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        "hgvs": "NP_001129601.1:p.Val576CysfsTer?",
        "hgvsWellDefined": "NP_001129601.1:p.[Val576_Met591delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys593_Tyr597delinsGlyAspAlaGluGluGlu;Ser599delinsValHis;His602_Val605delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677401"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 2100,
          "referenceAllele": "",
          "start": 2100
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136130.3:c.1950_1951insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129602.1:p.Val651CysfsTer?",
        "hgvsWellDefined": "NP_001129602.1:p.[Val651_Met666delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys668_Tyr672delinsGlyAspAlaGluGluGlu;Ser674delinsValHis;His677_Val680delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677402"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 2214,
          "referenceAllele": "",
          "start": 2214
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204301.2:c.2064_2065insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191230.1:p.Val689CysfsTer?",
        "hgvsWellDefined": "NP_001191230.1:p.[Val689_Met704delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys706_Tyr710delinsGlyAspAlaGluGluGlu;Ser712delinsValHis;His715_Val718delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679828"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 2157,
          "referenceAllele": "",
          "start": 2157
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204302.2:c.2007_2008insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191231.1:p.Val670CysfsTer?",
        "hgvsWellDefined": "NP_001191231.1:p.[Val670_Met685delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys687_Tyr691delinsGlyAspAlaGluGluGlu;Ser693delinsValHis;His696_Val699delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679829"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 1989,
          "referenceAllele": "",
          "start": 1989
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204303.2:c.1839_1840insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191232.1:p.Val614CysfsTer?",
        "hgvsWellDefined": "NP_001191232.1:p.[Val614_Met629delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys631_Tyr635delinsGlyAspAlaGluGluGlu;Ser637delinsValHis;His640_Val643delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679830"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 2211,
          "referenceAllele": "",
          "start": 2211
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201413.3:c.2061_2062insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_958816.1:p.Val688CysfsTer?",
        "hgvsWellDefined": "NP_958816.1:p.[Val688_Met703delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys705_Tyr709delinsGlyAspAlaGluGluGlu;Ser711delinsValHis;His714_Val717delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701541"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 2043,
          "referenceAllele": "",
          "start": 2043
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201414.3:c.1893_1894insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_958817.1:p.Val632CysfsTer?",
        "hgvsWellDefined": "NP_958817.1:p.[Val632_Met647delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys649_Tyr653delinsGlyAspAlaGluGluGlu;Ser655delinsValHis;His658_Val661delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701542"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 1980,
          "referenceAllele": "",
          "start": 1980
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136131.3:c.1788_1789insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129603.1:p.Val597CysfsTer?",
        "hgvsWellDefined": "NP_001129603.1:p.[Val597_Met612delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys614_Tyr618delinsGlyAspAlaGluGluGlu;Ser620delinsValHis;His623_Val626delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712494"
    },
    {
      "coordinates": [
        {
          "allele": "TGTTGGGTGT",
          "end": 2100,
          "referenceAllele": "",
          "start": 2100
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001385253.1:c.1950_1951insTGTTGGGTGT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372182.1:p.Val651CysfsTer?",
        "hgvsWellDefined": "NP_001372182.1:p.[Val651_Met666delinsCysTrpValCysGlyArgCysCysHisSerAspSerAspArgHisHis;Lys668_Tyr672delinsGlyAspAlaGluGluGlu;Ser674delinsValHis;His677_Val680delinsSerSerTrpCysGly]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723592"
    }
  ],
  "type": "nucleotide"
}