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      ],
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      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545947.2:c.2988dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544249.1:p.Ala997CysfsTer16",
        "hgvsWellDefined": "XP_011544249.1:p.[Ala997_Asn1005delinsCysArgArgTrpArgArg;Phe1007_Met1009delinsArgLys;Pro1011_Thr1014del;Leu1016_Phe1018delinsPheAsp;Glu1020_Glu1026delinsPro]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556316"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3274,
          "referenceAllele": "",
          "start": 3274
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545948.2:c.2097dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544250.1:p.Ala700CysfsTer16",
        "hgvsWellDefined": "XP_011544250.1:p.[Ala700_Asn708delinsCysArgArgTrpArgArg;Phe710_Met712delinsArgLys;Pro714_Thr717del;Leu719_Phe721delinsPheAsp;Glu723_Glu729delinsPro]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556317"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3952,
          "referenceAllele": "",
          "start": 3952
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023671.1:c.2988dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879160.1:p.Ala997CysfsTer16",
        "hgvsWellDefined": "XP_016879160.1:p.[Ala997_Asn1005delinsCysArgArgTrpArgArg;Phe1007_Met1009delinsArgLys;Pro1011_Thr1014del;Leu1016_Phe1018delinsPheAsp;Glu1020_Glu1026delinsPro]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574393"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3162,
          "referenceAllele": "",
          "start": 3162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023672.2:c.2982dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879161.1:p.Ala995CysfsTer16",
        "hgvsWellDefined": "XP_016879161.1:p.[Ala995_Asn1003delinsCysArgArgTrpArgArg;Phe1005_Met1007delinsArgLys;Pro1009_Thr1012del;Leu1014_Phe1016delinsPheAsp;Glu1018_Glu1024delinsPro]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574394"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3162,
          "referenceAllele": "",
          "start": 3162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023673.2:c.2982dup"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879162.1:p.Ala995CysfsTer16",
        "hgvsWellDefined": "XP_016879162.1:p.[Ala995_Asn1003delinsCysArgArgTrpArgArg;Phe1005_Met1007delinsArgLys;Pro1009_Thr1012del;Leu1014_Phe1016delinsPheAsp;Glu1018_Glu1024delinsPro]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574395"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 3135,
          "referenceAllele": "",
          "start": 3135
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "NM_024675.4:c.2982dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_078951.2:p.Ala995CysfsTer16",
        "hgvsWellDefined": "NP_078951.2:p.[Ala995_Asn1003delinsCysArgArgTrpArgArg;Phe1005_Met1007delinsArgLys;Pro1009_Thr1012del;Leu1014_Phe1016delinsPheAsp;Glu1018_Glu1024delinsPro]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS698739",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000261584.9:c.2982dup"
          },
          "RefSeq": {
            "hgvs": "NM_024675.4:c.2982dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000261584.4:p.Ala995CysfsTer16"
          },
          "RefSeq": {
            "hgvs": "NP_078951.2:p.Ala995CysfsTer16"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}