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      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
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      ],
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        "hgvs": "NP_958817.1:p.Met647Leu",
        "hgvsWellDefined": "NP_958817.1:p.Met647Leu"
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      "referenceSequence": "http://reg.genome.network/refseq/RS701542"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2026,
          "referenceAllele": "A",
          "start": 2025
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      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136131.3:c.1834A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129603.1:p.Met612Leu",
        "hgvsWellDefined": "NP_001129603.1:p.Met612Leu"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712494"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2146,
          "referenceAllele": "A",
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      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001385253.1:c.1996A>T"
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        "hgvs": "NP_001372182.1:p.Met666Leu",
        "hgvsWellDefined": "NP_001372182.1:p.Met666Leu"
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      "referenceSequence": "http://reg.genome.network/refseq/RS723592"
    }
  ],
  "type": "nucleotide"
}