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          "referenceAllele": "AT",
          "start": 1318
        }
      ],
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      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XM_011539981.1:c.607_608del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538283.1:p.Ile203SerfsTer?",
        "hgvsWellDefined": "XP_011538283.1:p.[Ile203_Cys211delinsSerAsnValGlnTrpArg;Pro213Leu;Phe215_Val216delinsSerSer;Gln219Gly;Lys221_Val222delinsProAla;Lys223_Ile224insGlyGluAsp;Tyr225_Pro231delinsPheLeuGlnPheArgThrHis]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106931"
    },
    {
      "coordinates": [
        {
          "allele": "",
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          "referenceAllele": "AT",
          "start": 4290
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
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      "hgvs": [
        "XM_011539982.1:c.511_512del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538284.1:p.Ile171SerfsTer?",
        "hgvsWellDefined": "XP_011538284.1:p.[Ile171_Cys179delinsSerAsnValGlnTrpArg;Pro181Leu;Phe183_Val184delinsSerSer;Gln187Gly;Lys189_Val190delinsProAla;Lys191_Ile192insGlyGluAsp;Tyr193_Pro199delinsPheLeuGlnPheArgThrHis]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106932"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1204,
          "endIntronDirection": "-",
          "endIntronOffset": 5619,
          "referenceAllele": "AT",
          "start": 1204,
          "startIntronDirection": "-",
          "startIntronOffset": 5621
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.1205-5621_1205-5620del"
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      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "",
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          "referenceAllele": "AT",
          "start": 1450
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.607_608del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Ile203SerfsTer?",
        "hgvsWellDefined": "NP_000305.3:p.[Ile203_Cys211delinsSerAsnValGlnTrpArg;Pro213Leu;Phe215_Val216delinsSerSer;Gln219Gly;Lys221_Val222delinsProAla;Lys223_Ile224insGlyGluAsp;Tyr225_Pro231delinsPheLeuGlnPheArgThrHis]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1452,
          "referenceAllele": "AT",
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.1126_1127del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Ile376SerfsTer?",
        "hgvsWellDefined": "NP_001291646.4:p.[Ile376_Cys384delinsSerAsnValGlnTrpArg;Pro386Leu;Phe388_Val389delinsSerSer;Gln392Gly;Lys394_Val395delinsProAla;Lys396_Ile397insGlyGluAsp;Tyr398_Pro404delinsPheLeuGlnPheArgThrHis]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
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          "allele": "",
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          "referenceAllele": "AT",
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      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.16_17del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:p.Ile6SerfsTer?",
        "hgvsWellDefined": "NP_001291647.1:p.[Ile6_Cys14delinsSerAsnValGlnTrpArg;Pro16Leu;Phe18_Val19delinsSerSer;Gln22Gly;Lys24_Val25delinsProAla;Lys26_Ile27insGlyGluAsp;Tyr28_Pro34delinsPheLeuGlnPheArgThrHis]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
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          "allele": "",
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          "referenceAllele": "AT",
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.607_608del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Ile203SerfsTer?",
        "hgvsWellDefined": "NP_000305.3:p.[Ile203_Cys211delinsSerAsnValGlnTrpArg;Pro213Leu;Phe215_Val216delinsSerSer;Gln219Gly;Lys221_Val222delinsProAla;Lys223_Ile224insGlyGluAsp;Tyr225_Pro231delinsPheLeuGlnPheArgThrHis]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.607_608del"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.607_608del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Ile203SerfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Ile203SerfsTer?"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}