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      "referenceSequence": "http://reg.genome.network/refseq/RS139422"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 752,
          "referenceAllele": "",
          "start": 752
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945790.1:n.752dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139423"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 752,
          "referenceAllele": "",
          "start": 752
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "XR_945791.1:n.752dup"
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS139424"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 884,
          "referenceAllele": "",
          "start": 884
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.7:c.40dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Arg14LysfsTer30",
        "hgvsWellDefined": "NP_000305.3:p.[Arg14_Asp22delinsLysGluIleSerArgGlyTrpIleArg;Asp24Arg;Thr26_Met35delinsAspLeuTyrLeuSerLysHisTyrCysTyr;Phe37_Glu40delinsIleSerCys;Leu42_Glu43delinsLysThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662397"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 884,
          "referenceAllele": "",
          "start": 884
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304717.5:c.559dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291646.4:p.Arg187LysfsTer30",
        "hgvsWellDefined": "NP_001291646.4:p.[Arg187_Asp195delinsLysGluIleSerArgGlyTrpIleArg;Asp197Arg;Thr199_Met208delinsAspLeuTyrLeuSerLysHisTyrCysTyr;Phe210_Glu213delinsIleSerCys;Leu215_Glu216delinsLysThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664314"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 884,
          "referenceAllele": "",
          "start": 884
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_001304718.2:c.-666dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001291647.1:n.-666dup"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS664315"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 885,
          "referenceAllele": "",
          "start": 885
        }
      ],
      "gene": "http://reg.genome.network/gene/GN009588",
      "geneNCBI_id": 5728,
      "geneSymbol": "PTEN",
      "hgvs": [
        "NM_000314.8:c.40dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_000305.3:p.Arg14LysfsTer30",
        "hgvsWellDefined": "NP_000305.3:p.[Arg14_Asp22delinsLysGluIleSerArgGlyTrpIleArg;Asp24Arg;Thr26_Met35delinsAspLeuTyrLeuSerLysHisTyrCysTyr;Phe37_Glu40delinsIleSerCys;Leu42_Glu43delinsLysThr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS674788",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000371953.8:c.40dup"
          },
          "RefSeq": {
            "hgvs": "NM_000314.8:c.40dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000361021.3:p.Arg14LysfsTer30"
          },
          "RefSeq": {
            "hgvs": "NP_000305.3:p.Arg14LysfsTer30"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}