{
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  "@id": "http://reg.genome.network/allele/CA2968109666",
  "communityStandardTitle": [
    "NM_000025.3(ADRB3):c.881del (p.Leu294TrpfsTer29)"
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          "allele": "",
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      "chromosome": "8",
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        {
          "allele": "",
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      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "",
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          "referenceAllele": "A",
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      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "",
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          "referenceAllele": "T",
          "start": 6077
        }
      ],
      "hgvs": [
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      "referenceSequence": "http://reg.genome.network/refseq/RS002062"
    }
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    {
      "coordinates": [
        {
          "allele": "",
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          "referenceAllele": "T",
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      "geneNCBI_id": 155,
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        "ENST00000345060.5:c.881del"
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      "proteinEffect": {
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      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748270",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
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          "RefSeq": {
            "hgvs": "NM_000025.3:c.881del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Leu294TrpfsTer29"
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          "RefSeq": {
            "hgvs": "NP_000016.1:p.Leu294TrpfsTer29"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1009,
          "referenceAllele": "T",
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      "gene": "http://reg.genome.network/gene/GN000288",
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      "geneSymbol": "ADRB3",
      "hgvs": [
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      "referenceSequence": "http://reg.genome.network/refseq/RS758684"
    },
    {
      "coordinates": [
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      ],
      "hgvs": [
        "ENST00000647937.1:c.365del"
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      "proteinEffect": {
        "hgvs": "ENSP00000497740.1:p.Leu122TrpfsTer29",
        "hgvsWellDefined": "ENSP00000497740.1:p.[Leu122_Leu134delinsTrpValSerSerTrpAlaProSerLeuSerAlaGlyCys;Phe136Ser;Leu138_Leu145delinsTrpProThrCysCysAlaProTrp;Gly147Ala;Ser149del;Val151del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769701"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1377,
          "referenceAllele": "T",
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      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.4:c.881del"
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      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Leu294TrpfsTer29",
        "hgvsWellDefined": "ENSP00000343782.3:p.[Leu294_Leu306delinsTrpValSerSerTrpAlaProSerLeuSerAlaGlyCys;Phe308Ser;Leu310_Leu317delinsTrpProThrCysCysAlaProTrp;Gly319Ala;Ser321del;Val323del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262124"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 156,
          "referenceAllele": "T",
          "start": 155
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      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.1:n.156del"
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      "referenceSequence": "http://reg.genome.network/refseq/RS347406"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1078,
          "referenceAllele": "T",
          "start": 1077
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000614635.1:c.881del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480325.1:p.Leu294TrpfsTer29",
        "hgvsWellDefined": "ENSP00000480325.1:p.[Leu294_Leu306delinsTrpValSerSerTrpAlaProSerLeuSerAlaGlyCys;Phe308Ser;Leu310_Leu317delinsTrpProThrCysCysAlaProTrp;Gly319Ala;Ser321del;Val323del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402283"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1078,
          "referenceAllele": "T",
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      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.2:c.881del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Leu294TrpfsTer29",
        "hgvsWellDefined": "NP_000016.1:p.[Leu294_Leu306delinsTrpValSerSerTrpAlaProSerLeuSerAlaGlyCys;Phe308Ser;Leu310_Leu317delinsTrpProThrCysCysAlaProTrp;Gly319Ala;Ser321del;Val323del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006090"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1011,
          "referenceAllele": "T",
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        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.3:c.881del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Leu294TrpfsTer29",
        "hgvsWellDefined": "NP_000016.1:p.[Leu294_Leu306delinsTrpValSerSerTrpAlaProSerLeuSerAlaGlyCys;Phe308Ser;Leu310_Leu317delinsTrpProThrCysCysAlaProTrp;Gly319Ala;Ser321del;Val323del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662288",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.881del"
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.881del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Leu294TrpfsTer29"
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Leu294TrpfsTer29"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}