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      "gene": "http://reg.genome.network/gene/GN011233",
      "geneNCBI_id": 6683,
      "geneSymbol": "SPAST",
      "hgvs": [
        "NM_001377959.1:c.453dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001364888.1:p.Gly152ArgfsTer3",
        "hgvsWellDefined": "NP_001364888.1:p.[Gly152_Glu172del;Ala174_Met181delinsTyr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS721340"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 729,
          "referenceAllele": "",
          "start": 729
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011233",
      "geneNCBI_id": 6683,
      "geneSymbol": "SPAST",
      "hgvs": [
        "NM_014946.4:c.453dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_055761.2:p.Gly152ArgfsTer3",
        "hgvsWellDefined": "NP_055761.2:p.[Gly152_Glu172del;Ala174_Met181delinsTyr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS728018",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000315285.9:c.453dup"
          },
          "RefSeq": {
            "hgvs": "NM_014946.4:c.453dup"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000320885.3:p.Gly152ArgfsTer3"
          },
          "RefSeq": {
            "hgvs": "NP_055761.2:p.Gly152ArgfsTer3"
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 729,
          "referenceAllele": "",
          "start": 729
        }
      ],
      "gene": "http://reg.genome.network/gene/GN011233",
      "geneNCBI_id": 6683,
      "geneSymbol": "SPAST",
      "hgvs": [
        "NM_199436.2:c.453dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_955468.1:p.Gly152ArgfsTer3",
        "hgvsWellDefined": "NP_955468.1:p.[Gly152_Glu172del;Ala174_Met181delinsTyr]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS729993"
    }
  ],
  "type": "nucleotide"
}