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      "proteinEffect": {
        "hgvs": "NP_001365398.1:p.Glu564Ter",
        "hgvsWellDefined": "NP_001365398.1:p.Glu564_His744delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnIleLeuAlaSerIleGluLeuLeuAlaArgSerLeuProLysIleHisArgSerAlaSerGluProSerLeuAsnArgAlaGlyPheGlnThrGluAspPheSerLeuTyrAlaCysAlaSerProLysThrProIleGlnAlaGlyGlyTyrGlyAlaPheProValHisTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721719"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1880,
          "referenceAllele": "G",
          "start": 1879
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378470.1:c.1654G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365399.1:p.Glu552Ter",
        "hgvsWellDefined": "NP_001365399.1:p.Glu552_Lys733delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnIleLeuAlaSerIleGluLeuLeuAlaArgSerLeuProLysIleHisArgSerAlaSerGluProSerLeuAsnArgAlaGlyPheGlnThrGluAspPheSerLeuTyrAlaCysAlaSerProLysThrProIleGlnAlaGlyGlyTyrGlyGluPheAlaAlaPheLysTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721720"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1871,
          "referenceAllele": "G",
          "start": 1870
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378471.1:c.1645G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365400.1:p.Glu549Ter",
        "hgvsWellDefined": "NP_001365400.1:p.Glu549_Lys730delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnIleLeuAlaSerIleGluLeuLeuAlaArgSerLeuProLysIleHisArgSerAlaSerGluProSerLeuAsnArgAlaGlyPheGlnThrGluAspPheSerLeuTyrAlaCysAlaSerProLysThrProIleGlnAlaGlyGlyTyrGlyGluPheAlaAlaPheLysTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721721"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1701,
          "referenceAllele": "G",
          "start": 1700
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378472.1:c.1600G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365401.1:p.Glu534Ter",
        "hgvsWellDefined": "NP_001365401.1:p.Glu534_Lys715delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnIleLeuAlaSerIleGluLeuLeuAlaArgSerLeuProLysIleHisArgSerAlaSerGluProSerLeuAsnArgAlaGlyPheGlnThrGluAspPheSerLeuTyrAlaCysAlaSerProLysThrProIleGlnAlaGlyGlyTyrGlyGluPheAlaAlaPheLysTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721722"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1701,
          "referenceAllele": "G",
          "start": 1700
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378473.1:c.1600G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365402.1:p.Glu534Ter",
        "hgvsWellDefined": "NP_001365402.1:p.Glu534_His714delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnIleLeuAlaSerIleGluLeuLeuAlaArgSerLeuProLysIleHisArgSerAlaSerGluProSerLeuAsnArgAlaGlyPheGlnThrGluAspPheSerLeuTyrAlaCysAlaSerProLysThrProIleGlnAlaGlyGlyTyrGlyAlaPheProValHisTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721723"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1982,
          "referenceAllele": "G",
          "start": 1981
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378474.1:c.1756G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365403.1:p.Glu586Ter",
        "hgvsWellDefined": "NP_001365403.1:p.Glu586_Ile711delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnValIleTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721724"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1718,
          "referenceAllele": "G",
          "start": 1717
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001097",
      "geneNCBI_id": 673,
      "geneSymbol": "BRAF",
      "hgvs": [
        "NM_001378475.1:c.1492G>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001365404.1:p.Glu498Ter",
        "hgvsWellDefined": "NP_001365404.1:p.Glu498_Lys679delinsAspLeuThrValLysIleGlyAspPheGlyLeuAlaThrValLysSerArgTrpSerGlySerHisGlnPheGluGlnLeuSerGlySerIleLeuTrpMetAlaProGluValIleArgMetGlnAspLysAsnProTyrSerPheGlnSerAspValTyrAlaPheGlyIleValLeuTyrGluLeuMetThrGlyGlnLeuProTyrSerAsnIleAsnAsnArgAspGlnIleIlePheMetValGlyArgGlyTyrLeuSerProAspLeuSerLysValArgSerAsnCysProLysAlaMetLysArgLeuMetAlaGluCysLeuLysLysLysArgAspGluArgProLeuPheProGlnIleLeuAlaSerIleGluLeuLeuAlaArgSerLeuProLysIleHisArgSerAlaSerGluProSerLeuAsnArgAlaGlyPheGlnThrGluAspPheSerLeuTyrAlaCysAlaSerProLysThrProIleGlnAlaGlyGlyTyrGlyGluPheAlaAlaPheLysTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721725"
    }
  ],
  "type": "nucleotide"
}