{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA4369675",
  "communityStandardTitle": [
    "NM_017460.6(CYP3A4):c.670+34G>T"
  ],
  "externalRecords": {
    "ExAC": [
      {
        "@id": "http://exac.broadinstitute.org/variant/7-99365943-C-A",
        "id": "7-99365943-C-A",
        "variant": "7:99365943 C / A"
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr7:g.99365943C>A?assembly=hg19",
        "id": "chr7:g.99365943C>A"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr7:g.99768320C>A?assembly=hg38",
        "id": "chr7:g.99768320C>A"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/2687116",
        "rs": 2687116
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/7-99365943-C-A?dataset=gnomad_r2_1",
        "id": "7-99365943-C-A",
        "variant": "7:99365943 C / A"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/7-99768320-C-A?dataset=gnomad_r3",
        "id": "7-99768320-C-A",
        "variant": "7:99768320 C / A"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/7-99768320-C-A?dataset=gnomad_r4",
        "id": "7-99768320-C-A",
        "variant": "7:99768320 C / A"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 99768320,
          "referenceAllele": "C",
          "start": 99768319
        }
      ],
      "hgvs": [
        "NC_000007.14:g.99768320C>A",
        "CM000669.2:g.99768320C>A"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000055"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 99365943,
          "referenceAllele": "C",
          "start": 99365942
        }
      ],
      "hgvs": [
        "NC_000007.13:g.99365943C>A",
        "CM000669.1:g.99365943C>A"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000031"
    },
    {
      "chromosome": "7",
      "coordinates": [
        {
          "allele": "A",
          "end": 99203879,
          "referenceAllele": "C",
          "start": 99203878
        }
      ],
      "hgvs": [
        "NC_000007.12:g.99203879C>A"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000007"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 20866,
          "referenceAllele": "G",
          "start": 20865
        }
      ],
      "hgvs": [
        "NG_008421.1:g.20866G>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001091"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 773,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 773,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "ENST00000336411.7:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000337915.3:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS747581"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 773,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 773,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "ENST00000651514.1:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000498939.1:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS771709",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000651514.1:c.670+34G>T"
          },
          "RefSeq": {
            "hgvs": "NM_017460.6:c.670+34G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000498939.1:n.670+34G>T"
          },
          "RefSeq": {
            "hgvs": "NP_059488.2:n.670+34G>T"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 211,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 211,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "ENST00000651783.1:c.211+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000498924.1:n.211+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS771852"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 690,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 690,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "ENST00000652018.1:c.523+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000498733.1:n.523+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS771981"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 854,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 854,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "ENST00000336411.6:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000337915.2:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260298"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 327,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 327,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "ENST00000354593.6:c.220+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000346607.2:n.220+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS263179"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 777,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 777,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "NM_001202855.2:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001189784.1:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS017456"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 777,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 777,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "NM_017460.5:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_059488.2:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS034956"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 775,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 775,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "XM_011515841.1:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514143.1:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083049"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 775,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 775,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "XM_011515842.1:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514144.1:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS083050"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 773,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 773,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "NM_017460.6:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_059488.2:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS669249",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000651514.1:c.670+34G>T"
          },
          "RefSeq": {
            "hgvs": "NM_017460.6:c.670+34G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000498939.1:n.670+34G>T"
          },
          "RefSeq": {
            "hgvs": "NP_059488.2:n.670+34G>T"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 773,
          "endIntronDirection": "+",
          "endIntronOffset": 34,
          "referenceAllele": "G",
          "start": 773,
          "startIntronDirection": "+",
          "startIntronOffset": 33
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002637",
      "geneNCBI_id": 1576,
      "geneSymbol": "CYP3A4",
      "hgvs": [
        "NM_001202855.3:c.670+34G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001189784.1:n.670+34G>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679729"
    }
  ],
  "type": "nucleotide"
}