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        "hgvsWellDefined": "NP_001129601.1:p.[Gly603Val;Val605_Thr612delinsTrpTrpArgLeuThrProLeuSer;Glu614_Asn628delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr631_Lys632delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677401"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2182,
          "referenceAllele": "",
          "start": 2182
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136130.3:c.2031_2032dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129602.1:p.Gly678ValfsTer?",
        "hgvsWellDefined": "NP_001129602.1:p.[Gly678Val;Val680_Thr687delinsTrpTrpArgLeuThrProLeuSer;Glu689_Asn703delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr706_Lys707delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS677402"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2296,
          "referenceAllele": "",
          "start": 2296
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204301.2:c.2145_2146dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191230.1:p.Gly716ValfsTer?",
        "hgvsWellDefined": "NP_001191230.1:p.[Gly716Val;Val718_Thr725delinsTrpTrpArgLeuThrProLeuSer;Glu727_Asn741delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr744_Lys745delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679828"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2239,
          "referenceAllele": "",
          "start": 2239
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204302.2:c.2088_2089dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191231.1:p.Gly697ValfsTer?",
        "hgvsWellDefined": "NP_001191231.1:p.[Gly697Val;Val699_Thr706delinsTrpTrpArgLeuThrProLeuSer;Glu708_Asn722delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr725_Lys726delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679829"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2071,
          "referenceAllele": "",
          "start": 2071
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001204303.2:c.1920_1921dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001191232.1:p.Gly641ValfsTer?",
        "hgvsWellDefined": "NP_001191232.1:p.[Gly641Val;Val643_Thr650delinsTrpTrpArgLeuThrProLeuSer;Glu652_Asn666delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr669_Lys670delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS679830"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2293,
          "referenceAllele": "",
          "start": 2293
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201413.3:c.2142_2143dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_958816.1:p.Gly715ValfsTer?",
        "hgvsWellDefined": "NP_958816.1:p.[Gly715Val;Val717_Thr724delinsTrpTrpArgLeuThrProLeuSer;Glu726_Asn740delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr743_Lys744delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701541"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2125,
          "referenceAllele": "",
          "start": 2125
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_201414.3:c.1974_1975dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_958817.1:p.Gly659ValfsTer?",
        "hgvsWellDefined": "NP_958817.1:p.[Gly659Val;Val661_Thr668delinsTrpTrpArgLeuThrProLeuSer;Glu670_Asn684delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr687_Lys688delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS701542"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2062,
          "referenceAllele": "",
          "start": 2062
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001136131.3:c.1869_1870dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001129603.1:p.Gly624ValfsTer?",
        "hgvsWellDefined": "NP_001129603.1:p.[Gly624Val;Val626_Thr633delinsTrpTrpArgLeuThrProLeuSer;Glu635_Asn649delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr652_Lys653delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS712494"
    },
    {
      "coordinates": [
        {
          "allele": "TG",
          "end": 2182,
          "referenceAllele": "",
          "start": 2182
        }
      ],
      "gene": "http://reg.genome.network/gene/GN000620",
      "geneNCBI_id": 351,
      "geneSymbol": "APP",
      "hgvs": [
        "NM_001385253.1:c.2031_2032dup"
      ],
      "proteinEffect": {
        "hgvs": "NP_001372182.1:p.Gly678ValfsTer?",
        "hgvsWellDefined": "NP_001372182.1:p.[Gly678Val;Val680_Thr687delinsTrpTrpArgLeuThrProLeuSer;Glu689_Asn703delinsGlnArgSerAlaThrCysProArgCysSerArgThrAlaThrLysIleGln;Tyr706_Lys707delinsSer]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS723592"
    }
  ],
  "type": "nucleotide"
}