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        "hgvs": "XP_011538283.1:p.Lys267GlyfsTer30",
        "hgvsWellDefined": "XP_011538283.1:p.[Lys267_Pro281delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArg;Pro283_Thr286delinsAsnLeuArgLys;Glu288Arg;Val290_Gly293delinsTrpLys;Leu295_Cys296delinsMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106931"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 4484,
          "referenceAllele": "AA",
          "start": 4482
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XM_011539982.1:c.703_704del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538284.1:p.Lys235GlyfsTer30",
        "hgvsWellDefined": "XP_011538284.1:p.[Lys235_Pro249delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArg;Pro251_Thr254delinsAsnLeuArgLys;Glu256Arg;Val258_Gly261delinsTrpLys;Leu263_Cys264delinsMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106932"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1370,
          "referenceAllele": "AA",
          "start": 1368
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.1369_1370del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1644,
          "referenceAllele": "AA",
          "start": 1642
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.799_800del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Lys267GlyfsTer30",
        "hgvsWellDefined": "NP_000305.3:p.[Lys267_Pro281delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArg;Pro283_Thr286delinsAsnLeuArgLys;Glu288Arg;Val290_Gly293delinsTrpLys;Leu295_Cys296delinsMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1644,
          "referenceAllele": "AA",
          "start": 1642
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.1318_1319del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Lys440GlyfsTer30",
        "hgvsWellDefined": "NP_001291646.4:p.[Lys440_Pro454delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArg;Pro456_Thr459delinsAsnLeuArgLys;Glu461Arg;Val463_Gly466delinsTrpLys;Leu468_Cys469delinsMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1758,
          "referenceAllele": "AA",
          "start": 1756
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.208_209del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:p.Lys70GlyfsTer30",
        "hgvsWellDefined": "NP_001291647.1:p.[Lys70_Pro84delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArg;Pro86_Thr89delinsAsnLeuArgLys;Glu91Arg;Val93_Gly96delinsTrpLys;Leu98_Cys99delinsMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1645,
          "referenceAllele": "AA",
          "start": 1643
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.799_800del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Lys267GlyfsTer30",
        "hgvsWellDefined": "NP_000305.3:p.[Lys267_Pro281delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArg;Pro283_Thr286delinsAsnLeuArgLys;Glu288Arg;Val290_Gly293delinsTrpLys;Leu295_Cys296delinsMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.799_800del"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.799_800del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Lys267GlyfsTer30"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Lys267GlyfsTer30"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}