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        "XM_011514966.1:c.553+32869C>T"
      ],
      "proteinEffect": {
        "hgvs": "XP_011513268.1:n.553+32869C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS082187"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2573064229",
      "coordinates": [
        {
          "allele": "T",
          "end": 1278,
          "referenceAllele": "C",
          "start": 1277
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010472",
      "geneNCBI_id": 860,
      "geneSymbol": "RUNX2",
      "hgvs": [
        "NM_001024630.4:c.1081C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001019801.3:p.Gln361Ter",
        "hgvsWellDefined": "NP_001019801.3:p.Gln361_Tyr521delinsAlaGlyAlaSerGluLeuGlyProPheSerAspProArgGlnPheProSerIleSerSerLeuThrGluSerArgPheSerAsnProArgMetHisTyrProAlaThrPheThrTyrThrProProValThrSerGlyMetSerLeuGlyMetSerAlaThrThrHisTyrHisThrTyrLeuProProProTyrProGlySerSerGlnSerGlnSerGlyProPheGlnThrSerSerThrProTyrLeuTyrTyrGlyThrSerSerGlySerTyrGlnPheProMetValProGlyGlyAspArgSerProSerArgMetLeuProProCysThrThrThrSerAsnGlySerThrLeuLeuAsnProAsnLeuProAsnGlnAsnAspGlyValAspAlaAspGlySerHisSerSerSerProThrValLeuAsnSerSerGlyArgMetAspGluSerValTrpArgProTyrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662993",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000647337.2:c.1081C>T"
          },
          "RefSeq": {
            "hgvs": "NM_001024630.4:c.1081C>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000495497.1:p.Gln361Ter"
          },
          "RefSeq": {
            "hgvs": "NP_001019801.3:p.Gln361Ter"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1281,
          "endIntronDirection": "-",
          "endIntronOffset": 1550,
          "referenceAllele": "C",
          "start": 1281,
          "startIntronDirection": "-",
          "startIntronOffset": 1551
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010472",
      "geneNCBI_id": 860,
      "geneSymbol": "RUNX2",
      "hgvs": [
        "NM_001278478.2:c.980-1551C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001265407.1:n.980-1551C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681492"
    },
    {
      "@id": "http://reg.genome.network/allele/PA2828329197",
      "coordinates": [
        {
          "allele": "T",
          "end": 1341,
          "referenceAllele": "C",
          "start": 1340
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010472",
      "geneNCBI_id": 860,
      "geneSymbol": "RUNX2",
      "hgvs": [
        "NM_001369405.1:c.1039C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001356334.1:p.Gln347Ter",
        "hgvsWellDefined": "NP_001356334.1:p.Gln347_Tyr507delinsAlaGlyAlaSerGluLeuGlyProPheSerAspProArgGlnPheProSerIleSerSerLeuThrGluSerArgPheSerAsnProArgMetHisTyrProAlaThrPheThrTyrThrProProValThrSerGlyMetSerLeuGlyMetSerAlaThrThrHisTyrHisThrTyrLeuProProProTyrProGlySerSerGlnSerGlnSerGlyProPheGlnThrSerSerThrProTyrLeuTyrTyrGlyThrSerSerGlySerTyrGlnPheProMetValProGlyGlyAspArgSerProSerArgMetLeuProProCysThrThrThrSerAsnGlySerThrLeuLeuAsnProAsnLeuProAsnGlnAsnAspGlyValAspAlaAspGlySerHisSerSerSerProThrValLeuAsnSerSerGlyArgMetAspGluSerValTrpArgProTyrTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS691630"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1218,
          "endIntronDirection": "-",
          "endIntronOffset": 1550,
          "referenceAllele": "C",
          "start": 1218,
          "startIntronDirection": "-",
          "startIntronOffset": 1551
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010472",
      "geneNCBI_id": 860,
      "geneSymbol": "RUNX2",
      "hgvs": [
        "NM_001015051.4:c.1022-1551C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001015051.3:n.1022-1551C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS711368"
    }
  ],
  "type": "nucleotide"
}