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      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204301.2:c.2065_2069dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191230.1:p.Gly691TrpfsTer6",
        "hgvsWellDefined": "NP_001191230.1:p.[Gly691_Ile694delinsTrp;Thr696del;Ile698_Thr701del;Val703_Thr711del;Ile713_Glu719del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679828"
    },
    {
      "coordinates": [
        {
          "allele": "TGGGG",
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          "referenceAllele": "",
          "start": 2162
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
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      "hgvs": [
        "NM_001204302.2:c.2008_2012dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191231.1:p.Gly672TrpfsTer6",
        "hgvsWellDefined": "NP_001191231.1:p.[Gly672_Ile675delinsTrp;Thr677del;Ile679_Thr682del;Val684_Thr692del;Ile694_Glu700del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679829"
    },
    {
      "coordinates": [
        {
          "allele": "TGGGG",
          "end": 1994,
          "referenceAllele": "",
          "start": 1994
        }
      ],
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      "hgvs": [
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      ],
      "proteinEffect": {
        "hgvs": "NP_001191232.1:p.Gly616TrpfsTer6",
        "hgvsWellDefined": "NP_001191232.1:p.[Gly616_Ile619delinsTrp;Thr621del;Ile623_Thr626del;Val628_Thr636del;Ile638_Glu644del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679830"
    },
    {
      "coordinates": [
        {
          "allele": "TGGGG",
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          "referenceAllele": "",
          "start": 2216
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      ],
      "gene": "http://reg.genome.network/gene/GN000620",
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      "hgvs": [
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      "proteinEffect": {
        "hgvs": "NP_958816.1:p.Gly690TrpfsTer6",
        "hgvsWellDefined": "NP_958816.1:p.[Gly690_Ile693delinsTrp;Thr695del;Ile697_Thr700del;Val702_Thr710del;Ile712_Glu718del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701541"
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    {
      "coordinates": [
        {
          "allele": "TGGGG",
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          "referenceAllele": "",
          "start": 2048
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      ],
      "gene": "http://reg.genome.network/gene/GN000620",
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      "geneSymbol": "APP",
      "hgvs": [
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      ],
      "proteinEffect": {
        "hgvs": "NP_958817.1:p.Gly634TrpfsTer6",
        "hgvsWellDefined": "NP_958817.1:p.[Gly634_Ile637delinsTrp;Thr639del;Ile641_Thr644del;Val646_Thr654del;Ile656_Glu662del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701542"
    },
    {
      "coordinates": [
        {
          "allele": "TGGGG",
          "end": 1985,
          "referenceAllele": "",
          "start": 1985
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      ],
      "gene": "http://reg.genome.network/gene/GN000620",
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      "hgvs": [
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      "proteinEffect": {
        "hgvs": "NP_001129603.1:p.Gly599TrpfsTer6",
        "hgvsWellDefined": "NP_001129603.1:p.[Gly599_Ile602delinsTrp;Thr604del;Ile606_Thr609del;Val611_Thr619del;Ile621_Glu627del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712494"
    },
    {
      "coordinates": [
        {
          "allele": "TGGGG",
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      ],
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      "hgvs": [
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      ],
      "proteinEffect": {
        "hgvs": "NP_001372182.1:p.Gly653TrpfsTer6",
        "hgvsWellDefined": "NP_001372182.1:p.[Gly653_Ile656delinsTrp;Thr658del;Ile660_Thr663del;Val665_Thr673del;Ile675_Glu681del]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723592"
    }
  ],
  "type": "nucleotide"
}