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      "gene": "http://reg.genome.network/gene/GN009008",
      "geneNCBI_id": 5310,
      "geneSymbol": "PKD1",
      "hgvs": [
        "NM_001009944.3:c.2180T>G"
      ],
      "proteinEffect": {
        "hgvs": "NP_001009944.3:p.Leu727Arg",
        "hgvsWellDefined": "NP_001009944.3:p.Leu727Arg"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS675359",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000262304.9:c.2180T>G"
          },
          "RefSeq": {
            "hgvs": "NM_001009944.3:c.2180T>G"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000262304.4:p.Leu727Arg"
          },
          "RefSeq": {
            "hgvs": "NP_001009944.3:p.Leu727Arg"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}