{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2580598892",
  "communityStandardTitle": [
    "NM_000770.3(CYP2C8):c.1291+106G>C"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/1934951",
        "rs": 1934951
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 95038791,
          "referenceAllele": "C",
          "start": 95038790
        }
      ],
      "hgvs": [
        "NC_000010.11:g.95038791C>G",
        "CM000672.2:g.95038791C>G"
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000058"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 96798548,
          "referenceAllele": "C",
          "start": 96798547
        }
      ],
      "hgvs": [
        "NC_000010.10:g.96798548C>G",
        "CM000672.1:g.96798548C>G"
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000034"
    },
    {
      "chromosome": "10",
      "coordinates": [
        {
          "allele": "G",
          "end": 96788538,
          "referenceAllele": "C",
          "start": 96788537
        }
      ],
      "hgvs": [
        "NC_000010.9:g.96788538C>G"
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000010"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 35707,
          "referenceAllele": "G",
          "start": 35706
        }
      ],
      "hgvs": [
        "NG_007972.1:g.35707G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000740"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1386,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1386,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000371270.6:c.1291+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000360317.3:n.1291+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS750761",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371270.6:c.1291+106G>C"
          },
          "RefSeq": {
            "hgvs": "NM_000770.3:c.1291+106G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000360317.3:n.1291+106G>C"
          },
          "RefSeq": {
            "hgvs": "NP_000761.3:n.1291+106G>C"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1386,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1386,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000371270.5:c.1291+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000360317.3:n.1291+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS268510"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1424,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1424,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000490994.6:c.*1077+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000433314.1:n.*1077+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS328698"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1261,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1261,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000525991.5:c.*866+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000433842.1:n.*866+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS351923"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1546,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1546,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000526814.5:n.1546+106G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS352616"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1331,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1331,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000527420.5:c.*148+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000433191.1:n.*148+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS353129"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1585,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1585,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000527953.5:n.1585+106G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS353566"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 479,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 479,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000531714.1:n.479+106G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS356762"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1525,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1525,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000533320.5:n.1525+106G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS358113"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1261,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1261,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000535898.5:c.985+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000445062.1:n.985+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS359981"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1486,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1486,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000539050.5:c.1081+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000442343.2:n.1081+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS361650"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1424,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1424,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "ENST00000623108.3:c.1081+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000485110.1:n.1081+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS405996"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1386,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1386,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "NM_000770.3:c.1291+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_000761.3:n.1291+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006800",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371270.6:c.1291+106G>C"
          },
          "RefSeq": {
            "hgvs": "NM_000770.3:c.1291+106G>C"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000360317.3:n.1291+106G>C"
          },
          "RefSeq": {
            "hgvs": "NP_000761.3:n.1291+106G>C"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1424,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1424,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "NM_001198853.1:c.1081+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001185782.1:n.1081+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS016886"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1261,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1261,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "NM_001198854.1:c.985+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001185783.1:n.985+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS016887"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1486,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1486,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "NM_001198855.1:c.1081+106G>C"
      ],
      "proteinEffect": {
        "hgvs": "NP_001185784.1:n.1081+106G>C"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS016888"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 1426,
          "endIntronDirection": "+",
          "endIntronOffset": 106,
          "referenceAllele": "G",
          "start": 1426,
          "startIntronDirection": "+",
          "startIntronOffset": 105
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002622",
      "geneNCBI_id": 1558,
      "geneSymbol": "CYP2C8",
      "hgvs": [
        "XR_945610.1:n.1426+106G>C"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139358"
    }
  ],
  "type": "nucleotide"
}