{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2866793",
  "communityStandardTitle": [
    "NM_006017.3(PROM1):c.1354dup (p.Tyr452LeufsTer13)"
  ],
  "externalRecords": {
    "COSMIC": [
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=3334856",
        "active": true,
        "id": "COSM3334856"
      },
      {
        "@id": "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=4337623",
        "active": true,
        "id": "COSM4337623"
      }
    ],
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=359518[alleleid]",
        "alleleId": 359518,
        "preferredName": "NM_006017.3(PROM1):c.1354dup (p.Tyr452fs)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/372711",
        "RCV": [
          "RCV000413568",
          "RCV000505153",
          "RCV000779436",
          "RCV001003127",
          "RCV000761312",
          "RCV001255712",
          "RCV000987422",
          "RCV001257789",
          "RCV002467446"
        ],
        "variationId": 372711
      }
    ],
    "ExAC": [
      {
        "@id": "http://exac.broadinstitute.org/variant/4-16008260-T-TA",
        "id": "4-16008260-T-TA",
        "variant": "4:16008260 T / TA"
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr4:g.16008261dupA?assembly=hg19",
        "id": "chr4:g.16008261dupA"
      },
      {
        "@id": "http://myvariant.info/v1/variant/chr4:g.16008260_16008261insA?assembly=hg19",
        "id": "chr4:g.16008260_16008261insA"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr4:g.16006638dupA?assembly=hg38",
        "id": "chr4:g.16006638dupA"
      },
      {
        "@id": "http://myvariant.info/v1/variant/chr4:g.16006637_16006638insA?assembly=hg38",
        "id": "chr4:g.16006637_16006638insA"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/543698823",
        "rs": 543698823
      }
    ],
    "gnomAD_2": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/4-16008260-T-TA?dataset=gnomad_r2_1",
        "id": "4-16008260-T-TA",
        "variant": "4:16008260 T / TA"
      }
    ],
    "gnomAD_3": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/4-16006637-T-TA?dataset=gnomad_r3",
        "id": "4-16006637-T-TA",
        "variant": "4:16006637 T / TA"
      }
    ],
    "gnomAD_4": [
      {
        "@id": "http://gnomad.broadinstitute.org/variant/4-16006637-T-TA?dataset=gnomad_r4",
        "id": "4-16006637-T-TA",
        "variant": "4:16006637 T / TA"
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "A",
          "end": 16006643,
          "referenceAllele": "",
          "start": 16006643
        }
      ],
      "hgvs": [
        "NC_000004.12:g.16006643dup",
        "CM000666.2:g.16006643dup"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000052"
    },
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "A",
          "end": 16008266,
          "referenceAllele": "",
          "start": 16008266
        }
      ],
      "hgvs": [
        "NC_000004.11:g.16008266dup",
        "CM000666.1:g.16008266dup"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000028"
    },
    {
      "chromosome": "4",
      "coordinates": [
        {
          "allele": "A",
          "end": 15617364,
          "referenceAllele": "",
          "start": 15617364
        }
      ],
      "hgvs": [
        "NC_000004.10:g.15617364dup"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000004"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 82363,
          "referenceAllele": "",
          "start": 82363
        }
      ],
      "hgvs": [
        "NG_011696.1:g.82363dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS001905"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 82422,
          "referenceAllele": "",
          "start": 82422
        }
      ],
      "hgvs": [
        "NG_011696.2:g.82422dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS706103"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1612,
          "referenceAllele": "",
          "start": 1612
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000447510.7:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000415481.2:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000415481.2:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS756130",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000447510.7:c.1354dup"
          },
          "RefSeq": {
            "hgvs": "NM_006017.3:c.1354dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000415481.2:p.Tyr452LeufsTer13"
          },
          "RefSeq": {
            "hgvs": "NP_006008.1:p.Tyr452LeufsTer13"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1523,
          "referenceAllele": "",
          "start": 1523
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000513946.2:c.*1037dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000424738.2:n.*1037dup"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS758341"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1740,
          "referenceAllele": "",
          "start": 1740
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000539194.6:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000443620.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000443620.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS759588"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1327,
          "referenceAllele": "",
          "start": 1327
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000540805.6:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000438045.2:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "ENSP00000438045.2:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS759647"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1354,
          "referenceAllele": "",
          "start": 1354
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000675377.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000502545.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000502545.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS775207"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1327,
          "referenceAllele": "",
          "start": 1327
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000675613.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000501741.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "ENSP00000501741.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS775406"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000447510.6:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000415481.2:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000415481.2:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS299274"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1940,
          "referenceAllele": "",
          "start": 1940
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000505450.5:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426090.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "ENSP00000426090.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS337238"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1607,
          "referenceAllele": "",
          "start": 1607
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000508167.5:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000427346.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "ENSP00000427346.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS339259"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1603,
          "referenceAllele": "",
          "start": 1603
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000510224.5:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000426809.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000426809.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS340795"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1412,
          "referenceAllele": "",
          "start": 1412
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000511153.5:c.1412dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS341486"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000539194.5:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000443620.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000443620.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS361722"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "ENST00000540805.5:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000438045.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "ENSP00000438045.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS362601"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1846,
          "referenceAllele": "",
          "start": 1846
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145847.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139319.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139319.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013785"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1562,
          "referenceAllele": "",
          "start": 1562
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145848.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139320.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139320.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013786"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145849.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139321.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "NP_001139321.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013787"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145850.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139322.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "NP_001139322.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013788"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1539,
          "referenceAllele": "",
          "start": 1539
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145851.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139323.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139323.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013789"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1539,
          "referenceAllele": "",
          "start": 1539
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145852.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139324.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139324.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS013790"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_006017.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_006008.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "NP_006008.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS031062"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1662,
          "referenceAllele": "",
          "start": 1662
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_005248195.3:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_005248252.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_005248252.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS058345"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1662,
          "referenceAllele": "",
          "start": 1662
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_005248196.3:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_005248253.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_005248253.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS058346"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1135,
          "referenceAllele": "",
          "start": 1135
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_006713974.2:c.1120dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_006714037.1:p.Tyr374LeufsTer13",
        "hgvsWellDefined": "XP_006714037.1:p.[Tyr374_Tyr375del;Gly377del;Leu379_Cys380delinsPro;Val382_Ala389delinsLeu;Pro391_Thr393delinsValTrp;Gly395_Cys396del;Ser398_Val403delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS070439"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513890.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512192.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512192.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081121"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1939,
          "referenceAllele": "",
          "start": 1939
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513891.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512193.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512193.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081122"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1663,
          "referenceAllele": "",
          "start": 1663
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513892.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512194.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512194.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081123"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1873,
          "referenceAllele": "",
          "start": 1873
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513893.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512195.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512195.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081124"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1964,
          "referenceAllele": "",
          "start": 1964
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513894.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512196.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512196.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081125"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2074,
          "referenceAllele": "",
          "start": 2074
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513895.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512197.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512197.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081126"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1703,
          "referenceAllele": "",
          "start": 1703
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513896.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512198.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512198.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081127"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1896,
          "referenceAllele": "",
          "start": 1896
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513897.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512199.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512199.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081128"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513898.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512200.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512200.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081129"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1662,
          "referenceAllele": "",
          "start": 1662
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513899.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512201.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_011512201.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081130"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513900.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512202.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512202.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081131"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513901.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512203.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512203.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081132"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513902.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512204.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512204.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081133"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1162,
          "referenceAllele": "",
          "start": 1162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513903.1:c.1147dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512205.1:p.Tyr383LeufsTer13",
        "hgvsWellDefined": "XP_011512205.1:p.[Tyr383_Tyr384del;Gly386del;Leu388_Cys389delinsPro;Val391_Ala398delinsLeu;Pro400_Thr402delinsValTrp;Gly404_Cys405del;Ser407_Val412delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081134"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1096,
          "referenceAllele": "",
          "start": 1096
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513904.1:c.1081dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512206.1:p.Tyr361LeufsTer13",
        "hgvsWellDefined": "XP_011512206.1:p.[Tyr361_Tyr362del;Gly364del;Leu366_Cys367delinsPro;Val369_Ala376delinsLeu;Pro378_Thr380delinsValTrp;Gly382_Cys383del;Ser385_Val390delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS081135"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1598,
          "referenceAllele": "",
          "start": 1598
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_005248195.5:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_005248252.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_005248252.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533016"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1598,
          "referenceAllele": "",
          "start": 1598
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_005248196.5:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_005248253.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_005248253.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS533017"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1167,
          "referenceAllele": "",
          "start": 1167
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_006713974.3:c.1120dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_006714037.1:p.Tyr374LeufsTer13",
        "hgvsWellDefined": "XP_006714037.1:p.[Tyr374_Tyr375del;Gly377del;Leu379_Cys380delinsPro;Val382_Ala389delinsLeu;Pro391_Thr393delinsValTrp;Gly395_Cys396del;Ser398_Val403delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS538623"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1799,
          "referenceAllele": "",
          "start": 1799
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513892.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512194.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512194.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543078"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1873,
          "referenceAllele": "",
          "start": 1873
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513893.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512195.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512195.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543079"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1800,
          "referenceAllele": "",
          "start": 1800
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513894.3:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512196.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512196.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543080"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 2074,
          "referenceAllele": "",
          "start": 2074
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513895.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512197.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512197.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543081"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1703,
          "referenceAllele": "",
          "start": 1703
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513896.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512198.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512198.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543082"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1891,
          "referenceAllele": "",
          "start": 1891
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513897.3:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512199.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512199.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543083"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513900.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512202.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512202.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543084"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513902.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512204.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_011512204.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543085"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1197,
          "referenceAllele": "",
          "start": 1197
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_011513903.2:c.1147dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011512205.1:p.Tyr383LeufsTer13",
        "hgvsWellDefined": "XP_011512205.1:p.[Tyr383_Tyr384del;Gly386del;Leu388_Cys389delinsPro;Val391_Ala398delinsLeu;Pro400_Thr402delinsValTrp;Gly404_Cys405del;Ser407_Val412delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS543086"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1692,
          "referenceAllele": "",
          "start": 1692
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_017008799.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016864288.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_016864288.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS563249"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1648,
          "referenceAllele": "",
          "start": 1648
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_017008800.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016864289.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_016864289.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS563250"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1740,
          "referenceAllele": "",
          "start": 1740
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_017008802.1:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016864291.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "XP_016864291.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS563251"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1637,
          "referenceAllele": "",
          "start": 1637
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_017008803.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016864292.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_016864292.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS563252"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1707,
          "referenceAllele": "",
          "start": 1707
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_017008804.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016864293.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_016864293.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS563253"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1580,
          "referenceAllele": "",
          "start": 1580
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_017008805.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016864294.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "XP_016864294.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS563254"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1542,
          "referenceAllele": "",
          "start": 1542
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "XM_024454276.1:c.1081dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_024310044.1:p.Tyr361LeufsTer13",
        "hgvsWellDefined": "XP_024310044.1:p.[Tyr361_Tyr362del;Gly364del;Leu366_Cys367delinsPro;Val369_Ala376delinsLeu;Pro378_Thr380delinsValTrp;Gly382_Cys383del;Ser385_Val390delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS587644"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1604,
          "referenceAllele": "",
          "start": 1604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145847.2:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139319.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139319.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677946"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1585,
          "referenceAllele": "",
          "start": 1585
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145848.2:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139320.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139320.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677947"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1566,
          "referenceAllele": "",
          "start": 1566
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145849.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139321.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "NP_001139321.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677948"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1603,
          "referenceAllele": "",
          "start": 1603
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145850.2:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139322.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "NP_001139322.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677949"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1539,
          "referenceAllele": "",
          "start": 1539
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145851.2:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139323.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139323.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677950"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1604,
          "referenceAllele": "",
          "start": 1604
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001145852.2:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001139324.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001139324.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677951"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1576,
          "referenceAllele": "",
          "start": 1576
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001371406.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001358335.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001358335.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS692886"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1644,
          "referenceAllele": "",
          "start": 1644
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001371407.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001358336.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001358336.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS692887"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1576,
          "referenceAllele": "",
          "start": 1576
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_001371408.1:c.1327dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001358337.1:p.Tyr443LeufsTer13",
        "hgvsWellDefined": "NP_001358337.1:p.[Tyr443_Tyr444del;Gly446del;Leu448_Cys449delinsPro;Val451_Ala458delinsLeu;Pro460_Thr462delinsValTrp;Gly464_Cys465del;Ser467_Val472delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS692888"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1612,
          "referenceAllele": "",
          "start": 1612
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009454",
      "geneNCBI_id": 8842,
      "geneSymbol": "PROM1",
      "hgvs": [
        "NM_006017.3:c.1354dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_006008.1:p.Tyr452LeufsTer13",
        "hgvsWellDefined": "NP_006008.1:p.[Tyr452_Tyr453del;Gly455del;Leu457_Cys458delinsPro;Val460_Ala467delinsLeu;Pro469_Thr471delinsValTrp;Gly473_Cys474del;Ser476_Val481delinsArgLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS696586",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000447510.7:c.1354dup"
          },
          "RefSeq": {
            "hgvs": "NM_006017.3:c.1354dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000415481.2:p.Tyr452LeufsTer13"
          },
          "RefSeq": {
            "hgvs": "NP_006008.1:p.Tyr452LeufsTer13"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}