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    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 4484,
          "referenceAllele": "",
          "start": 4484
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XM_011539982.1:c.704dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538284.1:p.Asp236GlyfsTer30",
        "hgvsWellDefined": "XP_011538284.1:p.[Asp236_Glu256delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArgGlyAsnLeuArg;Val258_Cys264delinsSerArgLysTrpLysSerMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106932"
    },
    {
      "coordinates": [
        {
          "allele": "A",
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          "referenceAllele": "",
          "start": 1370
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.1370dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1644,
          "referenceAllele": "",
          "start": 1644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.800dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Asp268GlyfsTer30",
        "hgvsWellDefined": "NP_000305.3:p.[Asp268_Glu288delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArgGlyAsnLeuArg;Val290_Cys296delinsSerArgLysTrpLysSerMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1644,
          "referenceAllele": "",
          "start": 1644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.1319dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Asp441GlyfsTer30",
        "hgvsWellDefined": "NP_001291646.4:p.[Asp441_Glu461delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArgGlyAsnLeuArg;Val463_Cys469delinsSerArgLysTrpLysSerMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1758,
          "referenceAllele": "",
          "start": 1758
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.209dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:p.Asp71GlyfsTer30",
        "hgvsWellDefined": "NP_001291647.1:p.[Asp71_Glu91delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArgGlyAsnLeuArg;Val93_Cys99delinsSerArgLysTrpLysSerMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1645,
          "referenceAllele": "",
          "start": 1645
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      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.800dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Asp268GlyfsTer30",
        "hgvsWellDefined": "NP_000305.3:p.[Asp268_Glu288delinsGlyGlnAsnValSerLeuLeuGlyLysTyrIleLeuHisThrArgThrArgGlyAsnLeuArg;Val290_Cys296delinsSerArgLysTrpLysSerMet]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.800dup"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.800dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Asp268GlyfsTer30"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Asp268GlyfsTer30"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}