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      "proteinEffect": {
        "hgvs": "NP_001155899.1:p.Arg369GlnfsTer22",
        "hgvsWellDefined": "NP_001155899.1:p.[Arg369_Lys370delinsGln;Glu372Gly;Met374_Arg383delinsGluAsnGlyPheCysLysThrMetSerThr;His385_Gly392delinsThrThrProSer;Glu395_Gly398del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS678219"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1370,
          "referenceAllele": "",
          "start": 1370
        }
      ],
      "gene": "http://reg.genome.network/gene/GN012362",
      "geneNCBI_id": 7248,
      "geneSymbol": "TSC1",
      "hgvs": [
        "NM_001362177.2:c.894dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001349106.1:p.Arg299GlnfsTer22",
        "hgvsWellDefined": "NP_001349106.1:p.[Arg299_Lys300delinsGln;Glu302Gly;Met304_Arg313delinsGluAsnGlyPheCysLysThrMetSerThr;His315_Gly322delinsThrThrProSer;Glu325_Gly328del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS690502"
    }
  ],
  "type": "nucleotide"
}