{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2779761118",
  "communityStandardTitle": [
    "NM_000025.3(ADRB3):c.884_887dup (p.Ile297SerfsTer?)"
  ],
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      "chromosome": "8",
      "coordinates": [
        {
          "allele": "AGAC",
          "end": 37965586,
          "referenceAllele": "",
          "start": 37965586
        }
      ],
      "hgvs": [
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        "CM000670.2:g.37965583_37965586dup"
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      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000056"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "AGAC",
          "end": 37823104,
          "referenceAllele": "",
          "start": 37823104
        }
      ],
      "hgvs": [
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        "CM000670.1:g.37823101_37823104dup"
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      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000032"
    },
    {
      "chromosome": "8",
      "coordinates": [
        {
          "allele": "AGAC",
          "end": 37942261,
          "referenceAllele": "",
          "start": 37942261
        }
      ],
      "hgvs": [
        "NC_000008.9:g.37942258_37942261dup"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000008"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 6084,
          "referenceAllele": "",
          "start": 6084
        }
      ],
      "hgvs": [
        "NG_011936.1:g.6081_6084dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS002062"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 1017,
          "referenceAllele": "",
          "start": 1017
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.5:c.884_887dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Ile297SerfsTer?",
        "hgvsWellDefined": "ENSP00000343782.3:p.[Ile297_Thr302delinsSerHisHisGlyHis;Cys304_Trp305delinsHisSer;Pro307_Phe309delinsLeuValAla;Ala311_Leu314delinsLeuSerGlyGln;Leu317delinsAlaArgPro;Ser321_Val323delinsLeuSerSer;Pro326dup]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS748270",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
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          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.884_887dup"
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          "RefSeq": {
            "hgvs": "NM_000025.3:c.884_887dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Ile297SerfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Ile297SerfsTer?"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 1015,
          "referenceAllele": "",
          "start": 1015
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.2:n.1012_1015dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS758684"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
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          "referenceAllele": "",
          "start": 371
        }
      ],
      "hgvs": [
        "ENST00000647937.1:c.368_371dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000497740.1:p.Ile125SerfsTer?",
        "hgvsWellDefined": "ENSP00000497740.1:p.[Ile125_Thr130delinsSerHisHisGlyHis;Cys132_Trp133delinsHisSer;Pro135_Phe137delinsLeuValAla;Ala139_Leu142delinsLeuSerGlyGln;Leu145delinsAlaArgPro;Ser149_Val151delinsLeuSerSer;Pro154dup]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS769701"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 1383,
          "referenceAllele": "",
          "start": 1383
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000345060.4:c.884_887dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000343782.3:p.Ile297SerfsTer?",
        "hgvsWellDefined": "ENSP00000343782.3:p.[Ile297_Thr302delinsSerHisHisGlyHis;Cys304_Trp305delinsHisSer;Pro307_Phe309delinsLeuValAla;Ala311_Leu314delinsLeuSerGlyGln;Leu317delinsAlaArgPro;Ser321_Val323delinsLeuSerSer;Pro326dup]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS262124"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 162,
          "referenceAllele": "",
          "start": 162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000520341.1:n.159_162dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS347406"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 1084,
          "referenceAllele": "",
          "start": 1084
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "ENST00000614635.1:c.884_887dup"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480325.1:p.Ile297SerfsTer?",
        "hgvsWellDefined": "ENSP00000480325.1:p.[Ile297_Thr302delinsSerHisHisGlyHis;Cys304_Trp305delinsHisSer;Pro307_Phe309delinsLeuValAla;Ala311_Leu314delinsLeuSerGlyGln;Leu317delinsAlaArgPro;Ser321_Val323delinsLeuSerSer;Pro326dup]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS402283"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 1084,
          "referenceAllele": "",
          "start": 1084
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.2:c.884_887dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Ile297SerfsTer?",
        "hgvsWellDefined": "NP_000016.1:p.[Ile297_Thr302delinsSerHisHisGlyHis;Cys304_Trp305delinsHisSer;Pro307_Phe309delinsLeuValAla;Ala311_Leu314delinsLeuSerGlyGln;Leu317delinsAlaArgPro;Ser321_Val323delinsLeuSerSer;Pro326dup]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006090"
    },
    {
      "coordinates": [
        {
          "allele": "GTCT",
          "end": 1017,
          "referenceAllele": "",
          "start": 1017
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000288",
      "geneNCBI_id": 155,
      "geneSymbol": "ADRB3",
      "hgvs": [
        "NM_000025.3:c.884_887dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000016.1:p.Ile297SerfsTer?",
        "hgvsWellDefined": "NP_000016.1:p.[Ile297_Thr302delinsSerHisHisGlyHis;Cys304_Trp305delinsHisSer;Pro307_Phe309delinsLeuValAla;Ala311_Leu314delinsLeuSerGlyGln;Leu317delinsAlaArgPro;Ser321_Val323delinsLeuSerSer;Pro326dup]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662288",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000345060.5:c.884_887dup"
          },
          "RefSeq": {
            "hgvs": "NM_000025.3:c.884_887dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000343782.3:p.Ile297SerfsTer?"
          },
          "RefSeq": {
            "hgvs": "NP_000016.1:p.Ile297SerfsTer?"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}