{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2398264231",
  "communityStandardTitle": [
    "NM_000675.6(ADORA2A):c.333-1820A="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/9624472",
        "rs": 9624472
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "A",
          "end": 24438763,
          "referenceAllele": "A",
          "start": 24438762
        }
      ],
      "hgvs": [
        "NC_000022.11:g.24438763A=",
        "CM000684.2:g.24438763A="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000070"
    },
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "A",
          "end": 24834731,
          "referenceAllele": "A",
          "start": 24834730
        }
      ],
      "hgvs": [
        "NC_000022.10:g.24834731A=",
        "CM000684.1:g.24834731A="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000046"
    },
    {
      "chromosome": "22",
      "coordinates": [
        {
          "allele": "A",
          "end": 23164731,
          "referenceAllele": "A",
          "start": 23164730
        }
      ],
      "hgvs": [
        "NC_000022.9:g.23164731A="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000022"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 20167,
          "referenceAllele": "A",
          "start": 20166
        }
      ],
      "hgvs": [
        "NG_052804.1:g.20167A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS617176"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 754,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 754,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "ENST00000337539.12:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000336630.6:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS747669",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000337539.12:c.333-1820A="
          },
          "RefSeq": {
            "hgvs": "NM_000675.6:c.333-1820A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000336630.6:n.333-1820A="
          },
          "RefSeq": {
            "hgvs": "NP_000666.2:n.333-1820A="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 791,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 791,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "ENST00000337539.11:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000336630.6:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260491"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 4430,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 4430,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN049185",
      "geneNCBI_id": 101730217,
      "geneSymbol": "SPECC1L-ADORA2A",
      "hgvs": [
        "ENST00000358654.2:c.*1468-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000351480.2:n.*1468-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS264528"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 754,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 754,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "ENST00000444262.6:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000414802.2:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS297724"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 100,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 100,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "ENST00000496497.1:n.101-1820A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS332945"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 962,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 962,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN049185",
      "geneNCBI_id": 101730217,
      "geneSymbol": "SPECC1L-ADORA2A",
      "hgvs": [
        "ENST00000610595.4:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000480012.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400492"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 638,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 638,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN049185",
      "geneNCBI_id": 101730217,
      "geneSymbol": "SPECC1L-ADORA2A",
      "hgvs": [
        "ENST00000611543.4:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000483102.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS400890"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 856,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 856,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN049185",
      "geneNCBI_id": 101730217,
      "geneSymbol": "SPECC1L-ADORA2A",
      "hgvs": [
        "ENST00000618076.3:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000481552.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS403774"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 791,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 791,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_000675.5:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_000666.2:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006715"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 962,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 962,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278497.1:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265426.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS021327"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 856,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 856,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278498.1:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265427.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS021328"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 771,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 771,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278499.1:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265428.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS021329"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 638,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 638,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278500.1:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265429.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS021330"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 1544,
          "endIntronDirection": "-",
          "endIntronOffset": 4,
          "referenceAllele": "T",
          "start": 1544,
          "startIntronDirection": "-",
          "startIntronOffset": 5
        }
      ],
      "gene": "http://reg.genome.network/gene/GN037122",
      "geneNCBI_id": 646023,
      "geneSymbol": "ADORA2A-AS1",
      "hgvs": [
        "NR_028483.2:n.1545-5T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS048087"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 833,
          "endIntronDirection": "+",
          "endIntronOffset": 3229,
          "referenceAllele": "T",
          "start": 833,
          "startIntronDirection": "+",
          "startIntronOffset": 3228
        }
      ],
      "gene": "http://reg.genome.network/gene/GN037122",
      "geneNCBI_id": 646023,
      "geneSymbol": "ADORA2A-AS1",
      "hgvs": [
        "NR_028484.2:n.833+3229T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS048088"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 185,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 185,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NR_103543.1:n.186-1820A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS052957"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 165,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 165,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NR_103544.1:n.166-1820A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS052958"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 4511,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 4511,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN049185",
      "geneNCBI_id": 101730217,
      "geneSymbol": "SPECC1L-ADORA2A",
      "hgvs": [
        "NR_103546.1:n.4512-1820A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS052960"
    },
    {
      "coordinates": [
        {
          "allele": "T",
          "end": 833,
          "endIntronDirection": "+",
          "endIntronOffset": 3229,
          "referenceAllele": "T",
          "start": 833,
          "startIntronDirection": "+",
          "startIntronOffset": 3228
        }
      ],
      "gene": "http://reg.genome.network/gene/GN037122",
      "geneNCBI_id": 646023,
      "geneSymbol": "ADORA2A-AS1",
      "hgvs": [
        "NR_028484.3:n.833+3229T="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS527215"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 754,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 754,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_000675.6:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_000666.2:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS662528",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000337539.12:c.333-1820A="
          },
          "RefSeq": {
            "hgvs": "NM_000675.6:c.333-1820A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000336630.6:n.333-1820A="
          },
          "RefSeq": {
            "hgvs": "NP_000666.2:n.333-1820A="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 734,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 734,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278499.2:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265428.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS681498"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 148,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 148,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NR_103543.2:n.149-1820A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS702867"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 128,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 128,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NR_103544.2:n.129-1820A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS702868"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 833,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 833,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278497.2:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265426.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715565"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 727,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 727,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278498.2:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265427.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715566"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 638,
          "endIntronDirection": "-",
          "endIntronOffset": 1819,
          "referenceAllele": "A",
          "start": 638,
          "startIntronDirection": "-",
          "startIntronOffset": 1820
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000263",
      "geneNCBI_id": 135,
      "geneSymbol": "ADORA2A",
      "hgvs": [
        "NM_001278500.2:c.333-1820A="
      ],
      "proteinEffect": {
        "hgvs": "NP_001265429.1:n.333-1820A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS715567"
    }
  ],
  "type": "nucleotide"
}