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      "hgvs": [
        "ENST00000615310.4:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480088.1:p.Glu90Ter",
        "hgvsWellDefined": "ENSP00000480088.1:p.Glu90_Ser458delinsAspThrGlyLeuLeuTyrLeuAsnArgSerLeuAspHisSerSerTrpGluLysLeuSerValArgAsnArgGlyPheProLeuLeuThrValTyrLeuLysValPheLeuSerProThrSerLeuArgGluGlyGluCysGlnTrpProGlyCysAlaArgValTyrPheSerPhePheAsnThrSerPheProAlaCysSerSerLeuLysProArgGluLeuCysPheProGluThrArgProSerPheArgIleArgGluAsnArgProProGlyThrPheHisGlnPheArgLeuLeuProValGlnPheLeuCysProAsnIleSerValAlaTyrArgLeuLeuGluGlyGluGlyLeuProPheArgCysAlaProAspSerLeuGluValSerThrArgTrpAlaLeuAspArgGluGlnArgGluLysTyrGluLeuValAlaValCysThrValHisAlaGlyAlaArgGluGluValValMetValProPheProValThrValTyrAspGluAspAspSerAlaProThrPheProAlaGlyValAspThrAlaSerAlaValValGluPheLysArgLysGluAspThrValValAlaThrLeuArgValPheAspAlaAspValValProAlaSerGlyGluLeuValArgArgTyrThrSerThrLeuLeuProGlyAspThrTrpAlaGlnGlnThrPheArgValGluHisTrpProAsnGluThrSerValGlnAlaAsnGlySerPheValArgAlaThrValHisAspTyrArgLeuValLeuAsnArgAsnLeuSerIleSerGluAsnArgThrMetGlnLeuAlaValLeuValAsnAspSerAspPheGlnGlyProGlyAlaGlyValLeuLeuLeuHisPheAsnValSerValLeuProValSerLeuHisLeuProSerThrTyrSerLeuSerValSerArgArgAlaArgArgPheAlaGlnIleGlyLysValCysValGluAsnCysLeuAlaAspLeuThrGlyAspAlaValSerGlyArgAspGluAlaArgSerSerGlyLeuGlySerGlnLysHisProGlySerTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402558"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829939363",
      "coordinates": [
        {
          "allele": "T",
          "end": 458,
          "referenceAllele": "G",
          "start": 457
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020630.4:c.268G>T",
        "LRG_518t2:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_065681.1:p.Glu90Ter",
        "hgvsWellDefined": "NP_065681.1:p.Glu90_Phe1072delinsAspThrGlyLeuLeuTyrLeuAsnArgSerLeuAspHisSerSerTrpGluLysLeuSerValArgAsnArgGlyPheProLeuLeuThrValTyrLeuLysValPheLeuSerProThrSerLeuArgGluGlyGluCysGlnTrpProGlyCysAlaArgValTyrPheSerPhePheAsnThrSerPheProAlaCysSerSerLeuLysProArgGluLeuCysPheProGluThrArgProSerPheArgIleArgGluAsnArgProProGlyThrPheHisGlnPheArgLeuLeuProValGlnPheLeuCysProAsnIleSerValAlaTyrArgLeuLeuGluGlyGluGlyLeuProPheArgCysAlaProAspSerLeuGluValSerThrArgTrpAlaLeuAspArgGluGlnArgGluLysTyrGluLeuValAlaValCysThrValHisAlaGlyAlaArgGluGluValValMetValProPheProValThrValTyrAspGluAspAspSerAlaProThrPheProAlaGlyValAspThrAlaSerAlaValValGluPheLysArgLysGluAspThrValValAlaThrLeuArgValPheAspAlaAspValValProAlaSerGlyGluLeuValArgArgTyrThrSerThrLeuLeuProGlyAspThrTrpAlaGlnGlnThrPheArgValGluHisTrpProAsnGluThrSerValGlnAlaAsnGlySerPheValArgAlaThrValHisAspTyrArgLeuValLeuAsnArgAsnLeuSerIleSerGluAsnArgThrMetGlnLeuAlaValLeuValAsnAspSerAspPheGlnGlyProGlyAlaGlyValLeuLeuLeuHisPheAsnValSerValLeuProValSerLeuHisLeuProSerThrTyrSerLeuSerValSerArgArgAlaArgArgPheAlaGlnIleGlyLysValCysValGluAsnCysGlnAlaPheSerGlyIleAsnValGlnTyrLysLeuHisSerSerGlyAlaAsnCysSerThrLeuGlyValValThrSerAlaGluAspThrSerGlyIleLeuPheValAsnAspThrLysAlaLeuArgArgProLysCysAlaGluLeuHisTyrMetValValAlaThrAspGlnGlnThrSerArgGlnAlaGlnAlaGlnLeuLeuValThrValGluGlySerTyrValAlaGluGluAlaGlyCysProLeuSerCysAlaValSerLysArgArgLeuGluCysGluGluCysGlyGlyLeuGlySerProThrGlyArgCysGluTrpArgGlnGlyAspGlyLysGlyIleThrArgAsnPheSerThrCysSerProSerThrLysThrCysProAspGlyHisCysAspValValGluThrGlnAspIleAsnIleCysProGlnAspCysLeuArgGlySerIleValGlyGlyHisGluProGlyGluProArgGlyIleLysAlaGlyTyrGlyThrCysAsnCysPheProGluGluGluLysCysPheCysGluProGluAspIleGlnAspProLeuCysAspGluLeuCysArgThrValIleAlaAlaAlaValLeuPheSerPheIleValSerValLeuLeuSerAlaPheCysIleHisCysTyrHisLysPheAlaHisLysProProIleSerSerAlaGluMetThrPheArgArgProAlaGlnAlaPheProValSerTyrSerSerSerGlyAlaArgArgProSerLeuAspSerMetGluAsnGlnValSerValAspAlaPheLysIleLeuGluAspProLysTrpGluPheProArgLysAsnLeuValLeuGlyLysThrLeuGlyGluGlyGluPheGlyLysValValLysAlaThrAlaPheHisLeuLysGlyArgAlaGlyTyrThrThrValAlaValLysMetLeuLysGluAsnAlaSerProSerGluLeuArgAspLeuLeuSerGluPheAsnValLeuLysGlnValAsnHisProHisValIleLysLeuTyrGlyAlaCysSerGlnAspGlyProLeuLeuLeuIleValGluTyrAlaLysTyrGlySerLeuArgGlyPheLeuArgGluSerArgLysValGlyProGlyTyrLeuGlySerGlyGlySerArgAsnSerSerSerLeuAspHisProAspGluArgAlaLeuThrMetGlyAspLeuIleSerPheAlaTrpGlnIleSerGlnGlyMetGlnTyrLeuAlaGluMetLysLeuValHisArgAspLeuAlaAlaArgAsnIleLeuValAlaGluGlyArgLysMetLysIleSerAspPheGlyLeuSerArgAspValTyrGluGluAspSerTyrValLysArgSerGlnGlyArgIleProValLysTrpMetAlaIleGluSerLeuPheAspHisIleTyrThrThrGlnSerAspValTrpSerPheGlyValLeuLeuTrpGluIleValThrLeuGlyGlyAsnProTyrProGlyIleProProGluArgLeuPheAsnLeuLeuLysThrGlyHisArgMetGluArgProAspAsnCysSerGluGluMetTyrArgLeuMetLeuGlnCysTrpLysGlnGluProAspLysArgProValPheAlaAspIleSerLysAspLeuGluLysMetMetValLysArgArgAspTyrLeuAspLeuAlaAlaSerThrProSerAspSerLeuIleTyrAspAspGlyLeuSerGluGluGluThrProLeuValAspCysAsnAsnAlaProLeuProArgAlaLeuProSerThrTrpIleGluAsnLysLeuTyrGlyArgIleSerHisAlaPheThrArgPheTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS036456"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 458,
          "referenceAllele": "G",
          "start": 457
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020975.4:c.268G>T",
        "LRG_518t1:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_066124.1:p.Glu90Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS036733"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 500,
          "referenceAllele": "G",
          "start": 499
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "XM_011540027.1:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011538329.1:p.Glu90Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS106977"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829939363",
      "coordinates": [
        {
          "allele": "T",
          "end": 500,
          "referenceAllele": "G",
          "start": 499
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020630.5:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_065681.1:p.Glu90Ter",
        "hgvsWellDefined": "NP_065681.1:p.Glu90_Phe1072delinsAspThrGlyLeuLeuTyrLeuAsnArgSerLeuAspHisSerSerTrpGluLysLeuSerValArgAsnArgGlyPheProLeuLeuThrValTyrLeuLysValPheLeuSerProThrSerLeuArgGluGlyGluCysGlnTrpProGlyCysAlaArgValTyrPheSerPhePheAsnThrSerPheProAlaCysSerSerLeuLysProArgGluLeuCysPheProGluThrArgProSerPheArgIleArgGluAsnArgProProGlyThrPheHisGlnPheArgLeuLeuProValGlnPheLeuCysProAsnIleSerValAlaTyrArgLeuLeuGluGlyGluGlyLeuProPheArgCysAlaProAspSerLeuGluValSerThrArgTrpAlaLeuAspArgGluGlnArgGluLysTyrGluLeuValAlaValCysThrValHisAlaGlyAlaArgGluGluValValMetValProPheProValThrValTyrAspGluAspAspSerAlaProThrPheProAlaGlyValAspThrAlaSerAlaValValGluPheLysArgLysGluAspThrValValAlaThrLeuArgValPheAspAlaAspValValProAlaSerGlyGluLeuValArgArgTyrThrSerThrLeuLeuProGlyAspThrTrpAlaGlnGlnThrPheArgValGluHisTrpProAsnGluThrSerValGlnAlaAsnGlySerPheValArgAlaThrValHisAspTyrArgLeuValLeuAsnArgAsnLeuSerIleSerGluAsnArgThrMetGlnLeuAlaValLeuValAsnAspSerAspPheGlnGlyProGlyAlaGlyValLeuLeuLeuHisPheAsnValSerValLeuProValSerLeuHisLeuProSerThrTyrSerLeuSerValSerArgArgAlaArgArgPheAlaGlnIleGlyLysValCysValGluAsnCysGlnAlaPheSerGlyIleAsnValGlnTyrLysLeuHisSerSerGlyAlaAsnCysSerThrLeuGlyValValThrSerAlaGluAspThrSerGlyIleLeuPheValAsnAspThrLysAlaLeuArgArgProLysCysAlaGluLeuHisTyrMetValValAlaThrAspGlnGlnThrSerArgGlnAlaGlnAlaGlnLeuLeuValThrValGluGlySerTyrValAlaGluGluAlaGlyCysProLeuSerCysAlaValSerLysArgArgLeuGluCysGluGluCysGlyGlyLeuGlySerProThrGlyArgCysGluTrpArgGlnGlyAspGlyLysGlyIleThrArgAsnPheSerThrCysSerProSerThrLysThrCysProAspGlyHisCysAspValValGluThrGlnAspIleAsnIleCysProGlnAspCysLeuArgGlySerIleValGlyGlyHisGluProGlyGluProArgGlyIleLysAlaGlyTyrGlyThrCysAsnCysPheProGluGluGluLysCysPheCysGluProGluAspIleGlnAspProLeuCysAspGluLeuCysArgThrValIleAlaAlaAlaValLeuPheSerPheIleValSerValLeuLeuSerAlaPheCysIleHisCysTyrHisLysPheAlaHisLysProProIleSerSerAlaGluMetThrPheArgArgProAlaGlnAlaPheProValSerTyrSerSerSerGlyAlaArgArgProSerLeuAspSerMetGluAsnGlnValSerValAspAlaPheLysIleLeuGluAspProLysTrpGluPheProArgLysAsnLeuValLeuGlyLysThrLeuGlyGluGlyGluPheGlyLysValValLysAlaThrAlaPheHisLeuLysGlyArgAlaGlyTyrThrThrValAlaValLysMetLeuLysGluAsnAlaSerProSerGluLeuArgAspLeuLeuSerGluPheAsnValLeuLysGlnValAsnHisProHisValIleLysLeuTyrGlyAlaCysSerGlnAspGlyProLeuLeuLeuIleValGluTyrAlaLysTyrGlySerLeuArgGlyPheLeuArgGluSerArgLysValGlyProGlyTyrLeuGlySerGlyGlySerArgAsnSerSerSerLeuAspHisProAspGluArgAlaLeuThrMetGlyAspLeuIleSerPheAlaTrpGlnIleSerGlnGlyMetGlnTyrLeuAlaGluMetLysLeuValHisArgAspLeuAlaAlaArgAsnIleLeuValAlaGluGlyArgLysMetLysIleSerAspPheGlyLeuSerArgAspValTyrGluGluAspSerTyrValLysArgSerGlnGlyArgIleProValLysTrpMetAlaIleGluSerLeuPheAspHisIleTyrThrThrGlnSerAspValTrpSerPheGlyValLeuLeuTrpGluIleValThrLeuGlyGlyAsnProTyrProGlyIleProProGluArgLeuPheAsnLeuLeuLysThrGlyHisArgMetGluArgProAspAsnCysSerGluGluMetTyrArgLeuMetLeuGlnCysTrpLysGlnGluProAspLysArgProValPheAlaAspIleSerLysAspLeuGluLysMetMetValLysArgArgAspTyrLeuAspLeuAlaAlaSerThrProSerAspSerLeuIleTyrAspAspGlyLeuSerGluGluGluThrProLeuValAspCysAsnAsnAlaProLeuProArgAlaLeuProSerThrTrpIleGluAsnLysLeuTyrGlyArgIleSerHisAlaPheThrArgPheTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525983"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 500,
          "referenceAllele": "G",
          "start": 499
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020975.5:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_066124.1:p.Glu90Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS526025"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 458,
          "referenceAllele": "G",
          "start": 457
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020975.6:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_066124.1:p.Glu90Ter"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS670171",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000355710.8:c.268G>T"
          },
          "RefSeq": {
            "hgvs": "NM_020975.6:c.268G>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000347942.3:p.Glu90Ter"
          },
          "RefSeq": {
            "hgvs": "NP_066124.1:p.Glu90Ter"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2829939363",
      "coordinates": [
        {
          "allele": "T",
          "end": 458,
          "referenceAllele": "G",
          "start": 457
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009967",
      "geneNCBI_id": 5979,
      "geneSymbol": "RET",
      "hgvs": [
        "NM_020630.6:c.268G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_065681.1:p.Glu90Ter",
        "hgvsWellDefined": "NP_065681.1:p.Glu90_Phe1072delinsAspThrGlyLeuLeuTyrLeuAsnArgSerLeuAspHisSerSerTrpGluLysLeuSerValArgAsnArgGlyPheProLeuLeuThrValTyrLeuLysValPheLeuSerProThrSerLeuArgGluGlyGluCysGlnTrpProGlyCysAlaArgValTyrPheSerPhePheAsnThrSerPheProAlaCysSerSerLeuLysProArgGluLeuCysPheProGluThrArgProSerPheArgIleArgGluAsnArgProProGlyThrPheHisGlnPheArgLeuLeuProValGlnPheLeuCysProAsnIleSerValAlaTyrArgLeuLeuGluGlyGluGlyLeuProPheArgCysAlaProAspSerLeuGluValSerThrArgTrpAlaLeuAspArgGluGlnArgGluLysTyrGluLeuValAlaValCysThrValHisAlaGlyAlaArgGluGluValValMetValProPheProValThrValTyrAspGluAspAspSerAlaProThrPheProAlaGlyValAspThrAlaSerAlaValValGluPheLysArgLysGluAspThrValValAlaThrLeuArgValPheAspAlaAspValValProAlaSerGlyGluLeuValArgArgTyrThrSerThrLeuLeuProGlyAspThrTrpAlaGlnGlnThrPheArgValGluHisTrpProAsnGluThrSerValGlnAlaAsnGlySerPheValArgAlaThrValHisAspTyrArgLeuValLeuAsnArgAsnLeuSerIleSerGluAsnArgThrMetGlnLeuAlaValLeuValAsnAspSerAspPheGlnGlyProGlyAlaGlyValLeuLeuLeuHisPheAsnValSerValLeuProValSerLeuHisLeuProSerThrTyrSerLeuSerValSerArgArgAlaArgArgPheAlaGlnIleGlyLysValCysValGluAsnCysGlnAlaPheSerGlyIleAsnValGlnTyrLysLeuHisSerSerGlyAlaAsnCysSerThrLeuGlyValValThrSerAlaGluAspThrSerGlyIleLeuPheValAsnAspThrLysAlaLeuArgArgProLysCysAlaGluLeuHisTyrMetValValAlaThrAspGlnGlnThrSerArgGlnAlaGlnAlaGlnLeuLeuValThrValGluGlySerTyrValAlaGluGluAlaGlyCysProLeuSerCysAlaValSerLysArgArgLeuGluCysGluGluCysGlyGlyLeuGlySerProThrGlyArgCysGluTrpArgGlnGlyAspGlyLysGlyIleThrArgAsnPheSerThrCysSerProSerThrLysThrCysProAspGlyHisCysAspValValGluThrGlnAspIleAsnIleCysProGlnAspCysLeuArgGlySerIleValGlyGlyHisGluProGlyGluProArgGlyIleLysAlaGlyTyrGlyThrCysAsnCysPheProGluGluGluLysCysPheCysGluProGluAspIleGlnAspProLeuCysAspGluLeuCysArgThrValIleAlaAlaAlaValLeuPheSerPheIleValSerValLeuLeuSerAlaPheCysIleHisCysTyrHisLysPheAlaHisLysProProIleSerSerAlaGluMetThrPheArgArgProAlaGlnAlaPheProValSerTyrSerSerSerGlyAlaArgArgProSerLeuAspSerMetGluAsnGlnValSerValAspAlaPheLysIleLeuGluAspProLysTrpGluPheProArgLysAsnLeuValLeuGlyLysThrLeuGlyGluGlyGluPheGlyLysValValLysAlaThrAlaPheHisLeuLysGlyArgAlaGlyTyrThrThrValAlaValLysMetLeuLysGluAsnAlaSerProSerGluLeuArgAspLeuLeuSerGluPheAsnValLeuLysGlnValAsnHisProHisValIleLysLeuTyrGlyAlaCysSerGlnAspGlyProLeuLeuLeuIleValGluTyrAlaLysTyrGlySerLeuArgGlyPheLeuArgGluSerArgLysValGlyProGlyTyrLeuGlySerGlyGlySerArgAsnSerSerSerLeuAspHisProAspGluArgAlaLeuThrMetGlyAspLeuIleSerPheAlaTrpGlnIleSerGlnGlyMetGlnTyrLeuAlaGluMetLysLeuValHisArgAspLeuAlaAlaArgAsnIleLeuValAlaGluGlyArgLysMetLysIleSerAspPheGlyLeuSerArgAspValTyrGluGluAspSerTyrValLysArgSerGlnGlyArgIleProValLysTrpMetAlaIleGluSerLeuPheAspHisIleTyrThrThrGlnSerAspValTrpSerPheGlyValLeuLeuTrpGluIleValThrLeuGlyGlyAsnProTyrProGlyIleProProGluArgLeuPheAsnLeuLeuLysThrGlyHisArgMetGluArgProAspAsnCysSerGluGluMetTyrArgLeuMetLeuGlnCysTrpLysGlnGluProAspLysArgProValPheAlaAspIleSerLysAspLeuGluLysMetMetValLysArgArgAspTyrLeuAspLeuAlaAlaSerThrProSerAspSerLeuIleTyrAspAspGlyLeuSerGluGluGluThrProLeuValAspCysAsnAsnAlaProLeuProArgAlaLeuProSerThrTrpIleGluAsnLysLeuTyrGlyArgIleSerHisAlaPheThrArgPheTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS728447"
    }
  ],
  "type": "nucleotide"
}