{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA269539",
  "communityStandardTitle": [
    "NM_024675.4(PALB2):c.2521del (p.Thr841GlnfsTer10)"
  ],
  "externalRecords": {
    "ClinVarAlleles": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/?term=132169[alleleid]",
        "alleleId": 132169,
        "preferredName": "NM_024675.4(PALB2):c.2521del (p.Thr841fs)"
      }
    ],
    "ClinVarVariations": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/clinvar/variation/126659",
        "RCV": [
          "RCV001030318",
          "RCV003500504"
        ],
        "variationId": 126659
      }
    ],
    "MyVariantInfo_hg19": [
      {
        "@id": "http://myvariant.info/v1/variant/chr16:g.23640590del?assembly=hg19",
        "id": "chr16:g.23640590del"
      }
    ],
    "MyVariantInfo_hg38": [
      {
        "@id": "http://myvariant.info/v1/variant/chr16:g.23629269del?assembly=hg38",
        "id": "chr16:g.23629269del"
      }
    ],
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/180177116",
        "rs": 180177116
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "16",
      "coordinates": [
        {
          "allele": "",
          "end": 23629271,
          "referenceAllele": "T",
          "start": 23629270
        }
      ],
      "hgvs": [
        "NC_000016.10:g.23629271del",
        "CM000678.2:g.23629271del"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000064"
    },
    {
      "chromosome": "16",
      "coordinates": [
        {
          "allele": "",
          "end": 23640592,
          "referenceAllele": "T",
          "start": 23640591
        }
      ],
      "hgvs": [
        "NC_000016.9:g.23640592del",
        "CM000678.1:g.23640592del"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000040"
    },
    {
      "chromosome": "16",
      "coordinates": [
        {
          "allele": "",
          "end": 23548093,
          "referenceAllele": "T",
          "start": 23548092
        }
      ],
      "hgvs": [
        "NC_000016.8:g.23548093del"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000016"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 17089,
          "referenceAllele": "A",
          "start": 17088
        }
      ],
      "hgvs": [
        "NG_007406.1:g.17089del",
        "LRG_308:g.17089del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000571"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3526,
          "referenceAllele": "A",
          "start": 3525
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000561514.3:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000460666.3:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "ENSP00000460666.3:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914287"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 292,
          "referenceAllele": "A",
          "start": 291
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000565038.2:c.*2del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000459882.2:n.*2del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914301"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2660,
          "referenceAllele": "A",
          "start": 2659
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000566069.6:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000459237.2:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "ENSP00000459237.2:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914305"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2920,
          "referenceAllele": "A",
          "start": 2919
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697377.2:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513286.2:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513286.2:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Gln869del;Val871_Pro872delinsAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914472"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2826,
          "referenceAllele": "A",
          "start": 2825
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697379.2:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513287.2:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513287.2:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS914473"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3526,
          "referenceAllele": "A",
          "start": 3525
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000561514.2:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000460666.2:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000460666.2:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS905930"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3044,
          "referenceAllele": "A",
          "start": 3043
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697374.1:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513284.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513284.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908744"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3868,
          "referenceAllele": "A",
          "start": 3867
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697375.1:n.3868del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS908745"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2823,
          "referenceAllele": "A",
          "start": 2822
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697376.1:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513285.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513285.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908746"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2920,
          "referenceAllele": "A",
          "start": 2919
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697377.1:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513286.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513286.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Gln572del;Val574_Pro575delinsAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908747"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3041,
          "referenceAllele": "A",
          "start": 3040
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697378.1:n.3041del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS908748"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2826,
          "referenceAllele": "A",
          "start": 2825
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697379.1:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513287.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513287.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908749"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1813,
          "referenceAllele": "A",
          "start": 1812
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697380.1:n.1813del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS908750"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 1216,
          "referenceAllele": "A",
          "start": 1215
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697381.1:n.1216del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS908751"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3549,
          "referenceAllele": "A",
          "start": 3548
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697382.1:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513288.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513288.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908752"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 219,
          "referenceAllele": "A",
          "start": 218
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697383.1:c.55del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000513289.1:p.Thr19GlnfsTer10",
        "hgvsWellDefined": "ENSP00000513289.1:p.[Thr19_Ala24delinsGlnGln;Asp26_Asn32delinsPhe;Gln34del;Val36_Glu38del;Lys40_Val48delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS908753"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2675,
          "referenceAllele": "A",
          "start": 2674
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000697384.1:n.2675del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS908754"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2674,
          "referenceAllele": "A",
          "start": 2673
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000261584.9:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000261584.4:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "ENSP00000261584.4:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS742164",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000261584.9:c.2521del"
          },
          "RefSeq": {
            "hgvs": "NM_024675.4:c.2521del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000261584.4:p.Thr841GlnfsTer10"
          },
          "RefSeq": {
            "hgvs": "NP_078951.2:p.Thr841GlnfsTer10"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2674,
          "referenceAllele": "A",
          "start": 2673
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000261584.8:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000261584.4:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "ENSP00000261584.4:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS250784"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 93,
          "referenceAllele": "A",
          "start": 92
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000565038.1:c.93del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS378503"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2632,
          "referenceAllele": "A",
          "start": 2631
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "ENST00000568219.5:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000454703.2:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "ENSP00000454703.2:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS380628"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2721,
          "referenceAllele": "A",
          "start": 2720
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "NM_024675.3:c.2521del",
        "LRG_308t1:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "NP_078951.2:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "NP_078951.2:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS037924"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3316,
          "referenceAllele": "A",
          "start": 3315
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545946.1:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544248.1:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "XP_011544248.1:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS112826"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3317,
          "referenceAllele": "A",
          "start": 3316
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545947.1:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544249.1:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "XP_011544249.1:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS112827"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2777,
          "referenceAllele": "A",
          "start": 2776
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545948.1:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544250.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "XP_011544250.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS112828"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3317,
          "referenceAllele": "A",
          "start": 3316
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XR_950851.1:n.3317del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS143781"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3526,
          "referenceAllele": "A",
          "start": 3525
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545946.2:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544248.1:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "XP_011544248.1:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556315"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3491,
          "referenceAllele": "A",
          "start": 3490
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545947.2:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544249.1:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "XP_011544249.1:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556316"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2813,
          "referenceAllele": "A",
          "start": 2812
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_011545948.2:c.1636del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011544250.1:p.Thr546GlnfsTer10",
        "hgvsWellDefined": "XP_011544250.1:p.[Thr546_Ala551delinsGlnGln;Asp553_Asn559delinsPhe;Gln561del;Val563_Glu565del;Lys567_Val575delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS556317"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 3491,
          "referenceAllele": "A",
          "start": 3490
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023671.1:c.2527del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879160.1:p.Thr843GlnfsTer10",
        "hgvsWellDefined": "XP_016879160.1:p.[Thr843_Ala848delinsGlnGln;Asp850_Asn856delinsPhe;Gln858del;Val860_Glu862del;Lys864_Val872delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574393"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2701,
          "referenceAllele": "A",
          "start": 2700
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023672.2:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879161.1:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "XP_016879161.1:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574394"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2701,
          "referenceAllele": "A",
          "start": 2700
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "XM_017023673.2:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016879162.1:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "XP_016879162.1:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS574395"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 2674,
          "referenceAllele": "A",
          "start": 2673
        }
      ],
      "gene": "http://reg.genome.network/gene/GN026144",
      "geneNCBI_id": 79728,
      "geneSymbol": "PALB2",
      "hgvs": [
        "NM_024675.4:c.2521del"
      ],
      "proteinEffect": {
        "hgvs": "NP_078951.2:p.Thr841GlnfsTer10",
        "hgvsWellDefined": "NP_078951.2:p.[Thr841_Ala846delinsGlnGln;Asp848_Asn854delinsPhe;Gln856del;Val858_Glu860del;Lys862_Val870delinsIleAla]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS698739",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000261584.9:c.2521del"
          },
          "RefSeq": {
            "hgvs": "NM_024675.4:c.2521del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000261584.4:p.Thr841GlnfsTer10"
          },
          "RefSeq": {
            "hgvs": "NP_078951.2:p.Thr841GlnfsTer10"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}