{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2336256106",
  "communityStandardTitle": [
    "NM_000767.5(CYP2B6):c.415A= (p.Lys139=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/12721655",
        "rs": 12721655
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "19",
      "coordinates": [
        {
          "allele": "A",
          "end": 41004377,
          "referenceAllele": "A",
          "start": 41004376
        }
      ],
      "hgvs": [
        "NC_000019.10:g.41004377A=",
        "CM000681.2:g.41004377A="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000067"
    },
    {
      "chromosome": "19",
      "coordinates": [
        {
          "allele": "A",
          "end": 41510282,
          "referenceAllele": "A",
          "start": 41510281
        }
      ],
      "hgvs": [
        "NC_000019.9:g.41510282A=",
        "CM000681.1:g.41510282A="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000043"
    },
    {
      "chromosome": "19",
      "coordinates": [
        {
          "allele": "A",
          "end": 46202122,
          "referenceAllele": "A",
          "start": 46202121
        }
      ],
      "hgvs": [
        "NC_000019.8:g.46202122A="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000019"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 18079,
          "referenceAllele": "A",
          "start": 18078
        }
      ],
      "hgvs": [
        "NG_007929.1:g.18079A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS000696"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 439,
          "referenceAllele": "A",
          "start": 438
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "ENST00000324071.10:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000324648.2:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS746603",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000324071.10:c.415A="
          },
          "RefSeq": {
            "hgvs": "NM_000767.5:c.415A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000324648.2:p.Lys139="
          },
          "RefSeq": {
            "hgvs": "NP_000758.1:p.Lys139="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 317,
          "referenceAllele": "A",
          "start": 316
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "ENST00000598834.2:c.317A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS761473"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 422,
          "referenceAllele": "A",
          "start": 421
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "ENST00000324071.8:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000324648.2:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS258295"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 299,
          "referenceAllele": "A",
          "start": 298
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "ENST00000593831.1:c.187A="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000470582.1:p.Lys63="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS394374"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 317,
          "referenceAllele": "A",
          "start": 316
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "ENST00000598834.1:n.317A="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS396579"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3085854827",
      "coordinates": [
        {
          "allele": "A",
          "end": 422,
          "referenceAllele": "A",
          "start": 421
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "NM_000767.4:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "NP_000758.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS006798"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 489,
          "referenceAllele": "A",
          "start": 488
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_005258569.3:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "XP_005258626.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS062106"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 490,
          "referenceAllele": "A",
          "start": 489
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_006723050.2:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "XP_006723113.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS074847"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 492,
          "referenceAllele": "A",
          "start": 491
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_011526546.1:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011524848.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS093648"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 490,
          "referenceAllele": "A",
          "start": 489
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_011526547.1:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011524849.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS093649"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 488,
          "referenceAllele": "A",
          "start": 487
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_011526548.1:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011524850.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS093650"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 20,
          "referenceAllele": "A",
          "start": 19
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_011526549.1:c.-145A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011524851.1:n.-145A="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS093651"
    },
    {
      "coordinates": [
        {
          "allele": "A",
          "end": 334,
          "referenceAllele": "A",
          "start": 333
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "XM_011526550.1:c.295A="
      ],
      "proteinEffect": {
        "hgvs": "XP_011524852.1:p.Lys99="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS093652"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3085854827",
      "coordinates": [
        {
          "allele": "A",
          "end": 439,
          "referenceAllele": "A",
          "start": 438
        }
      ],
      "gene": "http://reg.genome.network/gene/GN002615",
      "geneNCBI_id": 1555,
      "geneSymbol": "CYP2B6",
      "hgvs": [
        "NM_000767.5:c.415A="
      ],
      "proteinEffect": {
        "hgvs": "NP_000758.1:p.Lys139="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS510845",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000324071.10:c.415A="
          },
          "RefSeq": {
            "hgvs": "NM_000767.5:c.415A="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000324648.2:p.Lys139="
          },
          "RefSeq": {
            "hgvs": "NP_000758.1:p.Lys139="
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}