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        "hgvsWellDefined": "XP_011523270.1:p.[Pro55_Arg66delinsArgArgArgLeuSerAlaThrSerThrProAla;Lys68_Ile72delinsArgAlaAlaArgLeu;Ala74_Val76delinsLeuTrp;His78_Ser81delinsAlaThrArg;Ile83_Asp85delinsLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS092087"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 794,
          "referenceAllele": "CCTG",
          "start": 790
        }
      ],
      "gene": "http://reg.genome.network/gene/GN030260",
      "geneNCBI_id": 55163,
      "geneSymbol": "PNPO",
      "hgvs": [
        "XM_005257500.3:c.208_211del"
      ],
      "proteinEffect": {
        "hgvs": "XP_005257557.1:p.Pro70ArgfsTer27",
        "hgvsWellDefined": "XP_005257557.1:p.[Pro70_Arg81delinsArgArgArgLeuSerAlaThrSerThrProAla;Lys83_Ile87delinsArgAlaAlaArgLeu;Ala89_Val91delinsLeuTrp;His93_Ser96delinsAlaThrArg;Ile98_Asp100delinsLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS534668"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 377,
          "referenceAllele": "CCTG",
          "start": 373
        }
      ],
      "gene": "http://reg.genome.network/gene/GN030260",
      "geneNCBI_id": 55163,
      "geneSymbol": "PNPO",
      "hgvs": [
        "XM_011524968.2:c.163_166del"
      ],
      "proteinEffect": {
        "hgvs": "XP_011523270.1:p.Pro55ArgfsTer27",
        "hgvsWellDefined": "XP_011523270.1:p.[Pro55_Arg66delinsArgArgArgLeuSerAlaThrSerThrProAla;Lys68_Ile72delinsArgAlaAlaArgLeu;Ala74_Val76delinsLeuTrp;His78_Ser81delinsAlaThrArg;Ile83_Asp85delinsLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS547679"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 392,
          "referenceAllele": "CCTG",
          "start": 388
        }
      ],
      "gene": "http://reg.genome.network/gene/GN030260",
      "geneNCBI_id": 55163,
      "geneSymbol": "PNPO",
      "hgvs": [
        "XM_017024813.1:c.208_211del"
      ],
      "proteinEffect": {
        "hgvs": "XP_016880302.1:p.Pro70ArgfsTer27",
        "hgvsWellDefined": "XP_016880302.1:p.[Pro70_Arg81delinsArgArgArgLeuSerAlaThrSerThrProAla;Lys83_Ile87delinsArgAlaAlaArgLeu;Ala89_Val91delinsLeuTrp;His93_Ser96delinsAlaThrArg;Ile98_Asp100delinsLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS575286"
    },
    {
      "coordinates": [
        {
          "allele": "",
          "end": 556,
          "referenceAllele": "CCTG",
          "start": 552
        }
      ],
      "gene": "http://reg.genome.network/gene/GN030260",
      "geneNCBI_id": 55163,
      "geneSymbol": "PNPO",
      "hgvs": [
        "NM_018129.4:c.448_451del"
      ],
      "proteinEffect": {
        "hgvs": "NP_060599.1:p.Pro150ArgfsTer27",
        "hgvsWellDefined": "NP_060599.1:p.[Pro150_Arg161delinsArgArgArgLeuSerAlaThrSerThrProAla;Lys163_Ile167delinsArgAlaAlaArgLeu;Ala169_Val171delinsLeuTrp;His173_Ser176delinsAlaThrArg;Ile178_Asp180delinsLeu]"
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS697964",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000642017.2:c.448_451del"
          },
          "RefSeq": {
            "hgvs": "NM_018129.4:c.448_451del"
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000493302.2:p.Pro150ArgfsTer27"
          },
          "RefSeq": {
            "hgvs": "NP_060599.1:p.Pro150ArgfsTer27"
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}