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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XM_011539982.1:c.324dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538284.1:p.His109ThrfsTer?",
        "hgvsWellDefined": "XP_011538284.1:p.[His109_Arg110delinsThrSer;Lys112_Leu114delinsGlnIlePhe;Ala116_Asp121delinsGlyThrArgGlyProArg;Tyr123delinsLeuTrp;Glu125_Thr128delinsSerLysAspGln;Asp130Gln;Lys132del;Val134_Ser138delinsSerAsnTyrSerGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106932"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1132,
          "referenceAllele": "",
          "start": 1132
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945789.1:n.1132dup"
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      "referenceSequence": "http://reg.genome.network/refseq/RS139422"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1132,
          "referenceAllele": "",
          "start": 1132
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945790.1:n.1132dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139423"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1132,
          "referenceAllele": "",
          "start": 1132
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.1132dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1264,
          "referenceAllele": "",
          "start": 1264
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.420dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.His141ThrfsTer?",
        "hgvsWellDefined": "NP_000305.3:p.[His141_Arg142delinsThrSer;Lys144_Leu146delinsGlnIlePhe;Ala148_Asp153delinsGlyThrArgGlyProArg;Tyr155delinsLeuTrp;Glu157_Thr160delinsSerLysAspGln;Asp162Gln;Lys164del;Val166_Ser170delinsSerAsnTyrSerGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1264,
          "referenceAllele": "",
          "start": 1264
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.939dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.His314ThrfsTer?",
        "hgvsWellDefined": "NP_001291646.4:p.[His314_Arg315delinsThrSer;Lys317_Leu319delinsGlnIlePhe;Ala321_Asp326delinsGlyThrArgGlyProArg;Tyr328delinsLeuTrp;Glu330_Thr333delinsSerLysAspGln;Asp335Gln;Lys337del;Val339_Ser343delinsSerAsnTyrSerGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
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          "referenceAllele": "",
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.-331dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:n.-331dup"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
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          "allele": "A",
          "end": 1265,
          "referenceAllele": "",
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.420dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.His141ThrfsTer?",
        "hgvsWellDefined": "NP_000305.3:p.[His141_Arg142delinsThrSer;Lys144_Leu146delinsGlnIlePhe;Ala148_Asp153delinsGlyThrArgGlyProArg;Tyr155delinsLeuTrp;Glu157_Thr160delinsSerLysAspGln;Asp162Gln;Lys164del;Val166_Ser170delinsSerAsnTyrSerGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.420dup"
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          "RefSeq": {
            "hgvs": "NM_000314.8:c.420dup"
          }
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        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.His141ThrfsTer?"
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          "RefSeq": {
            "hgvs": "NP_000305.3:p.His141ThrfsTer?"
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        }
      }
    }
  ],
  "type": "nucleotide"
}