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      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204302.2:c.2009_2010insTT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191231.1:p.Gly671TrpfsTer6",
        "hgvsWellDefined": "NP_001191231.1:p.[Gly671_Ile675delinsTrp;Thr677del;Ile679_Thr682del;Val684_Thr692del;Ile694_Val699del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679829"
    },
    {
      "coordinates": [
        {
          "allele": "TT",
          "end": 1991,
          "referenceAllele": "",
          "start": 1991
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204303.2:c.1841_1842insTT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191232.1:p.Gly615TrpfsTer6",
        "hgvsWellDefined": "NP_001191232.1:p.[Gly615_Ile619delinsTrp;Thr621del;Ile623_Thr626del;Val628_Thr636del;Ile638_Val643del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679830"
    },
    {
      "coordinates": [
        {
          "allele": "TT",
          "end": 2213,
          "referenceAllele": "",
          "start": 2213
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201413.3:c.2063_2064insTT"
      ],
      "proteinEffect": {
        "hgvs": "NP_958816.1:p.Gly689TrpfsTer6",
        "hgvsWellDefined": "NP_958816.1:p.[Gly689_Ile693delinsTrp;Thr695del;Ile697_Thr700del;Val702_Thr710del;Ile712_Val717del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701541"
    },
    {
      "coordinates": [
        {
          "allele": "TT",
          "end": 2045,
          "referenceAllele": "",
          "start": 2045
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201414.3:c.1895_1896insTT"
      ],
      "proteinEffect": {
        "hgvs": "NP_958817.1:p.Gly633TrpfsTer6",
        "hgvsWellDefined": "NP_958817.1:p.[Gly633_Ile637delinsTrp;Thr639del;Ile641_Thr644del;Val646_Thr654del;Ile656_Val661del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701542"
    },
    {
      "coordinates": [
        {
          "allele": "TT",
          "end": 1982,
          "referenceAllele": "",
          "start": 1982
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136131.3:c.1790_1791insTT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129603.1:p.Gly598TrpfsTer6",
        "hgvsWellDefined": "NP_001129603.1:p.[Gly598_Ile602delinsTrp;Thr604del;Ile606_Thr609del;Val611_Thr619del;Ile621_Val626del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712494"
    },
    {
      "coordinates": [
        {
          "allele": "TT",
          "end": 2102,
          "referenceAllele": "",
          "start": 2102
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001385253.1:c.1952_1953insTT"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372182.1:p.Gly652TrpfsTer6",
        "hgvsWellDefined": "NP_001372182.1:p.[Gly652_Ile656delinsTrp;Thr658del;Ile660_Thr663del;Val665_Thr673del;Ile675_Val680del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723592"
    }
  ],
  "type": "nucleotide"
}