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  "communityStandardTitle": [
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        "RCV": [
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          "RCV000642442",
          "RCV001554327",
          "RCV003469031"
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      "proteinEffect": {
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        "hgvsWellDefined": "XP_005274065.1:p.Arg327_Arg552delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAlaAspThrGlyLeuGluThrSerThrArgSerArgAsnSerLysThrAlaValSerAlaSerArgAsnMetSerIleIleAspAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS537541"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1743,
          "referenceAllele": "C",
          "start": 1742
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "XM_006718842.3:c.1447C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_006718905.1:p.Arg483Ter",
        "hgvsWellDefined": "XP_006718905.1:p.Arg483_Arg707delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAspThrGlyLeuGluThrSerThrArgSerArgAsnSerLysThrAlaValSerAlaSerArgAsnMetSerIleIleAspAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539721"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2165,
          "referenceAllele": "C",
          "start": 2164
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "XM_011542837.2:c.1447C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011541139.1:p.Arg483Ter",
        "hgvsWellDefined": "XP_011541139.1:p.Arg483_Arg708delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAlaAspThrGlyLeuGluThrSerThrArgSerArgAsnSerLysThrAlaValSerAlaSerArgAsnMetSerIleIleAspAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS554947"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1743,
          "referenceAllele": "C",
          "start": 1742
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "XM_017017772.1:c.1447C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016873261.1:p.Arg483Ter",
        "hgvsWellDefined": "XP_016873261.1:p.Arg483_Arg708delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAlaAspThrGlyLeuGluThrSerThrArgSerArgAsnSerLysThrAlaValSerAlaSerArgAsnMetSerIleIleAspAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS569884"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1743,
          "referenceAllele": "C",
          "start": 1742
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "XR_947828.2:n.1743C>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS614830"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827304414",
      "coordinates": [
        {
          "allele": "T",
          "end": 1606,
          "referenceAllele": "C",
          "start": 1605
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "NM_001330347.2:c.1447C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001317276.1:p.Arg483Ter",
        "hgvsWellDefined": "NP_001317276.1:p.Arg483_Arg707delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAspThrGlyLeuGluThrSerThrArgSerArgAsnSerLysThrAlaValSerAlaSerArgAsnMetSerIleIleAspAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS686890"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829606721",
      "coordinates": [
        {
          "allele": "T",
          "end": 1713,
          "referenceAllele": "C",
          "start": 1712
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "NM_005590.4:c.1447C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_005581.2:p.Arg483Ter",
        "hgvsWellDefined": "NP_005581.2:p.Arg483_Arg680delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS696466"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645455881",
      "coordinates": [
        {
          "allele": "T",
          "end": 1606,
          "referenceAllele": "C",
          "start": 1605
        }
      ],
      "gene": "http://reg.genome.network/gene/GN007230",
      "geneNCBI_id": 4361,
      "geneSymbol": "MRE11",
      "hgvs": [
        "NM_005591.4:c.1447C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_005582.1:p.Arg483Ter",
        "hgvsWellDefined": "NP_005582.1:p.Arg483_Arg708delinsPheLeuLysGluArgHisIleAspAlaLeuGluAspLysIleAspGluGluValArgArgPheArgGluThrArgGlnLysAsnThrAsnGluGluAspAspGluValArgGluAlaMetThrArgAlaArgAlaLeuArgSerGlnSerGluGluSerAlaSerAlaPheSerAlaAspAspLeuMetSerIleAspLeuAlaGluGlnMetAlaAsnAspSerAspAspSerIleSerAlaAlaThrAsnLysGlyArgGlyArgGlyArgGlyArgArgGlyGlyArgGlyGlnAsnSerAlaSerArgGlyGlySerGlnArgGlyArgAlaAspThrGlyLeuGluThrSerThrArgSerArgAsnSerLysThrAlaValSerAlaSerArgAsnMetSerIleIleAspAlaPheLysSerThrArgGlnGlnProSerArgAsnValThrThrLysAsnTyrSerGluValIleGluValAspGluSerAspValGluGluAspIlePheProThrThrSerLysThrAspGlnArgTrpSerSerThrSerSerSerLysIleMetSerGlnSerGlnValSerLysGlyValAspPheGluSerSerGluAspAspAspAspAspProPheMetAsnThrSerSerLeuArgArgAsnArgArgTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS696467",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000323929.8:c.1447C>T"
          },
          "RefSeq": {
            "hgvs": "NM_005591.4:c.1447C>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000325863.4:p.Arg483Ter"
          },
          "RefSeq": {
            "hgvs": "NP_005582.1:p.Arg483Ter"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}