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      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139423"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 757,
          "referenceAllele": "GA",
          "start": 755
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.756_757del"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 889,
          "referenceAllele": "GA",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.44_45del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Arg15IlefsTer28",
        "hgvsWellDefined": "NP_000305.3:p.[Arg15_Asp22delinsIleSerArgGlyTrpIleArgLeuArg;Thr26del;Ile28_Met35delinsLeuSerLysHisTyrCysTyr;Phe37_Glu40delinsIleSerCys;Leu42_Val45delinsLysThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 889,
          "referenceAllele": "GA",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.563_564del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Arg188IlefsTer28",
        "hgvsWellDefined": "NP_001291646.4:p.[Arg188_Asp195delinsIleSerArgGlyTrpIleArgLeuArg;Thr199del;Ile201_Met208delinsLeuSerLysHisTyrCysTyr;Phe210_Glu213delinsIleSerCys;Leu215_Val218delinsLysThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 889,
          "referenceAllele": "GA",
          "start": 887
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.-662_-661del"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:n.-662_-661del"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 890,
          "referenceAllele": "GA",
          "start": 888
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.44_45del"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Arg15IlefsTer28",
        "hgvsWellDefined": "NP_000305.3:p.[Arg15_Asp22delinsIleSerArgGlyTrpIleArgLeuArg;Thr26del;Ile28_Met35delinsLeuSerLysHisTyrCysTyr;Phe37_Glu40delinsIleSerCys;Leu42_Val45delinsLysThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.44_45del"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.44_45del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Arg15IlefsTer28"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Arg15IlefsTer28"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}