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        "hgvsWellDefined": "XP_011523154.1:p.[Lys2577_Ala2582delinsGlnAsn;Thr2584_Tyr2586del;Met2588_Ile2593del;Ser2596_Leu2602del;Lys2604_Ser2606delinsAsn]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS091972"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 9522,
          "referenceAllele": "",
          "start": 9522
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007765",
      "geneNCBI_id": 4763,
      "geneSymbol": "NF1",
      "hgvs": [
        "XM_011524853.1:c.7692dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011523155.1:p.Lys2565GlnfsTer9",
        "hgvsWellDefined": "XP_011523155.1:p.[Lys2565_Ala2570delinsGlnAsn;Thr2572_Tyr2574del;Met2576_Ile2581del;Ser2584_Leu2590del;Lys2592_Ser2594delinsAsn]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS091973"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 8557,
          "referenceAllele": "",
          "start": 8557
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007765",
      "geneNCBI_id": 4763,
      "geneSymbol": "NF1",
      "hgvs": [
        "XM_011524854.1:c.7692dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011523156.1:p.Lys2565GlnfsTer9",
        "hgvsWellDefined": "XP_011523156.1:p.[Lys2565_Ala2570delinsGlnAsn;Thr2572_Tyr2574del;Met2576_Ile2581del;Ser2584_Leu2590del;Lys2592_Ser2594delinsAsn]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS091974"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 8589,
          "referenceAllele": "",
          "start": 8589
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007765",
      "geneNCBI_id": 4763,
      "geneSymbol": "NF1",
      "hgvs": [
        "XM_011524855.1:c.7692dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011523157.1:p.Lys2565GlnfsTer9",
        "hgvsWellDefined": "XP_011523157.1:p.[Lys2565_Ala2570delinsGlnAsn;Thr2572_Tyr2574del;Met2576_Ile2581del;Ser2584_Leu2590del;Lys2592_Ser2594delinsAsn]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS091975"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 9267,
          "referenceAllele": "",
          "start": 9267
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      ],
      "gene": "http://reg.genome.network/gene/GN007765",
      "geneNCBI_id": 4763,
      "geneSymbol": "NF1",
      "hgvs": [
        "XM_011524856.1:c.7692dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011523158.1:p.Lys2565GlnfsTer9",
        "hgvsWellDefined": "XP_011523158.1:p.[Lys2565_Ala2570delinsGlnAsn;Thr2572_Tyr2574del;Met2576_Ile2581del;Ser2584_Leu2590del;Lys2592_Ser2594delinsAsn]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS091976"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 7978,
          "endIntronDirection": "-",
          "endIntronOffset": 414,
          "referenceAllele": "",
          "start": 7978,
          "startIntronDirection": "-",
          "startIntronOffset": 414
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007765",
      "geneNCBI_id": 4763,
      "geneSymbol": "NF1",
      "hgvs": [
        "XM_011524857.1:c.7646-415dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011523159.1:n.7646-415dup"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS091977"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 8034,
          "referenceAllele": "",
          "start": 8034
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007765",
      "geneNCBI_id": 4763,
      "geneSymbol": "NF1",
      "hgvs": [
        "NM_001042492.3:c.7701dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001035957.1:p.Lys2568GlnfsTer9",
        "hgvsWellDefined": "NP_001035957.1:p.[Lys2568_Ala2573delinsGlnAsn;Thr2575_Tyr2577del;Met2579_Ile2584del;Ser2587_Leu2593del;Lys2595_Ser2597delinsAsn]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS676037",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000358273.9:c.7701dup"
          },
          "RefSeq": {
            "hgvs": "NM_001042492.3:c.7701dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000351015.4:p.Lys2568GlnfsTer9"
          },
          "RefSeq": {
            "hgvs": "NP_001035957.1:p.Lys2568GlnfsTer9"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}