{ "@context": "http://reg.genome.network/schema/allele.jsonld", "@id": "http://reg.genome.network/allele/CA377644033", "communityStandardTitle": [ "NM_016341.4(PLCE1):c.5780A>C (p.His1927Pro)" ], "externalRecords": { "MyVariantInfo_hg19": [ { "@id": "http://myvariant.info/v1/variant/chr10:g.96066341A>C?assembly=hg19", "id": "chr10:g.96066341A>C" } ], "MyVariantInfo_hg38": [ { "@id": "http://myvariant.info/v1/variant/chr10:g.94306584A>C?assembly=hg38", "id": "chr10:g.94306584A>C" } ], "dbSNP": [ { "@id": "http://www.ncbi.nlm.nih.gov/snp/2274223", "rs": 2274223 } ], "gnomAD_4": [ { "@id": "http://gnomad.broadinstitute.org/variant/10-94306584-A-C?dataset=gnomad_r4", "id": "10-94306584-A-C", "variant": "10:94306584 A / C" } ] }, "genomicAlleles": [ { "chromosome": "10", "coordinates": [ { "allele": "C", "end": 94306584, "referenceAllele": "A", "start": 94306583 } ], "hgvs": [ "NC_000010.11:g.94306584A>C", "CM000672.2:g.94306584A>C" ], "referenceGenome": "GRCh38", "referenceSequence": "http://reg.genome.network/refseq/RS000058" }, { "chromosome": "10", "coordinates": [ { "allele": "C", "end": 96066341, "referenceAllele": "A", "start": 96066340 } ], "hgvs": [ "NC_000010.10:g.96066341A>C", "CM000672.1:g.96066341A>C" ], "referenceGenome": "GRCh37", "referenceSequence": "http://reg.genome.network/refseq/RS000034" }, { "chromosome": "10", "coordinates": [ { "allele": "C", "end": 96056331, "referenceAllele": "A", "start": 96056330 } ], "hgvs": [ "NC_000010.9:g.96056331A>C" ], "referenceGenome": "NCBI36", "referenceSequence": "http://reg.genome.network/refseq/RS000010" }, { "coordinates": [ { "allele": "C", "end": 317596, "referenceAllele": "A", "start": 317595 } ], "hgvs": [ "NG_015799.1:g.317596A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS002831" } ], "transcriptAlleles": [ { "coordinates": [ { "allele": "C", "end": 4856, "referenceAllele": "A", "start": 4855 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000371375.2:c.4856A>C" ], "proteinEffect": { "hgvs": "ENSP00000360426.1:p.His1619Pro", "hgvsWellDefined": "ENSP00000360426.1:p.His1619Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS824257" }, { "coordinates": [ { "allele": "C", "end": 6067, "referenceAllele": "A", "start": 6066 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000685253.1:c.*2323A>C" ], "proteinEffect": { "hgvs": "ENSP00000509405.1:n.*2323A>C" }, "referenceSequence": "http://reg.genome.network/refseq/RS829968" }, { "coordinates": [ { "allele": "C", "end": 2515, "referenceAllele": "A", "start": 2514 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000685889.1:n.2515A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS830298" }, { "coordinates": [ { "allele": "C", "end": 1199, "referenceAllele": "A", "start": 1198 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000686807.1:n.1199A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS830755" }, { "coordinates": [ { "allele": "C", "end": 6257, "referenceAllele": "A", "start": 6256 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000686954.1:c.*1064A>C" ], "proteinEffect": { "hgvs": "ENSP00000508416.1:n.*1064A>C" }, "referenceSequence": "http://reg.genome.network/refseq/RS830832" }, { "coordinates": [ { "allele": "C", "end": 4808, "referenceAllele": "A", "start": 4807 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000688810.1:c.4808A>C" ], "proteinEffect": { "hgvs": "ENSP00000509140.1:p.His1603Pro", "hgvsWellDefined": "ENSP00000509140.1:p.His1603Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS831832" }, { "coordinates": [ { "allele": "C", "end": 9988, "referenceAllele": "A", "start": 9987 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000689233.1:n.9988A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS832066" }, { "coordinates": [ { "allele": "C", "end": 3453, "referenceAllele": "A", "start": 3452 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000690340.1:n.3453A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS832652" }, { "coordinates": [ { "allele": "C", "end": 5978, "referenceAllele": "A", "start": 5977 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000692286.1:c.5648A>C" ], "proteinEffect": { "hgvs": "ENSP00000509490.1:p.His1883Pro", "hgvsWellDefined": "ENSP00000509490.1:p.His1883Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS833642" }, { "coordinates": [ { "allele": "C", "end": 6321, "referenceAllele": "A", "start": 6320 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000692396.1:c.5732A>C" ], "proteinEffect": { "hgvs": "ENSP00000508605.1:p.His1911Pro", "hgvsWellDefined": "ENSP00000508605.1:p.His1911Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS833700" }, { "coordinates": [ { "allele": "C", "end": 6472, "referenceAllele": "A", "start": 6471 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000371380.8:c.5780A>C" ], "proteinEffect": { "hgvs": "ENSP00000360431.2:p.His1927Pro", "hgvsWellDefined": "ENSP00000360431.2:p.His1927Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS750778", "MANE": { "maneVersion": "1.3", "maneStatus": "MANE Select", "nucleotide": { "Ensembl": { "hgvs": "ENST00000371380.8:c.5780A>C" }, "RefSeq": { "hgvs": "NM_016341.4:c.5780A>C" } }, "protein": { "Ensembl": { "hgvs": "ENSP00000360431.2:p.His1927Pro" }, "RefSeq": { "hgvs": "NP_057425.3:p.His1927Pro" } } } }, { "coordinates": [ { "allele": "C", "end": 4809, "referenceAllele": "A", "start": 4808 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000371385.8:c.4754A>C" ], "proteinEffect": { "hgvs": "ENSP00000360438.4:p.His1585Pro", "hgvsWellDefined": "ENSP00000360438.4:p.His1585Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS750781" }, { "coordinates": [ { "allele": "C", "end": 4335, "referenceAllele": "A", "start": 4334 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000674738.1:c.4335A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS774660" }, { "coordinates": [ { "allele": "C", "end": 3896, "referenceAllele": "A", "start": 3895 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000674827.1:c.3896A>C" ], "proteinEffect": { "hgvs": "ENSP00000502523.1:p.His1299Pro", "hgvsWellDefined": "ENSP00000502523.1:p.His1299Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS774733" }, { "coordinates": [ { "allele": "C", "end": 4856, "referenceAllele": "A", "start": 4855 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000675218.1:c.4856A>C" ], "proteinEffect": { "hgvs": "ENSP00000501910.1:p.His1619Pro", "hgvsWellDefined": "ENSP00000501910.1:p.His1619Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS775069" }, { "coordinates": [ { "allele": "C", "end": 6013, "referenceAllele": "A", "start": 6012 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000675487.1:c.*1713A>C" ], "proteinEffect": { "hgvs": "ENSP00000502340.1:n.*1713A>C" }, "referenceSequence": "http://reg.genome.network/refseq/RS775302" }, { "coordinates": [ { "allele": "C", "end": 5049, "referenceAllele": "A", "start": 5048 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000675718.1:c.5049A>C" ], "referenceSequence": "http://reg.genome.network/refseq/RS775499" }, { "coordinates": [ { "allele": "C", "end": 6414, "referenceAllele": "A", "start": 6413 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000260766.7:c.5780A>C" ], "proteinEffect": { "hgvs": "ENSP00000260766.3:p.His1927Pro", "hgvsWellDefined": "ENSP00000260766.3:p.His1927Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS250633" }, { "coordinates": [ { "allele": "C", "end": 4856, "referenceAllele": "A", "start": 4855 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000371375.1:c.4856A>C" ], "proteinEffect": { "hgvs": "ENSP00000360426.1:p.His1619Pro", "hgvsWellDefined": "ENSP00000360426.1:p.His1619Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS268554" }, { "coordinates": [ { "allele": "C", "end": 6015, "referenceAllele": "A", "start": 6014 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000371380.7:c.5780A>C" ], "proteinEffect": { "hgvs": "ENSP00000360431.2:p.His1927Pro", "hgvsWellDefined": "ENSP00000360431.2:p.His1927Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS268558" }, { "coordinates": [ { "allele": "C", "end": 4925, "referenceAllele": "A", "start": 4924 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "ENST00000371385.7:c.4856A>C" ], "proteinEffect": { "hgvs": "ENSP00000360438.3:p.His1619Pro", "hgvsWellDefined": "ENSP00000360438.3:p.His1619Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS268561" }, { "coordinates": [ { "allele": "C", "end": 4925, "referenceAllele": "A", "start": 4924 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "NM_001165979.2:c.4856A>C" ], "proteinEffect": { "hgvs": "NP_001159451.1:p.His1619Pro", "hgvsWellDefined": "NP_001159451.1:p.His1619Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS014755" }, { "coordinates": [ { "allele": "C", "end": 6366, "referenceAllele": "A", "start": 6365 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "NM_001288989.1:c.5732A>C" ], "proteinEffect": { "hgvs": "NP_001275918.1:p.His1911Pro", "hgvsWellDefined": "NP_001275918.1:p.His1911Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS023698" }, { "@id": "http://reg.genome.network/allele/PA3076680142", "coordinates": [ { "allele": "C", "end": 6414, "referenceAllele": "A", "start": 6413 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "NM_016341.3:c.5780A>C" ], "proteinEffect": { "hgvs": "NP_057425.3:p.His1927Pro", "hgvsWellDefined": "NP_057425.3:p.His1927Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS034631" }, { "coordinates": [ { "allele": "C", "end": 6406, "referenceAllele": "A", "start": 6405 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717885.2:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_006717948.1:p.His1941Pro", "hgvsWellDefined": "XP_006717948.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS072360" }, { "coordinates": [ { "allele": "C", "end": 6406, "referenceAllele": "A", "start": 6405 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717886.2:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_006717949.1:p.His1941Pro", "hgvsWellDefined": "XP_006717949.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS072361" }, { "coordinates": [ { "allele": "C", "end": 6403, "referenceAllele": "A", "start": 6402 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717888.2:c.5819A>C" ], "proteinEffect": { "hgvs": "XP_006717951.1:p.His1940Pro", "hgvsWellDefined": "XP_006717951.1:p.His1940Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS072362" }, { "coordinates": [ { "allele": "C", "end": 6358, "referenceAllele": "A", "start": 6357 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717889.2:c.5774A>C" ], "proteinEffect": { "hgvs": "XP_006717952.1:p.His1925Pro", "hgvsWellDefined": "XP_006717952.1:p.His1925Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS072363" }, { "coordinates": [ { "allele": "C", "end": 4920, "referenceAllele": "A", "start": 4919 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717890.1:c.4898A>C" ], "proteinEffect": { "hgvs": "XP_006717953.1:p.His1633Pro", "hgvsWellDefined": "XP_006717953.1:p.His1633Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS072364" }, { "coordinates": [ { "allele": "C", "end": 6205, "referenceAllele": "A", "start": 6204 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_011539849.1:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_011538151.1:p.His1941Pro", "hgvsWellDefined": "XP_011538151.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS106799" }, { "coordinates": [ { "allele": "C", "end": 4702, "referenceAllele": "A", "start": 4701 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_011539850.1:c.4667A>C" ], "proteinEffect": { "hgvs": "XP_011538152.1:p.His1556Pro", "hgvsWellDefined": "XP_011538152.1:p.His1556Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS106800" }, { "coordinates": [ { "allele": "C", "end": 6404, "referenceAllele": "A", "start": 6403 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717885.4:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_006717948.1:p.His1941Pro", "hgvsWellDefined": "XP_006717948.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS539503" }, { "coordinates": [ { "allele": "C", "end": 6401, "referenceAllele": "A", "start": 6400 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717888.4:c.5819A>C" ], "proteinEffect": { "hgvs": "XP_006717951.1:p.His1940Pro", "hgvsWellDefined": "XP_006717951.1:p.His1940Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS539504" }, { "coordinates": [ { "allele": "C", "end": 6356, "referenceAllele": "A", "start": 6355 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717889.4:c.5774A>C" ], "proteinEffect": { "hgvs": "XP_006717952.1:p.His1925Pro", "hgvsWellDefined": "XP_006717952.1:p.His1925Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS539505" }, { "coordinates": [ { "allele": "C", "end": 4920, "referenceAllele": "A", "start": 4919 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_006717890.3:c.4898A>C" ], "proteinEffect": { "hgvs": "XP_006717953.1:p.His1633Pro", "hgvsWellDefined": "XP_006717953.1:p.His1633Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS539506" }, { "coordinates": [ { "allele": "C", "end": 7561, "referenceAllele": "A", "start": 7560 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_011539849.3:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_011538151.1:p.His1941Pro", "hgvsWellDefined": "XP_011538151.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS553823" }, { "coordinates": [ { "allele": "C", "end": 6049, "referenceAllele": "A", "start": 6048 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_011539850.3:c.4667A>C" ], "proteinEffect": { "hgvs": "XP_011538152.1:p.His1556Pro", "hgvsWellDefined": "XP_011538152.1:p.His1556Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS553824" }, { "coordinates": [ { "allele": "C", "end": 6451, "referenceAllele": "A", "start": 6450 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_017016310.2:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_016871799.1:p.His1941Pro", "hgvsWellDefined": "XP_016871799.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS568781" }, { "coordinates": [ { "allele": "C", "end": 6404, "referenceAllele": "A", "start": 6403 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_017016311.2:c.5822A>C" ], "proteinEffect": { "hgvs": "XP_016871800.1:p.His1941Pro", "hgvsWellDefined": "XP_016871800.1:p.His1941Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS568782" }, { "coordinates": [ { "allele": "C", "end": 4830, "referenceAllele": "A", "start": 4829 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "XM_017016312.2:c.4808A>C" ], "proteinEffect": { "hgvs": "XP_016871801.1:p.His1603Pro", "hgvsWellDefined": "XP_016871801.1:p.His1603Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS568783" }, { "coordinates": [ { "allele": "C", "end": 6424, "referenceAllele": "A", "start": 6423 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "NM_001288989.2:c.5732A>C" ], "proteinEffect": { "hgvs": "NP_001275918.1:p.His1911Pro", "hgvsWellDefined": "NP_001275918.1:p.His1911Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS682560" }, { "@id": "http://reg.genome.network/allele/PA3076680142", "coordinates": [ { "allele": "C", "end": 6472, "referenceAllele": "A", "start": 6471 } ], "gene": "http://reg.genome.network/gene/GN017175", "geneNCBI_id": 51196, "geneSymbol": "PLCE1", "hgvs": [ "NM_016341.4:c.5780A>C" ], "proteinEffect": { "hgvs": "NP_057425.3:p.His1927Pro", "hgvsWellDefined": "NP_057425.3:p.His1927Pro" }, "referenceSequence": "http://reg.genome.network/refseq/RS697711", "MANE": { "maneVersion": "1.3", "maneStatus": "MANE Select", "nucleotide": { "Ensembl": { "hgvs": "ENST00000371380.8:c.5780A>C" }, "RefSeq": { "hgvs": "NM_016341.4:c.5780A>C" } }, "protein": { "Ensembl": { "hgvs": "ENSP00000360431.2:p.His1927Pro" }, "RefSeq": { "hgvs": "NP_057425.3:p.His1927Pro" } } } } ], "type": "nucleotide" }