{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA397835794",
  "communityStandardTitle": [
    "NM_000546.6(TP53):c.977A>T (p.Glu326Val)"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=2743448[alleleid]",
        "alleleId": 2743448,
        "preferredName": "NM_000546.6(TP53):c.977A>T (p.Glu326Val)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/2578514",
        "RCV": [
          "RCV003326290"
        ],
        "variationId": 2578514
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7576869T>A?assembly=hg19",
        "id": "chr17:g.7576869T>A"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr17:g.7673551T>A?assembly=hg38",
        "id": "chr17:g.7673551T>A"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/2151011218",
        "rs": 2151011218
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "A",
          "end": 7673551,
          "referenceAllele": "T",
          "start": 7673550
        }
      ],
      "hgvs": [
        "NC_000017.11:g.7673551T>A",
        "CM000679.2:g.7673551T>A"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000065"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "A",
          "end": 7576869,
          "referenceAllele": "T",
          "start": 7576868
        }
      ],
      "hgvs": [
        "NC_000017.10:g.7576869T>A",
        "CM000679.1:g.7576869T>A"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000041"
    },
    {
      "chromosome": "17",
      "coordinates": [
        {
          "allele": "A",
          "end": 7517594,
          "referenceAllele": "T",
          "start": 7517593
        }
      ],
      "hgvs": [
        "NC_000017.9:g.7517594T>A"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000017"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 19000,
          "referenceAllele": "A",
          "start": 18999
        }
      ],
      "hgvs": [
        "NG_017013.2:g.19000A>T",
        "LRG_321:g.19000A>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003369"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1159,
          "referenceAllele": "A",
          "start": 1158
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000503591.2:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426252.2:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000426252.2:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914179"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1259,
          "referenceAllele": "A",
          "start": 1258
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000508793.6:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424104.2:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000424104.2:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914191"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 713,
          "referenceAllele": "A",
          "start": 712
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.6:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.2:p.Glu194Val",
        "hgvsWellDefined": "ENSP00000425104.2:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914194"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 777,
          "referenceAllele": "A",
          "start": 776
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000514944.6:c.698A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000423862.2:p.Glu233Val",
        "hgvsWellDefined": "ENSP00000423862.2:p.Glu233Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914205"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1095,
          "referenceAllele": "A",
          "start": 1094
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000604348.6:c.956A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000473895.2:p.Glu319Val",
        "hgvsWellDefined": "ENSP00000473895.2:p.Glu319Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914353"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.9:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000269305.4:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS743105",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.977A>T"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.977A>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Glu326Val"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Glu326Val"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1167,
          "referenceAllele": "A",
          "start": 1166
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000269305.8:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000269305.4:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000269305.4:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247246"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 977,
          "referenceAllele": "A",
          "start": 976
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000359597.8:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000352610.4:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000352610.4:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247341"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 782,
          "endIntronDirection": "+",
          "endIntronOffset": 630,
          "referenceAllele": "A",
          "start": 782,
          "startIntronDirection": "+",
          "startIntronOffset": 629
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000413465.6:c.782+630A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410739.2:n.782+630A>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247363"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1110,
          "referenceAllele": "A",
          "start": 1109
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000420246.6:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391127.2:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000391127.2:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247205"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1113,
          "referenceAllele": "A",
          "start": 1112
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000445888.6:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000391478.2:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000391478.2:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247156"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1110,
          "referenceAllele": "A",
          "start": 1109
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000455263.6:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000398846.2:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000398846.2:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS246735"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504290.5:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484409.1:p.Glu194Val",
        "hgvsWellDefined": "ENSP00000484409.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336391"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000504937.5:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481179.1:p.Glu194Val",
        "hgvsWellDefined": "ENSP00000481179.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS336854"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 713,
          "referenceAllele": "A",
          "start": 712
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000509690.5:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000425104.1:p.Glu194Val",
        "hgvsWellDefined": "ENSP00000425104.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS247215"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000510385.5:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478499.1:p.Glu194Val",
        "hgvsWellDefined": "ENSP00000478499.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340909"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 37,
          "referenceAllele": "A",
          "start": 36
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000576024.1:c.37A>T"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS247265"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1227,
          "referenceAllele": "A",
          "start": 1226
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610292.4:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000478219.1:p.Glu287Val",
        "hgvsWellDefined": "ENSP00000478219.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400360"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1110,
          "referenceAllele": "A",
          "start": 1109
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610538.4:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480868.1:p.Glu287Val",
        "hgvsWellDefined": "ENSP00000480868.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400464"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000610623.4:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000477531.1:p.Glu167Val",
        "hgvsWellDefined": "ENSP00000477531.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400503"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 944,
          "referenceAllele": "A",
          "start": 943
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000615910.4:c.944A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482903.1:p.Glu315Val",
        "hgvsWellDefined": "ENSP00000482903.1:p.Glu315Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402821"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000617185.4:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482258.1:p.Glu326Val",
        "hgvsWellDefined": "ENSP00000482258.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403371"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000618944.4:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481401.1:p.Glu167Val",
        "hgvsWellDefined": "ENSP00000481401.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404162"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619186.4:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484375.1:p.Glu167Val",
        "hgvsWellDefined": "ENSP00000484375.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404266"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1113,
          "referenceAllele": "A",
          "start": 1112
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000619485.4:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482537.1:p.Glu287Val",
        "hgvsWellDefined": "ENSP00000482537.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404399"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1167,
          "referenceAllele": "A",
          "start": 1166
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000620739.4:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481638.1:p.Glu287Val",
        "hgvsWellDefined": "ENSP00000481638.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS404959"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1110,
          "referenceAllele": "A",
          "start": 1109
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000622645.4:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000482222.1:p.Glu287Val",
        "hgvsWellDefined": "ENSP00000482222.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405818"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1120,
          "referenceAllele": "A",
          "start": 1119
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "ENST00000635293.1:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000488924.1:p.Glu287Val",
        "hgvsWellDefined": "ENSP00000488924.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS408095"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579952156",
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.5:c.977A>T",
        "LRG_321t1:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Glu326Val",
        "hgvsWellDefined": "NP_000537.3:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006605"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825602069",
      "coordinates": [
        {
          "allele": "T",
          "end": 1176,
          "referenceAllele": "A",
          "start": 1175
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.2:c.977A>T",
        "LRG_321t2:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Glu326Val",
        "hgvsWellDefined": "NP_001119584.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011490"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825605901",
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.2:c.977A>T",
        "LRG_321t4:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Glu326Val",
        "hgvsWellDefined": "NP_001119585.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011491"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825609359",
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.2:c.977A>T",
        "LRG_321t3:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Glu326Val",
        "hgvsWellDefined": "NP_001119586.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825611791",
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.1:c.581A>T",
        "LRG_321t5:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Glu194Val",
        "hgvsWellDefined": "NP_001119587.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011493"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825614537",
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.1:c.581A>T",
        "LRG_321t6:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Glu194Val",
        "hgvsWellDefined": "NP_001119588.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011494"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825616405",
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.1:c.581A>T",
        "LRG_321t7:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Glu194Val",
        "hgvsWellDefined": "NP_001119589.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011495"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825619131",
      "coordinates": [
        {
          "allele": "T",
          "end": 1296,
          "referenceAllele": "A",
          "start": 1295
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.1:c.860A>T",
        "LRG_321t8:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001119590.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS011496"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826560339",
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.1:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263624.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020927"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561800",
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.1:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263625.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020928"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562709",
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.1:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263626.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020929"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563830",
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.1:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263627.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020930"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826564537",
      "coordinates": [
        {
          "allele": "T",
          "end": 859,
          "referenceAllele": "A",
          "start": 858
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.1:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263628.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020931"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826566188",
      "coordinates": [
        {
          "allele": "T",
          "end": 1179,
          "referenceAllele": "A",
          "start": 1178
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.1:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263689.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567705",
      "coordinates": [
        {
          "allele": "T",
          "end": 1176,
          "referenceAllele": "A",
          "start": 1175
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.1:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263690.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS020943"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826560339",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.2:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263624.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681331"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561800",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.2:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263625.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681332"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562709",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.2:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263626.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681333"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563830",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.2:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263627.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681334"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826564537",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.2:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263628.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681335"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826566188",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.2:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263689.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681339"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567705",
      "coordinates": [
        {
          "allele": "T",
          "end": 1116,
          "referenceAllele": "A",
          "start": 1115
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.2:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263690.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681340"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2579952156",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_000546.6:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_000537.3:p.Glu326Val",
        "hgvsWellDefined": "NP_000537.3:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS710844",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000269305.9:c.977A>T"
          },
          "RefSeq": {
            "hgvs": "NM_000546.6:c.977A>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000269305.4:p.Glu326Val"
          },
          "RefSeq": {
            "hgvs": "NP_000537.3:p.Glu326Val"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825602069",
      "coordinates": [
        {
          "allele": "T",
          "end": 1116,
          "referenceAllele": "A",
          "start": 1115
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126112.3:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119584.1:p.Glu326Val",
        "hgvsWellDefined": "NP_001119584.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712176"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825605901",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126113.3:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119585.1:p.Glu326Val",
        "hgvsWellDefined": "NP_001119585.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712177"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825609359",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126114.3:c.977A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119586.1:p.Glu326Val",
        "hgvsWellDefined": "NP_001119586.1:p.Glu326Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712178"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825611791",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126115.2:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119587.1:p.Glu194Val",
        "hgvsWellDefined": "NP_001119587.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712179"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825614537",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126116.2:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119588.1:p.Glu194Val",
        "hgvsWellDefined": "NP_001119588.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712180"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825616405",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126117.2:c.581A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119589.1:p.Glu194Val",
        "hgvsWellDefined": "NP_001119589.1:p.Glu194Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712181"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2825619131",
      "coordinates": [
        {
          "allele": "T",
          "end": 1236,
          "referenceAllele": "A",
          "start": 1235
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001126118.2:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001119590.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001119590.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712182"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826560339",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276695.3:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263624.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263624.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715405"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826561800",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276696.3:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263625.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263625.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715406"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826562709",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276697.3:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263626.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263626.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715407"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826563830",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276698.3:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263627.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263627.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715408"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826564537",
      "coordinates": [
        {
          "allele": "T",
          "end": 610,
          "referenceAllele": "A",
          "start": 609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276699.3:c.500A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263628.1:p.Glu167Val",
        "hgvsWellDefined": "NP_001263628.1:p.Glu167Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715409"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826566188",
      "coordinates": [
        {
          "allele": "T",
          "end": 1119,
          "referenceAllele": "A",
          "start": 1118
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276760.3:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263689.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263689.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715416"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826567705",
      "coordinates": [
        {
          "allele": "T",
          "end": 1116,
          "referenceAllele": "A",
          "start": 1115
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011998",
      "geneNCBI_id": 7157,
      "geneSymbol": "TP53",
      "hgvs": [
        "NM_001276761.3:c.860A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001263690.1:p.Glu287Val",
        "hgvsWellDefined": "NP_001263690.1:p.Glu287Val"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715417"
    }
  ],
  "type": "nucleotide"
}