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          "referenceAllele": "T",
          "start": 2089
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201414.3:c.1940T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_958817.1:p.Met647Arg",
        "hgvsWellDefined": "NP_958817.1:p.Met647Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701542"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2027,
          "referenceAllele": "T",
          "start": 2026
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136131.3:c.1835T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129603.1:p.Met612Arg",
        "hgvsWellDefined": "NP_001129603.1:p.Met612Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712494"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 2147,
          "referenceAllele": "T",
          "start": 2146
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001385253.1:c.1997T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372182.1:p.Met666Arg",
        "hgvsWellDefined": "NP_001372182.1:p.Met666Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723592"
    }
  ],
  "type": "nucleotide"
}