{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA370693479",
  "communityStandardTitle": [
    "NM_000025.3(ADRB3):c.782C>A (p.Ala261Asp)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr8:g.37823206G>T?assembly=hg19",
        "id": "chr8:g.37823206G>T"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr8:g.37965688G>T?assembly=hg38",
        "id": "chr8:g.37965688G>T"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "T",
          "end": 37965688,
          "referenceAllele": "G",
          "start": 37965687
        }
      ],
      "hgvs": [
        "NC_000008.11:g.37965688G>T",
        "CM000670.2:g.37965688G>T"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000056"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "T",
          "end": 37823206,
          "referenceAllele": "G",
          "start": 37823205
        }
      ],
      "hgvs": [
        "NC_000008.10:g.37823206G>T",
        "CM000670.1:g.37823206G>T"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "T",
          "end": 37942363,
          "referenceAllele": "G",
          "start": 37942362
        }
      ],
      "hgvs": [
        "NC_000008.9:g.37942363G>T"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 5979,
          "referenceAllele": "C",
          "start": 5978
        }
      ],
      "hgvs": [
        "NG_011936.1:g.5979C>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002062"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 912,
          "referenceAllele": "C",
          "start": 911
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.5:c.782C>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Ala261Asp",
        "hgvsWellDefined": "ENSP00000343782.3:p.Ala261Asp"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748270",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.782C>A"
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.782C>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Ala261Asp"
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Ala261Asp"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 910,
          "referenceAllele": "C",
          "start": 909
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.2:n.910C>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS758684"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 266,
          "referenceAllele": "C",
          "start": 265
        }
      ],
      "hgvs": [
        "ENST00000647937.1:c.266C>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000497740.1:p.Ala89Asp",
        "hgvsWellDefined": "ENSP00000497740.1:p.Ala89Asp"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769701"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 1278,
          "referenceAllele": "C",
          "start": 1277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.4:c.782C>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Ala261Asp",
        "hgvsWellDefined": "ENSP00000343782.3:p.Ala261Asp"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262124"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 57,
          "referenceAllele": "C",
          "start": 56
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.1:n.57C>A"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS347406"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 979,
          "referenceAllele": "C",
          "start": 978
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000614635.1:c.782C>A"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480325.1:p.Ala261Asp",
        "hgvsWellDefined": "ENSP00000480325.1:p.Ala261Asp"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402283"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 979,
          "referenceAllele": "C",
          "start": 978
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.2:c.782C>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Ala261Asp",
        "hgvsWellDefined": "NP_000016.1:p.Ala261Asp"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006090"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 912,
          "referenceAllele": "C",
          "start": 911
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.3:c.782C>A"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Ala261Asp",
        "hgvsWellDefined": "NP_000016.1:p.Ala261Asp"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662288",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.782C>A"
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.782C>A"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Ala261Asp"
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Ala261Asp"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}