{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA378330348",
  "communityStandardTitle": [
    "NM_000141.5(FGFR2):c.923A>C (p.Tyr308Ser)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr10:g.123279509T>G?assembly=hg19",
        "id": "chr10:g.123279509T>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr10:g.121519995T>G?assembly=hg38",
        "id": "chr10:g.121519995T>G"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1057519040",
        "rs": 1057519040
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 121519995,
          "referenceAllele": "T",
          "start": 121519994
        }
      ],
      "hgvs": [
        "NC_000010.11:g.121519995T>G",
        "CM000672.2:g.121519995T>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000058"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 123279509,
          "referenceAllele": "T",
          "start": 123279508
        }
      ],
      "hgvs": [
        "NC_000010.10:g.123279509T>G",
        "CM000672.1:g.123279509T>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000034"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 123269499,
          "referenceAllele": "T",
          "start": 123269498
        }
      ],
      "hgvs": [
        "NC_000010.9:g.123269499T>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000010"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 83464,
          "referenceAllele": "A",
          "start": 83463
        }
      ],
      "hgvs": [
        "NG_012449.1:g.83464A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002410"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 83464,
          "referenceAllele": "A",
          "start": 83463
        }
      ],
      "hgvs": [
        "NG_012449.2:g.83464A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS616181"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1556,
          "referenceAllele": "A",
          "start": 1555
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000457416.7:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410294.2:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000410294.2:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS905054",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Plus Clinical",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000457416.7:c.923A>C"
          },
          "RefSeq": {
            "hgvs": "NM_022970.4:c.923A>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000410294.2:p.Tyr308Ser"
          },
          "RefSeq": {
            "hgvs": "NP_075259.4:p.Tyr308Ser"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1714,
          "referenceAllele": "A",
          "start": 1713
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000351936.11:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000309878.10:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000309878.10:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS824066"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 243,
          "referenceAllele": "A",
          "start": 242
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000638709.2:c.-248A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000491912.2:n.-248A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS826680"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 271,
          "referenceAllele": "A",
          "start": 270
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682296.1:n.271A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS827290"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 578,
          "referenceAllele": "A",
          "start": 577
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682400.1:n.578A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS827392"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 840,
          "referenceAllele": "A",
          "start": 839
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682550.1:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000507633.1:p.Tyr193Ser",
        "hgvsWellDefined": "ENSP00000507633.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS827540"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 591,
          "referenceAllele": "A",
          "start": 590
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000682772.1:c.-248A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000506848.1:n.-248A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS827761"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3917,
          "referenceAllele": "A",
          "start": 3916
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683211.1:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000508257.1:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000508257.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS828193"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 838,
          "endIntronDirection": "-",
          "endIntronOffset": 16053,
          "referenceAllele": "A",
          "start": 838,
          "startIntronDirection": "-",
          "startIntronOffset": 16054
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683250.1:c.404-16054A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000506847.1:n.404-16054A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS828232"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 3270,
          "referenceAllele": "A",
          "start": 3269
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683418.1:n.3270A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS828395"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 923,
          "referenceAllele": "A",
          "start": 922
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000683678.1:n.923A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS828649"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1133,
          "referenceAllele": "A",
          "start": 1132
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000684153.1:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000506937.1:p.Tyr193Ser",
        "hgvsWellDefined": "ENSP00000506937.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS829111"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1556,
          "referenceAllele": "A",
          "start": 1555
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000358487.10:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000351276.6:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000351276.6:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS749076",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000358487.10:c.923A>C"
          },
          "RefSeq": {
            "hgvs": "NM_000141.5:c.923A>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000351276.6:p.Tyr308Ser"
          },
          "RefSeq": {
            "hgvs": "NP_000132.3:p.Tyr308Ser"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1241,
          "referenceAllele": "A",
          "start": 1240
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000336553.10:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000337665.6:p.Tyr219Ser",
        "hgvsWellDefined": "ENSP00000337665.6:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260321"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 935,
          "referenceAllele": "A",
          "start": 934
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000346997.6:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000263451.5:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000263451.5:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262318"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 935,
          "referenceAllele": "A",
          "start": 934
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000351936.10:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000309878.9:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000309878.9:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262814"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1225,
          "referenceAllele": "A",
          "start": 1224
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000356226.8:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000348559.4:p.Tyr193Ser",
        "hgvsWellDefined": "ENSP00000348559.4:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS263693"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 975,
          "referenceAllele": "A",
          "start": 974
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000357555.9:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000350166.5:p.Tyr219Ser",
        "hgvsWellDefined": "ENSP00000350166.5:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS264152"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1196,
          "referenceAllele": "A",
          "start": 1195
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000358487.9:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000351276.5:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000351276.5:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS264468"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1277,
          "referenceAllele": "A",
          "start": 1276
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000360144.7:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000353262.3:p.Tyr219Ser",
        "hgvsWellDefined": "ENSP00000353262.3:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS265030"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 947,
          "referenceAllele": "A",
          "start": 946
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369056.5:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358052.1:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000358052.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267337"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1346,
          "referenceAllele": "A",
          "start": 1345
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369058.7:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358054.3:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000358054.3:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267338"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1219,
          "referenceAllele": "A",
          "start": 1218
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369059.5:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358055.1:p.Tyr193Ser",
        "hgvsWellDefined": "ENSP00000358055.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267339"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1410,
          "referenceAllele": "A",
          "start": 1409
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369060.8:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358056.4:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000358056.4:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267340"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 898,
          "endIntronDirection": "-",
          "endIntronOffset": 4675,
          "referenceAllele": "A",
          "start": 898,
          "startIntronDirection": "-",
          "startIntronOffset": 4676
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000369061.8:c.749-4676A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000358057.4:n.749-4676A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS267341"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1515,
          "referenceAllele": "A",
          "start": 1514
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000457416.6:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000410294.2:p.Tyr308Ser",
        "hgvsWellDefined": "ENSP00000410294.2:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS303943"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 954,
          "referenceAllele": "A",
          "start": 953
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000478859.5:c.239A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474011.1:p.Tyr80Ser",
        "hgvsWellDefined": "ENSP00000474011.1:p.Tyr80Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS319363"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1184,
          "referenceAllele": "A",
          "start": 1183
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000490349.5:n.1184A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS328193"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1180,
          "referenceAllele": "A",
          "start": 1179
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000604236.5:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000474109.1:p.Tyr193Ser",
        "hgvsWellDefined": "ENSP00000474109.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS398949"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1303,
          "referenceAllele": "A",
          "start": 1302
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "ENST00000613048.4:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000484154.1:p.Tyr219Ser",
        "hgvsWellDefined": "ENSP00000484154.1:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS401574"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3077078806",
      "coordinates": [
        {
          "allele": "C",
          "end": 1570,
          "referenceAllele": "A",
          "start": 1569
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_000141.4:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000132.3:p.Tyr308Ser",
        "hgvsWellDefined": "NP_000132.3:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006203"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1073,
          "referenceAllele": "A",
          "start": 1072
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144913.1:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138385.1:p.Tyr308Ser",
        "hgvsWellDefined": "NP_001138385.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013351"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 898,
          "endIntronDirection": "-",
          "endIntronOffset": 4675,
          "referenceAllele": "A",
          "start": 898,
          "startIntronDirection": "-",
          "startIntronOffset": 4676
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144914.1:c.749-4676A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138386.1:n.749-4676A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013352"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 975,
          "referenceAllele": "A",
          "start": 974
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144915.1:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138387.1:p.Tyr219Ser",
        "hgvsWellDefined": "NP_001138387.1:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013353"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1019,
          "referenceAllele": "A",
          "start": 1018
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144916.1:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138388.1:p.Tyr193Ser",
        "hgvsWellDefined": "NP_001138388.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013354"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1570,
          "referenceAllele": "A",
          "start": 1569
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144917.1:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138389.1:p.Tyr308Ser",
        "hgvsWellDefined": "NP_001138389.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013355"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1225,
          "referenceAllele": "A",
          "start": 1224
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144918.1:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138390.1:p.Tyr193Ser",
        "hgvsWellDefined": "NP_001138390.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013356"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1303,
          "referenceAllele": "A",
          "start": 1302
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144919.1:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138391.1:p.Tyr219Ser",
        "hgvsWellDefined": "NP_001138391.1:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013357"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1570,
          "referenceAllele": "A",
          "start": 1569
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_022970.3:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_075259.4:p.Tyr308Ser",
        "hgvsWellDefined": "NP_075259.4:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS037524"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 806,
          "referenceAllele": "A",
          "start": 805
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_023029.2:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_075418.1:p.Tyr219Ser",
        "hgvsWellDefined": "NP_075418.1:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS037544"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1225,
          "referenceAllele": "A",
          "start": 1224
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NR_073009.1:n.1225A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS052421"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1768,
          "referenceAllele": "A",
          "start": 1767
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717708.2:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717771.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_006717771.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072285"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1768,
          "referenceAllele": "A",
          "start": 1767
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717709.2:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717772.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_006717772.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072286"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1768,
          "referenceAllele": "A",
          "start": 1767
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717710.2:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717773.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_006717773.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072287"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 806,
          "referenceAllele": "A",
          "start": 805
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717711.2:c.713A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717774.1:p.Tyr238Ser",
        "hgvsWellDefined": "XP_006717774.1:p.Tyr238Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072288"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 728,
          "referenceAllele": "A",
          "start": 727
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717712.2:c.635A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717775.1:p.Tyr212Ser",
        "hgvsWellDefined": "XP_006717775.1:p.Tyr212Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072289"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1768,
          "referenceAllele": "A",
          "start": 1767
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717713.2:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717776.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_006717776.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS072290"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 436,
          "referenceAllele": "A",
          "start": 435
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_011539510.1:c.239A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_011537812.1:p.Tyr80Ser",
        "hgvsWellDefined": "XP_011537812.1:p.Tyr80Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106460"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 954,
          "referenceAllele": "A",
          "start": 953
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320654.1:c.239A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307583.1:p.Tyr80Ser",
        "hgvsWellDefined": "NP_001307583.1:p.Tyr80Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS513707"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1570,
          "referenceAllele": "A",
          "start": 1569
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320658.1:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307587.1:p.Tyr308Ser",
        "hgvsWellDefined": "NP_001307587.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS513711"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1198,
          "referenceAllele": "A",
          "start": 1197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717708.3:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717771.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_006717771.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539461"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1198,
          "referenceAllele": "A",
          "start": 1197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_006717710.4:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_006717773.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_006717773.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS539462"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1198,
          "referenceAllele": "A",
          "start": 1197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015920.2:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871409.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_016871409.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568504"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1198,
          "referenceAllele": "A",
          "start": 1197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015921.2:c.980A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871410.1:p.Tyr327Ser",
        "hgvsWellDefined": "XP_016871410.1:p.Tyr327Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568505"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 818,
          "referenceAllele": "A",
          "start": 817
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015924.2:c.635A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871413.1:p.Tyr212Ser",
        "hgvsWellDefined": "XP_016871413.1:p.Tyr212Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568506"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1098,
          "referenceAllele": "A",
          "start": 1097
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_017015925.2:c.635A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_016871414.1:p.Tyr212Ser",
        "hgvsWellDefined": "XP_016871414.1:p.Tyr212Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS568507"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 896,
          "referenceAllele": "A",
          "start": 895
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447887.1:c.713A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303655.1:p.Tyr238Ser",
        "hgvsWellDefined": "XP_024303655.1:p.Tyr238Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581468"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 896,
          "referenceAllele": "A",
          "start": 895
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447888.1:c.713A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303656.1:p.Tyr238Ser",
        "hgvsWellDefined": "XP_024303656.1:p.Tyr238Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581469"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 896,
          "referenceAllele": "A",
          "start": 895
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447889.1:c.713A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303657.1:p.Tyr238Ser",
        "hgvsWellDefined": "XP_024303657.1:p.Tyr238Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581470"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1303,
          "referenceAllele": "A",
          "start": 1302
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447890.1:c.713A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303658.1:p.Tyr238Ser",
        "hgvsWellDefined": "XP_024303658.1:p.Tyr238Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581471"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 818,
          "referenceAllele": "A",
          "start": 817
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447891.1:c.635A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303659.1:p.Tyr212Ser",
        "hgvsWellDefined": "XP_024303659.1:p.Tyr212Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581472"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 2933,
          "referenceAllele": "A",
          "start": 2932
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "XM_024447892.1:c.-248A>C"
      ],
      "proteinEffect": {
        "hgvs": "XP_024303660.1:n.-248A>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS581473"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3077078806",
      "coordinates": [
        {
          "allele": "C",
          "end": 1556,
          "referenceAllele": "A",
          "start": 1555
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_000141.5:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000132.3:p.Tyr308Ser",
        "hgvsWellDefined": "NP_000132.3:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674724",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000358487.10:c.923A>C"
          },
          "RefSeq": {
            "hgvs": "NM_000141.5:c.923A>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000351276.6:p.Tyr308Ser"
          },
          "RefSeq": {
            "hgvs": "NP_000132.3:p.Tyr308Ser"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1556,
          "referenceAllele": "A",
          "start": 1555
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144917.2:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138389.1:p.Tyr308Ser",
        "hgvsWellDefined": "NP_001138389.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677757"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1211,
          "referenceAllele": "A",
          "start": 1210
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144918.2:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138390.1:p.Tyr193Ser",
        "hgvsWellDefined": "NP_001138390.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677758"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1289,
          "referenceAllele": "A",
          "start": 1288
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144919.2:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138391.1:p.Tyr219Ser",
        "hgvsWellDefined": "NP_001138391.1:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677759"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1556,
          "referenceAllele": "A",
          "start": 1555
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320658.2:c.923A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307587.1:p.Tyr308Ser",
        "hgvsWellDefined": "NP_001307587.1:p.Tyr308Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684993"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1211,
          "referenceAllele": "A",
          "start": 1210
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NR_073009.2:n.1211A>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS702637"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 975,
          "referenceAllele": "A",
          "start": 974
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144915.2:c.656A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138387.1:p.Tyr219Ser",
        "hgvsWellDefined": "NP_001138387.1:p.Tyr219Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712725"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1019,
          "referenceAllele": "A",
          "start": 1018
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001144916.2:c.578A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001138388.1:p.Tyr193Ser",
        "hgvsWellDefined": "NP_001138388.1:p.Tyr193Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712726"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 954,
          "referenceAllele": "A",
          "start": 953
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003689",
      "geneNCBI_id": 2263,
      "geneSymbol": "FGFR2",
      "hgvs": [
        "NM_001320654.2:c.239A>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001307583.1:p.Tyr80Ser",
        "hgvsWellDefined": "NP_001307583.1:p.Tyr80Ser"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS717810"
    }
  ],
  "type": "nucleotide"
}