{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA2181295592",
  "communityStandardTitle": [
    "NM_134261.3(RORA):c.197-70915G="
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/340029",
        "rs": 340029
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "15",
      "coordinates": [
        {
          "allele": "C",
          "end": 60602766,
          "referenceAllele": "C",
          "start": 60602765
        }
      ],
      "hgvs": [
        "NC_000015.10:g.60602766C=",
        "CM000677.2:g.60602766C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000063"
    },
    {
      "chromosome": "15",
      "coordinates": [
        {
          "allele": "C",
          "end": 60894965,
          "referenceAllele": "C",
          "start": 60894964
        }
      ],
      "hgvs": [
        "NC_000015.9:g.60894965C=",
        "CM000677.1:g.60894965C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000039"
    },
    {
      "chromosome": "15",
      "coordinates": [
        {
          "allele": "C",
          "end": 58682257,
          "referenceAllele": "C",
          "start": 58682256
        }
      ],
      "hgvs": [
        "NC_000015.8:g.58682257C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000015"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 631538,
          "referenceAllele": "G",
          "start": 631537
        }
      ],
      "hgvs": [
        "NG_029246.1:g.631538G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS004341"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 280,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 280,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000335670.11:c.197-70915G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000335087.6:n.197-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS747514",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000335670.11:c.197-70915G="
          },
          "RefSeq": {
            "hgvs": "NM_134261.3:c.197-70915G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000335087.6:n.197-70915G="
          },
          "RefSeq": {
            "hgvs": "NP_599023.1:n.197-70915G="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 226,
          "endIntronDirection": "+",
          "endIntronOffset": 24472,
          "referenceAllele": "G",
          "start": 226,
          "startIntronDirection": "+",
          "startIntronOffset": 24471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000261523.9:c.137+24472G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000261523.5:n.137+24472G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS250773"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 341,
          "endIntronDirection": "+",
          "endIntronOffset": 12128,
          "referenceAllele": "G",
          "start": 341,
          "startIntronDirection": "+",
          "startIntronOffset": 12127
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000309157.8:c.271+12128G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000309753.3:n.271+12128G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS256163"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 297,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 297,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000335670.10:c.197-70915G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000335087.6:n.197-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS260170"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 193,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 193,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000551975.5:c.194-70915G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS368976"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 221,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 221,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000557822.5:n.222-70915G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS373335"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 151,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 151,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "ENST00000560004.5:n.152-70915G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS375023"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 427,
          "endIntronDirection": "+",
          "endIntronOffset": 12128,
          "referenceAllele": "G",
          "start": 427,
          "startIntronDirection": "+",
          "startIntronOffset": 12127
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "NM_002943.3:c.271+12128G="
      ],
      "proteinEffect": {
        "hgvs": "NP_002934.1:n.271+12128G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS028227"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 293,
          "endIntronDirection": "+",
          "endIntronOffset": 24472,
          "referenceAllele": "G",
          "start": 293,
          "startIntronDirection": "+",
          "startIntronOffset": 24471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "NM_134260.2:c.137+24472G="
      ],
      "proteinEffect": {
        "hgvs": "NP_599022.1:n.137+24472G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS040584"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 281,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 281,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "NM_134261.2:c.197-70915G="
      ],
      "proteinEffect": {
        "hgvs": "NP_599023.1:n.197-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS040585"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 499,
          "endIntronDirection": "+",
          "endIntronOffset": 1709,
          "referenceAllele": "C",
          "start": 499,
          "startIntronDirection": "+",
          "startIntronOffset": 1708
        }
      ],
      "gene": "http://reg.genome.network/gene/GN051410",
      "geneNCBI_id": 101928784,
      "geneSymbol": "RORA-AS1",
      "hgvs": [
        "NR_120341.1:n.499+1709C="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS055237"
    },
    {
      "coordinates": [
        {
          "allele": "C",
          "end": 567,
          "endIntronDirection": "+",
          "endIntronOffset": 1709,
          "referenceAllele": "C",
          "start": 567,
          "startIntronDirection": "+",
          "startIntronOffset": 1708
        }
      ],
      "gene": "http://reg.genome.network/gene/GN051410",
      "geneNCBI_id": 101928784,
      "geneSymbol": "RORA-AS1",
      "hgvs": [
        "NR_120342.1:n.567+1709C="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS055238"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 73,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 73,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_005254584.3:c.59-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005254641.1:n.59-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS060676"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 151,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 151,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_011521875.1:c.140-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011520177.1:n.140-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS089034"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 175,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 175,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_011521876.1:c.65-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011520178.1:n.65-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS089035"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 193,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 193,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_011521878.1:c.-215-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011520180.1:n.-215-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS089037"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4742,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 4742,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_005254584.5:c.59-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_005254641.1:n.59-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS534144"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 151,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 151,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_011521875.2:c.140-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011520177.1:n.140-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS546357"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 193,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 193,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_011521878.2:c.-215-70915G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011520180.1:n.-215-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS546359"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 4842,
          "endIntronDirection": "+",
          "endIntronOffset": 24472,
          "referenceAllele": "G",
          "start": 4842,
          "startIntronDirection": "+",
          "startIntronOffset": 24471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "XM_017022467.2:c.-216+24472G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016877956.1:n.-216+24472G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS573434"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 280,
          "endIntronDirection": "-",
          "endIntronOffset": 70914,
          "referenceAllele": "G",
          "start": 280,
          "startIntronDirection": "-",
          "startIntronOffset": 70915
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "NM_134261.3:c.197-70915G="
      ],
      "proteinEffect": {
        "hgvs": "NP_599023.1:n.197-70915G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS671851",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000335670.11:c.197-70915G="
          },
          "RefSeq": {
            "hgvs": "NM_134261.3:c.197-70915G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000335087.6:n.197-70915G="
          },
          "RefSeq": {
            "hgvs": "NP_599023.1:n.197-70915G="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 427,
          "endIntronDirection": "+",
          "endIntronOffset": 12128,
          "referenceAllele": "G",
          "start": 427,
          "startIntronDirection": "+",
          "startIntronOffset": 12127
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "NM_002943.4:c.271+12128G="
      ],
      "proteinEffect": {
        "hgvs": "NP_002934.1:n.271+12128G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS727337"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 293,
          "endIntronDirection": "+",
          "endIntronOffset": 24472,
          "referenceAllele": "G",
          "start": 293,
          "startIntronDirection": "+",
          "startIntronOffset": 24471
        }
      ],
      "gene": "http://reg.genome.network/gene/GN010258",
      "geneNCBI_id": 6095,
      "geneSymbol": "RORA",
      "hgvs": [
        "NM_134260.3:c.137+24472G="
      ],
      "proteinEffect": {
        "hgvs": "NP_599022.1:n.137+24472G="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS729123"
    }
  ],
  "type": "nucleotide"
}