{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA353671671",
  "communityStandardTitle": [
    "NM_000313.4(PROS1):c.1155G>C (p.Met385Ile)"
  ],
  "externalRecords": {
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr3:g.93611777C>G?assembly=hg19",
        "id": "chr3:g.93611777C>G"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr3:g.93892933C>G?assembly=hg38",
        "id": "chr3:g.93892933C>G"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "G",
          "end": 93892933,
          "referenceAllele": "C",
          "start": 93892932
        }
      ],
      "hgvs": [
        "NC_000003.12:g.93892933C>G",
        "CM000665.2:g.93892933C>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000051"
    },
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "G",
          "end": 93611777,
          "referenceAllele": "C",
          "start": 93611776
        }
      ],
      "hgvs": [
        "NC_000003.11:g.93611777C>G",
        "CM000665.1:g.93611777C>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000027"
    },
    {
      "chromosome": "3",
      "coordinates": [
        {
          "allele": "G",
          "end": 95094467,
          "referenceAllele": "C",
          "start": 95094466
        }
      ],
      "hgvs": [
        "NC_000003.10:g.95094467C>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000003"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 86158,
          "referenceAllele": "G",
          "start": 86157
        }
      ],
      "hgvs": [
        "NG_009813.1:g.86158G>C",
        "LRG_572:g.86158G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001650"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1239,
          "referenceAllele": "G",
          "start": 1238
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000348974.5:c.1155G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000330021.7:p.Met385Ile",
        "hgvsWellDefined": "ENSP00000330021.7:p.Met385Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748386"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1302,
          "referenceAllele": "G",
          "start": 1301
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000394236.9:c.1155G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000377783.3:p.Met385Ile",
        "hgvsWellDefined": "ENSP00000377783.3:p.Met385Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS753232",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000394236.9:c.1155G>C"
          },
          "RefSeq": {
            "hgvs": "NM_000313.4:c.1155G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000377783.3:p.Met385Ile"
          },
          "RefSeq": {
            "hgvs": "NP_000304.2:p.Met385Ile"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1258,
          "referenceAllele": "G",
          "start": 1257
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000407433.6:c.1110G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385794.2:p.Met370Ile",
        "hgvsWellDefined": "ENSP00000385794.2:p.Met370Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS754196"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1294,
          "referenceAllele": "G",
          "start": 1293
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000647936.1:c.1155G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000496822.1:p.Met385Ile",
        "hgvsWellDefined": "ENSP00000496822.1:p.Met385Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769700"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1323,
          "referenceAllele": "G",
          "start": 1322
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000648381.1:n.1323G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS769949"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1439,
          "referenceAllele": "G",
          "start": 1438
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000648853.1:c.1113G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000497262.1:p.Met371Ile",
        "hgvsWellDefined": "ENSP00000497262.1:p.Met371Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS770211"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1254,
          "referenceAllele": "G",
          "start": 1253
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000649103.1:c.1254G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000497962.1:n.1254G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS770351"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1435,
          "referenceAllele": "G",
          "start": 1434
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000650591.1:c.1251G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000497376.1:p.Met417Ile",
        "hgvsWellDefined": "ENSP00000497376.1:p.Met417Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS771199"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1472,
          "referenceAllele": "G",
          "start": 1471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000394236.7:c.1155G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000377783.3:p.Met385Ile",
        "hgvsWellDefined": "ENSP00000377783.3:p.Met385Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS276066"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1323,
          "referenceAllele": "G",
          "start": 1322
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "ENST00000407433.5:c.762G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000385794.1:p.Met254Ile",
        "hgvsWellDefined": "ENSP00000385794.1:p.Met254Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS280911"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3068436535",
      "coordinates": [
        {
          "allele": "C",
          "end": 1496,
          "referenceAllele": "G",
          "start": 1495
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "NM_000313.3:c.1155G>C",
        "LRG_572t1:c.1155G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000304.2:p.Met385Ile",
        "hgvsWellDefined": "NP_000304.2:p.Met385Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006375"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1583,
          "referenceAllele": "G",
          "start": 1582
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "NM_001314077.1:c.1251G>C",
        "LRG_572t2:c.1251G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001301006.1:p.Met417Ile",
        "hgvsWellDefined": "NP_001301006.1:p.Met417Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS026543"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3068436535",
      "coordinates": [
        {
          "allele": "C",
          "end": 1302,
          "referenceAllele": "G",
          "start": 1301
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "NM_000313.4:c.1155G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000304.2:p.Met385Ile",
        "hgvsWellDefined": "NP_000304.2:p.Met385Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674787",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000394236.9:c.1155G>C"
          },
          "RefSeq": {
            "hgvs": "NM_000313.4:c.1155G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000377783.3:p.Met385Ile"
          },
          "RefSeq": {
            "hgvs": "NP_000304.2:p.Met385Ile"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1398,
          "referenceAllele": "G",
          "start": 1397
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009456",
      "geneNCBI_id": 5627,
      "geneSymbol": "PROS1",
      "hgvs": [
        "NM_001314077.2:c.1251G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001301006.1:p.Met417Ile",
        "hgvsWellDefined": "NP_001301006.1:p.Met417Ile"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS717343"
    }
  ],
  "type": "nucleotide"
}