{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA384148531",
  "communityStandardTitle": [
    "NM_004985.5(KRAS):c.455T>C (p.Val152Ala)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr12:g.25362841A>G?assembly=hg19",
        "id": "chr12:g.25362841A>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr12:g.25209907A>G?assembly=hg38",
        "id": "chr12:g.25209907A>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/104894367",
        "rs": 104894367
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/12-25209907-A-G?dataset=gnomad_r3",
        "id": "12-25209907-A-G",
        "variant": "12:25209907 A / G"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/12-25209907-A-G?dataset=gnomad_r4",
        "id": "12-25209907-A-G",
        "variant": "12:25209907 A / G"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "12",
      "coordinates": [
        {
          "allele": "G",
          "end": 25209907,
          "referenceAllele": "A",
          "start": 25209906
        }
      ],
      "hgvs": [
        "NC_000012.12:g.25209907A>G",
        "CM000674.2:g.25209907A>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000060"
    },
    {
      "chromosome": "12",
      "coordinates": [
        {
          "allele": "G",
          "end": 25362841,
          "referenceAllele": "A",
          "start": 25362840
        }
      ],
      "hgvs": [
        "NC_000012.11:g.25362841A>G",
        "CM000674.1:g.25362841A>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000036"
    },
    {
      "chromosome": "12",
      "coordinates": [
        {
          "allele": "G",
          "end": 25254108,
          "referenceAllele": "A",
          "start": 25254107
        }
      ],
      "hgvs": [
        "NC_000012.10:g.25254108A>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000012"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 46014,
          "referenceAllele": "T",
          "start": 46013
        }
      ],
      "hgvs": [
        "NG_007524.1:g.46014T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000632"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 46097,
          "referenceAllele": "T",
          "start": 46096
        }
      ],
      "hgvs": [
        "NG_007524.2:g.46097T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS706074"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 313,
          "referenceAllele": "T",
          "start": 312
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000557334.6:c.116T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000452512.1:p.Val39Ala",
        "hgvsWellDefined": "ENSP00000452512.1:p.Val39Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS826054"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 638,
          "referenceAllele": "T",
          "start": 637
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000685328.1:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000508921.1:p.Val152Ala",
        "hgvsWellDefined": "ENSP00000508921.1:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS830011"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 763,
          "referenceAllele": "T",
          "start": 762
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000686877.1:c.*426T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000510431.1:n.*426T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS830790"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 464,
          "referenceAllele": "T",
          "start": 463
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000687356.1:c.*153T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000510511.1:n.*153T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS831046"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 929,
          "referenceAllele": "T",
          "start": 928
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000688228.1:n.929T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS831511"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 656,
          "referenceAllele": "T",
          "start": 655
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000688940.1:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000509238.1:p.Val152Ala",
        "hgvsWellDefined": "ENSP00000509238.1:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS831903"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 258,
          "referenceAllele": "T",
          "start": 257
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000690406.1:c.258T>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS832686"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 762,
          "referenceAllele": "T",
          "start": 761
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000690804.1:c.*416T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000508568.1:n.*416T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS832883"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 511,
          "referenceAllele": "T",
          "start": 510
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000692768.1:c.257T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000510254.1:p.Val86Ala",
        "hgvsWellDefined": "ENSP00000510254.1:p.Val86Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS833874"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 540,
          "referenceAllele": "T",
          "start": 539
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000693229.1:c.380T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000509223.1:p.Val127Ala",
        "hgvsWellDefined": "ENSP00000509223.1:p.Val127Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS834130"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 769,
          "referenceAllele": "T",
          "start": 768
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000256078.10:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000256078.5:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS741745",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000256078.10:c.*9T>C"
          },
          "RefSeq": {
            "hgvs": "NM_033360.4:c.*9T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000256078.5:n.*9T>C"
          },
          "RefSeq": {
            "hgvs": "NP_203524.1:n.*9T>C"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 645,
          "referenceAllele": "T",
          "start": 644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000311936.8:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000308495.3:p.Val152Ala",
        "hgvsWellDefined": "ENSP00000308495.3:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS745760",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000311936.8:c.455T>C"
          },
          "RefSeq": {
            "hgvs": "NM_004985.5:c.455T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000308495.3:p.Val152Ala"
          },
          "RefSeq": {
            "hgvs": "NP_004976.2:p.Val152Ala"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 643,
          "referenceAllele": "T",
          "start": 642
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000256078.8:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000256078.4:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS250141"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 647,
          "referenceAllele": "T",
          "start": 646
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000311936.7:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000308495.3:p.Val152Ala",
        "hgvsWellDefined": "ENSP00000308495.3:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS256608"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 313,
          "referenceAllele": "T",
          "start": 312
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "ENST00000557334.5:c.116T>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000452512.1:p.Val39Ala",
        "hgvsWellDefined": "ENSP00000452512.1:p.Val39Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS372942"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3079285273",
      "coordinates": [
        {
          "allele": "C",
          "end": 647,
          "referenceAllele": "T",
          "start": 646
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "NM_004985.4:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_004976.2:p.Val152Ala",
        "hgvsWellDefined": "NP_004976.2:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS030116"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 771,
          "referenceAllele": "T",
          "start": 770
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "NM_033360.3:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_203524.1:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS039698"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 733,
          "referenceAllele": "T",
          "start": 732
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "XM_006719069.2:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006719132.1:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072923"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 605,
          "referenceAllele": "T",
          "start": 604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "XM_011520653.1:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011518955.1:p.Val152Ala",
        "hgvsWellDefined": "XP_011518955.1:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS087819"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 830,
          "referenceAllele": "T",
          "start": 829
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "XM_006719069.4:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006719132.1:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539772"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 638,
          "referenceAllele": "T",
          "start": 637
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "XM_011520653.3:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011518955.1:p.Val152Ala",
        "hgvsWellDefined": "XP_011518955.1:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS545835"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 756,
          "referenceAllele": "T",
          "start": 755
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "NM_001369786.1:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001356715.1:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691970"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 632,
          "referenceAllele": "T",
          "start": 631
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "NM_001369787.1:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001356716.1:p.Val152Ala",
        "hgvsWellDefined": "NP_001356716.1:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691971"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3079285273",
      "coordinates": [
        {
          "allele": "C",
          "end": 645,
          "referenceAllele": "T",
          "start": 644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "NM_004985.5:c.455T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_004976.2:p.Val152Ala",
        "hgvsWellDefined": "NP_004976.2:p.Val152Ala"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS696291",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000311936.8:c.455T>C"
          },
          "RefSeq": {
            "hgvs": "NM_004985.5:c.455T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000308495.3:p.Val152Ala"
          },
          "RefSeq": {
            "hgvs": "NP_004976.2:p.Val152Ala"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 769,
          "referenceAllele": "T",
          "start": 768
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006407",
      "geneNCBI_id": 3845,
      "geneSymbol": "KRAS",
      "hgvs": [
        "NM_033360.4:c.*9T>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_203524.1:n.*9T>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS699342",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000256078.10:c.*9T>C"
          },
          "RefSeq": {
            "hgvs": "NM_033360.4:c.*9T>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000256078.5:n.*9T>C"
          },
          "RefSeq": {
            "hgvs": "NP_203524.1:n.*9T>C"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}