{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA497925664",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.455del (p.Pro152ArgfsTer18)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=43792",
        "active": true,
        "id": "COSM43792"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=43969",
        "active": true,
        "id": "COSM43969"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=45890",
        "active": true,
        "id": "COSM45890"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1180849",
        "active": true,
        "id": "COSM1180849"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1180850",
        "active": true,
        "id": "COSM1180850"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1180851",
        "active": true,
        "id": "COSM1180851"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1180852",
        "active": true,
        "id": "COSM1180852"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1731754",
        "active": true,
        "id": "COSM1731754"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1731755",
        "active": true,
        "id": "COSM1731755"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1731756",
        "active": true,
        "id": "COSM1731756"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1731757",
        "active": true,
        "id": "COSM1731757"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1731758",
        "active": true,
        "id": "COSM1731758"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=2744917",
        "active": true,
        "id": "COSM2744917"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=4336275",
        "active": true,
        "id": "COSM4336275"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=622624[alleleid]",
        "alleleId": 622624,
        "preferredName": "NM_000546.6(TP53):c.455del (p.Pro152fs)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/634779",
        "RCV": [
          "RCV000785525",
          "RCV001203494"
        ],
        "variationId": 634779
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7578479del?assembly=hg19",
        "id": "chr17:g.7578479del"
      },
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7578476del?assembly=hg19",
        "id": "chr17:g.7578476del"
      },
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7578475del?assembly=hg19",
        "id": "chr17:g.7578475del"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/730882019",
        "rs": 730882019
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "",
          "end": 7675161,
          "referenceAllele": "G",
          "start": 7675160
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7675161del",
        "CM000679.2:g.7675161del"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "",
          "end": 7578479,
          "referenceAllele": "G",
          "start": 7578478
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7578479del",
        "CM000679.1:g.7578479del"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "",
          "end": 7519204,
          "referenceAllele": "G",
          "start": 7519203
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7519204del"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 17394,
          "referenceAllele": "C",
          "start": 17393
        }
      ],
      "hgvs": [
        "NG_017013.2:g.17394del",
        "LRG_321:g.17394del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "",
          "end": 637,
          "referenceAllele": "C",
          "start": 636
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000426252.2:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 737,
          "referenceAllele": "C",
          "start": 736
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000424104.2:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 191,
          "referenceAllele": "C",
          "start": 190
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "ENSP00000425104.2:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 255,
          "referenceAllele": "C",
          "start": 254
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.176del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Pro59ArgfsTer18",
        "hgvsWellDefined": "ENSP00000423862.2:p.[Pro59Arg;Gly61_Arg65delinsAlaPro;Met67Ser;Ile69_Gln72delinsProTrpPro;Gln74_Met76del;Glu78_Pro84delinsSerSer;His86_Arg88delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 573,
          "referenceAllele": "C",
          "start": 572
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.434del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Pro145ArgfsTer18",
        "hgvsWellDefined": "ENSP00000473895.2:p.[Pro145Arg;Gly147_Arg151delinsAlaPro;Met153Ser;Ile155_Gln158delinsProTrpPro;Gln160_Met162del;Glu164_Pro170delinsSerSer;His172_Arg174delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000269305.4:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.455del"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.455del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Pro152ArgfsTer18"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Pro152ArgfsTer18"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 645,
          "referenceAllele": "C",
          "start": 644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000269305.4:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 455,
          "referenceAllele": "C",
          "start": 454
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000352610.4:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 455,
          "referenceAllele": "C",
          "start": 454
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000410739.2:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 588,
          "referenceAllele": "C",
          "start": 587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000391127.2:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 591,
          "referenceAllele": "C",
          "start": 590
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000391478.2:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 588,
          "referenceAllele": "C",
          "start": 587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000398846.2:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "ENSP00000484409.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "ENSP00000481179.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 711,
          "referenceAllele": "C",
          "start": 710
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000505014.5:n.711del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS336915"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 593,
          "referenceAllele": "C",
          "start": 592
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.5:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.1:p.Pro152ArgfsTer?",
        "hgvsWellDefined": "ENSP00000424104.1:p.[Pro152Arg;Gly154_Gln165delinsAlaProAlaSerAlaProTrpProSerThrSerSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247237"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 191,
          "referenceAllele": "C",
          "start": 190
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.5:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "ENSP00000425104.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247215"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "ENSP00000478499.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 255,
          "referenceAllele": "C",
          "start": 254
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.5:c.176del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.1:p.Pro59ArgfsTer18",
        "hgvsWellDefined": "ENSP00000423862.1:p.[Pro59Arg;Gly61_Arg65delinsAlaPro;Met67Ser;Ile69_Gln72delinsProTrpPro;Gln74_Met76del;Glu78_Pro84delinsSerSer;His86_Arg88delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247340"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 705,
          "referenceAllele": "C",
          "start": 704
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "ENSP00000478219.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 588,
          "referenceAllele": "C",
          "start": 587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "ENSP00000480868.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 422,
          "referenceAllele": "C",
          "start": 421
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.422del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Pro141ArgfsTer18",
        "hgvsWellDefined": "ENSP00000482903.1:p.[Pro141Arg;Gly143_Arg147delinsAlaPro;Met149Ser;Ile151_Gln154delinsProTrpPro;Gln156_Met158del;Glu160_Pro166delinsSerSer;His168_Arg170delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "ENSP00000482258.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 591,
          "referenceAllele": "C",
          "start": 590
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "ENSP00000482537.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 645,
          "referenceAllele": "C",
          "start": 644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "ENSP00000481638.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 588,
          "referenceAllele": "C",
          "start": 587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "ENSP00000482222.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 598,
          "referenceAllele": "C",
          "start": 597
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "ENSP00000488924.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.455del",
        "LRG_321t1:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_000537.3:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 654,
          "referenceAllele": "C",
          "start": 653
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.455del",
        "LRG_321t2:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_001119584.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.455del",
        "LRG_321t4:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_001119585.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.455del",
        "LRG_321t3:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_001119586.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.59del",
        "LRG_321t5:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "NP_001119587.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.59del",
        "LRG_321t6:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "NP_001119588.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.59del",
        "LRG_321t7:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "NP_001119589.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 774,
          "referenceAllele": "C",
          "start": 773
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.338del",
        "LRG_321t8:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001119590.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263624.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263625.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 337,
          "referenceAllele": "C",
          "start": 336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 657,
          "referenceAllele": "C",
          "start": 656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263689.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 654,
          "referenceAllele": "C",
          "start": 653
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263690.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263624.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263625.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263689.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 594,
          "referenceAllele": "C",
          "start": 593
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263690.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_000537.3:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.455del"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.455del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Pro152ArgfsTer18"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Pro152ArgfsTer18"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 594,
          "referenceAllele": "C",
          "start": 593
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_001119584.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_001119585.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.455del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Pro152ArgfsTer18",
        "hgvsWellDefined": "NP_001119586.1:p.[Pro152Arg;Gly154_Arg158delinsAlaPro;Met160Ser;Ile162_Gln165delinsProTrpPro;Gln167_Met169del;Glu171_Pro177delinsSerSer;His179_Arg181delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "NP_001119587.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "NP_001119588.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.59del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Pro20ArgfsTer18",
        "hgvsWellDefined": "NP_001119589.1:p.[Pro20Arg;Gly22_Arg26delinsAlaPro;Met28Ser;Ile30_Gln33delinsProTrpPro;Gln35_Met37del;Glu39_Pro45delinsSerSer;His47_Arg49delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 714,
          "referenceAllele": "C",
          "start": 713
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001119590.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263624.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263625.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 88,
          "referenceAllele": "C",
          "start": 87
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.-23del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:n.-23del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 597,
          "referenceAllele": "C",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263689.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 594,
          "referenceAllele": "C",
          "start": 593
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.338del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Pro113ArgfsTer18",
        "hgvsWellDefined": "NP_001263690.1:p.[Pro113Arg;Gly115_Arg119delinsAlaPro;Met121Ser;Ile123_Gln126delinsProTrpPro;Gln128_Met130del;Glu132_Pro138delinsSerSer;His140_Arg142delinsSerThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}