{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA452987728",
  "communityStandardTitle": [
    "NM_000125.4(ESR1):c.975G>T (p.Pro325=)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr6:g.152265522G>T?assembly=hg19",
        "id": "chr6:g.152265522G>T"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1801132",
        "rs": 1801132
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/6-151944387-G-T?dataset=gnomad_r4",
        "id": "6-151944387-G-T",
        "variant": "6:151944387 G / T"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "T",
          "end": 151944387,
          "referenceAllele": "G",
          "start": 151944386
        }
      ],
      "hgvs": [
        "NC_000006.12:g.151944387G>T",
        "CM000668.2:g.151944387G>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000054"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "T",
          "end": 152265522,
          "referenceAllele": "G",
          "start": 152265521
        }
      ],
      "hgvs": [
        "NC_000006.11:g.152265522G>T",
        "CM000668.1:g.152265522G>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000030"
    },
    {
      "chromosome": "6",
      "coordinates": [
        {
          "allele": "T",
          "end": 152307215,
          "referenceAllele": "G",
          "start": 152307214
        }
      ],
      "hgvs": [
        "NC_000006.10:g.152307215G>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000006"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1206,
          "referenceAllele": "G",
          "start": 1205
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000206249.8:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000206249.3:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS740179",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000206249.8:c.975G>T"
          },
          "RefSeq": {
            "hgvs": "NM_000125.4:c.975G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000206249.3:p.Pro325="
          },
          "RefSeq": {
            "hgvs": "NP_000116.2:p.Pro325="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 42,
          "endIntronDirection": "+",
          "endIntronOffset": 138,
          "referenceAllele": "G",
          "start": 42,
          "startIntronDirection": "+",
          "startIntronOffset": 137
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000638569.1:c.42+138G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000491412.1:n.42+138G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS764592"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 303,
          "referenceAllele": "G",
          "start": 302
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000641399.1:n.303G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS766058"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1337,
          "referenceAllele": "G",
          "start": 1336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000206249.7:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000206249.3:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247826"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2435,
          "referenceAllele": "G",
          "start": 2434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000338799.9:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000342630.5:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260729"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 686,
          "endIntronDirection": "-",
          "endIntronOffset": 116603,
          "referenceAllele": "G",
          "start": 686,
          "startIntronDirection": "-",
          "startIntronOffset": 116604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000406599.5:c.453-116604G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000384064.1:n.453-116604G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280687"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 115,
          "endIntronDirection": "+",
          "endIntronOffset": 63616,
          "referenceAllele": "G",
          "start": 115,
          "startIntronDirection": "+",
          "startIntronOffset": 63615
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000415488.1:c.115+63616G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000401995.1:n.115+63616G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS284013"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 688,
          "referenceAllele": "G",
          "start": 687
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000427531.6:c.456G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000394721.2:p.Pro152="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS289747"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1345,
          "referenceAllele": "G",
          "start": 1344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000440973.5:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000405330.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS296160"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1236,
          "referenceAllele": "G",
          "start": 1235
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000443427.5:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000387500.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS297331"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 803,
          "endIntronDirection": "+",
          "endIntronOffset": 63616,
          "referenceAllele": "G",
          "start": 803,
          "startIntronDirection": "+",
          "startIntronOffset": 63615
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000456483.3:c.*110+63616G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000415934.3:n.*110+63616G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS303508"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 216,
          "referenceAllele": "G",
          "start": 215
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "ENST00000482101.1:n.216G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS321881"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1332,
          "referenceAllele": "G",
          "start": 1331
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_006715374.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_006715437.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS071129"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 683,
          "referenceAllele": "G",
          "start": 682
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_006715375.2:c.456G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_006715438.1:p.Pro152="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS071130"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1446,
          "referenceAllele": "G",
          "start": 1445
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535543.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533845.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102547"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1354,
          "referenceAllele": "G",
          "start": 1353
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535544.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533846.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102548"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1197,
          "referenceAllele": "G",
          "start": 1196
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535545.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533847.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102549"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1063,
          "referenceAllele": "G",
          "start": 1062
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535546.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533848.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102550"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1332,
          "referenceAllele": "G",
          "start": 1331
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535547.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533849.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102551"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 597,
          "referenceAllele": "G",
          "start": 596
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535548.1:c.456G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533850.1:p.Pro152="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102552"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 314,
          "referenceAllele": "G",
          "start": 313
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535549.1:c.246G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533851.1:p.Pro82="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS102553"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1345,
          "referenceAllele": "G",
          "start": 1344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_006715374.3:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_006715437.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS538916"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1342,
          "referenceAllele": "G",
          "start": 1341
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_006715375.3:c.456G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_006715438.1:p.Pro152="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS538917"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3170,
          "referenceAllele": "G",
          "start": 3169
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535543.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533845.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552068"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1354,
          "referenceAllele": "G",
          "start": 1353
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535544.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533846.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552069"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1243,
          "referenceAllele": "G",
          "start": 1242
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535545.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533847.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552070"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1345,
          "referenceAllele": "G",
          "start": 1344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535547.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533849.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552071"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 356,
          "referenceAllele": "G",
          "start": 355
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_011535549.2:c.246G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011533851.1:p.Pro82="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS552072"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3792,
          "referenceAllele": "G",
          "start": 3791
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010376.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865865.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564458"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3851,
          "referenceAllele": "G",
          "start": 3850
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010377.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865866.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564459"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1303,
          "referenceAllele": "G",
          "start": 1302
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010378.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865867.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564460"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1337,
          "referenceAllele": "G",
          "start": 1336
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010379.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865868.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564461"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3661,
          "referenceAllele": "G",
          "start": 3660
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010380.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865869.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564462"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1089,
          "referenceAllele": "G",
          "start": 1088
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010381.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865870.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564463"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 459,
          "referenceAllele": "G",
          "start": 458
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010382.2:c.318G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865871.1:p.Pro106="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564464"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 714,
          "referenceAllele": "G",
          "start": 713
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XM_017010383.1:c.186G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_016865872.1:p.Pro62="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS564465"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1345,
          "referenceAllele": "G",
          "start": 1344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XR_001743223.2:n.1345G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS592604"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1345,
          "referenceAllele": "G",
          "start": 1344
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "XR_002956266.1:n.1345G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS602428"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825047419",
      "coordinates": [
        {
          "allele": "T",
          "end": 1206,
          "referenceAllele": "G",
          "start": 1205
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_000125.4:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000116.2:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674713",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000206249.8:c.975G>T"
          },
          "RefSeq": {
            "hgvs": "NM_000125.4:c.975G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000206249.3:p.Pro325="
          },
          "RefSeq": {
            "hgvs": "NP_000116.2:p.Pro325="
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2827260883",
      "coordinates": [
        {
          "allele": "T",
          "end": 688,
          "referenceAllele": "G",
          "start": 687
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001328100.2:c.456G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001315029.1:p.Pro152="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS686485"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825586097",
      "coordinates": [
        {
          "allele": "T",
          "end": 1359,
          "referenceAllele": "G",
          "start": 1358
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001122740.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001116212.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712143"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825586154",
      "coordinates": [
        {
          "allele": "T",
          "end": 1161,
          "referenceAllele": "G",
          "start": 1160
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001122741.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001116213.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712144"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825586209",
      "coordinates": [
        {
          "allele": "T",
          "end": 1314,
          "referenceAllele": "G",
          "start": 1313
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001122742.2:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001116214.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712145"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826790210",
      "coordinates": [
        {
          "allele": "T",
          "end": 1167,
          "referenceAllele": "G",
          "start": 1166
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001291230.2:c.981G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001278159.1:p.Pro327="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS716676"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826790248",
      "coordinates": [
        {
          "allele": "T",
          "end": 1158,
          "referenceAllele": "G",
          "start": 1157
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001291241.2:c.972G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001278170.1:p.Pro324="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS716677"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829034184",
      "coordinates": [
        {
          "allele": "T",
          "end": 1268,
          "referenceAllele": "G",
          "start": 1267
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001385568.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372497.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723889"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829034241",
      "coordinates": [
        {
          "allele": "T",
          "end": 1354,
          "referenceAllele": "G",
          "start": 1353
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001385569.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372498.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723890"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829034298",
      "coordinates": [
        {
          "allele": "T",
          "end": 1314,
          "referenceAllele": "G",
          "start": 1313
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001385570.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372499.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723891"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829034341",
      "coordinates": [
        {
          "allele": "T",
          "end": 1354,
          "referenceAllele": "G",
          "start": 1353
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001385571.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372500.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723892"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829034370",
      "coordinates": [
        {
          "allele": "T",
          "end": 1206,
          "referenceAllele": "G",
          "start": 1205
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003467",
      "geneNCBI_id": 2099,
      "geneSymbol": "ESR1",
      "hgvs": [
        "NM_001385572.1:c.975G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372501.1:p.Pro325="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723893"
    }
  ],
  "type": "nucleotide"
}