{
  "@context": "http://reg.genome.network/schema/allele.jsonld",
  "@id": "http://reg.genome.network/allele/CA1969144989",
  "communityStandardTitle": [
    "NM_002334.4(LRP4):c.1345G= (p.Asp449=)"
  ],
  "externalRecords": {
    "dbSNP": [
      {
        "@id": "http://www.ncbi.nlm.nih.gov/snp/267607224",
        "rs": 267607224
      }
    ]
  },
  "genomicAlleles": [
    {
      "chromosome": "11",
      "coordinates": [
        {
          "allele": "C",
          "end": 46894784,
          "referenceAllele": "C",
          "start": 46894783
        }
      ],
      "hgvs": [
        "NC_000011.10:g.46894784C=",
        "CM000673.2:g.46894784C="
      ],
      "referenceGenome": "GRCh38",
      "referenceSequence": "http://reg.genome.network/refseq/RS000059"
    },
    {
      "chromosome": "11",
      "coordinates": [
        {
          "allele": "C",
          "end": 46916335,
          "referenceAllele": "C",
          "start": 46916334
        }
      ],
      "hgvs": [
        "NC_000011.9:g.46916335C=",
        "CM000673.1:g.46916335C="
      ],
      "referenceGenome": "GRCh37",
      "referenceSequence": "http://reg.genome.network/refseq/RS000035"
    },
    {
      "chromosome": "11",
      "coordinates": [
        {
          "allele": "C",
          "end": 46872911,
          "referenceAllele": "C",
          "start": 46872910
        }
      ],
      "hgvs": [
        "NC_000011.8:g.46872911C="
      ],
      "referenceGenome": "NCBI36",
      "referenceSequence": "http://reg.genome.network/refseq/RS000011"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 28839,
          "referenceAllele": "G",
          "start": 28838
        }
      ],
      "hgvs": [
        "NG_021394.1:g.28839G="
      ],
      "referenceSequence": "http://reg.genome.network/refseq/RS003621"
    }
  ],
  "transcriptAlleles": [
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1516,
          "referenceAllele": "G",
          "start": 1515
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "ENST00000378623.6:c.1345G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000367888.1:p.Asp449="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS752113",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000378623.6:c.1345G="
          },
          "RefSeq": {
            "hgvs": "NM_002334.4:c.1345G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000367888.1:p.Asp449="
          },
          "RefSeq": {
            "hgvs": "NP_002325.2:p.Asp449="
          }
        }
      }
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1588,
          "referenceAllele": "G",
          "start": 1587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "ENST00000378623.5:c.1345G="
      ],
      "proteinEffect": {
        "hgvs": "ENSP00000367888.1:p.Asp449="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS272123"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3077798445",
      "coordinates": [
        {
          "allele": "G",
          "end": 1588,
          "referenceAllele": "G",
          "start": 1587
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "NM_002334.3:c.1345G="
      ],
      "proteinEffect": {
        "hgvs": "NP_002325.2:p.Asp449="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS027644"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1573,
          "referenceAllele": "G",
          "start": 1572
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "XM_011520102.1:c.1558G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011518404.1:p.Asp520="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS087271"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 646,
          "referenceAllele": "G",
          "start": 645
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "XM_011520103.1:c.541G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011518405.1:p.Asp181="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS087272"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 658,
          "referenceAllele": "G",
          "start": 657
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "XM_011520103.2:c.541G="
      ],
      "proteinEffect": {
        "hgvs": "XP_011518405.1:p.Asp181="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS545592"
    },
    {
      "coordinates": [
        {
          "allele": "G",
          "end": 1505,
          "referenceAllele": "G",
          "start": 1504
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "XM_017017734.1:c.1345G="
      ],
      "proteinEffect": {
        "hgvs": "XP_016873223.1:p.Asp449="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS569853"
    },
    {
      "@id": "http://reg.genome.network/allele/PA3077798445",
      "coordinates": [
        {
          "allele": "G",
          "end": 1516,
          "referenceAllele": "G",
          "start": 1515
        }
      ],
      "gene": "http://reg.genome.network/gene/GN006696",
      "geneNCBI_id": 4038,
      "geneSymbol": "LRP4",
      "hgvs": [
        "NM_002334.4:c.1345G="
      ],
      "proteinEffect": {
        "hgvs": "NP_002325.2:p.Asp449="
      },
      "referenceSequence": "http://reg.genome.network/refseq/RS665470",
      "MANE": {
        "maneVersion": "1.3",
        "maneStatus": "MANE Select",
        "nucleotide": {
          "Ensembl": {
            "hgvs": "ENST00000378623.6:c.1345G="
          },
          "RefSeq": {
            "hgvs": "NM_002334.4:c.1345G="
          }
        },
        "protein": {
          "Ensembl": {
            "hgvs": "ENSP00000367888.1:p.Asp449="
          },
          "RefSeq": {
            "hgvs": "NP_002325.2:p.Asp449="
          }
        }
      }
    }
  ],
  "type": "nucleotide"
}