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      "hgvs": [
        "XM_011545946.2:c.1597_1606del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544248.1:p.Pro534AlafsTer26",
        "hgvsWellDefined": "XP_011544248.1:p.[Pro534_Ser537delinsAlaCysArgLeu;Ser539_Asn542delinsThrGlyPro;Ser544Lys;Glu546_Val548delinsSerProHis;Ser550_Lys557delinsAsnIleSerThrLysAsnTyr;Ile560_Gly564del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556315"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2570,
          "referenceAllele": "CAACTTTTGC",
          "start": 2560
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545947.2:c.1597_1606del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544249.1:p.Pro534AlafsTer26",
        "hgvsWellDefined": "XP_011544249.1:p.[Pro534_Ser537delinsAlaCysArgLeu;Ser539_Asn542delinsThrGlyPro;Ser544Lys;Glu546_Val548delinsSerProHis;Ser550_Lys557delinsAsnIleSerThrLysAsnTyr;Ile560_Gly564del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556316"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1892,
          "referenceAllele": "CAACTTTTGC",
          "start": 1882
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545948.2:c.706_715del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544250.1:p.Pro237AlafsTer26",
        "hgvsWellDefined": "XP_011544250.1:p.[Pro237_Ser240delinsAlaCysArgLeu;Ser242_Asn245delinsThrGlyPro;Ser247Lys;Glu249_Val251delinsSerProHis;Ser253_Lys260delinsAsnIleSerThrLysAsnTyr;Ile263_Gly267del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556317"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2570,
          "referenceAllele": "CAACTTTTGC",
          "start": 2560
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023671.1:c.1597_1606del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879160.1:p.Pro534AlafsTer26",
        "hgvsWellDefined": "XP_016879160.1:p.[Pro534_Ser537delinsAlaCysArgLeu;Ser539_Asn542delinsThrGlyPro;Ser544Lys;Glu546_Val548delinsSerProHis;Ser550_Lys557delinsAsnIleSerThrLysAsnTyr;Ile560_Gly564del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574393"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1780,
          "referenceAllele": "CAACTTTTGC",
          "start": 1770
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023672.2:c.1591_1600del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879161.1:p.Pro532AlafsTer26",
        "hgvsWellDefined": "XP_016879161.1:p.[Pro532_Ser535delinsAlaCysArgLeu;Ser537_Asn540delinsThrGlyPro;Ser542Lys;Glu544_Val546delinsSerProHis;Ser548_Lys555delinsAsnIleSerThrLysAsnTyr;Ile558_Gly562del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574394"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1780,
          "referenceAllele": "CAACTTTTGC",
          "start": 1770
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023673.2:c.1591_1600del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879162.1:p.Pro532AlafsTer26",
        "hgvsWellDefined": "XP_016879162.1:p.[Pro532_Ser535delinsAlaCysArgLeu;Ser537_Asn540delinsThrGlyPro;Ser542Lys;Glu544_Val546delinsSerProHis;Ser548_Lys555delinsAsnIleSerThrLysAsnTyr;Ile558_Gly562del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574395"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1753,
          "referenceAllele": "CAACTTTTGC",
          "start": 1743
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "NM_024675.4:c.1591_1600del"
      ],
      "proteinEffect": {
        "hgvs": "NP_078951.2:p.Pro532AlafsTer26",
        "hgvsWellDefined": "NP_078951.2:p.[Pro532_Ser535delinsAlaCysArgLeu;Ser537_Asn540delinsThrGlyPro;Ser542Lys;Glu544_Val546delinsSerProHis;Ser548_Lys555delinsAsnIleSerThrLysAsnTyr;Ile558_Gly562del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS698739",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000261584.9:c.1591_1600del"
          },
          "RefSeq": {
            "hgvs": "NM_024675.4:c.1591_1600del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000261584.4:p.Pro532AlafsTer26"
          },
          "RefSeq": {
            "hgvs": "NP_078951.2:p.Pro532AlafsTer26"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}