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          "end": 1333,
          "referenceAllele": "TCAGT",
          "start": 1328
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XM_011539981.1:c.617_621del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538283.1:p.Phe206TrpfsTer?",
        "hgvsWellDefined": "XP_011538283.1:p.[Phe206_Cys211delinsTrpArg;Pro213Leu;Phe215_Val216delinsSerSer;Gln219Gly;Lys221_Val222delinsProAla;Ile224_Pro231delinsGlyGluAspIlePheLeuGlnPheArg;Arg233_Lys237delinsHisThrThrGlyArgGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106931"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 4305,
          "referenceAllele": "TCAGT",
          "start": 4300
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XM_011539982.1:c.521_525del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538284.1:p.Phe174TrpfsTer?",
        "hgvsWellDefined": "XP_011538284.1:p.[Phe174_Cys179delinsTrpArg;Pro181Leu;Phe183_Val184delinsSerSer;Gln187Gly;Lys189_Val190delinsProAla;Ile192_Pro199delinsGlyGluAspIlePheLeuGlnPheArg;Arg201_Lys205delinsHisThrThrGlyArgGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106932"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1204,
          "endIntronDirection": "-",
          "endIntronOffset": 5606,
          "referenceAllele": "TCAGT",
          "start": 1204,
          "startIntronDirection": "-",
          "startIntronOffset": 5611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.1205-5611_1205-5607del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1465,
          "referenceAllele": "TCAGT",
          "start": 1460
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.617_621del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Phe206TrpfsTer?",
        "hgvsWellDefined": "NP_000305.3:p.[Phe206_Cys211delinsTrpArg;Pro213Leu;Phe215_Val216delinsSerSer;Gln219Gly;Lys221_Val222delinsProAla;Ile224_Pro231delinsGlyGluAspIlePheLeuGlnPheArg;Arg233_Lys237delinsHisThrThrGlyArgGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1465,
          "referenceAllele": "TCAGT",
          "start": 1460
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.1136_1140del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Phe379TrpfsTer?",
        "hgvsWellDefined": "NP_001291646.4:p.[Phe379_Cys384delinsTrpArg;Pro386Leu;Phe388_Val389delinsSerSer;Gln392Gly;Lys394_Val395delinsProAla;Ile397_Pro404delinsGlyGluAspIlePheLeuGlnPheArg;Arg406_Lys410delinsHisThrThrGlyArgGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1579,
          "referenceAllele": "TCAGT",
          "start": 1574
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.26_30del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:p.Phe9TrpfsTer?",
        "hgvsWellDefined": "NP_001291647.1:p.[Phe9_Cys14delinsTrpArg;Pro16Leu;Phe18_Val19delinsSerSer;Gln22Gly;Lys24_Val25delinsProAla;Ile27_Pro34delinsGlyGluAspIlePheLeuGlnPheArg;Arg36_Lys40delinsHisThrThrGlyArgGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1466,
          "referenceAllele": "TCAGT",
          "start": 1461
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.617_621del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Phe206TrpfsTer?",
        "hgvsWellDefined": "NP_000305.3:p.[Phe206_Cys211delinsTrpArg;Pro213Leu;Phe215_Val216delinsSerSer;Gln219Gly;Lys221_Val222delinsProAla;Ile224_Pro231delinsGlyGluAspIlePheLeuGlnPheArg;Arg233_Lys237delinsHisThrThrGlyArgGln]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.617_621del"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.617_621del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Phe206TrpfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Phe206TrpfsTer?"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}