c.1578G= (p.Trp526=)
c.1287G= (p.Trp429=)
c.1215G= (p.Trp405=)
n.2081G=
n.2020G=
n.1974G=
2g.25244263C>GCA346071878DNMT3Ac.62G>C
c.889G>C (n.889G>C)
c.1074G>C (p.Trp358Cys)
c.1743G>C (p.Trp581Cys)
c.1176G>C (p.Trp392Cys)
n.62G>C
c.1299G>C (p.Trp433Cys)
c.1596G>C (p.Trp532Cys)
c.1578G>C (p.Trp526Cys)
c.1287G>C (p.Trp429Cys)
c.1215G>C (p.Trp405Cys)
n.2081G>C
n.2020G>C
n.1974G>C
 dbSNP gnomAD v2 gnomAD v4
2g.25244263C>TCA1555885DNMT3Ac.62G>A
c.889G>A (n.889G>A)
c.1074G>A (p.Trp358Ter)
c.1743G>A (p.Trp581Ter)
c.1176G>A (p.Trp392Ter)
n.62G>A
c.1299G>A (p.Trp433Ter)
c.1596G>A (p.Trp532Ter)
c.1578G>A (p.Trp526Ter)
c.1287G>A (p.Trp429Ter)
c.1215G>A (p.Trp405Ter)
n.2081G>A
n.2020G>A
n.1974G>A
 dbSNP ExAC gnomAD v2 gnomAD v4 COSMIC
2g.25244264delCA2576694317DNMT3Ac.62del
c.889del (n.889del)
c.1074del (p.Trp358Ter)
c.1743del (p.Trp581Ter)
c.1176del (p.Trp392Ter)
n.62del
c.1299del (p.Trp433Ter)
c.1596del (p.Trp532Ter)
c.1578del (p.Trp526Ter)
c.1287del (p.Trp429Ter)
c.1215del (p.Trp405Ter)
n.2081del
n.2020del
n.1974del
2g.25244263_25244268delCA2658168695DNMT3Ac.57_62del
c.884_889del (n.884_889del)
c.1069_1074del (p.Pro357_Trp358del)
c.1738_1743del (p.Pro580_Trp581del)
c.1171_1176del (p.Pro391_Trp392del)
n.57_62del
c.1294_1299del (p.Pro432_Trp433del)
c.1591_1596del (p.Pro531_Trp532del)
c.1573_1578del (p.Pro525_Trp526del)
c.1282_1287del (p.Pro428_Trp429del)
c.1210_1215del (p.Pro404_Trp405del)
n.2076_2081del
n.2015_2020del
n.1969_1974del
 gnomAD v4
2g.25244264C>ACA346071879DNMT3Ac.61G>T
c.888G>T (n.888G>T)
c.1073G>T (p.Trp358Leu)
c.1742G>T (p.Trp581Leu)
c.1175G>T (p.Trp392Leu)
n.61G>T
c.1298G>T (p.Trp433Leu)
c.1595G>T (p.Trp532Leu)
c.1577G>T (p.Trp526Leu)
c.1286G>T (p.Trp429Leu)
c.1214G>T (p.Trp405Leu)
n.2080G>T
n.2019G>T
n.1973G>T
 gnomAD v4
2g.25244264C=CA1239262922DNMT3Ac.61G=
c.888G= (n.888G=)
c.1073G= (p.Trp358=)
c.1742G= (p.Trp581=)
c.1175G= (p.Trp392=)
n.61G=
c.1298G= (p.Trp433=)
c.1595G= (p.Trp532=)
c.1577G= (p.Trp526=)
c.1286G= (p.Trp429=)
c.1214G= (p.Trp405=)
n.2080G=
n.2019G=
n.1973G=
2g.25244264C>GCA346071880DNMT3Ac.61G>C
c.888G>C (n.888G>C)
c.1073G>C (p.Trp358Ser)
c.1742G>C (p.Trp581Ser)
c.1175G>C (p.Trp392Ser)
n.61G>C
c.1298G>C (p.Trp433Ser)
c.1595G>C (p.Trp532Ser)
c.1577G>C (p.Trp526Ser)
c.1286G>C (p.Trp429Ser)
c.1214G>C (p.Trp405Ser)
n.2080G>C
n.2019G>C
n.1973G>C
 gnomAD v4
2g.25244264C>TCA43703376DNMT3Ac.61G>A
c.888G>A (n.888G>A)
c.1073G>A (p.Trp358Ter)
c.1742G>A (p.Trp581Ter)
c.1175G>A (p.Trp392Ter)
n.61G>A
c.1298G>A (p.Trp433Ter)
c.1595G>A (p.Trp532Ter)
c.1577G>A (p.Trp526Ter)
c.1286G>A (p.Trp429Ter)
c.1214G>A (p.Trp405Ter)
n.2080G>A
n.2019G>A
n.1973G>A
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244264_25244270delinsCAGGGGTCA1239262924DNMT3Ac.55_61delinsACCCCTG
c.882_888delinsACCCCTG (n.882_888delinsACCCCTG)
c.1067_1073delinsACCCCTG (p.Asp356=)
c.1736_1742delinsACCCCTG (p.Asp579=)
c.1169_1175delinsACCCCTG (p.Asp390=)
n.55_61delinsACCCCTG
c.1292_1298delinsACCCCTG (p.Asp431=)
c.1589_1595delinsACCCCTG (p.Asp530=)
c.1571_1577delinsACCCCTG (p.Asp524=)
c.1280_1286delinsACCCCTG (p.Asp427=)
c.1208_1214delinsACCCCTG (p.Asp403=)
n.2074_2080delinsACCCCTG
n.2013_2019delinsACCCCTG
n.1967_1973delinsACCCCTG
2g.25244265delCA1028509778DNMT3Ac.60del
c.887del (n.887del)
c.1072del (p.Trp358GlyfsTer?)
c.1741del (p.Trp581GlyfsTer?)
c.1174del (p.Trp392GlyfsTer?)
n.60del
c.1297del (p.Trp433GlyfsTer?)
c.1594del (p.Trp532GlyfsTer?)
c.1576del (p.Trp526GlyfsTer?)
c.1285del (p.Trp429GlyfsTer?)
c.1213del (p.Trp405GlyfsTer?)
n.2079del
n.2018del
n.1972del
 gnomAD v3 gnomAD v4
2g.25244265A=CA1239262930DNMT3Ac.60T=
c.887T= (n.887T=)
c.1072T= (p.Trp358=)
c.1741T= (p.Trp581=)
c.1174T= (p.Trp392=)
n.60T=
c.1297T= (p.Trp433=)
c.1594T= (p.Trp532=)
c.1576T= (p.Trp526=)
c.1285T= (p.Trp429=)
c.1213T= (p.Trp405=)
n.2079T=
n.2018T=
n.1972T=
2g.25244265A>CCA346071881DNMT3Ac.60T>G
c.887T>G (n.887T>G)
c.1072T>G (p.Trp358Gly)
c.1741T>G (p.Trp581Gly)
c.1174T>G (p.Trp392Gly)
n.60T>G
c.1297T>G (p.Trp433Gly)
c.1594T>G (p.Trp532Gly)
c.1576T>G (p.Trp526Gly)
c.1285T>G (p.Trp429Gly)
c.1213T>G (p.Trp405Gly)
n.2079T>G
n.2018T>G
n.1972T>G
 dbSNP gnomAD v2 gnomAD v4 COSMIC
2g.25244265A>GCA346071882DNMT3Ac.60T>C
c.887T>C (n.887T>C)
c.1072T>C (p.Trp358Arg)
c.1741T>C (p.Trp581Arg)
c.1174T>C (p.Trp392Arg)
n.60T>C
c.1297T>C (p.Trp433Arg)
c.1594T>C (p.Trp532Arg)
c.1576T>C (p.Trp526Arg)
c.1285T>C (p.Trp429Arg)
c.1213T>C (p.Trp405Arg)
n.2079T>C
n.2018T>C
n.1972T>C
 dbSNP gnomAD v4 COSMIC
2g.25244265A>TCA346071883DNMT3Ac.60T>A
c.887T>A (n.887T>A)
c.1072T>A (p.Trp358Arg)
c.1741T>A (p.Trp581Arg)
c.1174T>A (p.Trp392Arg)
n.60T>A
c.1297T>A (p.Trp433Arg)
c.1594T>A (p.Trp532Arg)
c.1576T>A (p.Trp526Arg)
c.1285T>A (p.Trp429Arg)
c.1213T>A (p.Trp405Arg)
n.2079T>A
n.2018T>A
n.1972T>A
 gnomAD v4 COSMIC
2g.25244265_25244266delinsAGCA1239262929DNMT3Ac.59_60delinsCT
c.886_887delinsCT (n.886_887delinsCT)
c.1071_1072delinsCT (p.Pro357=)
c.1740_1741delinsCT (p.Pro580=)
c.1173_1174delinsCT (p.Pro391=)
n.59_60delinsCT
c.1296_1297delinsCT (p.Pro432=)
c.1593_1594delinsCT (p.Pro531=)
c.1575_1576delinsCT (p.Pro525=)
c.1284_1285delinsCT (p.Pro428=)
c.1212_1213delinsCT (p.Pro404=)
n.2078_2079delinsCT
n.2017_2018delinsCT
n.1971_1972delinsCT
2g.25244265_25244270delCA1555886DNMT3Ac.55_60del
c.882_887del (n.882_887del)
c.1067_1072del (p.Asp356_Trp358delinsGly)
c.1736_1741del (p.Asp579_Trp581delinsGly)
c.1169_1174del (p.Asp390_Trp392delinsGly)
n.55_60del
c.1292_1297del (p.Asp431_Trp433delinsGly)
c.1589_1594del (p.Asp530_Trp532delinsGly)
c.1571_1576del (p.Asp524_Trp526delinsGly)
c.1280_1285del (p.Asp427_Trp429delinsGly)
c.1208_1213del (p.Asp403_Trp405delinsGly)
n.2074_2079del
n.2013_2018del
n.1967_1972del
 dbSNP ExAC
2g.25244265_25244285delCA2576694322DNMT3Ac.40_60del
c.867_887del (n.867_887del)
c.1052_1072del (p.Ala351_Trp358delinsGly)
c.1721_1741del (p.Ala574_Trp581delinsGly)
c.1154_1174del (p.Ala385_Trp392delinsGly)
n.40_60del
c.1277_1297del (p.Ala426_Trp433delinsGly)
c.1574_1594del (p.Ala525_Trp532delinsGly)
c.1556_1576del (p.Ala519_Trp526delinsGly)
c.1265_1285del (p.Ala422_Trp429delinsGly)
c.1193_1213del (p.Ala398_Trp405delinsGly)
n.2059_2079del
n.1998_2018del
n.1952_1972del
2g.25244266G>ACA425182423DNMT3Ac.59C>T
c.886C>T (n.886C>T)
c.1071C>T (p.Pro357=)
c.1740C>T (p.Pro580=)
c.1173C>T (p.Pro391=)
n.59C>T
c.1296C>T (p.Pro432=)
c.1593C>T (p.Pro531=)
c.1575C>T (p.Pro525=)
c.1284C>T (p.Pro428=)
c.1212C>T (p.Pro404=)
n.2078C>T
n.2017C>T
n.1971C>T
 gnomAD v4
2g.25244266G>CCA425182425DNMT3Ac.59C>G
c.886C>G (n.886C>G)
c.1071C>G (p.Pro357=)
c.1740C>G (p.Pro580=)
c.1173C>G (p.Pro391=)
n.59C>G
c.1296C>G (p.Pro432=)
c.1593C>G (p.Pro531=)
c.1575C>G (p.Pro525=)
c.1284C>G (p.Pro428=)
c.1212C>G (p.Pro404=)
n.2078C>G
n.2017C>G
n.1971C>G
2g.25244266G>TCA425182431DNMT3Ac.59C>A
c.886C>A (n.886C>A)
c.1071C>A (p.Pro357=)
c.1740C>A (p.Pro580=)
c.1173C>A (p.Pro391=)
n.59C>A
c.1296C>A (p.Pro432=)
c.1593C>A (p.Pro531=)
c.1575C>A (p.Pro525=)
c.1284C>A (p.Pro428=)
c.1212C>A (p.Pro404=)
n.2078C>A
n.2017C>A
n.1971C>A
2g.25244269dupCA645515200DNMT3Ac.59dup
c.886dup (n.886dup)
c.1071dup (p.Trp358LeufsTer?)
c.1740dup (p.Trp581LeufsTer?)
c.1173dup (p.Trp392LeufsTer?)
n.59dup
c.1296dup (p.Trp433LeufsTer?)
c.1593dup (p.Trp532LeufsTer?)
c.1575dup (p.Trp526LeufsTer?)
c.1284dup (p.Trp429LeufsTer?)
c.1212dup (p.Trp405LeufsTer?)
n.2078dup
n.2017dup
n.1971dup
 COSMIC
2g.25244269delCA1028509784DNMT3Ac.59del
c.886del (n.886del)
c.1071del (p.Trp358GlyfsTer?)
c.1740del (p.Trp581GlyfsTer?)
c.1173del (p.Trp392GlyfsTer?)
n.59del
c.1296del (p.Trp433GlyfsTer?)
c.1593del (p.Trp532GlyfsTer?)
c.1575del (p.Trp526GlyfsTer?)
c.1284del (p.Trp429GlyfsTer?)
c.1212del (p.Trp405GlyfsTer?)
n.2078del
n.2017del
n.1971del
 dbSNP gnomAD v3 gnomAD v4
2g.25244267_25244269delCA2658168741DNMT3Ac.57_59del
c.884_886del (n.884_886del)
c.1069_1071del (p.Pro357del)
c.1738_1740del (p.Pro580del)
c.1171_1173del (p.Pro391del)
n.57_59del
c.1294_1296del (p.Pro432del)
c.1591_1593del (p.Pro531del)
c.1573_1575del (p.Pro525del)
c.1282_1284del (p.Pro428del)
c.1210_1212del (p.Pro404del)
n.2076_2078del
n.2015_2017del
n.1969_1971del
 gnomAD v4
2g.25244267_25244282delCA2658168744DNMT3Ac.44_59del
c.871_886del (n.871_886del)
c.1056_1071del (p.Ile353GlyfsTer?)
c.1725_1740del (p.Ile576GlyfsTer?)
c.1158_1173del (p.Ile387GlyfsTer?)
n.44_59del
c.1281_1296del (p.Ile428GlyfsTer?)
c.1578_1593del (p.Ile527GlyfsTer?)
c.1560_1575del (p.Ile521GlyfsTer?)
c.1269_1284del (p.Ile424GlyfsTer?)
c.1197_1212del (p.Ile400GlyfsTer?)
n.2063_2078del
n.2002_2017del
n.1956_1971del
 gnomAD v4
2g.25244266_25244267insCCA425182440DNMT3Ac.58_59insG
c.885_886insG (n.885_886insG)
c.1070_1071insG (p.Trp358LeufsTer?)
c.1739_1740insG (p.Trp581LeufsTer?)
c.1172_1173insG (p.Trp392LeufsTer?)
n.58_59insG
c.1295_1296insG (p.Trp433LeufsTer?)
c.1592_1593insG (p.Trp532LeufsTer?)
c.1574_1575insG (p.Trp526LeufsTer?)
c.1283_1284insG (p.Trp429LeufsTer?)
c.1211_1212insG (p.Trp405LeufsTer?)
n.2077_2078insG
n.2016_2017insG
n.1970_1971insG
2g.25244267G>ACA346071884DNMT3Ac.58C>T
c.885C>T (n.885C>T)
c.1070C>T (p.Pro357Leu)
c.1739C>T (p.Pro580Leu)
c.1172C>T (p.Pro391Leu)
n.58C>T
c.1295C>T (p.Pro432Leu)
c.1592C>T (p.Pro531Leu)
c.1574C>T (p.Pro525Leu)
c.1283C>T (p.Pro428Leu)
c.1211C>T (p.Pro404Leu)
n.2077C>T
n.2016C>T
n.1970C>T
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244267G>CCA1555887DNMT3Ac.58C>G
c.885C>G (n.885C>G)
c.1070C>G (p.Pro357Arg)
c.1739C>G (p.Pro580Arg)
c.1172C>G (p.Pro391Arg)
n.58C>G
c.1295C>G (p.Pro432Arg)
c.1592C>G (p.Pro531Arg)
c.1574C>G (p.Pro525Arg)
c.1283C>G (p.Pro428Arg)
c.1211C>G (p.Pro404Arg)
n.2077C>G
n.2016C>G
n.1970C>G
 dbSNP ExAC gnomAD v2
2g.25244267G=CA1239262936DNMT3Ac.58C=
c.885C= (n.885C=)
c.1070C= (p.Pro357=)
c.1739C= (p.Pro580=)
c.1172C= (p.Pro391=)
n.58C=
c.1295C= (p.Pro432=)
c.1592C= (p.Pro531=)
c.1574C= (p.Pro525=)
c.1283C= (p.Pro428=)
c.1211C= (p.Pro404=)
n.2077C=
n.2016C=
n.1970C=
2g.25244267G>TCA346071885DNMT3Ac.58C>A
c.885C>A (n.885C>A)
c.1070C>A (p.Pro357His)
c.1739C>A (p.Pro580His)
c.1172C>A (p.Pro391His)
n.58C>A
c.1295C>A (p.Pro432His)
c.1592C>A (p.Pro531His)
c.1574C>A (p.Pro525His)
c.1283C>A (p.Pro428His)
c.1211C>A (p.Pro404His)
n.2077C>A
n.2016C>A
n.1970C>A
 dbSNP gnomAD v4
2g.25244268G>ACA346071886DNMT3Ac.57C>T
c.884C>T (n.884C>T)
c.1069C>T (p.Pro357Ser)
c.1738C>T (p.Pro580Ser)
c.1171C>T (p.Pro391Ser)
n.57C>T
c.1294C>T (p.Pro432Ser)
c.1591C>T (p.Pro531Ser)
c.1573C>T (p.Pro525Ser)
c.1282C>T (p.Pro428Ser)
c.1210C>T (p.Pro404Ser)
n.2076C>T
n.2015C>T
n.1969C>T
2g.25244268G>CCA346071887DNMT3Ac.57C>G
c.884C>G (n.884C>G)
c.1069C>G (p.Pro357Ala)
c.1738C>G (p.Pro580Ala)
c.1171C>G (p.Pro391Ala)
n.57C>G
c.1294C>G (p.Pro432Ala)
c.1591C>G (p.Pro531Ala)
c.1573C>G (p.Pro525Ala)
c.1282C>G (p.Pro428Ala)
c.1210C>G (p.Pro404Ala)
n.2076C>G
n.2015C>G
n.1969C>G
2g.25244268G>TCA346071888DNMT3Ac.57C>A
c.884C>A (n.884C>A)
c.1069C>A (p.Pro357Thr)
c.1738C>A (p.Pro580Thr)
c.1171C>A (p.Pro391Thr)
n.57C>A
c.1294C>A (p.Pro432Thr)
c.1591C>A (p.Pro531Thr)
c.1573C>A (p.Pro525Thr)
c.1282C>A (p.Pro428Thr)
c.1210C>A (p.Pro404Thr)
n.2076C>A
n.2015C>A
n.1969C>A
2g.25244272_25244316dupCA1028509793DNMT3Ac.13_57dup
c.840_884dup (n.840_884dup)
c.1025_1069dup (p.Asp356_Pro357insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
c.1694_1738dup (p.Asp579_Pro580insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
c.1127_1171dup (p.Asp390_Pro391insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
n.13_57dup
c.1250_1294dup (p.Asp431_Pro432insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
c.1547_1591dup (p.Asp530_Pro531insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
c.1529_1573dup (p.Asp524_Pro525insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
c.1238_1282dup (p.Asp427_Pro428insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
c.1166_1210dup (p.Asp403_Pro404insLeuLeuValGlyProGlyAlaAlaGlnAlaAlaIleLysGluAsp)
n.2032_2076dup
n.1971_2015dup
n.1925_1969dup
 gnomAD v3 gnomAD v4
2g.25244269G>ACA425182448DNMT3Ac.56C>T
c.883C>T (n.883C>T)
c.1068C>T (p.Asp356=)
c.1737C>T (p.Asp579=)
c.1170C>T (p.Asp390=)
n.56C>T
c.1293C>T (p.Asp431=)
c.1590C>T (p.Asp530=)
c.1572C>T (p.Asp524=)
c.1281C>T (p.Asp427=)
c.1209C>T (p.Asp403=)
n.2075C>T
n.2014C>T
n.1968C>T
 dbSNP
2g.25244269G>CCA346071889DNMT3Ac.56C>G
c.883C>G (n.883C>G)
c.1068C>G (p.Asp356Glu)
c.1737C>G (p.Asp579Glu)
c.1170C>G (p.Asp390Glu)
n.56C>G
c.1293C>G (p.Asp431Glu)
c.1590C>G (p.Asp530Glu)
c.1572C>G (p.Asp524Glu)
c.1281C>G (p.Asp427Glu)
c.1209C>G (p.Asp403Glu)
n.2075C>G
n.2014C>G
n.1968C>G
2g.25244269G>TCA346071890DNMT3Ac.56C>A
c.883C>A (n.883C>A)
c.1068C>A (p.Asp356Glu)
c.1737C>A (p.Asp579Glu)
c.1170C>A (p.Asp390Glu)
n.56C>A
c.1293C>A (p.Asp431Glu)
c.1590C>A (p.Asp530Glu)
c.1572C>A (p.Asp524Glu)
c.1281C>A (p.Asp427Glu)
c.1209C>A (p.Asp403Glu)
n.2075C>A
n.2014C>A
n.1968C>A
2g.25244269_25244279delCA2658168750DNMT3Ac.46_56del
c.873_883del (n.873_883del)
c.1058_1068del (p.Ile353ThrfsTer?)
c.1727_1737del (p.Ile576ThrfsTer?)
c.1160_1170del (p.Ile387ThrfsTer?)
n.46_56del
c.1283_1293del (p.Ile428ThrfsTer?)
c.1580_1590del (p.Ile527ThrfsTer?)
c.1562_1572del (p.Ile521ThrfsTer?)
c.1271_1281del (p.Ile424ThrfsTer?)
c.1199_1209del (p.Ile400ThrfsTer?)
n.2065_2075del
n.2004_2014del
n.1958_1968del
 gnomAD v4
2g.25244270delCA645515201DNMT3Ac.55del
c.882del (n.882del)
c.1067del (p.Asp356AlafsTer?)
c.1736del (p.Asp579AlafsTer?)
c.1169del (p.Asp390AlafsTer?)
n.55del
c.1292del (p.Asp431AlafsTer?)
c.1589del (p.Asp530AlafsTer?)
c.1571del (p.Asp524AlafsTer?)
c.1280del (p.Asp427AlafsTer?)
c.1208del (p.Asp403AlafsTer?)
n.2074del
n.2013del
n.1967del
 COSMIC COSMIC
2g.25244270T>ACA346071891DNMT3Ac.55A>T
c.882A>T (n.882A>T)
c.1067A>T (p.Asp356Val)
c.1736A>T (p.Asp579Val)
c.1169A>T (p.Asp390Val)
n.55A>T
c.1292A>T (p.Asp431Val)
c.1589A>T (p.Asp530Val)
c.1571A>T (p.Asp524Val)
c.1280A>T (p.Asp427Val)
c.1208A>T (p.Asp403Val)
n.2074A>T
n.2013A>T
n.1967A>T
2g.25244270T>CCA346071892DNMT3Ac.55A>G
c.882A>G (n.882A>G)
c.1067A>G (p.Asp356Gly)
c.1736A>G (p.Asp579Gly)
c.1169A>G (p.Asp390Gly)
n.55A>G
c.1292A>G (p.Asp431Gly)
c.1589A>G (p.Asp530Gly)
c.1571A>G (p.Asp524Gly)
c.1280A>G (p.Asp427Gly)
c.1208A>G (p.Asp403Gly)
n.2074A>G
n.2013A>G
n.1967A>G
2g.25244270T>GCA346071893DNMT3Ac.55A>C
c.882A>C (n.882A>C)
c.1067A>C (p.Asp356Ala)
c.1736A>C (p.Asp579Ala)
c.1169A>C (p.Asp390Ala)
n.55A>C
c.1292A>C (p.Asp431Ala)
c.1589A>C (p.Asp530Ala)
c.1571A>C (p.Asp524Ala)
c.1280A>C (p.Asp427Ala)
c.1208A>C (p.Asp403Ala)
n.2074A>C
n.2013A>C
n.1967A>C
2g.25244270dupCA2658168753DNMT3Ac.55dup
c.882dup (n.882dup)
c.1067dup (p.Asp356GlufsTer?)
c.1736dup (p.Asp579GlufsTer?)
c.1169dup (p.Asp390GlufsTer?)
n.55dup
c.1292dup (p.Asp431GlufsTer?)
c.1589dup (p.Asp530GlufsTer?)
c.1571dup (p.Asp524GlufsTer?)
c.1280dup (p.Asp427GlufsTer?)
c.1208dup (p.Asp403GlufsTer?)
n.2074dup
n.2013dup
n.1967dup
 gnomAD v4
2g.25244271C>ACA346071894DNMT3Ac.54G>T
c.881G>T (n.881G>T)
c.1066G>T (p.Asp356Tyr)
c.1735G>T (p.Asp579Tyr)
c.1168G>T (p.Asp390Tyr)
n.54G>T
c.1291G>T (p.Asp431Tyr)
c.1588G>T (p.Asp530Tyr)
c.1570G>T (p.Asp524Tyr)
c.1279G>T (p.Asp427Tyr)
c.1207G>T (p.Asp403Tyr)
n.2073G>T
n.2012G>T
n.1966G>T
2g.25244271C=CA1239262939DNMT3Ac.54G=
c.881G= (n.881G=)
c.1066G= (p.Asp356=)
c.1735G= (p.Asp579=)
c.1168G= (p.Asp390=)
n.54G=
c.1291G= (p.Asp431=)
c.1588G= (p.Asp530=)
c.1570G= (p.Asp524=)
c.1279G= (p.Asp427=)
c.1207G= (p.Asp403=)
n.2073G=
n.2012G=
n.1966G=
2g.25244271C>GCA346071895DNMT3Ac.54G>C
c.881G>C (n.881G>C)
c.1066G>C (p.Asp356His)
c.1735G>C (p.Asp579His)
c.1168G>C (p.Asp390His)
n.54G>C
c.1291G>C (p.Asp431His)
c.1588G>C (p.Asp530His)
c.1570G>C (p.Asp524His)
c.1279G>C (p.Asp427His)
c.1207G>C (p.Asp403His)
n.2073G>C
n.2012G>C
n.1966G>C
2g.25244271C>TCA346071896DNMT3Ac.54G>A
c.881G>A (n.881G>A)
c.1066G>A (p.Asp356Asn)
c.1735G>A (p.Asp579Asn)
c.1168G>A (p.Asp390Asn)
n.54G>A
c.1291G>A (p.Asp431Asn)
c.1588G>A (p.Asp530Asn)
c.1570G>A (p.Asp524Asn)
c.1279G>A (p.Asp427Asn)
c.1207G>A (p.Asp403Asn)
n.2073G>A
n.2012G>A
n.1966G>A
2g.25244274_25244277delCA2576694324DNMT3Ac.51_54del
c.878_881del (n.878_881del)
c.1063_1066del (p.Glu355ThrfsTer?)
c.1732_1735del (p.Glu578ThrfsTer?)
c.1165_1168del (p.Glu389ThrfsTer?)
n.51_54del
c.1288_1291del (p.Glu430ThrfsTer?)
c.1585_1588del (p.Glu529ThrfsTer?)
c.1567_1570del (p.Glu523ThrfsTer?)
c.1276_1279del (p.Glu426ThrfsTer?)
c.1204_1207del (p.Glu402ThrfsTer?)
n.2070_2073del
n.2009_2012del
n.1963_1966del
 gnomAD v4
2g.25244273_25244288delCA2658168758DNMT3Ac.39_54del
c.866_881del (n.866_881del)
c.1051_1066del (p.Ala351ThrfsTer?)
c.1720_1735del (p.Ala574ThrfsTer?)
c.1153_1168del (p.Ala385ThrfsTer?)
n.39_54del
c.1276_1291del (p.Ala426ThrfsTer?)
c.1573_1588del (p.Ala525ThrfsTer?)
c.1555_1570del (p.Ala519ThrfsTer?)
c.1264_1279del (p.Ala422ThrfsTer?)
c.1192_1207del (p.Ala398ThrfsTer?)
n.2058_2073del
n.1997_2012del
n.1951_1966del
 gnomAD v4
2g.25244272T>ACA346071897DNMT3Ac.53A>T
c.880A>T (n.880A>T)
c.1065A>T (p.Glu355Asp)
c.1734A>T (p.Glu578Asp)
c.1167A>T (p.Glu389Asp)
n.53A>T
c.1290A>T (p.Glu430Asp)
c.1587A>T (p.Glu529Asp)
c.1569A>T (p.Glu523Asp)
c.1278A>T (p.Glu426Asp)
c.1206A>T (p.Glu402Asp)
n.2072A>T
n.2011A>T
n.1965A>T
2g.25244272T>CCA425182462DNMT3Ac.53A>G
c.880A>G (n.880A>G)
c.1065A>G (p.Glu355=)
c.1734A>G (p.Glu578=)
c.1167A>G (p.Glu389=)
n.53A>G
c.1290A>G (p.Glu430=)
c.1587A>G (p.Glu529=)
c.1569A>G (p.Glu523=)
c.1278A>G (p.Glu426=)
c.1206A>G (p.Glu402=)
n.2072A>G
n.2011A>G
n.1965A>G
 dbSNP gnomAD v2 gnomAD v4
2g.25244272T>GCA346071898DNMT3Ac.53A>C
c.880A>C (n.880A>C)
c.1065A>C (p.Glu355Asp)
c.1734A>C (p.Glu578Asp)
c.1167A>C (p.Glu389Asp)
n.53A>C
c.1290A>C (p.Glu430Asp)
c.1587A>C (p.Glu529Asp)
c.1569A>C (p.Glu523Asp)
c.1278A>C (p.Glu426Asp)
c.1206A>C (p.Glu402Asp)
n.2072A>C
n.2011A>C
n.1965A>C
2g.25244272T=CA1239262940DNMT3Ac.53A=
c.880A= (n.880A=)
c.1065A= (p.Glu355=)
c.1734A= (p.Glu578=)
c.1167A= (p.Glu389=)
n.53A=
c.1290A= (p.Glu430=)
c.1587A= (p.Glu529=)
c.1569A= (p.Glu523=)
c.1278A= (p.Glu426=)
c.1206A= (p.Glu402=)
n.2072A=
n.2011A=
n.1965A=
2g.25244273delCA2658168766DNMT3Ac.53del
c.880del (n.880del)
c.1065del (p.Asp356ThrfsTer?)
c.1734del (p.Asp579ThrfsTer?)
c.1167del (p.Asp390ThrfsTer?)
n.53del
c.1290del (p.Asp431ThrfsTer?)
c.1587del (p.Asp530ThrfsTer?)
c.1569del (p.Asp524ThrfsTer?)
c.1278del (p.Asp427ThrfsTer?)
c.1206del (p.Asp403ThrfsTer?)
n.2072del
n.2011del
n.1965del
 gnomAD v4
2g.25244273_25244277dupCA531760993DNMT3Ac.49_53dup
c.876_880dup (n.876_880dup)
c.1061_1065dup (p.Asp356ArgfsTer?)
c.1730_1734dup (p.Asp579ArgfsTer?)
c.1163_1167dup (p.Asp390ArgfsTer?)
n.49_53dup
c.1286_1290dup (p.Asp431ArgfsTer?)
c.1583_1587dup (p.Asp530ArgfsTer?)
c.1565_1569dup (p.Asp524ArgfsTer?)
c.1274_1278dup (p.Asp427ArgfsTer?)
c.1202_1206dup (p.Asp403ArgfsTer?)
n.2068_2072dup
n.2007_2011dup
n.1961_1965dup
 dbSNP gnomAD v2
2g.25244273T>ACA346071899DNMT3Ac.52A>T
c.879A>T (n.879A>T)
c.1064A>T (p.Glu355Val)
c.1733A>T (p.Glu578Val)
c.1166A>T (p.Glu389Val)
n.52A>T
c.1289A>T (p.Glu430Val)
c.1586A>T (p.Glu529Val)
c.1568A>T (p.Glu523Val)
c.1277A>T (p.Glu426Val)
c.1205A>T (p.Glu402Val)
n.2071A>T
n.2010A>T
n.1964A>T
2g.25244273T>CCA346071900DNMT3Ac.52A>G
c.879A>G (n.879A>G)
c.1064A>G (p.Glu355Gly)
c.1733A>G (p.Glu578Gly)
c.1166A>G (p.Glu389Gly)
n.52A>G
c.1289A>G (p.Glu430Gly)
c.1586A>G (p.Glu529Gly)
c.1568A>G (p.Glu523Gly)
c.1277A>G (p.Glu426Gly)
c.1205A>G (p.Glu402Gly)
n.2071A>G
n.2010A>G
n.1964A>G
2g.25244273T>GCA346071901DNMT3Ac.52A>C
c.879A>C (n.879A>C)
c.1064A>C (p.Glu355Ala)
c.1733A>C (p.Glu578Ala)
c.1166A>C (p.Glu389Ala)
n.52A>C
c.1289A>C (p.Glu430Ala)
c.1586A>C (p.Glu529Ala)
c.1568A>C (p.Glu523Ala)
c.1277A>C (p.Glu426Ala)
c.1205A>C (p.Glu402Ala)
n.2071A>C
n.2010A>C
n.1964A>C
2g.25244274_25244276delCA2576694325DNMT3Ac.50_52del
c.877_879del (n.877_879del)
c.1062_1064del (p.Glu355del)
c.1731_1733del (p.Glu578del)
c.1164_1166del (p.Glu389del)
n.50_52del
c.1287_1289del (p.Glu430del)
c.1584_1586del (p.Glu529del)
c.1566_1568del (p.Glu523del)
c.1275_1277del (p.Glu426del)
c.1203_1205del (p.Glu402del)
n.2069_2071del
n.2008_2010del
n.1962_1964del
2g.25244273_25244295delCA1028509799DNMT3Ac.30_52del
c.857_879del (n.857_879del)
c.1042_1064del (p.Ala348ArgfsTer?)
c.1711_1733del (p.Ala571ArgfsTer?)
c.1144_1166del (p.Ala382ArgfsTer?)
n.30_52del
c.1267_1289del (p.Ala423ArgfsTer?)
c.1564_1586del (p.Ala522ArgfsTer?)
c.1546_1568del (p.Ala516ArgfsTer?)
c.1255_1277del (p.Ala419ArgfsTer?)
c.1183_1205del (p.Ala395ArgfsTer?)
n.2049_2071del
n.1988_2010del
n.1942_1964del
 gnomAD v3 gnomAD v4
2g.25244274C>ACA346071904DNMT3Ac.51G>T
c.878G>T (n.878G>T)
c.1063G>T (p.Glu355Ter)
c.1732G>T (p.Glu578Ter)
c.1165G>T (p.Glu389Ter)
n.51G>T
c.1288G>T (p.Glu430Ter)
c.1585G>T (p.Glu529Ter)
c.1567G>T (p.Glu523Ter)
c.1276G>T (p.Glu426Ter)
c.1204G>T (p.Glu402Ter)
n.2070G>T
n.2009G>T
n.1963G>T
 dbSNP gnomAD v3 gnomAD v4
2g.25244274C=CA1239262945DNMT3Ac.51G=
c.878G= (n.878G=)
c.1063G= (p.Glu355=)
c.1732G= (p.Glu578=)
c.1165G= (p.Glu389=)
n.51G=
c.1288G= (p.Glu430=)
c.1585G= (p.Glu529=)
c.1567G= (p.Glu523=)
c.1276G= (p.Glu426=)
c.1204G= (p.Glu402=)
n.2070G=
n.2009G=
n.1963G=
2g.25244274C>GCA346071903DNMT3Ac.51G>C
c.878G>C (n.878G>C)
c.1063G>C (p.Glu355Gln)
c.1732G>C (p.Glu578Gln)
c.1165G>C (p.Glu389Gln)
n.51G>C
c.1288G>C (p.Glu430Gln)
c.1585G>C (p.Glu529Gln)
c.1567G>C (p.Glu523Gln)
c.1276G>C (p.Glu426Gln)
c.1204G>C (p.Glu402Gln)
n.2070G>C
n.2009G>C
n.1963G>C
 dbSNP gnomAD v4
2g.25244274C>TCA346071902DNMT3Ac.51G>A
c.878G>A (n.878G>A)
c.1063G>A (p.Glu355Lys)
c.1732G>A (p.Glu578Lys)
c.1165G>A (p.Glu389Lys)
n.51G>A
c.1288G>A (p.Glu430Lys)
c.1585G>A (p.Glu529Lys)
c.1567G>A (p.Glu523Lys)
c.1276G>A (p.Glu426Lys)
c.1204G>A (p.Glu402Lys)
n.2070G>A
n.2009G>A
n.1963G>A
2g.25244275dupCA2576694328DNMT3Ac.51dup
c.878dup (n.878dup)
c.1063dup (p.Glu355GlyfsTer?)
c.1732dup (p.Glu578GlyfsTer?)
c.1165dup (p.Glu389GlyfsTer?)
n.51dup
c.1288dup (p.Glu430GlyfsTer?)
c.1585dup (p.Glu529GlyfsTer?)
c.1567dup (p.Glu523GlyfsTer?)
c.1276dup (p.Glu426GlyfsTer?)
c.1204dup (p.Glu402GlyfsTer?)
n.2070dup
n.2009dup
n.1963dup
2g.25244275delCA2576694327DNMT3Ac.51del
c.878del (n.878del)
c.1063del (p.Glu355LysfsTer?)
c.1732del (p.Glu578LysfsTer?)
c.1165del (p.Glu389LysfsTer?)
n.51del
c.1288del (p.Glu430LysfsTer?)
c.1585del (p.Glu529LysfsTer?)
c.1567del (p.Glu523LysfsTer?)
c.1276del (p.Glu426LysfsTer?)
c.1204del (p.Glu402LysfsTer?)
n.2070del
n.2009del
n.1963del
 gnomAD v4
2g.25244277_25244288delCA2658168773DNMT3Ac.40_51del
c.867_878del (n.867_878del)
c.1052_1063del (p.Ala351_Lys354del)
c.1721_1732del (p.Ala574_Lys577del)
c.1154_1165del (p.Ala385_Lys388del)
n.40_51del
c.1277_1288del (p.Ala426_Lys429del)
c.1574_1585del (p.Ala525_Lys528del)
c.1556_1567del (p.Ala519_Lys522del)
c.1265_1276del (p.Ala422_Lys425del)
c.1193_1204del (p.Ala398_Lys401del)
n.2059_2070del
n.1998_2009del
n.1952_1963del
 gnomAD v4
2g.25244275C>ACA346071905DNMT3Ac.50G>T
c.877G>T (n.877G>T)
c.1062G>T (p.Lys354Asn)
c.1731G>T (p.Lys577Asn)
c.1164G>T (p.Lys388Asn)
n.50G>T
c.1287G>T (p.Lys429Asn)
c.1584G>T (p.Lys528Asn)
c.1566G>T (p.Lys522Asn)
c.1275G>T (p.Lys425Asn)
c.1203G>T (p.Lys401Asn)
n.2069G>T
n.2008G>T
n.1962G>T
2g.25244275C>GCA346071906DNMT3Ac.50G>C
c.877G>C (n.877G>C)
c.1062G>C (p.Lys354Asn)
c.1731G>C (p.Lys577Asn)
c.1164G>C (p.Lys388Asn)
n.50G>C
c.1287G>C (p.Lys429Asn)
c.1584G>C (p.Lys528Asn)
c.1566G>C (p.Lys522Asn)
c.1275G>C (p.Lys425Asn)
c.1203G>C (p.Lys401Asn)
n.2069G>C
n.2008G>C
n.1962G>C
2g.25244275C>TCA425182484DNMT3Ac.50G>A
c.877G>A (n.877G>A)
c.1062G>A (p.Lys354=)
c.1731G>A (p.Lys577=)
c.1164G>A (p.Lys388=)
n.50G>A
c.1287G>A (p.Lys429=)
c.1584G>A (p.Lys528=)
c.1566G>A (p.Lys522=)
c.1275G>A (p.Lys425=)
c.1203G>A (p.Lys401=)
n.2069G>A
n.2008G>A
n.1962G>A
 gnomAD v4
2g.25244275_25244276delinsCTCA1239262947DNMT3Ac.49_50delinsAG
c.876_877delinsAG (n.876_877delinsAG)
c.1061_1062delinsAG (p.Lys354=)
c.1730_1731delinsAG (p.Lys577=)
c.1163_1164delinsAG (p.Lys388=)
n.49_50delinsAG
c.1286_1287delinsAG (p.Lys429=)
c.1583_1584delinsAG (p.Lys528=)
c.1565_1566delinsAG (p.Lys522=)
c.1274_1275delinsAG (p.Lys425=)
c.1202_1203delinsAG (p.Lys401=)
n.2068_2069delinsAG
n.2007_2008delinsAG
n.1961_1962delinsAG
2g.25244276T>ACA346071907DNMT3Ac.49A>T
c.876A>T (n.876A>T)
c.1061A>T (p.Lys354Met)
c.1730A>T (p.Lys577Met)
c.1163A>T (p.Lys388Met)
n.49A>T
c.1286A>T (p.Lys429Met)
c.1583A>T (p.Lys528Met)
c.1565A>T (p.Lys522Met)
c.1274A>T (p.Lys425Met)
c.1202A>T (p.Lys401Met)
n.2068A>T
n.2007A>T
n.1961A>T
2g.25244276T>CCA346071908DNMT3Ac.49A>G
c.876A>G (n.876A>G)
c.1061A>G (p.Lys354Arg)
c.1730A>G (p.Lys577Arg)
c.1163A>G (p.Lys388Arg)
n.49A>G
c.1286A>G (p.Lys429Arg)
c.1583A>G (p.Lys528Arg)
c.1565A>G (p.Lys522Arg)
c.1274A>G (p.Lys425Arg)
c.1202A>G (p.Lys401Arg)
n.2068A>G
n.2007A>G
n.1961A>G
2g.25244276T>GCA346071909DNMT3Ac.49A>C
c.876A>C (n.876A>C)
c.1061A>C (p.Lys354Thr)
c.1730A>C (p.Lys577Thr)
c.1163A>C (p.Lys388Thr)
n.49A>C
c.1286A>C (p.Lys429Thr)
c.1583A>C (p.Lys528Thr)
c.1565A>C (p.Lys522Thr)
c.1274A>C (p.Lys425Thr)
c.1202A>C (p.Lys401Thr)
n.2068A>C
n.2007A>C
n.1961A>C
2g.25244276_25244277delCA2658168785DNMT3Ac.48_49del
c.875_876del (n.875_876del)
c.1060_1061del (p.Lys354GlyfsTer?)
c.1729_1730del (p.Lys577GlyfsTer?)
c.1162_1163del (p.Lys388GlyfsTer?)
n.48_49del
c.1285_1286del (p.Lys429GlyfsTer?)
c.1582_1583del (p.Lys528GlyfsTer?)
c.1564_1565del (p.Lys522GlyfsTer?)
c.1273_1274del (p.Lys425GlyfsTer?)
c.1201_1202del (p.Lys401GlyfsTer?)
n.2067_2068del
n.2006_2007del
n.1960_1961del
 gnomAD v4
2g.25244277delCA1555888DNMT3Ac.49del
c.876del (n.876del)
c.1061del (p.Lys354ArgfsTer?)
c.1730del (p.Lys577ArgfsTer?)
c.1163del (p.Lys388ArgfsTer?)
n.49del
c.1286del (p.Lys429ArgfsTer?)
c.1583del (p.Lys528ArgfsTer?)
c.1565del (p.Lys522ArgfsTer?)
c.1274del (p.Lys425ArgfsTer?)
c.1202del (p.Lys401ArgfsTer?)
n.2068del
n.2007del
n.1961del
 dbSNP ExAC gnomAD v2
2g.25244277_25244280delCA2576694330DNMT3Ac.46_49del
c.873_876del (n.873_876del)
c.1058_1061del (p.Ile353ArgfsTer?)
c.1727_1730del (p.Ile576ArgfsTer?)
c.1160_1163del (p.Ile387ArgfsTer?)
n.46_49del
c.1283_1286del (p.Ile428ArgfsTer?)
c.1580_1583del (p.Ile527ArgfsTer?)
c.1562_1565del (p.Ile521ArgfsTer?)
c.1271_1274del (p.Ile424ArgfsTer?)
c.1199_1202del (p.Ile400ArgfsTer?)
n.2065_2068del
n.2004_2007del
n.1958_1961del
2g.25244277T>ACA346071910DNMT3Ac.48A>T
c.875A>T (n.875A>T)
c.1060A>T (p.Lys354Ter)
c.1729A>T (p.Lys577Ter)
c.1162A>T (p.Lys388Ter)
n.48A>T
c.1285A>T (p.Lys429Ter)
c.1582A>T (p.Lys528Ter)
c.1564A>T (p.Lys522Ter)
c.1273A>T (p.Lys425Ter)
c.1201A>T (p.Lys401Ter)
n.2067A>T
n.2006A>T
n.1960A>T
 gnomAD v4 COSMIC
2g.25244277T>CCA346071911DNMT3Ac.48A>G
c.875A>G (n.875A>G)
c.1060A>G (p.Lys354Glu)
c.1729A>G (p.Lys577Glu)
c.1162A>G (p.Lys388Glu)
n.48A>G
c.1285A>G (p.Lys429Glu)
c.1582A>G (p.Lys528Glu)
c.1564A>G (p.Lys522Glu)
c.1273A>G (p.Lys425Glu)
c.1201A>G (p.Lys401Glu)
n.2067A>G
n.2006A>G
n.1960A>G
2g.25244277T>GCA346071912DNMT3Ac.48A>C
c.875A>C (n.875A>C)
c.1060A>C (p.Lys354Gln)
c.1729A>C (p.Lys577Gln)
c.1162A>C (p.Lys388Gln)
n.48A>C
c.1285A>C (p.Lys429Gln)
c.1582A>C (p.Lys528Gln)
c.1564A>C (p.Lys522Gln)
c.1273A>C (p.Lys425Gln)
c.1201A>C (p.Lys401Gln)
n.2067A>C
n.2006A>C
n.1960A>C
2g.25244277_25244296delCA2658168794DNMT3Ac.29_48del
c.856_875del (n.856_875del)
c.1041_1060del (p.Ala348GlyfsTer?)
c.1710_1729del (p.Ala571GlyfsTer?)
c.1143_1162del (p.Ala382GlyfsTer?)
n.29_48del
c.1266_1285del (p.Ala423GlyfsTer?)
c.1563_1582del (p.Ala522GlyfsTer?)
c.1545_1564del (p.Ala516GlyfsTer?)
c.1254_1273del (p.Ala419GlyfsTer?)
c.1182_1201del (p.Ala395GlyfsTer?)
n.2048_2067del
n.1987_2006del
n.1941_1960del
 gnomAD v4
2g.25244278A>CCA346071913DNMT3Ac.47T>G
c.874T>G (n.874T>G)
c.1059T>G (p.Ile353Met)
c.1728T>G (p.Ile576Met)
c.1161T>G (p.Ile387Met)
n.47T>G
c.1284T>G (p.Ile428Met)
c.1581T>G (p.Ile527Met)
c.1563T>G (p.Ile521Met)
c.1272T>G (p.Ile424Met)
c.1200T>G (p.Ile400Met)
n.2066T>G
n.2005T>G
n.1959T>G
2g.25244278A>GCA425182506DNMT3Ac.47T>C
c.874T>C (n.874T>C)
c.1059T>C (p.Ile353=)
c.1728T>C (p.Ile576=)
c.1161T>C (p.Ile387=)
n.47T>C
c.1284T>C (p.Ile428=)
c.1581T>C (p.Ile527=)
c.1563T>C (p.Ile521=)
c.1272T>C (p.Ile424=)
c.1200T>C (p.Ile400=)
n.2066T>C
n.2005T>C
n.1959T>C
2g.25244278A>TCA425182508DNMT3Ac.47T>A
c.874T>A (n.874T>A)
c.1059T>A (p.Ile353=)
c.1728T>A (p.Ile576=)
c.1161T>A (p.Ile387=)
n.47T>A
c.1284T>A (p.Ile428=)
c.1581T>A (p.Ile527=)
c.1563T>A (p.Ile521=)
c.1272T>A (p.Ile424=)
c.1200T>A (p.Ile400=)
n.2066T>A
n.2005T>A
n.1959T>A
2g.25244278_25244279delCA2658168798DNMT3Ac.46_47del
c.873_874del (n.873_874del)
c.1058_1059del (p.Ile353LysfsTer?)
c.1727_1728del (p.Ile576LysfsTer?)
c.1160_1161del (p.Ile387LysfsTer?)
n.46_47del
c.1283_1284del (p.Ile428LysfsTer?)
c.1580_1581del (p.Ile527LysfsTer?)
c.1562_1563del (p.Ile521LysfsTer?)
c.1271_1272del (p.Ile424LysfsTer?)
c.1199_1200del (p.Ile400LysfsTer?)
n.2065_2066del
n.2004_2005del
n.1958_1959del
 gnomAD v4
2g.25244278_25244285delCA2658168801DNMT3Ac.40_47del
c.867_874del (n.867_874del)
c.1052_1059del (p.Ala351GlufsTer?)
c.1721_1728del (p.Ala574GlufsTer?)
c.1154_1161del (p.Ala385GlufsTer?)
n.40_47del
c.1277_1284del (p.Ala426GlufsTer?)
c.1574_1581del (p.Ala525GlufsTer?)
c.1556_1563del (p.Ala519GlufsTer?)
c.1265_1272del (p.Ala422GlufsTer?)
c.1193_1200del (p.Ala398GlufsTer?)
n.2059_2066del
n.1998_2005del
n.1952_1959del
 gnomAD v4
2g.25244278_25244295delCA2497028955DNMT3Ac.30_47del
c.857_874del (n.857_874del)
c.1042_1059del (p.Ala348_Ile353del)
c.1711_1728del (p.Ala571_Ile576del)
c.1144_1161del (p.Ala382_Ile387del)
n.30_47del
c.1267_1284del (p.Ala423_Ile428del)
c.1564_1581del (p.Ala522_Ile527del)
c.1546_1563del (p.Ala516_Ile521del)
c.1255_1272del (p.Ala419_Ile424del)
c.1183_1200del (p.Ala395_Ile400del)
n.2049_2066del
n.1988_2005del
n.1942_1959del
2g.25244279A=CA1239262950DNMT3Ac.46T=
c.873T= (n.873T=)
c.1058T= (p.Ile353=)
c.1727T= (p.Ile576=)
c.1160T= (p.Ile387=)
n.46T=
c.1283T= (p.Ile428=)
c.1580T= (p.Ile527=)
c.1562T= (p.Ile521=)
c.1271T= (p.Ile424=)
c.1199T= (p.Ile400=)
n.2065T=
n.2004T=
n.1958T=
2g.25244279A>CCA346071914DNMT3Ac.46T>G
c.873T>G (n.873T>G)
c.1058T>G (p.Ile353Ser)
c.1727T>G (p.Ile576Ser)
c.1160T>G (p.Ile387Ser)
n.46T>G
c.1283T>G (p.Ile428Ser)
c.1580T>G (p.Ile527Ser)
c.1562T>G (p.Ile521Ser)
c.1271T>G (p.Ile424Ser)
c.1199T>G (p.Ile400Ser)
n.2065T>G
n.2004T>G
n.1958T>G
 dbSNP gnomAD v2 gnomAD v4
2g.25244279A>GCA346071915DNMT3Ac.46T>C
c.873T>C (n.873T>C)
c.1058T>C (p.Ile353Thr)
c.1727T>C (p.Ile576Thr)
c.1160T>C (p.Ile387Thr)
n.46T>C
c.1283T>C (p.Ile428Thr)
c.1580T>C (p.Ile527Thr)
c.1562T>C (p.Ile521Thr)
c.1271T>C (p.Ile424Thr)
c.1199T>C (p.Ile400Thr)
n.2065T>C
n.2004T>C
n.1958T>C
2g.25244279A>TCA346071916DNMT3Ac.46T>A
c.873T>A (n.873T>A)
c.1058T>A (p.Ile353Asn)
c.1727T>A (p.Ile576Asn)
c.1160T>A (p.Ile387Asn)
n.46T>A
c.1283T>A (p.Ile428Asn)
c.1580T>A (p.Ile527Asn)
c.1562T>A (p.Ile521Asn)
c.1271T>A (p.Ile424Asn)
c.1199T>A (p.Ile400Asn)
n.2065T>A
n.2004T>A
n.1958T>A
 gnomAD v4
2g.25244279_25244289delCA2658168810DNMT3Ac.36_46del
c.863_873del (n.863_873del)
c.1048_1058del (p.Gln350Ter)
c.1717_1727del (p.Gln573Ter)
c.1150_1160del (p.Gln384Ter)
n.36_46del
c.1273_1283del (p.Gln425Ter)
c.1570_1580del (p.Gln524Ter)
c.1552_1562del (p.Gln518Ter)
c.1261_1271del (p.Gln421Ter)
c.1189_1199del (p.Gln397Ter)
n.2055_2065del
n.1994_2004del
n.1948_1958del
 gnomAD v4
2g.25244280T>ACA346071919DNMT3Ac.45A>T
c.872A>T (n.872A>T)
c.1057A>T (p.Ile353Phe)
c.1726A>T (p.Ile576Phe)
c.1159A>T (p.Ile387Phe)
n.45A>T
c.1282A>T (p.Ile428Phe)
c.1579A>T (p.Ile527Phe)
c.1561A>T (p.Ile521Phe)
c.1270A>T (p.Ile424Phe)
c.1198A>T (p.Ile400Phe)
n.2064A>T
n.2003A>T
n.1957A>T
2g.25244280T>CCA346071917DNMT3Ac.45A>G
c.872A>G (n.872A>G)
c.1057A>G (p.Ile353Val)
c.1726A>G (p.Ile576Val)
c.1159A>G (p.Ile387Val)
n.45A>G
c.1282A>G (p.Ile428Val)
c.1579A>G (p.Ile527Val)
c.1561A>G (p.Ile521Val)
c.1270A>G (p.Ile424Val)
c.1198A>G (p.Ile400Val)
n.2064A>G
n.2003A>G
n.1957A>G
2g.25244280T>GCA346071918DNMT3Ac.45A>C
c.872A>C (n.872A>C)
c.1057A>C (p.Ile353Leu)
c.1726A>C (p.Ile576Leu)
c.1159A>C (p.Ile387Leu)
n.45A>C
c.1282A>C (p.Ile428Leu)
c.1579A>C (p.Ile527Leu)
c.1561A>C (p.Ile521Leu)
c.1270A>C (p.Ile424Leu)
c.1198A>C (p.Ile400Leu)
n.2064A>C
n.2003A>C
n.1957A>C
2g.25244280_25244289delinsTGGCTGCCTGCA1239262954DNMT3Ac.36_45delinsCAGGCAGCCA
c.863_872delinsCAGGCAGCCA (n.863_872delinsCAGGCAGCCA)
c.1048_1057delinsCAGGCAGCCA (p.Gln350=)
c.1717_1726delinsCAGGCAGCCA (p.Gln573=)
c.1150_1159delinsCAGGCAGCCA (p.Gln384=)
n.36_45delinsCAGGCAGCCA
c.1273_1282delinsCAGGCAGCCA (p.Gln425=)
c.1570_1579delinsCAGGCAGCCA (p.Gln524=)
c.1552_1561delinsCAGGCAGCCA (p.Gln518=)
c.1261_1270delinsCAGGCAGCCA (p.Gln421=)
c.1189_1198delinsCAGGCAGCCA (p.Gln397=)
n.2055_2064delinsCAGGCAGCCA
n.1994_2003delinsCAGGCAGCCA
n.1948_1957delinsCAGGCAGCCA
2g.25244280_25244298delCA645515202DNMT3Ac.27_45del
c.854_872del (n.854_872del)
c.1039_1057del (p.Gly347LeufsTer?)
c.1708_1726del (p.Gly570LeufsTer?)
c.1141_1159del (p.Gly381LeufsTer?)
n.27_45del
c.1264_1282del (p.Gly422LeufsTer?)
c.1561_1579del (p.Gly521LeufsTer?)
c.1543_1561del (p.Gly515LeufsTer?)
c.1252_1270del (p.Gly418LeufsTer?)
c.1180_1198del (p.Gly394LeufsTer?)
n.2046_2064del
n.1985_2003del
n.1939_1957del
 COSMIC COSMIC
2g.25244280_25244299delinsTGGCTGCCTGGGCAGCCCCCCA1239262956DNMT3Ac.26_45delinsGGGGGCTGCCCAGGCAGCCA
c.853_872delinsGGGGGCTGCCCAGGCAGCCA (n.853_872delinsGGGGGCTGCCCAGGCAGCCA)
c.1038_1057delinsGGGGGCTGCCCAGGCAGCCA (p.Pro346=)
c.1707_1726delinsGGGGGCTGCCCAGGCAGCCA (p.Pro569=)
c.1140_1159delinsGGGGGCTGCCCAGGCAGCCA (p.Pro380=)
n.26_45delinsGGGGGCTGCCCAGGCAGCCA
c.1263_1282delinsGGGGGCTGCCCAGGCAGCCA (p.Pro421=)
c.1560_1579delinsGGGGGCTGCCCAGGCAGCCA (p.Pro520=)
c.1542_1561delinsGGGGGCTGCCCAGGCAGCCA (p.Pro514=)
c.1251_1270delinsGGGGGCTGCCCAGGCAGCCA (p.Pro417=)
c.1179_1198delinsGGGGGCTGCCCAGGCAGCCA (p.Pro393=)
n.2045_2064delinsGGGGGCTGCCCAGGCAGCCA
n.1984_2003delinsGGGGGCTGCCCAGGCAGCCA
n.1938_1957delinsGGGGGCTGCCCAGGCAGCCA
2g.25244281G>ACA425182522DNMT3Ac.44C>T
c.871C>T (n.871C>T)
c.1056C>T (p.Ala352=)
c.1725C>T (p.Ala575=)
c.1158C>T (p.Ala386=)
n.44C>T
c.1281C>T (p.Ala427=)
c.1578C>T (p.Ala526=)
c.1560C>T (p.Ala520=)
c.1269C>T (p.Ala423=)
c.1197C>T (p.Ala399=)
n.2063C>T
n.2002C>T
n.1956C>T
2g.25244281G>CCA425182520DNMT3Ac.44C>G
c.871C>G (n.871C>G)
c.1056C>G (p.Ala352=)
c.1725C>G (p.Ala575=)
c.1158C>G (p.Ala386=)
n.44C>G
c.1281C>G (p.Ala427=)
c.1578C>G (p.Ala526=)
c.1560C>G (p.Ala520=)
c.1269C>G (p.Ala423=)
c.1197C>G (p.Ala399=)
n.2063C>G
n.2002C>G
n.1956C>G
2g.25244281G>TCA425182524DNMT3Ac.44C>A
c.871C>A (n.871C>A)
c.1056C>A (p.Ala352=)
c.1725C>A (p.Ala575=)
c.1158C>A (p.Ala386=)
n.44C>A
c.1281C>A (p.Ala427=)
c.1578C>A (p.Ala526=)
c.1560C>A (p.Ala520=)
c.1269C>A (p.Ala423=)
c.1197C>A (p.Ala399=)
n.2063C>A
n.2002C>A
n.1956C>A
2g.25244282delCA2658168817DNMT3Ac.44del
c.871del (n.871del)
c.1056del (p.Ile353LeufsTer?)
c.1725del (p.Ile576LeufsTer?)
c.1158del (p.Ile387LeufsTer?)
n.44del
c.1281del (p.Ile428LeufsTer?)
c.1578del (p.Ile527LeufsTer?)
c.1560del (p.Ile521LeufsTer?)
c.1269del (p.Ile424LeufsTer?)
c.1197del (p.Ile400LeufsTer?)
n.2063del
n.2002del
n.1956del
 gnomAD v4
2g.25244284_25244292delCA531760994DNMT3Ac.36_44del
c.863_871del (n.863_871del)
c.1048_1056del (p.Gln350_Ala352del)
c.1717_1725del (p.Gln573_Ala575del)
c.1150_1158del (p.Gln384_Ala386del)
n.36_44del
c.1273_1281del (p.Gln425_Ala427del)
c.1570_1578del (p.Gln524_Ala526del)
c.1552_1560del (p.Gln518_Ala520del)
c.1261_1269del (p.Gln421_Ala423del)
c.1189_1197del (p.Gln397_Ala399del)
n.2055_2063del
n.1994_2002del
n.1948_1956del
 dbSNP gnomAD v2 COSMIC COSMIC
2g.25244281_25244295delCA425182519DNMT3Ac.30_44del
c.857_871del (n.857_871del)
c.1042_1056del (p.Ala348_Ala352del)
c.1711_1725del (p.Ala571_Ala575del)
c.1144_1158del (p.Ala382_Ala386del)
n.30_44del
c.1267_1281del (p.Ala423_Ala427del)
c.1564_1578del (p.Ala522_Ala526del)
c.1546_1560del (p.Ala516_Ala520del)
c.1255_1269del (p.Ala419_Ala423del)
c.1183_1197del (p.Ala395_Ala399del)
n.2049_2063del
n.1988_2002del
n.1942_1956del
 gnomAD v4
2g.25244284_25244302delCA1555889DNMT3Ac.26_44del
c.853_871del (n.853_871del)
c.1038_1056del (p.Gly347LeufsTer?)
c.1707_1725del (p.Gly570LeufsTer?)
c.1140_1158del (p.Gly381LeufsTer?)
n.26_44del
c.1263_1281del (p.Gly422LeufsTer?)
c.1560_1578del (p.Gly521LeufsTer?)
c.1542_1560del (p.Gly515LeufsTer?)
c.1251_1269del (p.Gly418LeufsTer?)
c.1179_1197del (p.Gly394LeufsTer?)
n.2045_2063del
n.1984_2002del
n.1938_1956del
 dbSNP ExAC gnomAD v4
2g.25244282G>ACA346071920DNMT3Ac.43C>T
c.870C>T (n.870C>T)
c.1055C>T (p.Ala352Val)
c.1724C>T (p.Ala575Val)
c.1157C>T (p.Ala386Val)
n.43C>T
c.1280C>T (p.Ala427Val)
c.1577C>T (p.Ala526Val)
c.1559C>T (p.Ala520Val)
c.1268C>T (p.Ala423Val)
c.1196C>T (p.Ala399Val)
n.2062C>T
n.2001C>T
n.1955C>T
 dbSNP gnomAD v4
2g.25244282G>CCA346071921DNMT3Ac.43C>G
c.870C>G (n.870C>G)
c.1055C>G (p.Ala352Gly)
c.1724C>G (p.Ala575Gly)
c.1157C>G (p.Ala386Gly)
n.43C>G
c.1280C>G (p.Ala427Gly)
c.1577C>G (p.Ala526Gly)
c.1559C>G (p.Ala520Gly)
c.1268C>G (p.Ala423Gly)
c.1196C>G (p.Ala399Gly)
n.2062C>G
n.2001C>G
n.1955C>G
 dbSNP
2g.25244282G>TCA346071922DNMT3Ac.43C>A
c.870C>A (n.870C>A)
c.1055C>A (p.Ala352Asp)
c.1724C>A (p.Ala575Asp)
c.1157C>A (p.Ala386Asp)
n.43C>A
c.1280C>A (p.Ala427Asp)
c.1577C>A (p.Ala526Asp)
c.1559C>A (p.Ala520Asp)
c.1268C>A (p.Ala423Asp)
c.1196C>A (p.Ala399Asp)
n.2062C>A
n.2001C>A
n.1955C>A
2g.25244282_25244303delCA2658168824DNMT3Ac.22_43del
c.849_870del (n.849_870del)
c.1034_1055del (p.Gly345AlafsTer?)
c.1703_1724del (p.Gly568AlafsTer?)
c.1136_1157del (p.Gly379AlafsTer?)
n.22_43del
c.1259_1280del (p.Gly420AlafsTer?)
c.1556_1577del (p.Gly519AlafsTer?)
c.1538_1559del (p.Gly513AlafsTer?)
c.1247_1268del (p.Gly416AlafsTer?)
c.1175_1196del (p.Gly392AlafsTer?)
n.2041_2062del
n.1980_2001del
n.1934_1955del
 gnomAD v4
2g.25244283delCA645515203DNMT3Ac.42del
c.869del (n.869del)
c.1054del (p.Ala352ProfsTer?)
c.1723del (p.Ala575ProfsTer?)
c.1156del (p.Ala386ProfsTer?)
n.42del
c.1279del (p.Ala427ProfsTer?)
c.1576del (p.Ala526ProfsTer?)
c.1558del (p.Ala520ProfsTer?)
c.1267del (p.Ala423ProfsTer?)
c.1195del (p.Ala399ProfsTer?)
n.2061del
n.2000del
n.1954del
 COSMIC COSMIC
2g.25244283C>ACA346071923DNMT3Ac.42G>T
c.869G>T (n.869G>T)
c.1054G>T (p.Ala352Ser)
c.1723G>T (p.Ala575Ser)
c.1156G>T (p.Ala386Ser)
n.42G>T
c.1279G>T (p.Ala427Ser)
c.1576G>T (p.Ala526Ser)
c.1558G>T (p.Ala520Ser)
c.1267G>T (p.Ala423Ser)
c.1195G>T (p.Ala399Ser)
n.2061G>T
n.2000G>T
n.1954G>T
2g.25244283C=CA1239262963DNMT3Ac.42G=
c.869G= (n.869G=)
c.1054G= (p.Ala352=)
c.1723G= (p.Ala575=)
c.1156G= (p.Ala386=)
n.42G=
c.1279G= (p.Ala427=)
c.1576G= (p.Ala526=)
c.1558G= (p.Ala520=)
c.1267G= (p.Ala423=)
c.1195G= (p.Ala399=)
n.2061G=
n.2000G=
n.1954G=
2g.25244283C>GCA346071924DNMT3Ac.42G>C
c.869G>C (n.869G>C)
c.1054G>C (p.Ala352Pro)
c.1723G>C (p.Ala575Pro)
c.1156G>C (p.Ala386Pro)
n.42G>C
c.1279G>C (p.Ala427Pro)
c.1576G>C (p.Ala526Pro)
c.1558G>C (p.Ala520Pro)
c.1267G>C (p.Ala423Pro)
c.1195G>C (p.Ala399Pro)
n.2061G>C
n.2000G>C
n.1954G>C
 gnomAD v4
2g.25244283C>TCA346071925DNMT3Ac.42G>A
c.869G>A (n.869G>A)
c.1054G>A (p.Ala352Thr)
c.1723G>A (p.Ala575Thr)
c.1156G>A (p.Ala386Thr)
n.42G>A
c.1279G>A (p.Ala427Thr)
c.1576G>A (p.Ala526Thr)
c.1558G>A (p.Ala520Thr)
c.1267G>A (p.Ala423Thr)
c.1195G>A (p.Ala399Thr)
n.2061G>A
n.2000G>A
n.1954G>A
 dbSNP gnomAD v3 gnomAD v4
2g.25244286_25244289delCA2658168831DNMT3Ac.39_42del
c.866_869del (n.866_869del)
c.1051_1054del (p.Ala351ProfsTer?)
c.1720_1723del (p.Ala574ProfsTer?)
c.1153_1156del (p.Ala385ProfsTer?)
n.39_42del
c.1276_1279del (p.Ala426ProfsTer?)
c.1573_1576del (p.Ala525ProfsTer?)
c.1555_1558del (p.Ala519ProfsTer?)
c.1264_1267del (p.Ala422ProfsTer?)
c.1192_1195del (p.Ala398ProfsTer?)
n.2058_2061del
n.1997_2000del
n.1951_1954del
 gnomAD v4
2g.25244284_25244296delCA2658168833DNMT3Ac.30_42del
c.857_869del (n.857_869del)
c.1042_1054del (p.Ala348ProfsTer?)
c.1711_1723del (p.Ala571ProfsTer?)
c.1144_1156del (p.Ala382ProfsTer?)
n.30_42del
c.1267_1279del (p.Ala423ProfsTer?)
c.1564_1576del (p.Ala522ProfsTer?)
c.1546_1558del (p.Ala516ProfsTer?)
c.1255_1267del (p.Ala419ProfsTer?)
c.1183_1195del (p.Ala395ProfsTer?)
n.2049_2061del
n.1988_2000del
n.1942_1954del
 gnomAD v4
2g.25244284delCA2658168844DNMT3Ac.41del
c.868del (n.868del)
c.1053del (p.Ala352ProfsTer?)
c.1722del (p.Ala575ProfsTer?)
c.1155del (p.Ala386ProfsTer?)
n.41del
c.1278del (p.Ala427ProfsTer?)
c.1575del (p.Ala526ProfsTer?)
c.1557del (p.Ala520ProfsTer?)
c.1266del (p.Ala423ProfsTer?)
c.1194del (p.Ala399ProfsTer?)
n.2060del
n.1999del
n.1953del
 gnomAD v4
2g.25244284T>ACA425182528DNMT3Ac.41A>T
c.868A>T (n.868A>T)
c.1053A>T (p.Ala351=)
c.1722A>T (p.Ala574=)
c.1155A>T (p.Ala385=)
n.41A>T
c.1278A>T (p.Ala426=)
c.1575A>T (p.Ala525=)
c.1557A>T (p.Ala519=)
c.1266A>T (p.Ala422=)
c.1194A>T (p.Ala398=)
n.2060A>T
n.1999A>T
n.1953A>T
2g.25244284T>CCA425182532DNMT3Ac.41A>G
c.868A>G (n.868A>G)
c.1053A>G (p.Ala351=)
c.1722A>G (p.Ala574=)
c.1155A>G (p.Ala385=)
n.41A>G
c.1278A>G (p.Ala426=)
c.1575A>G (p.Ala525=)
c.1557A>G (p.Ala519=)
c.1266A>G (p.Ala422=)
c.1194A>G (p.Ala398=)
n.2060A>G
n.1999A>G
n.1953A>G
 gnomAD v4
2g.25244284T>GCA425182530DNMT3Ac.41A>C
c.868A>C (n.868A>C)
c.1053A>C (p.Ala351=)
c.1722A>C (p.Ala574=)
c.1155A>C (p.Ala385=)
n.41A>C
c.1278A>C (p.Ala426=)
c.1575A>C (p.Ala525=)
c.1557A>C (p.Ala519=)
c.1266A>C (p.Ala422=)
c.1194A>C (p.Ala398=)
n.2060A>C
n.1999A>C
n.1953A>C
 dbSNP
2g.25244284T=CA1239262967DNMT3Ac.41A=
c.868A= (n.868A=)
c.1053A= (p.Ala351=)
c.1722A= (p.Ala574=)
c.1155A= (p.Ala385=)
n.41A=
c.1278A= (p.Ala426=)
c.1575A= (p.Ala525=)
c.1557A= (p.Ala519=)
c.1266A= (p.Ala422=)
c.1194A= (p.Ala398=)
n.2060A=
n.1999A=
n.1953A=
2g.25244284_25244293delinsTGCCTGGGCACA1239262966DNMT3Ac.32_41delinsTGCCCAGGCA
c.859_868delinsTGCCCAGGCA (n.859_868delinsTGCCCAGGCA)
c.1044_1053delinsTGCCCAGGCA (p.Ala348=)
c.1713_1722delinsTGCCCAGGCA (p.Ala571=)
c.1146_1155delinsTGCCCAGGCA (p.Ala382=)
n.32_41delinsTGCCCAGGCA
c.1269_1278delinsTGCCCAGGCA (p.Ala423=)
c.1566_1575delinsTGCCCAGGCA (p.Ala522=)
c.1548_1557delinsTGCCCAGGCA (p.Ala516=)
c.1257_1266delinsTGCCCAGGCA (p.Ala419=)
c.1185_1194delinsTGCCCAGGCA (p.Ala395=)
n.2051_2060delinsTGCCCAGGCA
n.1990_1999delinsTGCCCAGGCA
n.1944_1953delinsTGCCCAGGCA
2g.25244285delCA2576694332DNMT3Ac.40del
c.867del (n.867del)
c.1052del (p.Ala351GlufsTer?)
c.1721del (p.Ala574GlufsTer?)
c.1154del (p.Ala385GlufsTer?)
n.40del
c.1277del (p.Ala426GlufsTer?)
c.1574del (p.Ala525GlufsTer?)
c.1556del (p.Ala519GlufsTer?)
c.1265del (p.Ala422GlufsTer?)
c.1193del (p.Ala398GlufsTer?)
n.2059del
n.1998del
n.1952del
 gnomAD v4
2g.25244285G>ACA346071926DNMT3Ac.40C>T
c.867C>T (n.867C>T)
c.1052C>T (p.Ala351Val)
c.1721C>T (p.Ala574Val)
c.1154C>T (p.Ala385Val)
n.40C>T
c.1277C>T (p.Ala426Val)
c.1574C>T (p.Ala525Val)
c.1556C>T (p.Ala519Val)
c.1265C>T (p.Ala422Val)
c.1193C>T (p.Ala398Val)
n.2059C>T
n.1998C>T
n.1952C>T
2g.25244285G>CCA346071927DNMT3Ac.40C>G
c.867C>G (n.867C>G)
c.1052C>G (p.Ala351Gly)
c.1721C>G (p.Ala574Gly)
c.1154C>G (p.Ala385Gly)
n.40C>G
c.1277C>G (p.Ala426Gly)
c.1574C>G (p.Ala525Gly)
c.1556C>G (p.Ala519Gly)
c.1265C>G (p.Ala422Gly)
c.1193C>G (p.Ala398Gly)
n.2059C>G
n.1998C>G
n.1952C>G
2g.25244285G>TCA346071928DNMT3Ac.40C>A
c.867C>A (n.867C>A)
c.1052C>A (p.Ala351Glu)
c.1721C>A (p.Ala574Glu)
c.1154C>A (p.Ala385Glu)
n.40C>A
c.1277C>A (p.Ala426Glu)
c.1574C>A (p.Ala525Glu)
c.1556C>A (p.Ala519Glu)
c.1265C>A (p.Ala422Glu)
c.1193C>A (p.Ala398Glu)
n.2059C>A
n.1998C>A
n.1952C>A
2g.25244285_25244292delCA915940699DNMT3Ac.33_40del
c.860_867del (n.860_867del)
c.1045_1052del (p.Ala349SerfsTer3)
c.1714_1721del (p.Ala572SerfsTer3)
c.1147_1154del (p.Ala383SerfsTer3)
n.33_40del
c.1270_1277del (p.Ala424SerfsTer3)
c.1567_1574del (p.Ala523SerfsTer3)
c.1549_1556del (p.Ala517SerfsTer3)
c.1258_1265del (p.Ala420SerfsTer3)
c.1186_1193del (p.Ala396SerfsTer3)
n.2052_2059del
n.1991_1998del
n.1945_1952del
2g.25244285_25244295delinsACA915940458DNMT3Ac.30_40delinsT
c.857_867delinsT (n.857_867delinsT)
c.1042_1052delinsT (p.Ala348Ter)
c.1711_1721delinsT (p.Ala571Ter)
c.1144_1154delinsT (p.Ala382Ter)
n.30_40delinsT
c.1267_1277delinsT (p.Ala423Ter)
c.1564_1574delinsT (p.Ala522Ter)
c.1546_1556delinsT (p.Ala516Ter)
c.1255_1265delinsT (p.Ala419Ter)
c.1183_1193delinsT (p.Ala395Ter)
n.2049_2059delinsT
n.1988_1998delinsT
n.1942_1952delinsT
2g.25244288_25244296delCA1555890DNMT3Ac.32_40del
c.859_867del (n.859_867del)
c.1044_1052del (p.Ala349_Ala351del)
c.1713_1721del (p.Ala572_Ala574del)
c.1146_1154del (p.Ala383_Ala385del)
n.32_40del
c.1269_1277del (p.Ala424_Ala426del)
c.1566_1574del (p.Ala523_Ala525del)
c.1548_1556del (p.Ala517_Ala519del)
c.1257_1265del (p.Ala420_Ala422del)
c.1185_1193del (p.Ala396_Ala398del)
n.2051_2059del
n.1990_1998del
n.1944_1952del
 dbSNP ExAC gnomAD v2 gnomAD v3 gnomAD v4 COSMIC
2g.25244286C>ACA346071931DNMT3Ac.39G>T
c.866G>T (n.866G>T)
c.1051G>T (p.Ala351Ser)
c.1720G>T (p.Ala574Ser)
c.1153G>T (p.Ala385Ser)
n.39G>T
c.1276G>T (p.Ala426Ser)
c.1573G>T (p.Ala525Ser)
c.1555G>T (p.Ala519Ser)
c.1264G>T (p.Ala422Ser)
c.1192G>T (p.Ala398Ser)
n.2058G>T
n.1997G>T
n.1951G>T
2g.25244286C=CA1239262972DNMT3Ac.39G=
c.866G= (n.866G=)
c.1051G= (p.Ala351=)
c.1720G= (p.Ala574=)
c.1153G= (p.Ala385=)
n.39G=
c.1276G= (p.Ala426=)
c.1573G= (p.Ala525=)
c.1555G= (p.Ala519=)
c.1264G= (p.Ala422=)
c.1192G= (p.Ala398=)
n.2058G=
n.1997G=
n.1951G=
2g.25244286C>GCA346071929DNMT3Ac.39G>C
c.866G>C (n.866G>C)
c.1051G>C (p.Ala351Pro)
c.1720G>C (p.Ala574Pro)
c.1153G>C (p.Ala385Pro)
n.39G>C
c.1276G>C (p.Ala426Pro)
c.1573G>C (p.Ala525Pro)
c.1555G>C (p.Ala519Pro)
c.1264G>C (p.Ala422Pro)
c.1192G>C (p.Ala398Pro)
n.2058G>C
n.1997G>C
n.1951G>C
 dbSNP
2g.25244286C>TCA346071930DNMT3Ac.39G>A
c.866G>A (n.866G>A)
c.1051G>A (p.Ala351Thr)
c.1720G>A (p.Ala574Thr)
c.1153G>A (p.Ala385Thr)
n.39G>A
c.1276G>A (p.Ala426Thr)
c.1573G>A (p.Ala525Thr)
c.1555G>A (p.Ala519Thr)
c.1264G>A (p.Ala422Thr)
c.1192G>A (p.Ala398Thr)
n.2058G>A
n.1997G>A
n.1951G>A
 dbSNP
2g.25244287delCA2658168854DNMT3Ac.39del
c.866del (n.866del)
c.1051del (p.Ala351GlnfsTer?)
c.1720del (p.Ala574GlnfsTer?)
c.1153del (p.Ala385GlnfsTer?)
n.39del
c.1276del (p.Ala426GlnfsTer?)
c.1573del (p.Ala525GlnfsTer?)
c.1555del (p.Ala519GlnfsTer?)
c.1264del (p.Ala422GlnfsTer?)
c.1192del (p.Ala398GlnfsTer?)
n.2058del
n.1997del
n.1951del
 gnomAD v4
2g.25244288_25244297delCA2658168855DNMT3Ac.30_39del
c.857_866del (n.857_866del)
c.1042_1051del (p.Ala348GlnfsTer?)
c.1711_1720del (p.Ala571GlnfsTer?)
c.1144_1153del (p.Ala382GlnfsTer?)
n.30_39del
c.1267_1276del (p.Ala423GlnfsTer?)
c.1564_1573del (p.Ala522GlnfsTer?)
c.1546_1555del (p.Ala516GlnfsTer?)
c.1255_1264del (p.Ala419GlnfsTer?)
c.1183_1192del (p.Ala395GlnfsTer?)
n.2049_2058del
n.1988_1997del
n.1942_1951del
 gnomAD v4
2g.25244286_25244287insTTTTTTACA1239262976DNMT3Ac.38_39insTAAAAAA
c.865_866insTAAAAAA (n.865_866insTAAAAAA)
c.1050_1051insTAAAAAA (p.Ala351Ter)
c.1719_1720insTAAAAAA (p.Ala574Ter)
c.1152_1153insTAAAAAA (p.Ala385Ter)
n.38_39insTAAAAAA
c.1275_1276insTAAAAAA (p.Ala426Ter)
c.1572_1573insTAAAAAA (p.Ala525Ter)
c.1554_1555insTAAAAAA (p.Ala519Ter)
c.1263_1264insTAAAAAA (p.Ala422Ter)
c.1191_1192insTAAAAAA (p.Ala398Ter)
n.2057_2058insTAAAAAA
n.1996_1997insTAAAAAA
n.1950_1951insTAAAAAA
 dbSNP
2g.25244287C>ACA346071932DNMT3Ac.38G>T
c.865G>T (n.865G>T)
c.1050G>T (p.Gln350His)
c.1719G>T (p.Gln573His)
c.1152G>T (p.Gln384His)
n.38G>T
c.1275G>T (p.Gln425His)
c.1572G>T (p.Gln524His)
c.1554G>T (p.Gln518His)
c.1263G>T (p.Gln421His)
c.1191G>T (p.Gln397His)
n.2057G>T
n.1996G>T
n.1950G>T
 dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244287C=CA1239262980DNMT3Ac.38G=
c.865G= (n.865G=)
c.1050G= (p.Gln350=)
c.1719G= (p.Gln573=)
c.1152G= (p.Gln384=)
n.38G=
c.1275G= (p.Gln425=)
c.1572G= (p.Gln524=)
c.1554G= (p.Gln518=)
c.1263G= (p.Gln421=)
c.1191G= (p.Gln397=)
n.2057G=
n.1996G=
n.1950G=
2g.25244287C>GCA346071933DNMT3Ac.38G>C
c.865G>C (n.865G>C)
c.1050G>C (p.Gln350His)
c.1719G>C (p.Gln573His)
c.1152G>C (p.Gln384His)
n.38G>C
c.1275G>C (p.Gln425His)
c.1572G>C (p.Gln524His)
c.1554G>C (p.Gln518His)
c.1263G>C (p.Gln421His)
c.1191G>C (p.Gln397His)
n.2057G>C
n.1996G>C
n.1950G>C
2g.25244287C>TCA425182554DNMT3Ac.38G>A
c.865G>A (n.865G>A)
c.1050G>A (p.Gln350=)
c.1719G>A (p.Gln573=)
c.1152G>A (p.Gln384=)
n.38G>A
c.1275G>A (p.Gln425=)
c.1572G>A (p.Gln524=)
c.1554G>A (p.Gln518=)
c.1263G>A (p.Gln421=)
c.1191G>A (p.Gln397=)
n.2057G>A
n.1996G>A
n.1950G>A
2g.25244287_25244293delCA2658168859DNMT3Ac.32_38del
c.859_865del (n.859_865del)
c.1044_1050del (p.Ala349GlnfsTer?)
c.1713_1719del (p.Ala572GlnfsTer?)
c.1146_1152del (p.Ala383GlnfsTer?)
n.32_38del
c.1269_1275del (p.Ala424GlnfsTer?)
c.1566_1572del (p.Ala523GlnfsTer?)
c.1548_1554del (p.Ala517GlnfsTer?)
c.1257_1263del (p.Ala420GlnfsTer?)
c.1185_1191del (p.Ala396GlnfsTer?)
n.2051_2057del
n.1990_1996del
n.1944_1950del
 gnomAD v4
2g.25244287_25244294delinsCTGGGCAGCA1239262977DNMT3Ac.31_38delinsCTGCCCAG
c.858_865delinsCTGCCCAG (n.858_865delinsCTGCCCAG)
c.1043_1050delinsCTGCCCAG (p.Ala348=)
c.1712_1719delinsCTGCCCAG (p.Ala571=)
c.1145_1152delinsCTGCCCAG (p.Ala382=)
n.31_38delinsCTGCCCAG
c.1268_1275delinsCTGCCCAG (p.Ala423=)
c.1565_1572delinsCTGCCCAG (p.Ala522=)
c.1547_1554delinsCTGCCCAG (p.Ala516=)
c.1256_1263delinsCTGCCCAG (p.Ala419=)
c.1184_1191delinsCTGCCCAG (p.Ala395=)
n.2050_2057delinsCTGCCCAG
n.1989_1996delinsCTGCCCAG
n.1943_1950delinsCTGCCCAG
2g.25244288_25244295delCA2576694334DNMT3Ac.31_38del
c.858_865del (n.858_865del)
c.1043_1050del (p.Ala348GlyfsTer4)
c.1712_1719del (p.Ala571GlyfsTer4)
c.1145_1152del (p.Ala382GlyfsTer4)
n.31_38del
c.1268_1275del (p.Ala423GlyfsTer4)
c.1565_1572del (p.Ala522GlyfsTer4)
c.1547_1554del (p.Ala516GlyfsTer4)
c.1256_1263del (p.Ala419GlyfsTer4)
c.1184_1191del (p.Ala395GlyfsTer4)
n.2050_2057del
n.1989_1996del
n.1943_1950del
 gnomAD v4
2g.25244287_25244288insCACA2658168867DNMT3Ac.37_38insTG
c.864_865insTG (n.864_865insTG)
c.1049_1050insTG (p.Gln350HisfsTer?)
c.1718_1719insTG (p.Gln573HisfsTer?)
c.1151_1152insTG (p.Gln384HisfsTer?)
n.37_38insTG
c.1274_1275insTG (p.Gln425HisfsTer?)
c.1571_1572insTG (p.Gln524HisfsTer?)
c.1553_1554insTG (p.Gln518HisfsTer?)
c.1262_1263insTG (p.Gln421HisfsTer?)
c.1190_1191insTG (p.Gln397HisfsTer?)
n.2056_2057insTG
n.1995_1996insTG
n.1949_1950insTG
 gnomAD v4
2g.25244288T>ACA346071934DNMT3Ac.37A>T
c.864A>T (n.864A>T)
c.1049A>T (p.Gln350Leu)
c.1718A>T (p.Gln573Leu)
c.1151A>T (p.Gln384Leu)
n.37A>T
c.1274A>T (p.Gln425Leu)
c.1571A>T (p.Gln524Leu)
c.1553A>T (p.Gln518Leu)
c.1262A>T (p.Gln421Leu)
c.1190A>T (p.Gln397Leu)
n.2056A>T
n.1995A>T
n.1949A>T
2g.25244288T>CCA346071935DNMT3Ac.37A>G
c.864A>G (n.864A>G)
c.1049A>G (p.Gln350Arg)
c.1718A>G (p.Gln573Arg)
c.1151A>G (p.Gln384Arg)
n.37A>G
c.1274A>G (p.Gln425Arg)
c.1571A>G (p.Gln524Arg)
c.1553A>G (p.Gln518Arg)
c.1262A>G (p.Gln421Arg)
c.1190A>G (p.Gln397Arg)
n.2056A>G
n.1995A>G
n.1949A>G
2g.25244288T>GCA346071936DNMT3Ac.37A>C
c.864A>C (n.864A>C)
c.1049A>C (p.Gln350Pro)
c.1718A>C (p.Gln573Pro)
c.1151A>C (p.Gln384Pro)
n.37A>C
c.1274A>C (p.Gln425Pro)
c.1571A>C (p.Gln524Pro)
c.1553A>C (p.Gln518Pro)
c.1262A>C (p.Gln421Pro)
c.1190A>C (p.Gln397Pro)
n.2056A>C
n.1995A>C
n.1949A>C
2g.25244288_25244290delCA2658168869DNMT3Ac.35_37del
c.862_864del (n.862_864del)
c.1047_1049del (p.Gln350del)
c.1716_1718del (p.Gln573del)
c.1149_1151del (p.Gln384del)
n.35_37del
c.1272_1274del (p.Gln425del)
c.1569_1571del (p.Gln524del)
c.1551_1553del (p.Gln518del)
c.1260_1262del (p.Gln421del)
c.1188_1190del (p.Gln397del)
n.2054_2056del
n.1993_1995del
n.1947_1949del
 gnomAD v4
2g.25244288_25244294delCA1555891DNMT3Ac.31_37del
c.858_864del (n.858_864del)
c.1043_1049del (p.Ala348GlyfsTer?)
c.1712_1718del (p.Ala571GlyfsTer?)
c.1145_1151del (p.Ala382GlyfsTer?)
n.31_37del
c.1268_1274del (p.Ala423GlyfsTer?)
c.1565_1571del (p.Ala522GlyfsTer?)
c.1547_1553del (p.Ala516GlyfsTer?)
c.1256_1262del (p.Ala419GlyfsTer?)
c.1184_1190del (p.Ala395GlyfsTer?)
n.2050_2056del
n.1989_1995del
n.1943_1949del
 dbSNP ExAC gnomAD v2 gnomAD v4
2g.25244289G>ACA43703403DNMT3Ac.36C>T
c.863C>T (n.863C>T)
c.1048C>T (p.Gln350Ter)
c.1717C>T (p.Gln573Ter)
c.1150C>T (p.Gln384Ter)
n.36C>T
c.1273C>T (p.Gln425Ter)
c.1570C>T (p.Gln524Ter)
c.1552C>T (p.Gln518Ter)
c.1261C>T (p.Gln421Ter)
c.1189C>T (p.Gln397Ter)
n.2055C>T
n.1994C>T
n.1948C>T
 dbSNP gnomAD v2 gnomAD v4 COSMIC COSMIC
2g.25244289G>CCA346071937DNMT3Ac.36C>G
c.863C>G (n.863C>G)
c.1048C>G (p.Gln350Glu)
c.1717C>G (p.Gln573Glu)
c.1150C>G (p.Gln384Glu)
n.36C>G
c.1273C>G (p.Gln425Glu)
c.1570C>G (p.Gln524Glu)
c.1552C>G (p.Gln518Glu)
c.1261C>G (p.Gln421Glu)
c.1189C>G (p.Gln397Glu)
n.2055C>G
n.1994C>G
n.1948C>G
2g.25244289G=CA1239262985DNMT3Ac.36C=
c.863C= (n.863C=)
c.1048C= (p.Gln350=)
c.1717C= (p.Gln573=)
c.1150C= (p.Gln384=)
n.36C=
c.1273C= (p.Gln425=)
c.1570C= (p.Gln524=)
c.1552C= (p.Gln518=)
c.1261C= (p.Gln421=)
c.1189C= (p.Gln397=)
n.2055C=
n.1994C=
n.1948C=
2g.25244289G>TCA346071938DNMT3Ac.36C>A
c.863C>A (n.863C>A)
c.1048C>A (p.Gln350Lys)
c.1717C>A (p.Gln573Lys)
c.1150C>A (p.Gln384Lys)
n.36C>A
c.1273C>A (p.Gln425Lys)
c.1570C>A (p.Gln524Lys)
c.1552C>A (p.Gln518Lys)
c.1261C>A (p.Gln421Lys)
c.1189C>A (p.Gln397Lys)
n.2055C>A
n.1994C>A
n.1948C>A
2g.25244289_25244291delCA2580618095DNMT3Ac.34_36del
c.861_863del (n.861_863del)
c.1046_1048del (p.Ala349_Gln350delinsGlu)
c.1715_1717del (p.Ala572_Gln573delinsGlu)
c.1148_1150del (p.Ala383_Gln384delinsGlu)
n.34_36del
c.1271_1273del (p.Ala424_Gln425delinsGlu)
c.1568_1570del (p.Ala523_Gln524delinsGlu)
c.1550_1552del (p.Ala517_Gln518delinsGlu)
c.1259_1261del (p.Ala420_Gln421delinsGlu)
c.1187_1189del (p.Ala396_Gln397delinsGlu)
n.2053_2055del
n.1992_1994del
n.1946_1948del
2g.25244290_25244301delCA645515204DNMT3Ac.25_36del
c.852_863del (n.852_863del)
c.1037_1048del (p.Pro346_Ala349del)
c.1706_1717del (p.Pro569_Ala572del)
c.1139_1150del (p.Pro380_Ala383del)
n.25_36del
c.1262_1273del (p.Pro421_Ala424del)
c.1559_1570del (p.Pro520_Ala523del)
c.1541_1552del (p.Pro514_Ala517del)
c.1250_1261del (p.Pro417_Ala420del)
c.1178_1189del (p.Pro393_Ala396del)
n.2044_2055del
n.1983_1994del
n.1937_1948del
 COSMIC
2g.25244289_25244290insATACCA1239262989DNMT3Ac.35_36insGTAT
c.862_863insGTAT (n.862_863insGTAT)
c.1047_1048insGTAT (p.Gln350ValfsTer6)
c.1716_1717insGTAT (p.Gln573ValfsTer6)
c.1149_1150insGTAT (p.Gln384ValfsTer6)
n.35_36insGTAT
c.1272_1273insGTAT (p.Gln425ValfsTer6)
c.1569_1570insGTAT (p.Gln524ValfsTer6)
c.1551_1552insGTAT (p.Gln518ValfsTer6)
c.1260_1261insGTAT (p.Gln421ValfsTer6)
c.1188_1189insGTAT (p.Gln397ValfsTer6)
n.2054_2055insGTAT
n.1993_1994insGTAT
n.1947_1948insGTAT
 dbSNP
2g.25244290G>ACA425182565DNMT3Ac.35C>T
c.862C>T (n.862C>T)
c.1047C>T (p.Ala349=)
c.1716C>T (p.Ala572=)
c.1149C>T (p.Ala383=)
n.35C>T
c.1272C>T (p.Ala424=)
c.1569C>T (p.Ala523=)
c.1551C>T (p.Ala517=)
c.1260C>T (p.Ala420=)
c.1188C>T (p.Ala396=)
n.2054C>T
n.1993C>T
n.1947C>T
2g.25244290G>CCA43703404DNMT3Ac.35C>G
c.862C>G (n.862C>G)
c.1047C>G (p.Ala349=)
c.1716C>G (p.Ala572=)
c.1149C>G (p.Ala383=)
n.35C>G
c.1272C>G (p.Ala424=)
c.1569C>G (p.Ala523=)
c.1551C>G (p.Ala517=)
c.1260C>G (p.Ala420=)
c.1188C>G (p.Ala396=)
n.2054C>G
n.1993C>G
n.1947C>G
 ClinVar dbSNP gnomAD v2 gnomAD v3 gnomAD v4
2g.25244290G=CA1239262990DNMT3Ac.35C=
c.862C= (n.862C=)
c.1047C= (p.Ala349=)
c.1716C= (p.Ala572=)
c.1149C= (p.Ala383=)
n.35C=
c.1272C= (p.Ala424=)
c.1569C= (p.Ala523=)
c.1551C= (p.Ala517=)
c.1260C= (p.Ala420=)
c.1188C= (p.Ala396=)
n.2054C=
n.1993C=
n.1947C=
2g.25244290G>TCA425182570DNMT3Ac.35C>A
c.862C>A (n.862C>A)
c.1047C>A (p.Ala349=)
c.1716C>A (p.Ala572=)
c.1149C>A (p.Ala383=)
n.35C>A
c.1272C>A (p.Ala424=)
c.1569C>A (p.Ala523=)
c.1551C>A (p.Ala517=)
c.1260C>A (p.Ala420=)
c.1188C>A (p.Ala396=)
n.2054C>A
n.1993C>A
n.1947C>A
2g.25244290_25244293delinsGGCACA1239262992DNMT3Ac.32_35delinsTGCC
c.859_862delinsTGCC (n.859_862delinsTGCC)
c.1044_1047delinsTGCC (p.Ala348=)
c.1713_1716delinsTGCC (p.Ala571=)
c.1146_1149delinsTGCC (p.Ala382=)
n.32_35delinsTGCC
c.1269_1272delinsTGCC (p.Ala423=)
c.1566_1569delinsTGCC (p.Ala522=)
c.1548_1551delinsTGCC (p.Ala516=)
c.1257_1260delinsTGCC (p.Ala419=)
c.1185_1188delinsTGCC (p.Ala395=)
n.2051_2054delinsTGCC
n.1990_1993delinsTGCC
n.1944_1947delinsTGCC
2g.25244290_25244298delCA2658168887DNMT3Ac.27_35del
c.854_862del (n.854_862del)
c.1039_1047del (p.Gly347_Ala349del)
c.1708_1716del (p.Gly570_Ala572del)
c.1141_1149del (p.Gly381_Ala383del)
n.27_35del
c.1264_1272del (p.Gly422_Ala424del)
c.1561_1569del (p.Gly521_Ala523del)
c.1543_1551del (p.Gly515_Ala517del)
c.1252_1260del (p.Gly418_Ala420del)
c.1180_1188del (p.Gly394_Ala396del)
n.2046_2054del
n.1985_1993del
n.1939_1947del
 gnomAD v4
2g.25244291G>ACA346071939DNMT3Ac.34C>T
c.861C>T (n.861C>T)
c.1046C>T (p.Ala349Val)
c.1715C>T (p.Ala572Val)
c.1148C>T (p.Ala383Val)
n.34C>T
c.1271C>T (p.Ala424Val)
c.1568C>T (p.Ala523Val)
c.1550C>T (p.Ala517Val)
c.1259C>T (p.Ala420Val)
c.1187C>T (p.Ala396Val)
n.2053C>T
n.1992C>T
n.1946C>T
 dbSNP
2g.25244291G>CCA346071940DNMT3Ac.34C>G
c.861C>G (n.861C>G)
c.1046C>G (p.Ala349Gly)
c.1715C>G (p.Ala572Gly)
c.1148C>G (p.Ala383Gly)
n.34C>G
c.1271C>G (p.Ala424Gly)
c.1568C>G (p.Ala523Gly)
c.1550C>G (p.Ala517Gly)
c.1259C>G (p.Ala420Gly)
c.1187C>G (p.Ala396Gly)
n.2053C>G
n.1992C>G
n.1946C>G
 dbSNP
2g.25244291G>TCA346071941DNMT3Ac.34C>A
c.861C>A (n.861C>A)
c.1046C>A (p.Ala349Asp)
c.1715C>A (p.Ala572Asp)
c.1148C>A (p.Ala383Asp)
n.34C>A
c.1271C>A (p.Ala424Asp)
c.1568C>A (p.Ala523Asp)
c.1550C>A (p.Ala517Asp)
c.1259C>A (p.Ala420Asp)
c.1187C>A (p.Ala396Asp)
n.2053C>A
n.1992C>A
n.1946C>A
2g.25244291_25244292delCA2658168894DNMT3Ac.33_34del
c.860_861del (n.860_861del)
c.1045_1046del (p.Ala349ProfsTer5)
c.1714_1715del (p.Ala572ProfsTer5)
c.1147_1148del (p.Ala383ProfsTer5)
n.33_34del
c.1270_1271del (p.Ala424ProfsTer5)
c.1567_1568del (p.Ala523ProfsTer5)
c.1549_1550del (p.Ala517ProfsTer5)
c.1258_1259del (p.Ala420ProfsTer5)
c.1186_1187del (p.Ala396ProfsTer5)
n.2052_2053del
n.1991_1992del
n.1945_1946del
 gnomAD v4
2g.25244291_25244295delCA2576694340DNMT3Ac.30_34del
c.857_861del (n.857_861del)
c.1042_1046del (p.Ala348ProfsTer5)
c.1711_1715del (p.Ala571ProfsTer5)
c.1144_1148del (p.Ala382ProfsTer5)
n.30_34del
c.1267_1271del (p.Ala423ProfsTer5)
c.1564_1568del (p.Ala522ProfsTer5)
c.1546_1550del (p.Ala516ProfsTer5)
c.1255_1259del (p.Ala419ProfsTer5)
c.1183_1187del (p.Ala395ProfsTer5)
n.2049_2053del
n.1988_1992del
n.1942_1946del
2g.25244293_25244295dupCA2658168893DNMT3Ac.32_34dup
c.859_861dup (n.859_861dup)
c.1044_1046dup (p.Ala349_Gln350insAla)
c.1713_1715dup (p.Ala572_Gln573insAla)
c.1146_1148dup (p.Ala383_Gln384insAla)
n.32_34dup
c.1269_1271dup (p.Ala424_Gln425insAla)
c.1566_1568dup (p.Ala523_Gln524insAla)
c.1548_1550dup (p.Ala517_Gln518insAla)
c.1257_1259dup (p.Ala420_Gln421insAla)
c.1185_1187dup (p.Ala396_Gln397insAla)
n.2051_2053dup
n.1990_1992dup
n.1944_1946dup
 gnomAD v4
2g.25244293_25244295delCA645515205DNMT3Ac.32_34del
c.859_861del (n.859_861del)
c.1044_1046del (p.Ala349del)
c.1713_1715del (p.Ala572del)
c.1146_1148del (p.Ala383del)
n.32_34del
c.1269_1271del (p.Ala424del)
c.1566_1568del (p.Ala523del)
c.1548_1550del (p.Ala517del)
c.1257_1259del (p.Ala420del)
c.1185_1187del (p.Ala396del)
n.2051_2053del
n.1990_1992del
n.1944_1946del
 dbSNP COSMIC
2g.25244291_25244298delCA2576694339DNMT3Ac.27_34del
c.854_861del (n.854_861del)
c.1039_1046del (p.Gly347ProfsTer5)
c.1708_1715del (p.Gly570ProfsTer5)
c.1141_1148del (p.Gly381ProfsTer5)
n.27_34del
c.1264_1271del (p.Gly422ProfsTer5)
c.1561_1568del (p.Gly521ProfsTer5)
c.1543_1550del (p.Gly515ProfsTer5)
c.1252_1259del (p.Gly418ProfsTer5)
c.1180_1187del (p.Gly394ProfsTer5)
n.2046_2053del
n.1985_1992del
n.1939_1946del
2g.25244292C>ACA346071942DNMT3Ac.33G>T
c.860G>T (n.860G>T)
c.1045G>T (p.Ala349Ser)
c.1714G>T (p.Ala572Ser)
c.1147G>T (p.Ala383Ser)
n.33G>T
c.1270G>T (p.Ala424Ser)
c.1567G>T (p.Ala523Ser)
c.1549G>T (p.Ala517Ser)
c.1258G>T (p.Ala420Ser)
c.1186G>T (p.Ala396Ser)
n.2052G>T
n.1991G>T
n.1945G>T
 COSMIC COSMIC
2g.25244292C=CA1239262997DNMT3Ac.33G=
c.860G= (n.860G=)
c.1045G= (p.Ala349=)
c.1714G= (p.Ala572=)
c.1147G= (p.Ala383=)
n.33G=
c.1270G= (p.Ala424=)
c.1567G= (p.Ala523=)
c.1549G= (p.Ala517=)
c.1258G= (p.Ala420=)
c.1186G= (p.Ala396=)
n.2052G=
n.1991G=
n.1945G=
2g.25244292C>GCA346071943DNMT3Ac.33G>C
c.860G>C (n.860G>C)
c.1045G>C (p.Ala349Pro)
c.1714G>C (p.Ala572Pro)
c.1147G>C (p.Ala383Pro)
n.33G>C
c.1270G>C (p.Ala424Pro)
c.1567G>C (p.Ala523Pro)
c.1549G>C (p.Ala517Pro)
c.1258G>C (p.Ala420Pro)
c.1186G>C (p.Ala396Pro)
n.2052G>C
n.1991G>C
n.1945G>C
 ClinVar
2g.25244292C>TCA346071944DNMT3Ac.33G>A
c.860G>A (n.860G>A)
c.1045G>A (p.Ala349Thr)
c.1714G>A (p.Ala572Thr)
c.1147G>A (p.Ala383Thr)
n.33G>A
c.1270G>A (p.Ala424Thr)
c.1567G>A (p.Ala523Thr)
c.1549G>A (p.Ala517Thr)
c.1258G>A (p.Ala420Thr)
c.1186G>A (p.Ala396Thr)
n.2052G>A
n.1991G>A
n.1945G>A
 dbSNP
2g.25244292_25244293insGCA1028509809DNMT3Ac.32_33insC
c.859_860insC (n.859_860insC)
c.1044_1045insC (p.Ala349ArgfsTer6)
c.1713_1714insC (p.Ala572ArgfsTer6)
c.1146_1147insC (p.Ala383ArgfsTer6)
n.32_33insC
c.1269_1270insC (p.Ala424ArgfsTer6)
c.1566_1567insC (p.Ala523ArgfsTer6)
c.1548_1549insC (p.Ala517ArgfsTer6)
c.1257_1258insC (p.Ala420ArgfsTer6)
c.1185_1186insC (p.Ala396ArgfsTer6)
n.2051_2052insC
n.1990_1991insC
n.1944_1945insC
 dbSNP gnomAD v3 gnomAD v4
2g.25244293delCA2658168896DNMT3Ac.32del
c.859del (n.859del)
c.1044del (p.Ala349ProfsTer?)
c.1713del (p.Ala572ProfsTer?)
c.1146del (p.Ala383ProfsTer?)
n.32del
c.1269del (p.Ala424ProfsTer?)
c.1566del (p.Ala523ProfsTer?)
c.1548del (p.Ala517ProfsTer?)
c.1257del (p.Ala420ProfsTer?)
c.1185del (p.Ala396ProfsTer?)
n.2051del
n.1990del
n.1944del
 gnomAD v4
2g.25244293A=CA1239263000DNMT3Ac.32T=
c.859T= (n.859T=)
c.1044T= (p.Ala348=)
c.1713T= (p.Ala571=)
c.1146T= (p.Ala382=)
n.32T=
c.1269T= (p.Ala423=)
c.1566T= (p.Ala522=)
c.1548T= (p.Ala516=)
c.1257T= (p.Ala419=)
c.1185T= (p.Ala395=)
n.2051T=
n.1990T=
n.1944T=
2g.25244293A>CCA425182582DNMT3Ac.32T>G
c.859T>G (n.859T>G)
c.1044T>G (p.Ala348=)
c.1713T>G (p.Ala571=)
c.1146T>G (p.Ala382=)
n.32T>G
c.1269T>G (p.Ala423=)
c.1566T>G (p.Ala522=)
c.1548T>G (p.Ala516=)
c.1257T>G (p.Ala419=)
c.1185T>G (p.Ala395=)
n.2051T>G
n.1990T>G
n.1944T>G
 dbSNP
2g.25244293A>GCA425182584DNMT3Ac.32T>C
c.859T>C (n.859T>C)
c.1044T>C (p.Ala348=)
c.1713T>C (p.Ala571=)
c.1146T>C (p.Ala382=)
n.32T>C
c.1269T>C (p.Ala423=)
c.1566T>C (p.Ala522=)
c.1548T>C (p.Ala516=)
c.1257T>C (p.Ala419=)
c.1185T>C (p.Ala395=)
n.2051T>C
n.1990T>C
n.1944T>C
2g.25244293A>TCA425182586DNMT3Ac.32T>A
c.859T>A (n.859T>A)
c.1044T>A (p.Ala348=)
c.1713T>A (p.Ala571=)
c.1146T>A (p.Ala382=)
n.32T>A
c.1269T>A (p.Ala423=)
c.1566T>A (p.Ala522=)
c.1548T>A (p.Ala516=)
c.1257T>A (p.Ala419=)
c.1185T>A (p.Ala395=)
n.2051T>A
n.1990T>A
n.1944T>A
2g.25244293_25244303delinsAGCCCCCGGCCCA1239263001DNMT3Ac.22_32delinsGGCCGGGGGCT
c.849_859delinsGGCCGGGGGCT (n.849_859delinsGGCCGGGGGCT)
c.1034_1044delinsGGCCGGGGGCT (p.Gly345=)
c.1703_1713delinsGGCCGGGGGCT (p.Gly568=)
c.1136_1146delinsGGCCGGGGGCT (p.Gly379=)
n.22_32delinsGGCCGGGGGCT
c.1259_1269delinsGGCCGGGGGCT (p.Gly420=)
c.1556_1566delinsGGCCGGGGGCT (p.Gly519=)
c.1538_1548delinsGGCCGGGGGCT (p.Gly513=)
c.1247_1257delinsGGCCGGGGGCT (p.Gly416=)
c.1175_1185delinsGGCCGGGGGCT (p.Gly392=)
n.2041_2051delinsGGCCGGGGGCT
n.1980_1990delinsGGCCGGGGGCT
n.1934_1944delinsGGCCGGGGGCT

Number of alleles fetched