{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA397839990",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.645T>A (p.Ser215Arg)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=45122",
        "active": true,
        "id": "COSM45122"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1268353",
        "active": true,
        "id": "COSM1268353"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1268354",
        "active": true,
        "id": "COSM1268354"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1268355",
        "active": true,
        "id": "COSM1268355"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1268356",
        "active": true,
        "id": "COSM1268356"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3701297",
        "active": true,
        "id": "COSM3701297"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3701298",
        "active": true,
        "id": "COSM3701298"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=2079833[alleleid]",
        "alleleId": 2079833,
        "preferredName": "NM_000546.6(TP53):c.645T>A (p.Ser215Arg)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/2020649",
        "RCV": [
          "RCV002857438"
        ],
        "variationId": 2020649
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7578204A>T?assembly=hg19",
        "id": "chr17:g.7578204A>T"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7674886A>T?assembly=hg38",
        "id": "chr17:g.7674886A>T"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057520001",
        "rs": 1057520001
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "T",
          "end": 7674886,
          "referenceAllele": "A",
          "start": 7674885
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7674886A>T",
        "CM000679.2:g.7674886A>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "T",
          "end": 7578204,
          "referenceAllele": "A",
          "start": 7578203
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7578204A>T",
        "CM000679.1:g.7578204A>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "T",
          "end": 7518929,
          "referenceAllele": "A",
          "start": 7518928
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7518929A>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 17665,
          "referenceAllele": "T",
          "start": 17664
        }
      ],
      "hgvs": [
        "NG_017013.2:g.17665T>A",
        "LRG_321:g.17665T>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 827,
          "referenceAllele": "T",
          "start": 826
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000426252.2:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 927,
          "referenceAllele": "T",
          "start": 926
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000424104.2:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 381,
          "referenceAllele": "T",
          "start": 380
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Ser83Arg",
        "hgvsWellDefined": "ENSP00000425104.2:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 445,
          "referenceAllele": "T",
          "start": 444
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.366T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Ser122Arg",
        "hgvsWellDefined": "ENSP00000423862.2:p.Ser122Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 763,
          "referenceAllele": "T",
          "start": 762
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.624T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Ser208Arg",
        "hgvsWellDefined": "ENSP00000473895.2:p.Ser208Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000269305.4:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.645T>A"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.645T>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Ser215Arg"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Ser215Arg"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 835,
          "referenceAllele": "T",
          "start": 834
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000269305.4:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 645,
          "referenceAllele": "T",
          "start": 644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000352610.4:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 645,
          "referenceAllele": "T",
          "start": 644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000410739.2:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 778,
          "referenceAllele": "T",
          "start": 777
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000391127.2:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 781,
          "referenceAllele": "T",
          "start": 780
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000391478.2:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 778,
          "referenceAllele": "T",
          "start": 777
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000398846.2:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:p.Ser83Arg",
        "hgvsWellDefined": "ENSP00000484409.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Ser83Arg",
        "hgvsWellDefined": "ENSP00000481179.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 901,
          "referenceAllele": "T",
          "start": 900
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000505014.5:n.901T>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS336915"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 381,
          "referenceAllele": "T",
          "start": 380
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.5:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.1:p.Ser83Arg",
        "hgvsWellDefined": "ENSP00000425104.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247215"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:p.Ser83Arg",
        "hgvsWellDefined": "ENSP00000478499.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 445,
          "referenceAllele": "T",
          "start": 444
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.5:c.366T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.1:p.Ser122Arg",
        "hgvsWellDefined": "ENSP00000423862.1:p.Ser122Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247340"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 67,
          "endIntronDirection": "+",
          "endIntronOffset": 167,
          "referenceAllele": "T",
          "start": 67,
          "startIntronDirection": "+",
          "startIntronOffset": 166
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000574684.1:n.67+167T>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS383784"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 895,
          "referenceAllele": "T",
          "start": 894
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Ser176Arg",
        "hgvsWellDefined": "ENSP00000478219.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 778,
          "referenceAllele": "T",
          "start": 777
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:p.Ser176Arg",
        "hgvsWellDefined": "ENSP00000480868.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:p.Ser56Arg",
        "hgvsWellDefined": "ENSP00000477531.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 612,
          "referenceAllele": "T",
          "start": 611
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.612T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Ser204Arg",
        "hgvsWellDefined": "ENSP00000482903.1:p.Ser204Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:p.Ser215Arg",
        "hgvsWellDefined": "ENSP00000482258.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:p.Ser56Arg",
        "hgvsWellDefined": "ENSP00000481401.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:p.Ser56Arg",
        "hgvsWellDefined": "ENSP00000484375.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 781,
          "referenceAllele": "T",
          "start": 780
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Ser176Arg",
        "hgvsWellDefined": "ENSP00000482537.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 835,
          "referenceAllele": "T",
          "start": 834
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Ser176Arg",
        "hgvsWellDefined": "ENSP00000481638.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 778,
          "referenceAllele": "T",
          "start": 777
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:p.Ser176Arg",
        "hgvsWellDefined": "ENSP00000482222.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 788,
          "referenceAllele": "T",
          "start": 787
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Ser176Arg",
        "hgvsWellDefined": "ENSP00000488924.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579935339",
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.645T>A",
        "LRG_321t1:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Ser215Arg",
        "hgvsWellDefined": "NP_000537.3:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825600533",
      "coordinates": [
        {
          "allele": "A",
          "end": 844,
          "referenceAllele": "T",
          "start": 843
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.645T>A",
        "LRG_321t2:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Ser215Arg",
        "hgvsWellDefined": "NP_001119584.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825604599",
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.645T>A",
        "LRG_321t4:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Ser215Arg",
        "hgvsWellDefined": "NP_001119585.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825608123",
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.645T>A",
        "LRG_321t3:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Ser215Arg",
        "hgvsWellDefined": "NP_001119586.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825610415",
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.249T>A",
        "LRG_321t5:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Ser83Arg",
        "hgvsWellDefined": "NP_001119587.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825613222",
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.249T>A",
        "LRG_321t6:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Ser83Arg",
        "hgvsWellDefined": "NP_001119588.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645436298",
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.249T>A",
        "LRG_321t7:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Ser83Arg",
        "hgvsWellDefined": "NP_001119589.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825618065",
      "coordinates": [
        {
          "allele": "A",
          "end": 964,
          "referenceAllele": "T",
          "start": 963
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.528T>A",
        "LRG_321t8:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001119590.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559746",
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263624.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561204",
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263625.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562115",
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263626.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563244",
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263627.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826564110",
      "coordinates": [
        {
          "allele": "A",
          "end": 527,
          "referenceAllele": "T",
          "start": 526
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263628.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565598",
      "coordinates": [
        {
          "allele": "A",
          "end": 847,
          "referenceAllele": "T",
          "start": 846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263689.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567115",
      "coordinates": [
        {
          "allele": "A",
          "end": 844,
          "referenceAllele": "T",
          "start": 843
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263690.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559746",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263624.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561204",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263625.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562115",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263626.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563244",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263627.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826564110",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263628.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565598",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263689.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567115",
      "coordinates": [
        {
          "allele": "A",
          "end": 784,
          "referenceAllele": "T",
          "start": 783
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263690.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579935339",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Ser215Arg",
        "hgvsWellDefined": "NP_000537.3:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.645T>A"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.645T>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Ser215Arg"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Ser215Arg"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825600533",
      "coordinates": [
        {
          "allele": "A",
          "end": 784,
          "referenceAllele": "T",
          "start": 783
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Ser215Arg",
        "hgvsWellDefined": "NP_001119584.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825604599",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Ser215Arg",
        "hgvsWellDefined": "NP_001119585.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825608123",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.645T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Ser215Arg",
        "hgvsWellDefined": "NP_001119586.1:p.Ser215Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825610415",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Ser83Arg",
        "hgvsWellDefined": "NP_001119587.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825613222",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Ser83Arg",
        "hgvsWellDefined": "NP_001119588.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "@id": "http://reg.genome.network/allele/PA645436298",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.249T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Ser83Arg",
        "hgvsWellDefined": "NP_001119589.1:p.Ser83Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825618065",
      "coordinates": [
        {
          "allele": "A",
          "end": 904,
          "referenceAllele": "T",
          "start": 903
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001119590.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826559746",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263624.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561204",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263625.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562115",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263626.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563244",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263627.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826564110",
      "coordinates": [
        {
          "allele": "A",
          "end": 278,
          "referenceAllele": "T",
          "start": 277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.168T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Ser56Arg",
        "hgvsWellDefined": "NP_001263628.1:p.Ser56Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826565598",
      "coordinates": [
        {
          "allele": "A",
          "end": 787,
          "referenceAllele": "T",
          "start": 786
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263689.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567115",
      "coordinates": [
        {
          "allele": "A",
          "end": 784,
          "referenceAllele": "T",
          "start": 783
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.528T>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Ser176Arg",
        "hgvsWellDefined": "NP_001263690.1:p.Ser176Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}