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        "hgvsWellDefined": "NP_001304114.1:p.Arg82_Asp366delinsThrIlePhePheCysGluArgAsnProLysProGlnValIleAsnIleIleAspAlaAspLeuProProAsnThrSerProPheThrAlaGluLeuThrHisGlyAlaSerAlaAsnTrpThrIleGlnTyrAsnAspProThrGlnGluSerIleIleLeuLysProLysMetAlaLeuGluValGlyAspTyrLysIleAsnLeuLysLeuMetAspAsnGlnAsnLysAspGlnValThrThrLeuGluValSerValCysAspCysGluGlyAlaAlaGlyValCysArgLysAlaGlnProValGluAlaGlyLeuGlnIleProAlaIleLeuGlyIleLeuGlyGlyIleLeuAlaLeuLeuIleLeuIleLeuLeuLeuLeuLeuPheLeuArgArgArgAlaValValLysGluProLeuLeuProProGluAspAspThrArgAspAsnValTyrTyrTyrAspGluGluGlyGlyGlyGluGluAspGlnAspPheAspLeuSerGlnLeuHisArgGlyLeuAspAlaArgProGluValThrArgAsnAspValAlaProThrLeuMetSerValProArgTyrLeuProArgProAlaAsnProAspGluIleGlyAsnPheIleAspGluAsnLeuLysAlaAlaAspThrAspProThrAlaProProTyrAspSerLeuLeuValPheAspTyrGluGlySerGlySerGluAlaAlaSerLeuSerSerLeuAsnSerSerGluSerAspLysAspGlnAspTyrAspTyrLeuAsnGluTrpGlyAsnArgPheLysLysLeuAlaAspMetTyrGlyGlyGlyGluAspAspTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS512454"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1772,
          "referenceAllele": "C",
          "start": 1771
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001748",
      "geneNCBI_id": 999,
      "geneSymbol": "CDH1",
      "hgvs": [
        "NM_001317186.1:c.-174C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001304115.1:n.-174C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS512455"
    },
    {
      "@id": "http://reg.genome.network/allele/PA281002",
      "coordinates": [
        {
          "allele": "T",
          "end": 1918,
          "referenceAllele": "C",
          "start": 1917
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001748",
      "geneNCBI_id": 999,
      "geneSymbol": "CDH1",
      "hgvs": [
        "NM_004360.4:c.1792C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_004351.1:p.Arg598Ter",
        "hgvsWellDefined": "NP_004351.1:p.Arg598_Asp882delinsThrIlePhePheCysGluArgAsnProLysProGlnValIleAsnIleIleAspAlaAspLeuProProAsnThrSerProPheThrAlaGluLeuThrHisGlyAlaSerAlaAsnTrpThrIleGlnTyrAsnAspProThrGlnGluSerIleIleLeuLysProLysMetAlaLeuGluValGlyAspTyrLysIleAsnLeuLysLeuMetAspAsnGlnAsnLysAspGlnValThrThrLeuGluValSerValCysAspCysGluGlyAlaAlaGlyValCysArgLysAlaGlnProValGluAlaGlyLeuGlnIleProAlaIleLeuGlyIleLeuGlyGlyIleLeuAlaLeuLeuIleLeuIleLeuLeuLeuLeuLeuPheLeuArgArgArgAlaValValLysGluProLeuLeuProProGluAspAspThrArgAspAsnValTyrTyrTyrAspGluGluGlyGlyGlyGluGluAspGlnAspPheAspLeuSerGlnLeuHisArgGlyLeuAspAlaArgProGluValThrArgAsnAspValAlaProThrLeuMetSerValProArgTyrLeuProArgProAlaAsnProAspGluIleGlyAsnPheIleAspGluAsnLeuLysAlaAlaAspThrAspProThrAlaProProTyrAspSerLeuLeuValPheAspTyrGluGlySerGlySerGluAlaAlaSerLeuSerSerLeuAsnSerSerGluSerAspLysAspGlnAspTyrAspTyrLeuAsnGluTrpGlyAsnArgPheLysLysLeuAlaAspMetTyrGlyGlyGlyGluAspAspTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS525201"
    },
    {
      "@id": "http://reg.genome.network/allele/PA281002",
      "coordinates": [
        {
          "allele": "T",
          "end": 1916,
          "referenceAllele": "C",
          "start": 1915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001748",
      "geneNCBI_id": 999,
      "geneSymbol": "CDH1",
      "hgvs": [
        "NM_004360.5:c.1792C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_004351.1:p.Arg598Ter",
        "hgvsWellDefined": "NP_004351.1:p.Arg598_Asp882delinsThrIlePhePheCysGluArgAsnProLysProGlnValIleAsnIleIleAspAlaAspLeuProProAsnThrSerProPheThrAlaGluLeuThrHisGlyAlaSerAlaAsnTrpThrIleGlnTyrAsnAspProThrGlnGluSerIleIleLeuLysProLysMetAlaLeuGluValGlyAspTyrLysIleAsnLeuLysLeuMetAspAsnGlnAsnLysAspGlnValThrThrLeuGluValSerValCysAspCysGluGlyAlaAlaGlyValCysArgLysAlaGlnProValGluAlaGlyLeuGlnIleProAlaIleLeuGlyIleLeuGlyGlyIleLeuAlaLeuLeuIleLeuIleLeuLeuLeuLeuLeuPheLeuArgArgArgAlaValValLysGluProLeuLeuProProGluAspAspThrArgAspAsnValTyrTyrTyrAspGluGluGlyGlyGlyGluGluAspGlnAspPheAspLeuSerGlnLeuHisArgGlyLeuAspAlaArgProGluValThrArgAsnAspValAlaProThrLeuMetSerValProArgTyrLeuProArgProAlaAsnProAspGluIleGlyAsnPheIleAspGluAsnLeuLysAlaAlaAspThrAspProThrAlaProProTyrAspSerLeuLeuValPheAspTyrGluGlySerGlySerGluAlaAlaSerLeuSerSerLeuAsnSerSerGluSerAspLysAspGlnAspTyrAspTyrLeuAsnGluTrpGlyAsnArgPheLysLysLeuAlaAspMetTyrGlyGlyGlyGluAspAspTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS666445",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000261769.10:c.1792C>T"
          },
          "RefSeq": {
            "hgvs": "NM_004360.5:c.1792C>T"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000261769.4:p.Arg598Ter"
          },
          "RefSeq": {
            "hgvs": "NP_004351.1:p.Arg598Ter"
          }
        }
      }
    },
    {
      "@id": "http://reg.genome.network/allele/PA2826962085",
      "coordinates": [
        {
          "allele": "T",
          "end": 1733,
          "referenceAllele": "C",
          "start": 1732
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001748",
      "geneNCBI_id": 999,
      "geneSymbol": "CDH1",
      "hgvs": [
        "NM_001317184.2:c.1609C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001304113.1:p.Arg537Ter",
        "hgvsWellDefined": "NP_001304113.1:p.Arg537_Asp821delinsThrIlePhePheCysGluArgAsnProLysProGlnValIleAsnIleIleAspAlaAspLeuProProAsnThrSerProPheThrAlaGluLeuThrHisGlyAlaSerAlaAsnTrpThrIleGlnTyrAsnAspProThrGlnGluSerIleIleLeuLysProLysMetAlaLeuGluValGlyAspTyrLysIleAsnLeuLysLeuMetAspAsnGlnAsnLysAspGlnValThrThrLeuGluValSerValCysAspCysGluGlyAlaAlaGlyValCysArgLysAlaGlnProValGluAlaGlyLeuGlnIleProAlaIleLeuGlyIleLeuGlyGlyIleLeuAlaLeuLeuIleLeuIleLeuLeuLeuLeuLeuPheLeuArgArgArgAlaValValLysGluProLeuLeuProProGluAspAspThrArgAspAsnValTyrTyrTyrAspGluGluGlyGlyGlyGluGluAspGlnAspPheAspLeuSerGlnLeuHisArgGlyLeuAspAlaArgProGluValThrArgAsnAspValAlaProThrLeuMetSerValProArgTyrLeuProArgProAlaAsnProAspGluIleGlyAsnPheIleAspGluAsnLeuLysAlaAlaAspThrAspProThrAlaProProTyrAspSerLeuLeuValPheAspTyrGluGlySerGlySerGluAlaAlaSerLeuSerSerLeuAsnSerSerGluSerAspLysAspGlnAspTyrAspTyrLeuAsnGluTrpGlyAsnArgPheLysLysLeuAlaAspMetTyrGlyGlyGlyGluAspAspTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684261"
    },
    {
      "@id": "http://reg.genome.network/allele/PA916022015",
      "coordinates": [
        {
          "allele": "T",
          "end": 1983,
          "referenceAllele": "C",
          "start": 1982
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001748",
      "geneNCBI_id": 999,
      "geneSymbol": "CDH1",
      "hgvs": [
        "NM_001317185.2:c.244C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001304114.1:p.Arg82Ter",
        "hgvsWellDefined": "NP_001304114.1:p.Arg82_Asp366delinsThrIlePhePheCysGluArgAsnProLysProGlnValIleAsnIleIleAspAlaAspLeuProProAsnThrSerProPheThrAlaGluLeuThrHisGlyAlaSerAlaAsnTrpThrIleGlnTyrAsnAspProThrGlnGluSerIleIleLeuLysProLysMetAlaLeuGluValGlyAspTyrLysIleAsnLeuLysLeuMetAspAsnGlnAsnLysAspGlnValThrThrLeuGluValSerValCysAspCysGluGlyAlaAlaGlyValCysArgLysAlaGlnProValGluAlaGlyLeuGlnIleProAlaIleLeuGlyIleLeuGlyGlyIleLeuAlaLeuLeuIleLeuIleLeuLeuLeuLeuLeuPheLeuArgArgArgAlaValValLysGluProLeuLeuProProGluAspAspThrArgAspAsnValTyrTyrTyrAspGluGluGlyGlyGlyGluGluAspGlnAspPheAspLeuSerGlnLeuHisArgGlyLeuAspAlaArgProGluValThrArgAsnAspValAlaProThrLeuMetSerValProArgTyrLeuProArgProAlaAsnProAspGluIleGlyAsnPheIleAspGluAsnLeuLysAlaAlaAspThrAspProThrAlaProProTyrAspSerLeuLeuValPheAspTyrGluGlySerGlySerGluAlaAlaSerLeuSerSerLeuAsnSerSerGluSerAspLysAspGlnAspTyrAspTyrLeuAsnGluTrpGlyAsnArgPheLysLysLeuAlaAspMetTyrGlyGlyGlyGluAspAspTer"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684262"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1770,
          "referenceAllele": "C",
          "start": 1769
        }
      ],
      "gene": "http://reg.genome.network/gene/GN001748",
      "geneNCBI_id": 999,
      "geneSymbol": "CDH1",
      "hgvs": [
        "NM_001317186.2:c.-174C>T"
      ],
      "proteinEffect": {
        "hgvs": "NP_001304115.1:n.-174C>T"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS684263"
    }
  ],
  "type": "nucleotide"
}