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          "allele": "A",
          "end": 2733,
          "referenceAllele": "",
          "start": 2733
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001884",
      "geneNCBI_id": 1080,
      "geneSymbol": "CFTR",
      "hgvs": [
        "XM_011515752.1:c.2691dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514054.1:p.Val898SerfsTer28",
        "hgvsWellDefined": "XP_011514054.1:p.[Val898_Ile899delinsSerAsn;Leu901_Ala906del;Leu908_Leu914delinsGlyArgGlyGlyCysPhePhe;Asn916_Asp921delinsCysAlaValAlaProTrp;Gly923_Asn924delinsHisSer;Thr926_His927delinsSerArgGlnArgGlu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS082963"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 2823,
          "referenceAllele": "",
          "start": 2823
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001884",
      "geneNCBI_id": 1080,
      "geneSymbol": "CFTR",
      "hgvs": [
        "XM_011515753.1:c.2358dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514055.1:p.Val787SerfsTer28",
        "hgvsWellDefined": "XP_011514055.1:p.[Val787_Ile788delinsSerAsn;Leu790_Ala795del;Leu797_Leu803delinsGlyArgGlyGlyCysPhePhe;Asn805_Asp810delinsCysAlaValAlaProTrp;Gly812_Asn813delinsHisSer;Thr815_His816delinsSerArgGlnArgGlu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS082964"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 3741,
          "referenceAllele": "",
          "start": 3741
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001884",
      "geneNCBI_id": 1080,
      "geneSymbol": "CFTR",
      "hgvs": [
        "XM_011515754.1:c.2358dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011514056.1:p.Val787SerfsTer28",
        "hgvsWellDefined": "XP_011514056.1:p.[Val787_Ile788delinsSerAsn;Leu790_Ala795del;Leu797_Leu803delinsGlyArgGlyGlyCysPhePhe;Asn805_Asp810delinsCysAlaValAlaProTrp;Gly812_Asn813delinsHisSer;Thr815_His816delinsSerArgGlnArgGlu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS082965"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 2671,
          "referenceAllele": "",
          "start": 2671
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001884",
      "geneNCBI_id": 1080,
      "geneSymbol": "CFTR",
      "hgvs": [
        "NM_000492.4:c.2601dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000483.3:p.Val868SerfsTer28",
        "hgvsWellDefined": "NP_000483.3:p.[Val868_Ile869delinsSerAsn;Leu871_Ala876del;Leu878_Leu884delinsGlyArgGlyGlyCysPhePhe;Asn886_Asp891delinsCysAlaValAlaProTrp;Gly893_Asn894delinsHisSer;Thr896_His897delinsSerArgGlnArgGlu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674867",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000003084.11:c.2601dup"
          },
          "RefSeq": {
            "hgvs": "NM_000492.4:c.2601dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000003084.6:p.Val868SerfsTer28"
          },
          "RefSeq": {
            "hgvs": "NP_000483.3:p.Val868SerfsTer28"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}