{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA471648531",
  "communityStandardTitle": [
    "NM_000141.5(FGFR2):c.1849T>C (p.Leu617=)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr10:g.123256060A>G?assembly=hg19",
        "id": "chr10:g.123256060A>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057519796",
        "rs": 1057519796
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/10-121496546-A-G?dataset=gnomad_r4",
        "id": "10-121496546-A-G",
        "variant": "10:121496546 A / G"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 121496546,
          "referenceAllele": "A",
          "start": 121496545
        }
      ],
      "hgvs": [
        "NC_000010.11:g.121496546A>G",
        "CM000672.2:g.121496546A>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000058"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 123256060,
          "referenceAllele": "A",
          "start": 123256059
        }
      ],
      "hgvs": [
        "NC_000010.10:g.123256060A>G",
        "CM000672.1:g.123256060A>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000034"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 123246050,
          "referenceAllele": "A",
          "start": 123246049
        }
      ],
      "hgvs": [
        "NC_000010.9:g.123246050A>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000010"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 106913,
          "referenceAllele": "T",
          "start": 106912
        }
      ],
      "hgvs": [
        "NG_012449.1:g.106913T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002410"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 106913,
          "referenceAllele": "T",
          "start": 106912
        }
      ],
      "hgvs": [
        "NG_012449.2:g.106913T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS616181"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2485,
          "referenceAllele": "T",
          "start": 2484
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000457416.7:c.1852T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410294.2:p.Leu618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS905054",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000457416.7:c.1852T>C"
          },
          "RefSeq": {
            "hgvs": "NM_022970.4:c.1852T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000410294.2:p.Leu618="
          },
          "RefSeq": {
            "hgvs": "NP_075259.4:p.Leu618="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2634,
          "referenceAllele": "T",
          "start": 2633
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000351936.11:c.1843T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000309878.10:p.Leu615="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS824066"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1163,
          "referenceAllele": "T",
          "start": 1162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000638709.2:c.673T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000491912.2:p.Leu225="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS826680"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1191,
          "referenceAllele": "T",
          "start": 1190
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682296.1:n.1191T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS827290"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1760,
          "referenceAllele": "T",
          "start": 1759
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682550.1:c.1498T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000507633.1:p.Leu500="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS827540"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1511,
          "referenceAllele": "T",
          "start": 1510
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682772.1:c.673T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000506848.1:p.Leu225="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS827761"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 669,
          "referenceAllele": "T",
          "start": 668
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682904.1:n.669T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS827892"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 261,
          "referenceAllele": "T",
          "start": 260
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683029.1:n.261T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS828016"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 4837,
          "referenceAllele": "T",
          "start": 4836
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683211.1:c.1843T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000508257.1:p.Leu615="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS828193"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1400,
          "referenceAllele": "T",
          "start": 1399
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683250.1:c.*551T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000506847.1:n.*551T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS828232"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 4190,
          "referenceAllele": "T",
          "start": 4189
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683418.1:n.4190T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS828395"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2053,
          "referenceAllele": "T",
          "start": 2052
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000684153.1:c.1498T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000506937.1:p.Leu500="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS829111"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2862,
          "referenceAllele": "T",
          "start": 2861
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000684516.1:n.2862T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS829469"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2482,
          "referenceAllele": "T",
          "start": 2481
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000358487.10:c.1849T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000351276.6:p.Leu617="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS749076",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000358487.10:c.1849T>C"
          },
          "RefSeq": {
            "hgvs": "NM_000141.5:c.1849T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000351276.6:p.Leu617="
          },
          "RefSeq": {
            "hgvs": "NP_000132.3:p.Leu617="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2161,
          "referenceAllele": "T",
          "start": 2160
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000336553.10:c.1576T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000337665.6:p.Leu526="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260321"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1855,
          "referenceAllele": "T",
          "start": 1854
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000346997.6:c.1843T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000263451.5:p.Leu615="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262318"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1861,
          "referenceAllele": "T",
          "start": 1860
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000351936.10:c.1849T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000309878.9:p.Leu617="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262814"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2145,
          "referenceAllele": "T",
          "start": 2144
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000356226.8:c.1498T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000348559.4:p.Leu500="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS263693"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1901,
          "referenceAllele": "T",
          "start": 1900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000357555.9:c.1582T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000350166.5:p.Leu528="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS264152"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2122,
          "referenceAllele": "T",
          "start": 2121
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000358487.9:c.1849T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000351276.5:p.Leu617="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS264468"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2206,
          "referenceAllele": "T",
          "start": 2205
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000360144.7:c.1585T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000353262.3:p.Leu529="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS265030"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1876,
          "referenceAllele": "T",
          "start": 1875
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369056.5:c.1852T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358052.1:p.Leu618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267337"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2275,
          "referenceAllele": "T",
          "start": 2274
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369058.7:c.1852T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358054.3:p.Leu618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267338"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2148,
          "referenceAllele": "T",
          "start": 2147
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369059.5:c.1507T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358055.1:p.Leu503="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267339"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1988,
          "referenceAllele": "T",
          "start": 1987
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369060.8:c.1501T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358056.4:p.Leu501="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267340"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1663,
          "referenceAllele": "T",
          "start": 1662
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369061.8:c.1513T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358057.4:p.Leu505="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267341"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 625,
          "referenceAllele": "T",
          "start": 624
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000429361.5:c.625T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000404219.1:p.Leu209="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS290628"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2444,
          "referenceAllele": "T",
          "start": 2443
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000457416.6:c.1852T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410294.2:p.Leu618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS303943"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1880,
          "referenceAllele": "T",
          "start": 1879
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000478859.5:c.1165T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474011.1:p.Leu389="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS319363"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2254,
          "referenceAllele": "T",
          "start": 2253
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000604236.5:c.*896T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474109.1:n.*896T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS398949"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2229,
          "referenceAllele": "T",
          "start": 2228
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000613048.4:c.1582T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484154.1:p.Leu528="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS401574"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3077078823",
      "coordinates": [
        {
          "allele": "C",
          "end": 2496,
          "referenceAllele": "T",
          "start": 2495
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_000141.4:c.1849T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000132.3:p.Leu617="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006203"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2002,
          "referenceAllele": "T",
          "start": 2001
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144913.1:c.1852T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138385.1:p.Leu618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013351"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1663,
          "referenceAllele": "T",
          "start": 1662
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144914.1:c.1513T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138386.1:p.Leu505="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013352"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1901,
          "referenceAllele": "T",
          "start": 1900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144915.1:c.1582T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138387.1:p.Leu528="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013353"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1945,
          "referenceAllele": "T",
          "start": 1944
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144916.1:c.1504T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138388.1:p.Leu502="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013354"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2148,
          "referenceAllele": "T",
          "start": 2147
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144917.1:c.1501T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138389.1:p.Leu501="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013355"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2145,
          "referenceAllele": "T",
          "start": 2144
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144918.1:c.1498T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138390.1:p.Leu500="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013356"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2232,
          "referenceAllele": "T",
          "start": 2231
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144919.1:c.1585T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138391.1:p.Leu529="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013357"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2499,
          "referenceAllele": "T",
          "start": 2498
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_022970.3:c.1852T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_075259.4:p.Leu618="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS037524"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1732,
          "referenceAllele": "T",
          "start": 1731
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_023029.2:c.1582T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_075418.1:p.Leu528="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS037544"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2299,
          "referenceAllele": "T",
          "start": 2298
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NR_073009.1:n.2299T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS052421"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2691,
          "referenceAllele": "T",
          "start": 2690
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717708.2:c.1903T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717771.1:p.Leu635="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072285"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2688,
          "referenceAllele": "T",
          "start": 2687
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717709.2:c.1900T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717772.1:p.Leu634="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072286"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2697,
          "referenceAllele": "T",
          "start": 2696
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717710.2:c.1909T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717773.1:p.Leu637="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072287"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1735,
          "referenceAllele": "T",
          "start": 1734
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717711.2:c.1642T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717774.1:p.Leu548="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072288"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1657,
          "referenceAllele": "T",
          "start": 1656
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717712.2:c.1564T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717775.1:p.Leu522="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072289"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2694,
          "referenceAllele": "T",
          "start": 2693
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717713.2:c.1906T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717776.1:p.Leu636="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072290"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1362,
          "referenceAllele": "T",
          "start": 1361
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_011539510.1:c.1165T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011537812.1:p.Leu389="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106460"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1880,
          "referenceAllele": "T",
          "start": 1879
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320654.1:c.1165T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307583.1:p.Leu389="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS513707"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2490,
          "referenceAllele": "T",
          "start": 2489
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320658.1:c.1843T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307587.1:p.Leu615="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS513711"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2121,
          "referenceAllele": "T",
          "start": 2120
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717708.3:c.1903T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717771.1:p.Leu635="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539461"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2127,
          "referenceAllele": "T",
          "start": 2126
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717710.4:c.1909T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717773.1:p.Leu637="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539462"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2121,
          "referenceAllele": "T",
          "start": 2120
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015920.2:c.1903T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871409.1:p.Leu635="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568504"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2118,
          "referenceAllele": "T",
          "start": 2117
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015921.2:c.1900T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871410.1:p.Leu634="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568505"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1744,
          "referenceAllele": "T",
          "start": 1743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015924.2:c.1561T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871413.1:p.Leu521="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568506"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2018,
          "referenceAllele": "T",
          "start": 2017
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015925.2:c.1555T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871414.1:p.Leu519="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568507"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1822,
          "referenceAllele": "T",
          "start": 1821
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447887.1:c.1639T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303655.1:p.Leu547="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581468"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1819,
          "referenceAllele": "T",
          "start": 1818
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447888.1:c.1636T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303656.1:p.Leu546="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581469"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1816,
          "referenceAllele": "T",
          "start": 1815
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447889.1:c.1633T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303657.1:p.Leu545="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581470"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2232,
          "referenceAllele": "T",
          "start": 2231
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447890.1:c.1642T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303658.1:p.Leu548="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581471"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1747,
          "referenceAllele": "T",
          "start": 1746
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447891.1:c.1564T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303659.1:p.Leu522="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581472"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3859,
          "referenceAllele": "T",
          "start": 3858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447892.1:c.679T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303660.1:p.Leu227="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581473"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3077078823",
      "coordinates": [
        {
          "allele": "C",
          "end": 2482,
          "referenceAllele": "T",
          "start": 2481
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_000141.5:c.1849T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000132.3:p.Leu617="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674724",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000358487.10:c.1849T>C"
          },
          "RefSeq": {
            "hgvs": "NM_000141.5:c.1849T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000351276.6:p.Leu617="
          },
          "RefSeq": {
            "hgvs": "NP_000132.3:p.Leu617="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2134,
          "referenceAllele": "T",
          "start": 2133
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144917.2:c.1501T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138389.1:p.Leu501="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677757"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2131,
          "referenceAllele": "T",
          "start": 2130
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144918.2:c.1498T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138390.1:p.Leu500="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677758"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2218,
          "referenceAllele": "T",
          "start": 2217
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144919.2:c.1585T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138391.1:p.Leu529="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677759"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2476,
          "referenceAllele": "T",
          "start": 2475
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320658.2:c.1843T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307587.1:p.Leu615="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684993"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2285,
          "referenceAllele": "T",
          "start": 2284
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NR_073009.2:n.2285T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS702637"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1901,
          "referenceAllele": "T",
          "start": 1900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144915.2:c.1582T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138387.1:p.Leu528="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712725"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1945,
          "referenceAllele": "T",
          "start": 1944
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144916.2:c.1504T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138388.1:p.Leu502="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712726"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1880,
          "referenceAllele": "T",
          "start": 1879
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320654.2:c.1165T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307583.1:p.Leu389="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS717810"
    }
  ],
  "type": "nucleotide"
}