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        "hgvsWellDefined": "NP_001333829.1:p.Lys807_Ala1157delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS517700"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2034,
          "referenceAllele": "A",
          "start": 2033
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_001346941.1:c.1777A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001333870.1:p.Lys593Ter",
        "hgvsWellDefined": "NP_001333870.1:p.Lys593_Ala943delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS517714"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3074413633",
      "coordinates": [
        {
          "allele": "T",
          "end": 2835,
          "referenceAllele": "A",
          "start": 2834
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_005228.4:c.2578A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_005219.2:p.Lys860Ter",
        "hgvsWellDefined": "NP_005219.2:p.Lys860_Ala1210delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525294"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3074413633",
      "coordinates": [
        {
          "allele": "T",
          "end": 2839,
          "referenceAllele": "A",
          "start": 2838
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_005228.5:c.2578A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_005219.2:p.Lys860Ter",
        "hgvsWellDefined": "NP_005219.2:p.Lys860_Ala1210delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS666873",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000275493.7:c.2578A>T"
          },
          "RefSeq": {
            "hgvs": "NM_005228.5:c.2578A>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000275493.2:p.Lys860Ter"
          },
          "RefSeq": {
            "hgvs": "NP_005219.2:p.Lys860Ter"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2704,
          "referenceAllele": "A",
          "start": 2703
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_001346897.2:c.2443A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001333826.1:p.Lys815Ter",
        "hgvsWellDefined": "NP_001333826.1:p.Lys815_Gln1091delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGlyGluTrpLeuValTrpLysGlnSerCysSerSerThrSerSerThrHisSerAlaAlaAlaSerLeuGlnCysProSerGlnValLeuProProAlaSerProGluGlyGluThrValAlaAspLeuGlnThrGlnTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS687442"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2839,
          "referenceAllele": "A",
          "start": 2838
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_001346898.2:c.2578A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001333827.1:p.Lys860Ter",
        "hgvsWellDefined": "NP_001333827.1:p.Lys860_Gln1136delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGlyGluTrpLeuValTrpLysGlnSerCysSerSerThrSerSerThrHisSerAlaAlaAlaSerLeuGlnCysProSerGlnValLeuProProAlaSerProGluGlyGluThrValAlaAspLeuGlnThrGlnTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS687443"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2610,
          "referenceAllele": "A",
          "start": 2609
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_001346900.2:c.2419A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001333829.1:p.Lys807Ter",
        "hgvsWellDefined": "NP_001333829.1:p.Lys807_Ala1157delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS687444"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2038,
          "referenceAllele": "A",
          "start": 2037
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_001346941.2:c.1777A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001333870.1:p.Lys593Ter",
        "hgvsWellDefined": "NP_001333870.1:p.Lys593_Ala943delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS687456"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2704,
          "referenceAllele": "A",
          "start": 2703
        }
      ],
      "gene": "http://reg.genome.network/gene/GN003236",
      "geneNCBI_id": 1956,
      "geneSymbol": "EGFR",
      "hgvs": [
        "NM_001346899.2:c.2443A>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001333828.1:p.Lys815Ter",
        "hgvsWellDefined": "NP_001333828.1:p.Lys815_Ala1165delinsLeuLeuGlyAlaGluGluLysGluTyrHisAlaGluGlyGlyLysValProIleLysTrpMetAlaLeuGluSerIleLeuHisArgIleTyrThrHisGlnSerAspValTrpSerTyrGlyValThrValTrpGluLeuMetThrPheGlySerLysProTyrAspGlyIleProAlaSerGluIleSerSerIleLeuGluLysGlyGluArgLeuProGlnProProIleCysThrIleAspValTyrMetIleMetValLysCysTrpMetIleAspAlaAspSerArgProLysPheArgGluLeuIleIleGluPheSerLysMetAlaArgAspProGlnArgTyrLeuValIleGlnGlyAspGluArgMetHisLeuProSerProThrAspSerAsnPheTyrArgAlaLeuMetAspGluGluAspMetAspAspValValAspAlaAspGluTyrLeuIleProGlnGlnGlyPhePheSerSerProSerThrSerArgThrProLeuLeuSerSerLeuSerAlaThrSerAsnAsnSerThrValAlaCysIleAspArgAsnGlyLeuGlnSerCysProIleLysGluAspSerPheLeuGlnArgTyrSerSerAspProThrGlyAlaLeuThrGluAspSerIleAspAspThrPheLeuProValProGluTyrIleAsnGlnSerValProLysArgProAlaGlySerValGlnAsnProValTyrHisAsnGlnProLeuAsnProAlaProSerArgAspProHisTyrGlnAspProHisSerThrAlaValGlyAsnProGluTyrLeuAsnThrValGlnProThrCysValAsnSerThrPheAspSerProAlaHisTrpAlaGlnLysGlySerHisGlnIleSerLeuAspAsnProAspTyrGlnGlnAspPhePheProLysGluAlaLysProAsnGlyIlePheLysGlySerThrAlaGluAsnAlaGluTyrLeuArgValAlaProGlnSerSerGluPheIleGlyAlaTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS719000"
    }
  ],
  "type": "nucleotide"
}