{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2968109583",
  "communityStandardTitle": [
    "NM_000025.3(ADRB3):c.1162dup (p.Arg388ProfsTer?)"
  ],
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      "chromosome": "8",
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        {
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          "referenceAllele": "",
          "start": 37965310
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        "CM000670.2:g.37965310dup"
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    },
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          "end": 37822828,
          "referenceAllele": "",
          "start": 37822828
        }
      ],
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        "CM000670.1:g.37822828dup"
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      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
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        {
          "allele": "G",
          "end": 37941985,
          "referenceAllele": "",
          "start": 37941985
        }
      ],
      "hgvs": [
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      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 6359,
          "referenceAllele": "",
          "start": 6359
        }
      ],
      "hgvs": [
        "NG_011936.1:g.6359dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002062"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
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          "end": 1292,
          "referenceAllele": "",
          "start": 1292
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
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      "hgvs": [
        "ENST00000345060.5:c.1162dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Arg388ProfsTer?"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748270",
      "MANE": {
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        "maneStatus": "MANE Select",
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          "RefSeq": {
            "hgvs": "NM_000025.3:c.1162dup"
          }
        },
        "protein": {
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          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Arg388ProfsTer?"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1290,
          "referenceAllele": "",
          "start": 1290
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      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
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      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS758684"
    },
    {
      "coordinates": [
        {
          "allele": "C",
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          "referenceAllele": "",
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        }
      ],
      "hgvs": [
        "ENST00000647937.1:c.646dup"
      ],
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        "hgvs": "ENSP00000497740.1:p.Arg216ProfsTer?",
        "hgvsWellDefined": "ENSP00000497740.1:p.[Arg216_Ser218delinsProGluGln;Pro219_Ala220insSer;Gln221_Arg223delinsAlaGlnAla;Cys225_Gln232delinsProThrAlaArgArgGluAlaGlu;Leu234_Val238delinsLysArgSerCysArg;Asn240_Lys245delinsHisHisAlaAsnGln]"
      },
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    },
    {
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        {
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          "start": 1658
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      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.4:c.1162dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Arg388ProfsTer?"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262124"
    },
    {
      "coordinates": [
        {
          "allele": "C",
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          "referenceAllele": "",
          "start": 437
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      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.1:n.437dup"
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      "referenceSequence": "http://reg.genome.network/refseq/RS347406"
    },
    {
      "coordinates": [
        {
          "allele": "C",
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          "referenceAllele": "",
          "start": 1359
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000614635.1:c.1162dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480325.1:p.Arg388ProfsTer?"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402283"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1359,
          "referenceAllele": "",
          "start": 1359
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.2:c.1162dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Arg388ProfsTer?"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006090"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1292,
          "referenceAllele": "",
          "start": 1292
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.3:c.1162dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Arg388ProfsTer?"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662288",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
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          "RefSeq": {
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          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Arg388ProfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Arg388ProfsTer?"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}